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Isabelle Fournier

Professor Senior Member Institut Universitaire de France Vice President for Doctoral Research at University of Lille
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Présentation

Prof. Fournier is Distinguished Professor at University of Lille, and she holds a position as co-director of the PRISM Inserm U1192 Lab and as Vice President for Doctoral Research for the university. She is a bioanalytical chemist specialized in clinical mass spectrometry and proteomics. She started research working on fundamental of MALDI during her PhD at University Pierre & Marie Curie in Paris first and then, as a postdoctoral fellow within the group of Prof. Michael Karas in Frankfurt. In 2002, she established her own group at University of Lille where she started developing MALDI MS Imaging. She contributed to the field with several developments including strategies for imaging of FFPE tissues and proteins, and the development of tagged probes for specific imaging of mRNA and antigens. In 2009, she was hired as Full Professor and awarded a Junior position at Institut Universitaire de France. Since 2012, she got interested by the development of Spatially Resolved Proteomics in combination to MALDI MSI for applications in oncology. Over the past 5 years, she also worked on the development of in vivo MS for guided surgery and intraoperative analysis. She confounded the Imabiotech Company which provides services in MALDI MSI and recently CELEOS that will commercialize the SpiderMass technology. She was recently distinguished by the international distinguish award from MSACL and was awarded a senior position at Institut Universitaire de France in 2019.

Domaines de recherche

Chimie analytique Génomique, Transcriptomique et Protéomique [q-bio.GN] Imagerie

Compétences

mass spectrometry imaging proteomics spatial proteomics lipidomics health technology

Publications

"julienfranck59"
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Toward high spatially resolved proteomics using expansion microscopy

Lauranne Drelich , Soulaimane Aboulouard , Julien Franck , Michel Salzet , Isabelle Fournier
Analytical Chemistry, 2021, Analytical Chemistry, 93 (36), pp.12195-12203. ⟨10.1021/acs.analchem.0c05372⟩
Article dans une revue hal-04011475v1

A Hidden Human Proteome Signature Characterizes the Epithelial Mesenchymal Transition Program

Daniele Vergara , Tiziano Verri , Marina Damato , Marco Trerotola , Pasquale Simeone
Current Pharmaceutical Design, 2020, 26 (3), pp.372-375. ⟨10.2174/1381612826666200129091610⟩
Article dans une revue inserm-02941785v1
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Carbonic Anhydrase XII Expression Is Modulated during Epithelial Mesenchymal Transition and Regulated through Protein Kinase C Signaling

Daniele Vergara , Sara Ravaioli , Eugenio Fonzi , Loredaria Adamo , Marina Damato
International Journal of Molecular Sciences, 2020, 21 (3), pp.715. ⟨10.3390/ijms21030715⟩
Article dans une revue inserm-02941786v1
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Alternative proteins are functional regulators in cell reprogramming by PKA activation

Tristan Cardon , Julien Franck , Etienne Coyaud , Estelle Laurent , Marina Damato
Nucleic Acids Research, 2020, 48 (14), pp.7864-7882. ⟨10.1093/nar/gkaa277⟩
Article dans une revue inserm-02941812v1
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Nuclei of HeLa cells interactomes unravel a network of ghost proteins involved in proteins translation

Tristan Cardon , Michel Salzet , Julien Franck , Isabelle Fournier
Biochimica et Biophysica Acta (BBA) - General Subjects, 2019, 1863 (10), pp.1458-1470. ⟨10.1016/j.bbagen.2019.05.009⟩
Article dans une revue inserm-02941645v1
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The multiverse nature of epithelial to mesenchymal transition

Pasquale Simeone , Marco Trerotola , Julien Franck , Tristan Cardon , Marco Marchisio
Seminars in Cancer Biology, 2019, 58, pp.1-10. ⟨10.1016/j.semcancer.2018.11.004⟩
Article dans une revue inserm-02940760v1

Optimized Sample Preparation Workflow for Improved Identification of Ghost Proteins

Tristan Cardon , Flore Hervé , Vivian Delcourt , Xavier Roucou , Michel Salzet
Analytical Chemistry, 2019, 92 (1), pp.1122-1129. ⟨10.1021/acs.analchem.9b04188⟩
Article dans une revue inserm-02941813v1

A specific lipid metabolic profile is associated with the epithelial mesenchymal transition program

Anna Maria Giudetti , Stefania de Domenico , Andrea Ragusa , Paola Lunetti , Antonio Gaballo
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2019, 1864 (3), pp.344-357. ⟨10.1016/j.bbalip.2018.12.011⟩
Article dans une revue inserm-02941613v1
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Distinct Protein Expression Networks are Activated in Microglia Cells after Stimulation with IFN-γ and IL-4

Daniele Vergara , Annamaria Nigro , Alessandro Romano , Stefania de Domenico , Marina Damato
Cells, 2019, 8 (6), pp.580. ⟨10.3390/cells8060580⟩
Article dans une revue inserm-02941561v1
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Spatially-Resolved Top-down Proteomics Bridged to MALDI MS Imaging Reveals the Molecular Physiome of Brain Regions

Vivian Delcourt , Julien Franck , Jusal Quanico , Jean-Pascal Gimeno , Maxence Wisztorski
Molecular and Cellular Proteomics, 2018, 17 (2), pp.357-372. ⟨10.1074/mcp.M116.065755⟩
Article dans une revue inserm-02941492v1
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Proteomic expression profile of injured rat peripheral nerves revealed biological networks and processes associated with nerve regeneration

Daniele Vergara , Alessandro Romano , Eleonora Stanca , Velia La Pesa , Laura Aloisi
Journal of Cellular Physiology, 2018, 233 (8), pp.6207-6223. ⟨10.1002/jcp.26478⟩
Article dans une revue inserm-02940755v1
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β-Catenin Knockdown Affects Mitochondrial Biogenesis and Lipid Metabolism in Breast Cancer Cells

Daniele Vergara , Eleonora Stanca , Flora Guerra , Paola Priore , Antonio Gaballo
Frontiers in Physiology, 2017, 8, pp.544. ⟨10.3389/fphys.2017.00544⟩
Article dans une revue inserm-02940615v1
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NanoLC-MS coupling of liquid microjunction microextraction for on-tissue proteomic analysis

Jusal Quanico , Julien Franck , Tristan Cardon , Eric Leblanc , Maxence Wisztorski
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2017, 1865 (7), pp.891-900. ⟨10.1016/j.bbapap.2016.11.002⟩
Article dans une revue inserm-02940625v1

Integrated mass spectrometry imaging and omics workflows on the same tissue section using grid-aided, parafilm-assisted microdissection

Jusal Quanico , Julien Franck , Maxence Wisztorski , Michel Salzet , Isabelle Fournier
Biochimica et Biophysica Acta (BBA) - General Subjects, 2017, 1861 (7), pp.1702-1714. ⟨10.1016/j.bbagen.2017.03.006⟩
Article dans une revue inserm-02940635v1
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ATP Modifies the Proteome of Extracellular Vesicles Released by Microglia and Influences Their Action on Astrocytes

Francesco Drago , Marta Lombardi , Ilaria Prada , Martina Gabrielli , Pooja Joshi
Frontiers in Pharmacology, 2017, 8, pp.910. ⟨10.3389/fphar.2017.00910⟩
Article dans une revue inserm-02940650v1

Combined Mass Spectrometry Imaging and Top-down Microproteomics Reveals Evidence of a Hidden Proteome in Ovarian Cancer

Vivian Delcourt , Julien Franck , Eric Leblanc , Fabrice Narducci , Yves-Marie Robin
EBioMedicine, 2017, 21, pp.55-64. ⟨10.1016/j.ebiom.2017.06.001⟩
Article dans une revue inserm-02940659v1

On-tissue Direct Monitoring of Global Hydrogen/Deuterium Exchange by MALDI Mass Spectrometry: Tissue Deuterium Exchange Mass Spectrometry (TDXMS)

Jusal Quanico , Julien Franck , Michel Salzet , Isabelle Fournier
Molecular and Cellular Proteomics, 2016, 15 (10), pp.3321-3330. ⟨10.1074/mcp.O116.059832⟩
Article dans une revue hal-04449154v1
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Spatially-resolved protein surface microsampling from tissue sections using liquid extraction surface analysis

Maxence Wisztorski , Annie Desmons , Jusal Quanico , Benoit Fatou , Jean-Pascal Gimeno
Proteomics, 2016, 16 (11-12), pp.1622-1632. ⟨10.1002/pmic.201500508⟩
Article dans une revue inserm-02940393v1

A Proteomic Analysis of Human Uterine Myoma

Antonio Rizzello , Julien Franck , Marcello Pellegrino , Francesco Nuccio , Pasquale Simeone
Current Protein and Peptide Science, 2016, 18 (2), pp.167-174. ⟨10.2174/1389203717666160322150603⟩
Article dans une revue hal-04447450v1
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Translating epithelial mesenchymal transition markers into the clinic: Novel insights from proteomics

Daniele Vergara , Pasquale Simeone , Julien Franck , Marco Trerotola , Anna Giudetti
EuPA Open Proteomics, 2016, 10, pp.31-41. ⟨10.1016/j.euprot.2016.01.003⟩
Article dans une revue inserm-02940397v1

Proteomic Analysis of the Spatio-temporal Based Molecular Kinetics of Acute Spinal Cord Injury Identifies a Time- and Segment-specific Window for Effective Tissue Repair

Stephanie Devaux , Dasa Cizkova , Jusal Quanico , Julien Franck , Serge Nataf
Molecular and Cellular Proteomics, 2016, 15 (8), pp.2641-2670. ⟨10.1074/mcp.M115.057794⟩
Article dans une revue hal-01850361v1
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Proteome-wide characterization of signalling interactions in the hippocampal CA4/DG subfield of patients with Alzheimer’s disease

Jae Ho Kim , Julien Franck , Taewook Kang , Helmut Heinsen , Rivka Ravid
Scientific Reports, 2015, 5, pp.11138. ⟨10.1038/srep11138⟩
Article dans une revue inserm-02940247v1

Parafilm-assisted microdissection: a sampling method for mass spectrometry-based identification of differentially expressed prostate cancer protein biomarkers

J. Quanico , J. Franck , J. Gimeno , R. Sabbagh , M. Salzet
Chemical Communications, 2015, 51 (22), pp.4564-4567. ⟨10.1039/C4CC08331H⟩
Article dans une revue hal-04449501v1

Human temporal lobe epilepsy analyses by tissue proteomics

Céline Mériaux , Julien Franck , Dan Bi Park , Jusal Quanico , Young Hye Kim
Hippocampus, 2014, 24 (6), pp.628-642. ⟨10.1002/hipo.22246⟩
Article dans une revue hal-04455749v1

Modulation properties of factors released by bone marrow stromal cells on activated microglia: an in vitro study

Dasa Cizkova , Stéphanie Devaux , Françoise Le Marrec-Croq , Julien Franck , Lucia Slovinska
Scientific Reports, 2014, 4 (1), pp.7514. ⟨10.1038/srep07514⟩
Article dans une revue hal-04449213v1

On the origin of increased sensitivity and mass resolution using silicon masks in MALDI

Laurent Diologent , Julien Franck , Maxence Wisztorski , A. Treizebre , Cristian Focsa
Analytical Chemistry, 2014, 86, pp.1404-1413. ⟨10.1021/ac401329r⟩
Article dans une revue hal-00946711v1

Alterations of protein composition along the rostro-caudal axis after spinal cord injury: proteomic, in vitro and in vivo analyses

Dasa Cizkova , Julien Franck , Lucia Slovinska , Ivana Grulova , Christophe Lefebvre
Frontiers in Cellular Neuroscience, 2014, 8, ⟨10.3389/fncel.2014.00105⟩
Article dans une revue hal-04455729v1

Quantification-Based Mass Spectrometry Imaging of Proteins by Parafilm Assisted Microdissection

Julien Franck , Jusal Quanico , Maxence Wisztorski , Robert Day , Michel Salzet
Analytical Chemistry, 2013, 85 (17), pp.8127-8134. ⟨10.1021/ac4009397⟩
Article dans une revue hal-04455753v1

Ionic matrices pre-spotted matrix-assisted laser desorption/ionization plates for patient maker following in course of treatment, drug titration, and MALDI mass spectrometry imaging

David Bonnel , Julien Franck , Céline Mériaux , Michel Salzet , Isabelle Fournier
Analytical Biochemistry, 2013, 434 (1), pp.187-198. ⟨10.1016/j.ab.2012.10.035⟩
Article dans une revue hal-04455799v1

Microproteomics by liquid extraction surface analysis: Application to FFPE tissue to study the fimbria region of tubo‐ovarian cancer

Maxence Wisztorski , Benoit Fatou , Julien Franck , Annie Desmons , Isabelle Farré
PROTEOMICS - Clinical Applications, 2013, 7 (3-4), pp.234-240. ⟨10.1002/prca.201200070⟩
Article dans une revue hal-04455765v1

Development of liquid microjunction extraction strategy for improving protein identification from tissue sections

Jusal Quanico , Julien Franck , Claire Dauly , Kerstin Strupat , Jocelyn Dupuy
Journal of Proteomics, 2013, 79, pp.200-218. ⟨10.1016/j.jprot.2012.11.025⟩
Article dans une revue hal-04455771v1

TARGETED MASS spectrometry Imaging: Specific Targeting Mass Spectrometry imaging technologies from history to perspective

Hugo Gagnon , Julien Franck , Maxence Wisztorski , Robert Day , Isabelle Fournier
Progress in Histochemistry and Cytochemistry, 2012, 47 (3), pp.133-174. ⟨10.1016/j.proghi.2012.08.002⟩
Article dans une revue hal-04455827v1

Multivariate analyses for biomarkers hunting and validation through on-tissue bottom-up or in-source decay in MALDI-MSI: application to prostate cancer

David Bonnel , Rémi Longuespee , Julien Franck , Morad Roudbaraki , Pierre Gosset
Analytical and Bioanalytical Chemistry, 2011, 401 (1), pp.149-165. ⟨10.1007/s00216-011-5020-5⟩
Article dans une revue hal-04455842v1

MALDI imaging and profiling MS of higher mass proteins from tissue

Alexandra Van Remoortere , René van Zeijl , Nico van den Oever , Julien Franck , Rémi Longuespée
Journal of The American Society for Mass Spectrometry, 2010, 21 (11), pp.1922-1929. ⟨10.1016/j.jasms.2010.07.011⟩
Article dans une revue hal-04456009v1

MALDI imaging mass spectrometry in ovarian cancer for tracking, identifying, and validating biomarkers.

Mohamed El Ayed , David Bonnel , Remi Longuespée , Céline Castelier , Julien Franck
Medical Science Monitor, 2010, 16 (8), pp.BR233-45
Article dans une revue hal-04456012v1

Liquid ionic matrixes for MALDI mass spectrometry imaging of lipids

Céline Meriaux , Julien Franck , Maxence Wisztorski , Michel Salzet , Isabelle Fournier
Journal of Proteomics, 2010, 73 (6), pp.1204-1218. ⟨10.1016/j.jprot.2010.02.010⟩
Article dans une revue hal-04456017v1

On-tissue protein identification and imaging by MALDI-Ion mobility mass spectrometry

Jonathan Stauber , Luke Macaleese , Julien Franck , Emmanuelle Claude , Marten Snel
Journal of The American Society for Mass Spectrometry, 2010, 21 (3), pp.338-347. ⟨10.1016/j.jasms.2009.09.016⟩
Article dans une revue hal-04456026v1

MALDI mass spectrometry imaging of proteins exceeding 30,000 daltons.

Julien Franck , Rémi Longuespée , Maxence Wisztorski , Alexandra van Remoortere , René van Zeijl
Medical Science Monitor, 2010, 16 (9), pp.BR293-9
Article dans une revue hal-04456014v1

MALDI imaging mass spectrometry: state of the art technology in clinical proteomics

Julien Franck , Karim Arafah , Mohamed Elayed , David Bonnel , Daniele Vergara
Molecular and Cellular Proteomics, 2009, 8 (9), pp.2023-2033. ⟨10.1074/mcp.R800016-MCP200⟩
Article dans une revue hal-04456037v1

On-Tissue N-Terminal Peptide Derivatizations for Enhancing Protein Identification in MALDI Mass Spectrometric Imaging Strategies

J. Franck , M. El Ayed , M. Wisztorski , M. Salzet , I. Fournier
Analytical Chemistry, 2009, 81 (20), pp.8305-8317. ⟨10.1021/ac901043n⟩
Article dans une revue hal-04456028v1

Improving Tissue Preparation for Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging. Part 1: Using Microspotting

Julien Franck , Karim Arafah , Alan Barnes , Maxence Wisztorski , Michel Salzet
Analytical Chemistry, 2009, 81 (19), pp.8193-8202. ⟨10.1021/ac901328p⟩
Article dans une revue hal-04456031v1
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MALDI Imaging of Formalin-Fixed Paraffin-Embedded Tissues: Application to Model Animals of Parkinson Disease for Biomarker Hunting.

J. Stauber , R. Lemaire , M. Wisztorski , Julien Franck , Bonnel David
Journal of Proteome Research, 2008, 7 (7), pp.969-978
Article dans une revue hal-00268379v1

MITICS (MALDI Imaging Team Imaging Computing System): a new open source mass spectrometry imaging software.

Olivia Jardin-Mathé , David Bonnel , Julien Franck , Maxence Wisztorski , Eduardo Macagno
Journal of Proteomics, 2008, 71 (3), pp.332-45. ⟨10.1016/j.jprot.2008.07.004⟩
Article dans une revue hal-00350101v1

Résolution structural 3D et ciblage thérapeutique du complexe oncogénique MUC4-ErbB2 dans le cancer du pancréas.

Nicolas Stoup , Maxime Liberelle , Julien Franck , Nicolas Renault , Patricia Melnyk
14èmes Journées Scientifiques Annuelles du Cancéropole Nord-Ouest (CNO), May 2022, Deauville, France
Poster de conférence hal-04547404v1

Progress and Potential of Imaging Mass Spectrometry Applied to Biomarker Discovery

Jusal Quanico , Julien Franck , Maxence Wisztorski , Michel Salzet , Isabelle Fournier
Progress and potential of imaging mass spectrometry applied to biomarker discovery, pp.21-43, 2017, ⟨10.1007/978-1-4939-6952-4_2⟩
Chapitre d'ouvrage inserm-02940629v1

Droplet-Based Liquid Extraction for Spatially-Resolved Microproteomics Analysis of Tissue Sections

Maxence Wisztorski , Jusal Quanico , Julien Franck , Benoit Fatou , Michel Salzet
Droplet-Based Liquid Extraction for Spatially-Resolved Microproteomics Analysis of Tissue Sections, pp.49-63, 2017, ⟨10.1007/978-1-4939-7051-3_6⟩
Chapitre d'ouvrage inserm-02940613v1

Combined MALDI Mass Spectrometry Imaging and Parafilm-Assisted Microdissection-Based LC-MS/MS Workflows in the Study of the Brain

Jusal Quanico , Julien Franck , Maxence Wisztorski , Michel Salzet , Isabelle Fournier
Combined MALDI Mass Spectrometry Imaging and Parafilm-Assisted Microdissection-Based LC-MS/MS Workflows in the Study of the Brain, 1598, pp.269-283, 2017, ⟨10.1007/978-1-4939-6952-4_13⟩
Chapitre d'ouvrage inserm-02940633v1