Abdelhadi Saoudi

Publications

Pré-publication, Document de travail (1)

The multiple sclerosis associated CD226 risk variant alters vitamin D-induced human type I regulatory T cell differentiation by impairing LFA-1 activation Anne Laurence Astier,Saniya Kari,Aymeline Debonlier,Thibault Angles,Beatriz Chaveset al. 2025 Pré-publication, Document de travail hal-05083602v1

Article dans une revue (49)

Increased levels of circulating soluble CD226 in multiple sclerosis Saniya Kari,Florence Bucciarelli,Thibault Angles,Anne-Cecile Oster,Pauline Cauboueet al. Multiple Sclerosis Journal, 2024, 30 (6), pp.654-663. ⟨10.1177/13524585241234489⟩ Article dans une revue hal-04759633v1
THEMIS promotes T cell development and maintenance by rising the signaling threshold of the inhibitory receptor BTLA Suzanne Mélique,Aurélie Vadel,Nelly Rouquié,Cui Yang,Cyrielle Borieset al. Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (20), pp.654-663. ⟨10.1073/pnas.2318773121⟩ Article dans une revue hal-04757063v1
Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions Elena Morandi,Véronique Adoue,Isabelle Bernard,Ekaterina Friebel,Nicolas Nunezet al. Neurology Neuroimmunology & Neuroinflammation, 2024, 11 (6), pp.e200306. ⟨10.1212/NXI.0000000000200306⟩ Article dans une revue hal-04780777v1
Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4+ T cells during inflammation Emeline Joulia,Michaël F. Michieletto,Arantxa Agesta,Cindy Peillex,Virgine Giraultet al. Journal of Experimental Medicine, 2024, 221 (2), pp.e20230449. ⟨10.1084/jem.20230449⟩ Article dans une revue hal-04443514v1
Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation Remi Marrocco,Isabelle Bernard,Emeline Joulia,Rebecca Barascud,Anne S Dejeanet al. Cellular and Molecular Life Sciences, 2024, 81 (1), pp.161. ⟨10.1007/s00018-024-05203-5⟩ Article dans une revue inserm-04757623v1
Cerebrospinal fluid proteomics in recent-onset Narcolepsy type 1 reveals activation of the complement system Ikram Ayoub,Yves Dauvilliers,Lucie Barateau,Thaïs Vermeulen,Emmanuelle Mouton-Barbosaet al. Frontiers in Immunology, 2023, 14, pp.1108682. ⟨10.3389/fimmu.2023.1108682⟩ Article dans une revue hal-04291297v1
A selective LIS1 requirement for mitotic spindle assembly discriminates distinct T-cell division mechanisms within the T-cell lineage Jérémy Argenty,Nelly Rouquié,Cyrielle Bories,Suzanne Mélique,Valérie Duplan-Echeet al. eLife, 2022, 11, pp.e80277. ⟨10.7554/eLife.80277⟩ Article dans une revue hal-04291340v1
THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals Cui Yang,Gaëtan Blaize,Rémi Marrocco,Nelly Rouquié,Cyrielle Borieset al. Science Signaling, 2022, 15 (742), pp.eabl5343. ⟨10.1126/scisignal.abl5343⟩ Article dans une revue hal-04002199v1
Identification of bacterial lipopeptides as key players in IBS Camille Petitfils,Sarah Maurel,Gaelle Payros,Amandine Hueber,Bahija Agaizet al. Gut, 2022, pp.939-950. ⟨10.1136/gutjnl-2022-328084⟩ Article dans une revue hal-03833107v1
Influenza vaccination induces autoimmunity against orexinergic neurons in a mouse model for narcolepsy Raphaël Bernard-Valnet,David Frieser,Xuan-Hung Nguyen,Leila Khajavi,Clémence Quériaultet al. Brain - A Journal of Neurology , 2022, 145 (6), pp.2018-2030. ⟨10.1093/brain/awab455⟩ Article dans une revue hal-03669984v1
Peripheral Opioid Receptor Blockade Enhances Epithelial Damage in Piroxicam-Accelerated Colitis in IL-10-Deficient Mice Xavier Mas-Orea,Morgane Sebert,Mehdi Benamar,Camille Petitfils,Catherine Blanpiedet al. International Journal of Molecular Sciences, 2021, 22 (14), pp.7387. ⟨10.3390/ijms22147387⟩ Article dans une revue hal-03330200v1
Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy Marianne Weulersse,Assia Asrir,Andrea C Pichler,Lea Lemaitre,Matthias Braunet al. Immunity, 2020, 53 (4), pp.824-839.e10. ⟨10.1016/j.immuni.2020.09.006⟩ Article dans une revue hal-03030829v1
A Virus Hosted in Malaria-Infected Blood Protects against T Cell-Mediated Inflammatory Diseases by Impairing DC Function in a Type I IFN-Dependent Manner Ali Hassan,Myriam Wlodarczyk,Mehdi Benamar,Emilie Bassot,Anna Salvioniet al. mBio, 2020, 11 (2), pp.1-18. ⟨10.1128/mBio.03394-19⟩ Article dans une revue hal-03015978v1
Treatment of experimental autoimmune encephalomyelitis with engineered bi-specific Foxp3+ regulatory CD4+ T cells. Manish Malviya,Abdelhadi Saoudi,Jan Bauer,Simon Fillatreau,Roland Liblau Journal of Autoimmunity, 2020, 108, pp.102401. ⟨10.1016/j.jaut.2020.102401⟩ Article dans une revue hal-03023558v1
Endogenous control of inflammatory visceral pain by T cell‐derived opioids in IL‐10‐deficient mice Lilian Basso,Mehdi Benamar,Xavier Mas‐orea,Céline Deraison,Catherine Blanpiedet al. Neurogastroenterology & Motility, 2020, 32 (2), pp.e13743. ⟨10.1111/nmo.13743⟩ Article dans une revue hal-03026676v1
CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens Gaëtan Blaize,Hélène Daniels-Treffandier,Meryem Aloulou,Nelly Rouquié,Cui Yanget al. Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (23), pp.12969-12979. ⟨10.1073/pnas.1917182117⟩ Article dans une revue hal-03016005v1
Smooth muscle cells-derived CXCL10 prevents endothelial healing through PI3Kγ-dependent T cells response Adrien Lupieri,Natalia F. Smirnova,Romain Solinhac,Nicole Malet,Mehdi Benamaret al. Cardiovascular Research, 2019, 116 (2), pp.438-449. ⟨10.1093/cvr/cvz122⟩ Article dans une revue hal-02349692v1
Pre-transplant CD45RC expression on blood T cells differentiates patients with cancer and rejection after kidney transplantation Anne-Sophie Garnier,Martin Planchais,Jérémie Riou,Clément Jacquemin,Laurence Ordonezet al. PLoS ONE, 2019, 14 (3), pp.e0214321. ⟨10.1371/journal.pone.0214321⟩ Article dans une revue inserm-02100184v1
The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4(+) T cells Guillaume Gaud,Romain Roncagalli,Karima Chaoui,Isabelle Bernard-Cadenat,Julien Familiadeset al. Science Signaling, 2018, 11 (538), ⟨10.1126/scisignal.aar3083⟩ Article dans une revue hal-02117993v1
The probiotic strain Escherichia coli Nissle 1917 prevents papain-induced respiratory barrier injury and severe allergic inflammation in mice Thomas Secher,Isabelle Maillet,Claire Mackowiak,Jessica Le Bérichel,Amandine Philippeauet al. Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-29689-9⟩ Article dans une revue hal-02126575v1
The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4 + T cells Guillaume Gaud,Romain Roncagalli,Karima Chaoui,Isabelle Bernard,Julien Familiadeset al. Science Signaling, 2018, 11 (538), pp.eaar3083. ⟨10.1126/scisignal.aar3083⟩ Article dans une revue inserm-04284289v1
A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire Isabelle Bernard,Antoine Sacquin,Sahar Kassem,Mehdi Benamar,Celine Colacioset al. Frontiers in Immunology, 2018, 9, pp.2399. ⟨10.3389/fimmu.2018.02399⟩ Article dans une revue inserm-02439866v1
Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection Anne Garreau,Gaëtan Blaize,Jérémy Argenty,Nelly Rouquié,Audrey Tourdèset al. Journal of Immunology, 2017, 199 (8), pp.2758-2766. ⟨10.4049/jimmunol.1700566⟩ Article dans une revue inserm-04284309v1
Proteomic Analysis of Regulatory T Cells Reveals the Importance of Themis1 in the Control of Their Suppressive Function. Fanny Duguet,Marie Locard-Paulet,Marlène Marcellin,Karima Chaoui,Isabelle Bernard-Cadenatet al. Molecular and Cellular Proteomics, 2017, 16 (8), pp.1416-1432. ⟨10.1074/mcp.M116.062745⟩ Article dans une revue hal-01595559v1
Oral Administration of the Probiotic Strain &lt;em&gt;Escherichia coli&lt;/em&gt; Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier Dysfunction Thomas Secher,Sahar Kassem,Mehdi Benamar,Isabelle Bernard-Cadenat,Michèle Bouryet al. Frontiers in Immunology, 2017, 8, ⟨10.3389/fimmu.2017.01096⟩ Article dans une revue hal-02624001v1
A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation Sahar Kassem,Guillaume Gaud,Isabelle Bernard-Cadenat,Mehdi Benamar,Anne S. Dejeanet al. PLoS Genetics, 2016, 12 (7), ⟨10.1371/journal.pgen.1006185⟩ Article dans une revue hal-01438135v1
Foxo3 transcription factor drives pathogenic T helper 1 differentiation by inducing the expression of eomes Caroline Stienne,Michael Michieletto,Mehdi Benamar,Nadège Carrié,Isabelle Bernard-Cadenatet al. Immunity, 2016, 45 (4), pp.774-787. ⟨10.1016/j.immuni.2016.09.010⟩ Article dans une revue hal-02631699v1
Vaccine-associated inflammatory diseases of the central nervous system Xuan-Hung Nguyen,Abdelhadi Saoudi,Roland Liblau Current Opinion in Neurology, 2016, 29 (3), pp.362-371. ⟨10.1097/WCO.0000000000000318⟩ Article dans une revue inserm-04284200v1
An epistatic interaction between &lt;em&gt;Themis1&lt;/em&gt; and &lt;em&gt;Vav1&lt;/em&gt; modulates regulatory T cell function and inflammatory bowel disease development Christophe Pedros,Guillaume Gaud,Isabelle Bernard-Cadenat,Sahar Kassem,Marianne Chabodet al. Journal of Immunology, 2015, 195 (4), pp.1608-1616. ⟨10.4049/jimmunol.1402562⟩ Article dans une revue hal-02634615v1
Phosphorus-based dendrimer ABP treats neuroinflammation by promoting IL-10-producing CD4+ T Cells Myriam Hayder,Marjorie Varilh,Cédric-Olivier Turrin,Abdelhadi Saoudi,A.-M. Caminadeet al. Biomacromolecules, 2015, 16 (11), pp.3425-3433. ⟨10.1021/acs.biomac.5b00643⟩ Article dans une revue hal-01923202v1
Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin Thomas Secher,Delphine Payros,Camille Brehin,Michèle Boury,Claude Watrinet al. Infection and Immunity, 2015, 83 (6), pp.2420-2429. ⟨10.1128/IAI.00064-15⟩ Article dans une revue hal-02634629v1
Rho-GTPases as key regulators of T lymphocyte biology Abdelhadi Saoudi,Sahar Kassem,Anne Dejean,Guillaume Gaud Small GTPases, 2014, 5 (4), pp.e983862. ⟨10.4161/sgtp.28208⟩ Article dans une revue inserm-04284152v1
VAV 1 and BAFF , via NF κB pathway, are genetic risk factors for myasthenia gravis Nili Avidan,Rozen Le Panse,Hanne Harbo,Pia Bernasconi,Konstantinos Poulaset al. Annals of Clinical and Translational Neurology, 2014, 1 (5), pp.329-339. ⟨10.1002/acn3.51⟩ Article dans une revue inserm-04284319v1
Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response Natalia F. Smirnova,Stephanie Gayral,Christophe Pedros,Gervaise Loirand,Nathalie Vaillantet al. Journal of Experimental Medicine, 2014, 211 (9), pp.1779-1792. ⟨10.1084/jem.20131276⟩ Article dans une revue hal-02519407v1
Genetic control of HgCl2-induced IgE and autoimmunity by a 117-kb interval on rat chromosome 9 through CD4 CD45RChigh T cells Christophe Pedros,O Papapietro,C Colacios,A Casemayou,I Bernardet al. Genes and Immunity, 2013, 14 (4), pp.258-267. ⟨10.1038/gene.2013.21⟩ Article dans une revue inserm-04284227v1
A Higher Risk of Acute Rejection of Human Kidney Allografts Can Be Predicted from the Level of CD45RC Expressed by the Recipients’ CD8 T Cells Laurence Ordonez,Isabelle Bernard-Cadenat,Marianne Chabod,Jean-François Augusto,Valérie Lauwers-Canceset al. PLoS ONE, 2013, 8 (7), pp.e69791. ⟨10.1371/journal.pone.0069791⟩ Article dans une revue inserm-02164657v1
A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease. Marianne Chabod,Christophe Pedros,Lucille Lamouroux,Céline Colacios,Isabelle Bernard-Cadenatet al. PLoS Genetics, 2012, 8 (1), pp.e1002461. ⟨10.1371/journal.pgen.1002461⟩ Article dans une revue hal-02650348v1
Cutting Edge: Neuronal Recognition by CD8 T Cells Elicits Central Diabetes Insipidus Tanja Scheikl,Béatrice Pignolet,Cécile Dalard,Sabine Desbois,Danièle Raisonet al. Journal of Immunology, 2012, 188 (10), pp.4731-4735. ⟨10.4049/jimmunol.1102998⟩ Article dans une revue inserm-04284304v1
A Spontaneous Mutation of the Rat Themis Gene Leads to Impaired Function of Regulatory T Cells Linked to Inflammatory Bowel Disease Marianne Chabod,Christophe Pedros,Lucille Lamouroux,Céline Colacios,Isabelle Bernardet al. PLoS Genetics, 2012, 8 (1), pp.e1002461. ⟨10.1371/journal.pgen.1002461⟩ Article dans une revue inserm-04284166v1
Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility N. Couturier,F. Bucciarelli,R. Nurtdinov,M. Debouverie,C. Lebrun-Frenayet al. Brain - A Journal of Neurology , 2011, 134 (3), pp.693-703. ⟨10.1093/brain/awr010⟩ Article dans une revue inserm-04284261v1
The p.Arg63Trp polymorphism controls Vav1 functions and Foxp3 regulatory T cell development Céline Colacios,Audrey Casemayou,Anne Dejean,Frédérique Gaits-Iacovoni,Christophe Pedroset al. Journal of Experimental Medicine, 2011, 208 (11), pp.2183-2191. ⟨10.1084/jem.20102191⟩ Article dans une revue inserm-04284249v1
Effects of BCL-2 over-expression on B cells in transgenic rats and rat hybridomas Anne-Laure Iscache,Séverine Ménoret,Laurent Tesson,Séverine Rémy,Claire Usalet al. International Immunology, 2011, 23 (10), pp.625-636. ⟨10.1093/intimm/dxr071⟩ Article dans une revue inserm-04284324v1
Tracking antigen-specific CD8+ T cells in the rat using MHC class I multimers. Valérie Duplan,Elsa Suberbielle,Catherine E. Napper,Etienne Joly,Abdelhadi Saoudiet al. Journal of Immunological Methods, 2007, 320 (1-2), pp.30-9. ⟨10.1016/j.jim.2006.11.008⟩ Article dans une revue inserm-00212050v1
The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms. Pierre Cavaillès,Véronique Sergent,Cordelia Bisanz,Olivier Papapietro,Céline Colacioset al. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (3), pp.744-9. ⟨10.1073/pnas.0506643103⟩ Article dans une revue hal-00171244v1
[The rat Toxo1 locus controls the outcome of the toxoplasmic infection according to a mendelian mode] Pierre Cavaillès,Cordelia Bisanz,Olivier Papapietro,Céline Colacios,Véronique Sergentet al. Médecine/Sciences, 2006, 22 (8-9), pp.679-80 Article dans une revue hal-00171242v1
Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage Julie Cabarrocas,Cécile Cassan,Fay Magnusson,Eliane Piaggio,Lennart T. Marset al. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (22), pp.8453-8458. ⟨10.1073/pnas.0603086103⟩ Article dans une revue hal-03095902v1
Estrogen enhances susceptibility to experimental autoimmune myasthenia gravis by promoting type 1-polarized immune responses. Laurent Delpy,Victorine Douin-Echinard,Lucile Garidou,Corinne Bruand,Abdelhadi Saoudiet al. Journal of Immunology, 2005, 175 (8), pp.5050-7 Article dans une revue hal-00458865v1
Innate refractoriness of the Lewis rat to toxoplasmosis is a dominant trait that is intrinsic to bone marrow-derived cells. Véronique Sergent,Bastien Cautain,Jamal Khalife,Didier Deslée,Patrick Bastienet al. Infection and Immunity, 2005, 73 (10), pp.6990-7. ⟨10.1128/IAI.73.10.6990-6997.2005⟩ Article dans une revue hal-00173268v1
Cutting Edge: Vα14-Jα281 NKT Cells Naturally Regulate Experimental Autoimmune Encephalomyelitis in Nonobese Diabetic Mice Lennart Mars,Véronique Laloux,Karine Goude,Sabine Desbois,Abdelhadi Saoudiet al. Journal of Immunology, 2002, 168 (12), pp.6007-6011. ⟨10.4049/jimmunol.168.12.6007⟩ Article dans une revue hal-03595264v1

Communication dans un congrès (3)

Themis1/vav1 signaling hub controls T cell pathogenicity in a mouse model of multiple sclerosis Rémi Marrocco,Isabelle Bernard-Cadenat,Renaud Lesourne,Abdelhadi Saoudi 6 th European Congress of Immunology, 1–4 September 2021, Virtual meeting, Sep 2021, Virtual conference, France. OP-030, page 35, ⟨10.1002/eji.202170200⟩ Communication dans un congrès hal-04979860v1
Role of vitamin D and CD226 in a T cell regulatory pathway altered in MS Saniya Kari,Thibault Angles,Elena Morandi,David Frieser,Abdelhadi Saoudiet al. 6th European Congress of Immunology, Sep 2021, Virtual meeting, France. pp.144, ⟨10.1002/eji.202170200⟩ Communication dans un congrès hal-04979442v1
Vav1 cooperate with Themis to modulate regulatory T cell suppressive functions Christophe Pedros,Marianne Chabod,Anne S. Dejean,Isabelle Bernard-Cadenat,Dominique Lagrangeet al. 100. Annual Meeting of the American Association of Immunologists, May 2013, Honolulu, Hawaii, United States Communication dans un congrès hal-02744604v1