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Phil M. Oger

18
Documents
Identifiants chercheurs

Présentation

Education 2007 Habilitation (University of Lyon) 1995 PhD summa cum laude in Plant Pathology (Paris University X1- Orsay) 1991 MS Plant Pathology (Paris University X1- Orsay) 1991 Engineer degree in Agronomy (National Institute ofr Agronomy, Paris) Professional experience 2016-present CNRS Scientist, Head Adaptation to Extreme Environment group, UMR 5240, INSA Lyon 2000-2015 CNRS Scientist, Head Geomicrobiology group, Earth Sciences Laboratory, ENS Lyon 1999-2000 Post-Doctoral Investigator, Institut des Sciences du Végétal, CNRS, Gif-sur-Yvette 1996-1999 Post-Doctoral Investigator, University of Illinois, Urbana-Champaign (USA) Teaching 2014 - 2nd and 3rd year BS at INSA de Lyon and ENS de Lyon 2005 - 2014 4th year BS and MS level at ENS de Lyon and University of Lyon 1992 - 1995 1st year BS at University of Paris XI-Orsay Teaching 2014 - 2005 - 2014 1992 - 1995 CNRS Scientist, Head Adaptation to Extreme Environment group, UMR 5240, INSA Lyon CNRS Scientist, Head Geomicrobiology group, Earth Sciences Laboratory, ENS Lyon Post-Doctoral Investigator, Institut des Sciences du Végétal, CNRS, Gif-sur-Yvette Post-Doctoral Investigator, University of Illinois, Urbana-Champaign (USA) 2nd and 3rd year BS at INSA de Lyon and ENS de Lyon 4th year BS and MS level at ENS de Lyon and University of Lyon 1st year BS at University of Paris XI-Orsay Research interests Research in my group aims at deciphering from the atomic to the genetic level the behavior and adaptation of Archaea in response to environmental stresses. Our aim is to explore the limits of life in the deep-biosphere, with an emphasis on the adaptation to hydrostatic pressure, temperature and salinity variations in deep-sea hydrothermal vents. Over the years we have developped the two widely accepted hypethermophilic archaea, e.g. Thermococcus barophilus and Pyrococcus yayanosii, as genetic models for the study of high-hydrostatic pressure adaptation in deep-sea hydrothermal vents. Our approaches are multi- and trans-disciplinary since we aim at understanding the physics behind the physiologic adaptation of cells. To this avail we use techniques ranging from spectral physics (Xray and Neutron diffraction and diffusion) to meta-omics (RNASeq and Proteomics, in order to track the genetic imprint of these adaptations from the cell level to the molecule. This combination of approaches has led to two major scientific discoveries over the last two years. First, we have described the first atomistic model of of high hydrostatic pressure adaptation (Martinez Sci Rep 2016; Cario Sci Rep 2016) and described a novel membrane ultrstructure as a new adaptation strategy to high hydrostatic pressure and temperature in hyperthermohpiv Archaea (Cario Front Microbiol 2105).
Education 2007 Habilitation à Diriger des Recherches de l'Université Claude Bernard Lyon 1 1995 PhD summa cum laude en Phytopathologie (Université Paris X1-Orsay) 1991 DEA en Phytopathologie (Université Paris X1-Orsay/INAP-G) 1991 Ingénieur agronome (Institut National Agronomique Paris-Grignon) Expérience professionelle 2016-present DR CNRS, Adaptation aux Milieux Extrêmes, UMR 5240, INSA Lyon 2000-2015 CR puis DR CNRS, Géomicrobiology, Lab. de Géologie de Lyon, ENS de Lyon 1999-2000 Post-Doc, Institut des Sciences du Végétal, CNRS, Gif-sur-Yvette 1996-1999 Post-Doc, University of Illinois, Urbana-Champaign (USA) Enseignement 2014 - auj. 2005 - 2014 1992 - 1995

Publications

42970
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Incorporation and localisation of alkanes in a protomembrane model

Loreto Misuraca , Josephine Loricco , Philippe Oger , Judith Peters , Bruno Demé
Biochimica et Biophysica Acta:Biomembranes, 2023, 1865 (3), pp.184119. ⟨10.1016/j.bbamem.2023.184119⟩
Article dans une revue hal-04297309v1
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Alkanes as Membrane Regulators of the Response of Early Membranes to Extreme Temperatures

Loreto Misuraca , Antonino Caliò , Josephine Loricco , Ingo Hoffmann , Roland Winter
Life, 2022, 12 (3), pp.445. ⟨10.3390/life12030445⟩
Article dans une revue hal-03930744v1
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Membrane adaptation in the hyperthermophilic archaeon Pyrococcus furiosus relies upon a novel strategy involving glycerol monoalkyl glycerol tetraether lipids

Maxime Tourte , Philippe Schaeffer , Vincent Grossi , Philippe M Oger
Environmental Microbiology, 2022, 24 (4), pp.2029-2046. ⟨10.1111/1462-2920.15923⟩
Article dans une revue hal-03845187v1
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Unravelling the Adaptation Mechanisms to High Pressure in Proteins

Antonino Caliò , Cécile Dubois , Stéphane Fontanay , Michael Marek Koza , François Hoh
International Journal of Molecular Sciences, 2022, 23 (15), pp.8469. ⟨10.3390/ijms23158469⟩
Article dans une revue hal-03744880v1
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High temperature molecular motions within a model protomembrane architecture

Loreto Misuraca , Tatsuhito Matsuo , Aline Cisse , Josephine Loricco , Antonio Caliò
Physical Chemistry Chemical Physics, 2022, 24, pp.15083-15090. ⟨10.1039/D2CP01205G⟩
Article dans une revue hal-03722910v1

Straightforward Synthesis of Chiral Terpenoid Building Blocks by Ru-Catalyzed Enantioselective Hydrogenation

Johal Ruiz , Philippe Oger , Laurent Soulère , Florence Popowycz
Journal of Organic Chemistry, 2021, ⟨10.1021/acs.joc.1c00677⟩
Article dans une revue hal-03275385v1
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Non-Polar Lipids as Regulators of Membrane Properties in Archaeal Lipid Bilayer Mimics

Marta Salvador-Castell , Nicholas J Brooks , Roland Winter , Judith Peters , Philippe M. Oger
International Journal of Molecular Sciences, 2021, 22 (11), ⟨10.3390/ijms22116087⟩
Article dans une revue hal-03272006v1
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Alkanes increase the stability of early life membrane models under extreme pressure and temperature conditions

Loreto Misuraca , Bruno Demé , Philippe Oger , Judith Peters
Communications Chemistry, 2021, ⟨10.1038/s42004-021-00467-5⟩
Article dans une revue hal-03154757v1
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Characterisation of a synthetic Archeal membrane reveals a possible new adaptation route to extreme conditions

Marta Salvador-Castell , Maksym Golub , Nelli Erwin , Bruno Demé , Nicholas J Brooks
Communications Biology, 2021, 4, ⟨10.1038/s42003-021-02178-y⟩
Article dans une revue hal-03272003v1
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Acid Hydrolysis for the Extraction of Archaeal Core Lipids and HPLC-MS Analysis

Maxime Tourte , Philippe Schaeffer , Vincent Grossi , Phil Oger
Bio-protocol , 2021, 11 (16), ⟨10.21769/bioprotoc.4118⟩
Article dans une revue hal-03379753v1
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High-Temperature Behavior of Early Life Membrane Models

Loreto Misuraca , Antonino Caliò , Isabelle Grillo , Axelle Grélard , Philippe Marie Oger
Article dans une revue hal-02988681v1
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Induction of non-lamellar phases in archaeal lipids at high temperature and high hydrostatic pressure by apolar polyisoprenoids

Marta Salvador-Castell , Nicholas Brooks , Judith Peters , P. Oger
Biochimica et Biophysica Acta:Biomembranes, 2020, 1862 (2), pp.183130. ⟨10.1016/j.bbamem.2019.183130⟩
Article dans une revue hal-02364592v1
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Novel intact polar and core lipid compositions in the Pyrococcus model species, P. furiosus and P. yayanosii, reveal the largest lipid diversity amongst Thermococcales

Maxime Tourte , Vanessa Kuentz , Philippe Schaeffer , Vincent Grossi , Anaïs Cario
Biomolecules, 2020, 10 (6), pp.830. ⟨10.3390/biom10060830⟩
Article dans une revue hal-02861881v1
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Functionalized Membrane Domains: An Ancestral Feature of Archaea?

Maxime Tourte , Philippe Schaeffer , Vincent Grossi , Phil Oger
Frontiers in Microbiology, 2020, 11, pp.526. ⟨10.3389/fmicb.2020.00526⟩
Article dans une revue hal-02553764v1
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Apolar Polyisoprenoids Located in the Midplane of the Bilayer Regulate the Response of an Archaeal-Like Membrane to High Temperature and Pressure

Josephine G Loricco , Marta Salvador-Castell , Bruno Demé , Judith Peters , Philippe Oger
Frontiers in Chemistry, 2020, 8, ⟨10.3389/fchem.2020.594039⟩
Article dans une revue hal-03000614v1
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Structural Characterization of an Archaeal Lipid Bilayer as a Function of Hydration and Temperature

Marta Salvador-Castell , Bruno Demé , Philippe M. Oger , Judith Peters
International Journal of Molecular Sciences, 2020, 21 (5), pp.1816. ⟨10.3390/ijms21051816⟩
Article dans une revue hal-02508365v1
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Lipid phase separation induced by the apolar polyisoprenoid squalane demonstrates its role in membrane domain formation in archaeal membranes

Marta Salvador-Castell , Bruno Demé , Phil Oger , Judith Peters
Langmuir, 2020, 36 (26), pp.7375-7382. ⟨10.1021/acs.langmuir.0c00901⟩
Article dans une revue hal-02862864v1
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In Search for the Membrane Regulators of Archaea

Marta Salvador-Castell , Maxime Tourte , Philippe M. Oger
International Journal of Molecular Sciences, 2019, 20 (18), pp.4434. ⟨10.3390/ijms20184434⟩
Article dans une revue hal-02283370v1