Alain Gobert DR2, INRAE,Institut de Recherche en Santé Digestive (IRSD), Toulouse, France

Publications

Article dans une revue (51)

Epithelial hypusination regulates Helicobacter pylori-induced gastric inflammation Alain Gobert,Kara Mcnamara,Caroline Hawkins,Mohammad Asim,Daniel Barryet al. Amino Acids, 2026, ⟨10.1007/s00726-026-03496-3⟩ Article dans une revue hal-05496769v1
Alterations in polyamine metabolism induced by the pathogen Helicobacter pylori: Implications for gastric inflammation and carcinogenesis Alain Gobert,Caroline Hawkins,Kara Mcnamara,Keith Wilson Methods in Enzymology, 2025, Methods in Enzymology, 715, pp.137-153. ⟨10.1016/bs.mie.2025.01.037⟩ Article dans une revue hal-05494888v1
Aconitate Decarboxylase 1 Downregulates Colitis and Maintains Homeostasis of the Gut Metabolome and Microbiome Kara Mcnamara,Yvonne Latour,Caroline Hawkins,Kamery Williams,Daniel Barryet al. Gastro Hep Advances, 2025, 4 (9), pp.100748. ⟨10.1016/j.gastha.2025.100748⟩ Article dans une revue hal-05494859v1
Protective role of epithelial deoxyhypusine synthase in colorectal carcinogenesis caused by deletion of the adenomatous polyposis coli gene Alain Gobert,Kara Mcnamara,Caroline Hawkins,Mohammad Asim,Daniel Barryet al. Cancer Letters, 2025, 633, pp.218002. ⟨10.1016/j.canlet.2025.218002⟩ Article dans une revue hal-05494852v1
Analysis of the effect of hypusination in myeloid cells on colitis and colitis-associated cancer Alain Gobert,Jordan Finley,Mohammad Asim,Daniel Barry,Margaret Allamanet al. Heliyon, 2024, 10 (13), pp.e33838. ⟨10.1016/j.heliyon.2024.e33838⟩ Article dans une revue hal-05494907v1
Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn’s disease Jia Li,Alan Simmons,Caroline Hawkins,Sophie Chiron,Marisol Ramirez-Solanoet al. Nature Communications, 2024, 15 (1), pp.7204. ⟨10.1038/s41467-024-51580-7⟩ Article dans une revue hal-05494905v1
Spermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis through acrolein production Kara Mcnamara,Johanna Sierra,Yvonne Latour,Caroline Hawkins,Mohammad Asimet al. Oncogene, 2024, 44 (5), pp.296-306. ⟨10.1038/s41388-024-03218-7⟩ Article dans une revue hal-05494898v1
The reverse transsulfuration pathway affects the colonic microbiota and contributes to colitis in mice Alain Gobert,Yvonne Latour,Kara Mcnamara,Caroline Hawkins,Kamery Williamset al. Amino Acids, 2024, 56 (1), pp.63. ⟨10.1007/s00726-024-03423-4⟩ Article dans une revue hal-05494900v1
Hypusination in intestinal epithelial cells protects mice from infectious colitis Alain Gobert,Caroline Hawkins,Kamery Williams,Lydia Snyder,Daniel Barryet al. Gut microbes, 2024, 16 (1), ⟨10.1080/19490976.2024.2438828⟩ Article dans une revue hal-05494893v1
The nutraceutical electrophile scavenger 2-hydroxybenzylamine (2-HOBA) attenuates gastric cancer development caused by Helicobacter pylori Alain Gobert,Mohammad Asim,Thaddeus Smith,Kamery Williams,Daniel Barryet al. Biomedicine and Pharmacotherapy, 2023, 158, pp.114092. ⟨10.1016/j.biopha.2022.114092⟩ Article dans une revue hal-05494931v1
Epithelial talin-1 protects mice from Citrobacter rodentium -induced colitis by restricting bacterial crypt intrusion and enhancing T cell immunity Yvonne Latour,Margaret Allaman,Daniel Barry,Thaddeus Smith,Kamery Williamset al. Gut microbes, 2023, 15 (1), ⟨10.1080/19490976.2023.2192623⟩ Article dans une revue hal-05494928v1
Electrophilic reactive aldehydes as a therapeutic target in colorectal cancer prevention and treatment Alain Gobert,Mohammad Asim,Thaddeus Smith,Kamery Williams,Daniel Barryet al. Oncogene, 2023, 42 (20), pp.1685-1691. ⟨10.1038/s41388-023-02691-w⟩ Article dans une revue hal-05494925v1
Myeloid deletion of talin-1 reduces mucosal macrophages and protects mice from colonic inflammation Yvonne Latour,Kara Mcnamara,Margaret Allaman,Daniel Barry,Thaddeus Smithet al. Scientific Reports, 2023, 13 (1), pp.22368. ⟨10.1038/s41598-023-49614-z⟩ Article dans une revue hal-05494918v1
Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification Alain Gobert,Thaddeus Smith,Yvonne Latour,Mohammad Asim,Daniel Barryet al. Gastroenterology, 2023, 165 (3), pp.656-669.e8. ⟨10.1053/j.gastro.2023.05.041⟩ Article dans une revue hal-05494922v1
Ornithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis of Helicobacter pylori Infection Yvonne Latour,Johanna Sierra,Kara Mcnamara,Thaddeus Smith,Paula Luiset al. Journal of Immunology, 2022, 209 (4), pp.796-805. ⟨10.4049/jimmunol.2100795⟩ Article dans une revue hal-05494932v1
Cystathionine γ-lyase exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation Yvonne Latour,Johanna Sierra,Jordan Finley,Mohammad Asim,Daniel Barryet al. JCI Insight, 2022, 7 (12), ⟨10.1172/jci.insight.155338⟩ Article dans une revue hal-05494934v1
Protective Role of Spermidine in Colitis and Colon Carcinogenesis Alain Gobert,Yvonne Latour,Mohammad Asim,Daniel Barry,Margaret Allamanet al. Gastroenterology, 2022, 162 (3), pp.813-827.e8. ⟨10.1053/j.gastro.2021.11.005⟩ Article dans une revue hal-05494941v1
Induction and Regulation of the Innate Immune Response in Helicobacter pylori Infection Alain Gobert,Keith Wilson Cellular and Molecular Gastroenterology and Hepatology, 2022, 13 (5), pp.1347-1363. ⟨10.1016/j.jcmgh.2022.01.022⟩ Article dans une revue hal-05494937v1
Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis Alain Gobert,Olivier Boutaud,Mohammad Asim,Irene Zagol-Ikapitte,Alberto Delgadoet al. Gastroenterology, 2021, 160 (4), pp.1256-1268.e9. ⟨10.1053/j.gastro.2020.11.006⟩ Article dans une revue hal-05495013v1
CCL11 exacerbates colitis and inflammation-associated colon tumorigenesis Dina Polosukhina,Kshipra Singh,Mohammad Asim,Daniel Barry,Margaret Allamanet al. Oncogene, 2021, 40 (47), pp.6540-6546. ⟨10.1038/s41388-021-02046-3⟩ Article dans une revue hal-05494943v1
The role of polyamines in gastric cancer Kara Mcnamara,Alain Gobert,Keith Wilson Oncogene, 2021, 40 (26), pp.4399-4412. ⟨10.1038/s41388-021-01862-x⟩ Article dans une revue hal-05495008v1
Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling Johanna Sierra,M. Blanca Piazuelo,Paula Luis,Daniel Barry,Margaret Allamanet al. Oncogene, 2020, 39 (22), pp.4465-4474. ⟨10.1038/s41388-020-1304-6⟩ Article dans une revue hal-05495018v1
Hypusination Orchestrates the Antimicrobial Response of Macrophages Alain Gobert,Jordan Finley,Yvonne Latour,Mohammad Asim,Thaddeus Smithet al. Cell Reports, 2020, 33 (11), pp.108510. ⟨10.1016/j.celrep.2020.108510⟩ Article dans une revue hal-05495012v1
Dietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic Microbiome Kshipra Singh,Alain Gobert,Lori Coburn,Daniel Barry,Margaret Allamanet al. Frontiers in Cellular and Infection Microbiology, 2019, 9, ⟨10.3389/fcimb.2019.00066⟩ Article dans une revue hal-05495025v1
α-Difluoromethylornithine reduces gastric carcinogenesis by causing mutations in Helicobacter pylori cagY Johanna Sierra,Giovanni Suarez,M. Blanca Piazuelo,Paula Luis,Dara Bakeret al. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (11), pp.5077-5085. ⟨10.1073/pnas.1814497116⟩ Article dans une revue hal-05495028v1
The role of polyamines in the regulation of macrophage polarization and function Yvonne Latour,Alain Gobert,Keith Wilson Amino Acids, 2019, 52 (2), pp.151-160. ⟨10.1007/s00726-019-02719-0⟩ Article dans une revue hal-05495023v1
Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway Alain Gobert,Yvonne Latour,Mohammad Asim,Jordan Finley,Thomas Verriereet al. mBio, 2019, 10 (5), ⟨10.1128/mBio.02174-19⟩ Article dans une revue hal-05495022v1
Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses Kshipra Singh,Lori Coburn,Mohammad Asim,Daniel Barry,Margaret Allamanet al. Cancer Research, 2018, 78 (15), pp.4303-4315. ⟨10.1158/0008-5472.CAN-18-0116⟩ Article dans une revue hal-05495043v1
BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability Yash Choksi,Vishruth Reddy,Kshipra Singh,Caitlyn Barrett,Sarah Shortet al. Mucosal Immunology, 2018, 11 (5), pp.1363-1374. ⟨10.1038/s41385-018-0043-2⟩ Article dans une revue hal-05495040v1
Helicobacter: Inflammation, immunology, and vaccines Alice Blosse,Philippe Lehours,Keith Wilson,Alain Gobert Helicobacter, 2018, 23 (S1), ⟨10.1111/hel.12517⟩ Article dans une revue hal-05495031v1
Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection Alain Gobert,Nicole Al-Greene,Kshipra Singh,Lori Coburn,Johanna Sierraet al. Frontiers in Immunology, 2018, 9, ⟨10.3389/fimmu.2018.01242⟩ Article dans une revue hal-05495036v1
Epidermal growth factor receptor inhibition downregulates Helicobacter pylori -induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis Johanna Sierra,Mohammad Asim,Thomas Verriere,M Blanca Piazuelo,Giovanni Suarezet al. Gut, 2018, 67 (7), pp.1247-1260. ⟨10.1136/gutjnl-2016-312888⟩ Article dans une revue hal-05495052v1
Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis Lori Coburn,Kshipra Singh,Mohammad Asim,Daniel Barry,Margaret Allamanet al. Oncogene, 2018, 38 (7), pp.1067-1079. ⟨10.1038/s41388-018-0492-9⟩ Article dans une revue hal-05495032v1
Effect of CO2 on Peroxynitrite-Mediated Bacteria Killing: Response to Tsikas et al. Alain Gobert,Keith Wilson Trends in Microbiology, 2017, 25 (8), pp.602-603. ⟨10.1016/j.tim.2017.05.009⟩ Article dans une revue hal-05495045v1
Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications Dana Hardbower,Mohammad Asim,Paula Luis,Kshipra Singh,Daniel Barryet al. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (5), ⟨10.1073/pnas.1614958114⟩ Article dans une revue hal-05495059v1
Polyamine- and NADPH-dependent generation of ROS during Helicobacter pylori infection: A blessing in disguise Alain Gobert,Keith Wilson Free Radical Biology and Medicine, 2017, 105, pp.16-27. ⟨10.1016/j.freeradbiomed.2016.09.024⟩ Article dans une revue hal-05495075v1
Human and Helicobacter pylori Interactions Determine the Outcome of Gastric Diseases Alain Gobert,Keith Wilson Current Topics in Microbiology and Immunology, 2017, Current Topics in Microbiology and Immunology, 400, pp.27-52. ⟨10.1007/978-3-319-50520-6_2⟩ Article dans une revue hal-05495058v1
The Immune Battle against Helicobacter pylori Infection: NO Offense Alain Gobert,Keith Wilson Trends in Microbiology, 2016, 24 (5), pp.366-376. ⟨10.1016/j.tim.2016.02.005⟩ Article dans une revue hal-05495079v1
The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria Kshipra Singh,Nicole Al-Greene,Thomas Verriere,Lori Coburn,Mohammad Asimet al. PLoS Pathogens, 2016, 12 (10), pp.e1005984. ⟨10.1371/journal.ppat.1005984⟩ Article dans une revue hal-05495070v1
Cellular responses to attaching and effacing bacteria: activation and implication of the innate immune system. Alain Gobert,Keith Wilson,Christine Martin Archivum Immunologiae et Therapiae Experimentalis, 2005, 53 (3), pp.234-44. ⟨10.1074/jbc.C400498200⟩ Article dans une revue hal-05495936v1
Protective Role of Arginase in a Mouse Model of Colitis Alain Gobert,Yulan Cheng,Mahmood Akhtar,Benjamin Mersey,Darren Blumberget al. Journal of Immunology, 2004, 173 (3), pp.2109-2117. ⟨10.4049/jimmunol.173.3.2109⟩ Article dans une revue hal-05495931v1
Helicobacter pylori Heat Shock Protein 60 Mediates Interleukin-6 Production by Macrophages via a Toll-like Receptor (TLR)-2-, TLR-4-, and Myeloid Differentiation Factor 88-independent Mechanism Alain Gobert,Jean-Christophe Bambou,Catherine Werts,Viviane Balloy,Michel Chignardet al. Journal of Biological Chemistry, 2004, 279 (1), pp.245-250. ⟨10.1074/jbc.M307858200⟩ Article dans une revue hal-05495925v1
Mouse Strain Susceptibility to Trypanosome Infection: An Arginase-Dependent Effect Sébastien Duleu,Philippe Vincendeau,Pierrette Courtois,Silla Semballa,Isabelle Lagroyeet al. Journal of Immunology, 2004, 172 (10), pp.6298-6303. ⟨10.4049/jimmunol.172.10.6298⟩ Article dans une revue hal-05495929v1
Cutting Edge: Cyclooxygenase-2 Activation Suppresses Th1 Polarization in Response to Helicobacter pylori Frank Meyer,Kalathur Ramanujam,Alain Gobert,Stephen James,Keith Wilson Journal of Immunology, 2003, 171 (8), pp.3913-3917. ⟨10.4049/jimmunol.171.8.3913⟩ Article dans une revue hal-05495921v1
Arginases in parasitic diseases Philippe Vincendeau,Alain Gobert,Sylvie Daulouède,Daniel Moynet,M Djavad Mossalayi Trends in Parasitology, 2003, 19 (1), pp.9-12. ⟨10.1016/s1471-4922(02)00010-7⟩ Article dans une revue istex hal-05495919v1
Helicobacter pylori Induces Macrophage Apoptosis by Activation of Arginase II Alain Gobert,Yulan Cheng,Jian-Ying Wang,Jean-Luc Boucher,Ramaswamy Iyeret al. Journal of Immunology, 2002, 168 (9), pp.4692-4700. ⟨10.4049/jimmunol.168.9.4692⟩ Article dans une revue hal-05495912v1
Cutting Edge: Urease Release by Helicobacter pylori Stimulates Macrophage Inducible Nitric Oxide Synthase Alain Gobert,Benjamin Mersey,Yulan Cheng,Darren Blumberg,Jamie Newtonet al. Journal of Immunology, 2002, 168 (12), pp.6002-6006. ⟨10.4049/jimmunol.168.12.6002⟩ Article dans une revue hal-05495914v1
Helicobacter pylori arginase inhibits nitric oxide production by eukaryotic cells: A strategy for bacterial survival Alain Gobert,David Mcgee,Mahmood Akhtar,George Mendz,Jamie Newtonet al. Proceedings of the National Academy of Sciences of the United States of America, 2001, 98 (24), pp.13844-13849. ⟨10.1073/pnas.241443798⟩ Article dans une revue hal-05495911v1
l -Arginine Availability Modulates Local Nitric Oxide Production and Parasite Killing in Experimental Trypanosomiasis Alain Gobert,Sylvie Daulouede,Michel Lepoivre,Jean Luc Boucher,Bernard Bouteilleet al. Infection and Immunity, 2000, 68 (8), pp.4653-4657. ⟨10.1128/IAI.68.8.4653-4657.2000⟩ Article dans une revue hal-05495908v1
Mechanism of Extracellular Thiol Nitrosylation by N2O3 Produced by Activated Macrophages Alain Gobert,Philippe Vincendeau,Djavad Mossalayi,Bernard Veyret Nitric Oxide: Biology and Chemistry, 1999, 3 (6), pp.467-472. ⟨10.1006/niox.1999.0260⟩ Article dans une revue istex hal-05495903v1
Murine Macrophages Use Oxygen- and Nitric Oxide-Dependent Mechanisms To Synthesize S -Nitroso-Albumin and To Kill Extracellular Trypanosomes Alain Gobert,Silla Semballa,Sylvie Daulouede,Sophie Lesthelle,Murielle Taxileet al. Infection and Immunity, 1998, 66 (9), pp.4068-4072. ⟨10.1128/IAI.66.9.4068-4072.1998⟩ Article dans une revue hal-05495898v1