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Impaired Lysosomal Function Underlies Monoclonal Light Chain–Associated Renal Fanconi Syndrome
Alessandro Luciani
,
Christophe Sirac
,
Sara Terryn
,
Vincent Javaugue
,
Jenny Ann Prange
Article dans une revue
hal-02364437v1
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Immunoglobulin genes undergo legitimate repair in human B cells not only after cis- but also frequent trans-class switch recombination.
Brice Laffleur
,
Sylvia M. Bardet
,
Armand Garot
,
M Brousse
,
A Baylet
Article dans une revue
hal-01112042v1
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The Eμ enhancer region influences H chain expression and B cell fate without impacting IgVH repertoire and immune response in vivo.
Marie Marquet
,
Armand Garot
,
Sébastien Bender
,
Claire Carrion
,
Pauline Rouaud
Article dans une revue
hal-01110453v1
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The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells.
Pauline Rouaud
,
Christelle Vincent-Fabert
,
Alexis Saintamand
,
Rémi Fiancette
,
Marie Marquet
Article dans une revue
hal-00903790v1
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Production of human or humanized antibodies in mice.
Brice Laffleur
,
Virginie Pascal
,
Christophe Sirac
,
Michel Cogné
Article dans une revue
hal-00779395v1
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[IgH locus suicide recombination, or when B cells surrender!].
Sophie Péron
,
Brice Laffleur
,
Nicolas Denis-Lagache
,
Jeanne Cook-Moreau
,
Matthieu Filloux
Article dans une revue
hal-00779352v1
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Enhancers located in heavy chain regulatory region (hs3a, hs1,2, hs3b, and hs4) are dispensable for diversity of VDJ recombination.
Pauline Rouaud
,
Christelle Vincent-Fabert
,
Rémi Fiancette
,
Michel Cogné
,
Eric Pinaud
Article dans une revue
hal-00696502v1
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Transglutaminase is essential for IgA nephropathy development acting through IgA receptors.
Laureline Berthelot
,
Christina Papista
,
Thiago T Maciel
,
Martine Biarnes-Pelicot
,
Emilie Tissandie
Article dans une revue
hal-00903832v1
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Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53+/- mice and c-myc-3'RR/Cdk4R24C mice: differential oncogenic mechanisms but similar cellular origin.
Pauline Rouaud
,
Rémi Fiancette
,
Christelle Vincent-Fabert
,
Virginie Magnone
,
Michel Cogné
Oncotarget, 2012, 3 (5), pp.586-93
Article dans une revue
hal-00779350v1
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Class-specific effector functions of therapeutic antibodies.
Virginie Pascal
,
Brice Laffleur
,
Michel Cogné
Article dans une revue
hal-00779398v1
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Cross talk between immunoglobulin heavy-chain transcription and RNA surveillance during B cell development.
Aurélien Tinguely
,
Guillaume Chemin
,
Sophie Péron
,
Christophe Sirac
,
Stéphane Reynaud
Article dans une revue
hal-00696497v1
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Toward understanding renal Fanconi syndrome: step by step advances through experimental models.
Christophe Sirac
,
Franck Bridoux
,
Marie Essig
,
Olivier Devuyst
,
Guy Touchard
Article dans une revue
hal-00696465v1
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Similarity of fine specificity of IgA anti-gliadin antibodies between patients with celiac disease and humanized α1KI mice.
Daniel Sánchez
,
Gaël Champier
,
Armelle Cuvillier
,
Michel Cogné
,
Aneta Pekáriková
Article dans une revue
hal-00696473v1
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The IgH locus 3' regulatory region: pulling the strings from behind.
Eric Pinaud
,
Marie Marquet
,
Rémi Fiancette
,
Sophie Péron
,
Christelle Vincent-Fabert
Article dans une revue
hal-00696444v1
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Strategies to model AL amyloidosis in mice.
Christophe Sirac
,
Sébastien Bender
,
Arnaud Jaccard
,
Franck Bridoux
,
C. Lacombe
Article dans une revue
hal-00617188v2
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Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia.
Séverine Coulon
,
Michaël Dussiot
,
Damien Grapton
,
Thiago Trovati Maciel
,
Pamella Huey Mei Wang
Article dans une revue
hal-00696490v1
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A p53 defect sensitizes various stages of B cell development to lymphomagenesis in mice carrying an IgH 3' regulatory region-driven c-myc transgene.
Rémi Fiancette
,
Pauline Rouaud
,
Christelle Vincent-Fabert
,
Brice Laffleur
,
Virginie Magnone
Article dans une revue
hal-00696493v1
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Multiple RNA surveillance mechanisms cooperate to reduce the amount of nonfunctional Ig kappa transcripts.
Guillaume Chemin
,
Aurélien Tinguely
,
Christophe Sirac
,
Fabien Lechouane
,
Sophie Duchez
Article dans une revue
hal-00511941v1
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A myeloma translocation-like model associating CCND1 with the immunoglobulin heavy-chain locus 3' enhancers does not promote by itself B-cell malignancies.
Rémi Fiancette
,
Rada Amin
,
Véronique Truffinet
,
Christelle Vincent-Fabert
,
Nadine Cogné
Article dans une revue
hal-00514237v1
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In vivo redundant function of the 3' IgH regulatory element HS3b in the mouse.
Anne-Gaëlle Bébin
,
Claire Carrion
,
Marie Marquet
,
Nadine Cogné
,
Sandrine Lecardeur
Article dans une revue
hal-00514232v1
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Ig synthesis and class switching do not require the presence of the hs4 enhancer in the 3' IgH regulatory region.
Christelle Vincent-Fabert
,
Véronique Truffinet
,
Rémi Fiancette
,
Nadine Cogné
,
Michel Cogné
Article dans une revue
hal-00443742v1
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Genetic background modulates susceptibility to oncogen-driven proliferation and lymphoma occurrence in mice carrying a deregulated c-myc transgene.
Christelle Vincent-Fabert
,
Rémi Fiancette
,
Véronique Truffinet
,
Nadine Cogné
,
Michel Cogné
Article dans une revue
hal-00514240v1
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[Physiopathology of herpetiform dermatitis. Current data]
V. Doffoel-Hantz
,
Michel Cogné
,
Agnès Sparsa
,
J.-M. Bonnetblanc
,
Mireille Drouet
Article dans une revue
hal-00363969v1
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S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.
Robert Wuerffel
,
Lili Wang
,
Fernando Grigera
,
John Manis
,
Erik Selsing
Article dans une revue
hal-00363968v1
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The 3' IgH locus control region is sufficient to deregulate a c-myc transgene and promote mature B cell malignancies with a predominant Burkitt-like phenotype.
Véronique Truffinet
,
Eric Pinaud
,
Nadine Cogné
,
Barbara Petit
,
Laurence Guglielmi
Journal of Immunology, 2007, 179 (9), pp.6033-6042
Article dans une revue
hal-00181178v1
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Use of both CD63 up regulation and IgE down regulation for the flow cytometric analysis of allergen induced basophil activation. Definition of an activation index.
Jean Sainte-Laudy
,
Ahmed Boumédiène
,
F. Touraine
,
Isabelle Orsel
,
C. Brianchon
Article dans une revue
hal-00166018v1
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Light chain inclusion permits terminal B cell differentiation and does not necessarily result in autoreactivity.
Christophe Sirac
,
Claire Carrion
,
Sophie Duchez
,
Isabelle Comte
,
Michel Cogné
Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (20), pp.7747-52. ⟨10.1073/pnas.0509121103⟩
Article dans une revue
hal-00073857v1
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Role of the monoclonal kappa chain V domain and reversibility of renal damage in a transgenic model of acquired Fanconi syndrome.
Christophe Sirac
,
Franck Bridoux
,
Claire Carrion
,
Olivier Devuyst
,
Béatrice Fernandez
Article dans une revue
hal-00085051v1
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Germ line transcription in mice bearing neor gene downstream of Igamma3 exon in the Ig heavy chain locus.
Maha Samara
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Zéliha Oruc
,
Hei-Lanne Dougier
,
Tawer Essawi
,
Michel Cogné
Article dans une revue
hal-00021571v1
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Interallelic class switch recombination can reverse allelic exclusion and allow trans-complementation of an IgH locus switching defect.
Hei-Lanne Dougier
,
Stéphane Reynaud
,
Eric Pinaud
,
Claire Carrion
,
Laurent Delpy
Article dans une revue
hal-00088115v1
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Interallelic class switch recombination contributes significantly to class switching in mouse B cells.
Stéphane Reynaud
,
Laurent Delpy
,
Laurence Fleury
,
Hei-Lanne Dougier
,
Christophe Sirac
Journal of Immunology, 2005, 174 (10), pp.6176-83
Article dans une revue
hal-00458866v1
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Transcription-dependent somatic hypermutation occurs at similar levels on functional and nonfunctional rearranged IgH alleles.
Laurent Delpy
,
Christophe Sirac
,
Caroline Le Morvan
,
Michel Cogné
Journal of Immunology, 2004, 173 (3), pp.1842-8
Article dans une revue
hal-00023372v1
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Induction of somatic hypermutation by antigen-specific B cell receptors in the human BL2 cell line.
Florence Glaudet
,
Vincent Denis
,
Michel Cogné
,
Ahmed Amine Khamlichi
Article dans une revue
hal-00023350v1
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Immunoglobulin class-switch recombination in mice devoid of any S mu tandem repeat.
Ahmed Amine Khamlichi
,
Florence Glaudet
,
Zéliha Oruc
,
Vincent Denis
,
Marc Le Bert
Article dans une revue
hal-00023269v1
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Immunologic basis for the rare occurrence of true nonsecretory plasma cell dyscrasias.
Catherine Decourt
,
Horia Radu Galea
,
Christophe Sirac
,
Michel Cogné
Article dans une revue
hal-00023271v1
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RNA surveillance down-regulates expression of nonfunctional kappa alleles and detects premature termination within the last kappa exon.
Laurent Delpy
,
Christophe Sirac
,
Emmanuelle Magnoux
,
Sophie Duchez
,
Michel Cogné
Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (19), pp.7375-80. ⟨10.1073/pnas.0305586101⟩
Article dans une revue
hal-00023270v1
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Germ-line transcription occurs on both the functional and the non-functional alleles of immunoglobulin constant heavy chain genes.
Laurent Delpy
,
Marc Le Bert
,
Michel Cogné
,
Ahmed Amine Khamlichi
Article dans une revue
hal-00023385v1
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Insulators to improve expression of a 3(')IgH LCR-driven reporter gene in transgenic mouse models.
Laurence Guglielmi
,
Marc Le Bert
,
Véronique Truffinet
,
Michel Cogné
,
Yves Denizot
Article dans une revue
hal-00023524v1
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Combination of 3' and 5' IgH regulatory elements mimics the B-specific endogenous expression pattern of IgH genes from pro-B cells to mature B cells in a transgenic mouse model.
Laurence Guglielmi
,
Marc Le Bert
,
Isabelle Comte
,
Marie Laure Dessain
,
Mireille Drouet
Article dans une revue
hal-00023378v1
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The immunoglobulin heavy-chain locus hs3b and hs4 3' enhancers are dispensable for VDJ assembly and somatic hypermutation.
Caroline Le Morvan
,
Eric Pinaud
,
Catherine Decourt
,
Armelle Cuvillier
,
Michel Cogné
Article dans une revue
hal-00023823v1
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Light chain myeloma plasma cells induce a strong cell-mediated immune response mainly directed against the monoclonal light chain determinants in a murine experimental model.
Horia Galea
,
Yves Denizot
,
Michel Cogné
Article dans une revue
hal-00023825v1
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GM-CSF and IL-12 production by malignant plasma cells promotes cell-mediated immune responses against monoclonal Ig determinants in a light chain myeloma model.
H.R. Galea
,
Michel Cogné
Article dans une revue
hal-00023536v1
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B cell development arrest upon insertion of a neo gene between JH and Emu: promoter competition results in transcriptional silencing of germline JH and complete VDJ rearrangements.
Laurent Delpy
,
Catherine Decourt
,
Marc Le Bert
,
Michel Cogné
Journal of Immunology, 2002, 169 (12), pp.6875-82
Article dans une revue
hal-00023696v1
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Characterization of the murine gene for subunit VIIaL of cytochrome c oxidase.
K. Chantrel-Groussard
,
Laurent Delpy
,
Marie-Hélène Ratinaud
,
Michel Cogné
Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, 2001, 324 (12), pp.1117-23
Article dans une revue
hal-00458870v1
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