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Diving into the complexity of the spirochetal endoflagellum
Fabiana San Martin
,
Lenka Fule
,
Gregorio Iraola
,
Alejandro Buschiazzo
,
Mathieu Picardeau
Article dans une revue
(article de synthèse)
pasteur-04117804
v1
|
|
An allosteric switch ensures efficient unidirectional information transmission by the histidine kinase DesK from Bacillus subtilis
Sofía Lima
,
Juan Blanco
,
Federico Olivieri
,
Juan Imelio
,
Marcos Nieves
et al.
Article dans une revue
pasteur-04117648
v1
|
|
Structural features of sensory two component systems: a synthetic biology perspective
Marcos Nieves
,
Alejandro Buschiazzo
,
Felipe Trajtenberg
Article dans une revue
pasteur-04117794
v1
|
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Listeria innocua isolated from diseased ruminants harbour minor virulence genes of L. monocytogenes
Carolina Matto
,
Bruno d'Alessandro
,
María Inés Mota
,
Valeria Braga
,
Alejandro Buschiazzo
et al.
Article dans une revue
hal-04117822
v1
|
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Horizontal transfer of the rfb cluster in Leptospira is a genetic determinant of serovar identity
Cecilia Nieves
,
Antony Vincent
,
Leticia Zarantonelli
,
Mathieu Picardeau
,
Frédéric Veyrier
et al.
Article dans une revue
pasteur-04117799
v1
|
|
3D cryo-EM imaging of bacterial flagella: Novel structural and mechanistic insights into cell motility
Sonia Mondino
,
Fabiana San Martin
,
Alejandro Buschiazzo
Article dans une revue
pasteur-04117813
v1
|
|
The crystal structure of yeast regulatory subunit reveals key evolutionary insights into Protein Kinase A oligomerization
Nicolás González Bardeci
,
Enzo Tofolón
,
Felipe Trajtenberg
,
Julio Caramelo
,
Nicole Larrieux
et al.
Article dans une revue
pasteur-03246652
v1
|
|
Role of the major determinant of polar flagellation FlhG in the endoflagella‐containing spirochete Leptospira
Lenka Fule
,
Ruben Halifa
,
Celia Fontana
,
Odile Sismeiro
,
Rachel Legendre
et al.
Article dans une revue
pasteur-03411258
v1
|
|
AID overexpression leads to aggressive murine CLL and non-Ig mutations that mirror human neoplasms.
Pablo Elías Morande
,
Xiao-Jie Yan
,
Julieta Haydee Sepulveda-Yanez
,
Noé Seija
,
Maria Elena Marquez
et al.
Article dans une revue
pasteur-03246646
v1
|
|
Allostery and protein plasticity: the keystones for bacterial signaling and regulation
J. Imelio
,
F. Trajtenberg
,
Alejandro Buschiazzo
Article dans une revue
pasteur-04117817
v1
|
|
Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine
Julia Lara
,
Lautaro Diacovich
,
Felipe Trajtenberg
,
Nicole Larrieux
,
Emilio L. Malchiodi
et al.
Article dans une revue
pasteur-03246643
v1
|
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An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete
Kimberley H Gibson
,
Felipe Trajtenberg
,
Elsio A. Jr Wunder
,
Megan R Brady
,
Fabiana San Martin
et al.
Article dans une revue
pasteur-02549761
v1
|
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Causes of abortion in dairy cows in Uruguay
Melissa Macías-Rioseco
,
Caroline Silveira
,
Martin Fraga
,
Laura Casaux
,
Andrés Cabrera
et al.
Article dans une revue
pasteur-03246634
v1
|
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Glucose-6-Phosphate Dehydrogenase from the Human Pathogen Trypanosoma cruzi Evolved Unique Structural Features to Support Efficient Product Formation
Cecilia Ortíz
,
Horacio Botti
,
Alejandro Buschiazzo
,
Marcelo Comini
Article dans une revue
pasteur-02554318
v1
|
|
Draft Genome Sequences of 40 Pathogenic Leptospira Strains Isolated from Cattle in Uruguay
Cecilia Nieves
,
Ignacio Ferrés
,
Florencia Díaz-Viraqué
,
Alejandro Buschiazzo
,
Leticia Zarantonelli
et al.
Article dans une revue
pasteur-02554324
v1
|
|
Two-Component Sensing and Regulation: How Do Histidine Kinases Talk with Response Regulators at the Molecular Level?
Alejandro Buschiazzo
,
Felipe Trajtenberg
Article dans une revue
pasteur-02554319
v1
|
|
Molecular adaptations of NADP-malic enzyme for its function in C4 photosynthesis in grasses
Clarisa Alvarez
,
Anastasiia Bovdilova
,
Astrid Höppner
,
Christian-Claus Wolff
,
Mariana Saigo
et al.
Article dans une revue
pasteur-02554321
v1
|
|
Isolation of pathogenic Leptospira strains from naturally infected cattle in Uruguay reveals high serovar diversity, and uncovers a relevant risk for human leptospirosis
Leticia Zarantonelli
,
Alejandra Suanes
,
Paulina Meny
,
Florencia Buroni
,
Cecilia Nieves
et al.
Article dans une revue
pasteur-01881268
v1
|
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Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira
Haritha Adhikarla
,
Elsio A. Jr Wunder
,
Ariel E Mechaly
,
Sameet Mehta
,
Zheng Wang
et al.
Article dans une revue
pasteur-02100138
v1
|
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The crystal structure of the malic enzyme from Candidatus Phytoplasma reveals the minimal structural determinants for a malic enzyme
C. Alvarez
,
F. Trajtenberg
,
N. Larrieux
,
M. Saigo
,
A. Golic
et al.
Article dans une revue
pasteur-02554314
v1
|
|
FcpB Is a Surface Filament Protein of the Endoflagellum Required for the Motility of the Spirochete Leptospira
Elsio A. Jr Wunder
,
Leyla Slamti
,
David N Suwondo
,
Kimberley H Gibson
,
Zhiguo Shang
et al.
Article dans une revue
pasteur-02100036
v1
|
|
SIMBAD: a sequence-independent molecular-replacement pipeline
Adam J Simpkin
,
Felix Simkovic
,
Jens Thomas
,
Martin Savko
,
Andrey Lebedev
et al.
Article dans une revue
pasteur-02554316
v1
|
|
Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance
Ariel E Mechaly
,
Ahmed Haouz
,
Nathalie Sassoon
,
Alejandro Buschiazzo
,
Jean-Michel Betton
et al.
Article dans une revue
hal-02322059
v1
|
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Snapshots of the Signaling Complex DesK:DesR in Different Functional States Using Rational Mutagenesis and X-ray Crystallography
Juan A Imelio
,
Nicole Larrieux
,
Ariel E Mechaly
,
Felipe Trajtenberg
,
Alejandro Buschiazzo
Article dans une revue
pasteur-02872312
v1
|
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Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis
Fabiana San Martin
,
Nicole Larrieux
,
Ariel E Mechaly
,
Elsio A. Jr Wunder
,
Albert I Ko
et al.
Acta crystallographica Section F : Structural biology communications [2014-..], 2017, 73 (3), pp.123 - 129. ⟨10.1107/S2053230X17002096⟩
Article dans une revue
pasteur-02554311
v1
|
|
Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase
Ariel E Mechaly
,
Silvia Soto Diaz
,
Nathalie Sassoon
,
Alejandro Buschiazzo
,
Jean-Michel Betton
et al.
Article dans une revue
pasteur-02554313
v1
|
|
Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis.
Alexandra East
,
Ariel E Mechaly
,
Gerard H M Huysmans
,
Cédric Bernarde
,
Diana Tello-Manigne
et al.
Article dans une revue
pasteur-01498343
v1
|
|
Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action
Felipe Trajtenberg
,
Juan A Imelio
,
Matías R Machado
,
Nicole Larrieux
,
Marcelo A Marti
et al.
Article dans une revue
pasteur-02554309
v1
|
|
Crystal Structure of the Metallo-β-Lactamase GOB in the Periplasmic Dizinc Form Reveals an Unusual Metal Site.
Jorgelina Morán-Barrio
,
María-Natalia Lisa
,
Nicole Larrieux
,
Salvador I Drusin
,
Alejandro M Viale
et al.
Article dans une revue
pasteur-01499013
v1
|
|
A novel flagellar sheath protein, FcpA, determines filament coiling, translational motility and virulence for the Leptospira spirochete
Elsio A. Jr Wunder
,
Cláudio Pereira Figueira
,
Nadia Benaroudj
,
Bo Hu
,
Brian Tong
et al.
Article dans une revue
pasteur-02548535
v1
|
|
What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira.
Derrick E Fouts
,
Michael A Matthias
,
Haritha Adhikarla
,
Ben Adler
,
Luciane Amorim-Santos
et al.
Article dans une revue
pasteur-01436457
v1
|
|
Data publication with the structural biology data grid supports live analysis
Peter A. Meyer
,
Stephanie Socias
,
Jason Key
,
Elizabeth Ransey
,
Emily C. Tjon
et al.
Article dans une revue
hal-01299025
v1
|
|
Conformational plasticity of a native retroviral capsid revealed by x-ray crystallography
G. Obal
,
F. Trajtenberg
,
F. Carrión
,
L. Tomé
,
N. Larrieux
et al.
Article dans une revue
pasteur-02554123
v1
|
|
Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm
Stephen Methot
,
Ludivine Litzler
,
Felipe Trajtenberg
,
Astrid Zahn
,
Francis Robert
et al.
Article dans une revue
pasteur-02554122
v1
|
|
A coiled coil switch mediates cold sensing by the thermosensory protein DesK
Emilio Saita
,
Luciano A Abriata
,
Yi Ting Tsai
,
Felipe Trajtenberg
,
Thomas Lemmin
et al.
Article dans une revue
pasteur-02554124
v1
|
|
Allosteric Activation of Bacterial Response Regulators: the Role of the Cognate Histidine Kinase Beyond Phosphorylation
Felipe Trajtenberg
,
Daniela Albanesi
,
Natalia Ruétalo
,
Horacio Botti
,
Ariel E Mechaly
et al.
Article dans une revue
pasteur-02554121
v1
|
|
HemR is an OmpR/PhoB-like response regulator from Leptospira, which simultaneously effects transcriptional activation and repression of key haem metabolism genes
Natalia R Morero
,
Horacio Botti
,
Kazuhiro Nitta
,
Federico Carrión
,
Gonzalo Obal
et al.
Article dans une revue
pasteur-02554119
v1
|
|
Structural insights into bacterial resistance to cerulenin
Felipe Trajtenberg
,
Silvia Altabe
,
Nicole Larrieux
,
Florencia Ficarra
,
Diego de Mendoza
et al.
Article dans une revue
pasteur-02554118
v1
|
|
Structure of a human IgA1 Fab fragment at 1.55 Å resolution: potential effect of the constant domains on antigen-affinity modulation.
Agustin Correa
,
Felipe Trajtenberg
,
Gonzalo Obal
,
Otto Pritsch
,
Guillermo Dighiero
et al.
Article dans une revue
pasteur-00847149
v1
|
|
Structural basis for feed-forward transcriptional regulation of membrane lipid homeostasis in Staphylococcus aureus.
Daniela Albanesi
,
Georgina Reh
,
Marcelo E Guerin
,
Francis Schaeffer
,
Michel Debarbouille
et al.
Article dans une revue
pasteur-00846686
v1
|
|
The Crystal Structure of the MAP Kinase LmaMPK10 from Leishmania Major Reveals Parasite-Specific Features and Regulatory Mechanisms.
Sofía Horjales
,
Dirk Schmidt-Arras
,
Ramiro Rodriguez Limardo
,
Olivier Leclercq
,
Gonzalo Obal
et al.
Article dans une revue
pasteur-00727033
v1
|
|
Trypanosoma cruzi trans-sialidase in complex with a neutralizing antibody: structure/function studies towards the rational design of inhibitors.
Alejandro Buschiazzo
,
Romina Muiá
,
Nicole Larrieux
,
Tamara Pitcovsky
,
Juan Mucci
et al.
Article dans une revue
pasteur-00686326
v1
|
|
Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity.
Pablo Oppezzo
,
Gonzalo Obal
,
Martín A Baraibar
,
Otto Pritsch
,
Pedro M Alzari
et al.
Article dans une revue
istex
pasteur-00685050
v1
|
|
Expression, crystallization and preliminary X-ray crystallographic analysis of glucose-6-phosphate dehydrogenase from the human pathogen Trypanosoma cruzi in complex with substrate.
Cecilia Ortíz
,
Nicole Larrieux
,
Andrea Medeiros
,
Horacio Botti
,
Marcelo Comini
et al.
Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2011, 67 (Pt 11), pp.1457-61. ⟨10.1107/S1744309111037821⟩
Article dans une revue
pasteur-00686320
v1
|
|
Swapping FAD binding motifs between plastidic and bacterial ferredoxin-NADP(H) reductases.
Matías A Musumeci
,
Horacio Botti
,
Alejandro Buschiazzo
,
Eduardo A Ceccarelli
Article dans une revue
pasteur-00685048
v1
|
|
Crystal structure of Mycobacterium tuberculosis LppA, a lipoprotein confined to pathogenic mycobacteria.
Martin Graña
,
Marco Bellinzoni
,
Jacques Bellalou
,
Ahmed Haouz
,
Isabelle Miras
et al.
Article dans une revue
istex
pasteur-00508937
v1
|
|
Evidence of adaptability in metal coordination geometry and active-site loop conformation among B1 metallo-beta-lactamases .
Javier M González
,
Alejandro Buschiazzo
,
Alejandro J Vila
Article dans une revue
pasteur-00684682
v1
|
|
Phylogenetic analysis of bovine leukemia viruses isolated in South America reveals diversification in seven distinct genotypes.
Gonzalo Moratorio
,
Gonzalo Obal
,
Ana Dubra
,
Agustín Correa
,
Sergio Bianchi
et al.
Article dans une revue
istex
pasteur-00684630
v1
|
|
Structural and enzymatic insights into the ATP binding and autophosphorylation mechanism of a sensor histidine kinase.
Felipe Trajtenberg
,
Martin Graña
,
Natalia Ruétalo
,
Horacio Botti
,
Alejandro Buschiazzo
Article dans une revue
pasteur-00508936
v1
|
|
Structural plasticity and catalysis regulation of a thermosensor histidine kinase
Daniela Albanesi
,
Mariana Martin
,
Felipe Trajtenberg
,
María Mansilla
,
Ahmed Haouz
et al.
Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (38), pp.16185-16190. ⟨10.1073/pnas.0906699106⟩
Article dans une revue
pasteur-02554116
v1
|
|
Structure of Mycobacterium tuberculosis Rv2714, a representative of a duplicated gene family in Actinobacteria.
Martin Graña
,
Marco Bellinzoni
,
Isabelle Miras
,
Cedric Fiez-Vandal
,
Ahmed Haouz
et al.
Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2009, 65 (Pt 10), pp.972-7. ⟨10.1107/S1744309109035027⟩
Article dans une revue
pasteur-00508938
v1
|
|
Active nuclear import and cytoplasmic retention of activation-induced deaminase
Anne-Marie Patenaude
,
Alexandre Orthwein
,
Yi Hu
,
Vanina A Campo
,
Bodil Kavli
et al.
Article dans une revue
pasteur-02554115
v1
|
|
Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening
João Neres
,
Mark L Brewer
,
Laura Ratier
,
Horacio Botti
,
Alejandro Buschiazzo
et al.
Article dans une revue
istex
pasteur-02554114
v1
|
|
Structural insights into sialic acid enzymology
Alejandro Buschiazzo
,
Pedro Alzari
Article dans une revue
istex
pasteur-02554113
v1
|
|
A New Generation of Specific Trypanosoma Cruzi Trans-Sialidase Inhibitors
Sabrina Buchini
,
Alejandro Buschiazzo
,
Stephen G. Withers
Article dans une revue
istex
pasteur-02554112
v1
|
|
Kinetic and Mechanistic Analysis of Trypanosoma cruzi Trans-Sialidase Reveals a Classical Ping-Pong Mechanism with Acid/Base Catalysis
Iben Damager
,
Sabrina Buchini
,
Maria F Amaya
,
Alejandro Buschiazzo
,
Pedro Alzari
et al.
Article dans une revue
istex
pasteur-02554111
v1
|
|
Molecular Recognition and Interfacial Catalysis by the Essential Phosphatidylinositol Mannosyltransferase PimA from Mycobacteria
Marcelo E Guerin
,
Jana Korduláková
,
Francis Schaeffer
,
Zuzana Svetlikova
,
Alejandro Buschiazzo
et al.
Article dans une revue
pasteur-02554110
v1
|
|
The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria.
Martin Graña
,
Ahmed Haouz
,
Alejandro Buschiazzo
,
Isabelle Miras
,
Annemarie Wehenkel
et al.
Article dans une revue
pasteur-00508941
v1
|
|
The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria.
William Shepard
,
Ahmed Haouz
,
Martin Graña
,
Alejandro Buschiazzo
,
Jean-Michel Betton
et al.
Article dans une revue
pasteur-00508943
v1
|
|
Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase
João Neres
,
Pascal Bonnet
,
Philip N Edwards
,
Pravin L Kotian
,
Alejandro Buschiazzo
et al.
Article dans une revue
istex
pasteur-02554109
v1
|
|
Structural basis of lipid biosynthesis regulation in Gram-positive bacteria
Gustavo E Schujman
,
Marcelo E Guerin
,
Alejandro Buschiazzo
,
Francis Schaeffer
,
Leticia I Llarrull
et al.
Article dans une revue
pasteur-02554108
v1
|
|
Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase
Alejandro Buschiazzo
,
Maira Goytia
,
Francis Schaeffer
,
Wim M. Degrave
,
William Shepard
et al.
Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (6), pp.1705-1710. ⟨10.1073/pnas.0509010103⟩
Article dans une revue
hal-02523212
v1
|
|
Structural and Kinetic Analysis of Two Covalent Sialosyl-Enzyme Intermediates on Trypanosoma Rangeli Sialidase
Andrew G Watts
,
Pablo Oppezzo
,
Stephen Withers
,
Pedro Alzari
,
Alejandro Buschiazzo
Article dans une revue
pasteur-02554104
v1
|
|
Continuous fluorimetric assay for high-throughput screening of inhibitors of trans-sialidase from Trypanosoma cruzi
João Neres
,
Alejandro Buschiazzo
,
Pedro Alzari
,
Lindsey Walsh
,
Kenneth T Douglas
Article dans une revue
istex
pasteur-02554106
v1
|
|
Structural Biology and Crystallization Communications Crystallization and preliminary crystallographic analysis of PimA, an essential mannosyltransferase from Mycobacterium smegmatis
Marcelo E Guerin
,
Alejandro Buschiazzo
,
Jana Korduláková
,
Mary Jackson
,
Pedro Alzari
Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2005, 61 (5), pp.518-520. ⟨10.1107/S1744309105012364⟩
Article dans une revue
pasteur-02554105
v1
|
|
Structural Insights Into the Catalytic Mechanism of Trypanosoma Cruzi Trans-Sialidase
María Fernanda Amaya
,
Andrew G Watts
,
Iben Damager
,
Annemarie Wehenkel
,
Tong Nguyen
et al.
Article dans une revue
pasteur-02554101
v1
|
|
Crystal Structure of Glycogen Synthase: Homologous Enzymes Catalyze Glycogen Synthesis and Degradation
Alejandro Buschiazzo
,
Juan E Ugalde
,
Marcelo E Guerin
,
William Shepard
,
Rodolfo A Ugalde
et al.
Article dans une revue
pasteur-02554103
v1
|
|
Trypanosoma cruzi Trans-sialidase Operates through a Covalent Sialyl-Enzyme Intermediate: Tyrosine Is the Catalytic Nucleophile
Andrew G Watts
,
Iben Damager
,
Maria L Amaya
,
Alejandro Buschiazzo
,
Pedro Alzari
et al.
Article dans une revue
istex
pasteur-02554098
v1
|
|
Preliminary Crystallographic Studies of Glycogen Synthase From Agrobacterium Tumefaciens
Marcelo E Guerin
,
Alejandro Buschiazzo
,
Juan E Ugalde
,
Rodolfo A Ugalde
,
Pedro Alzari
Article dans une revue
istex
pasteur-02554095
v1
|
|
The High Resolution Structures of Free and Inhibitor- bound Trypanosoma rangeli Sialidase and its Comparison with T. cruzi Trans-sialidase
Maria Fernanda Amaya
,
Alejandro Buschiazzo
,
Tong Nguyen
,
Pedro Alzari
Article dans une revue
istex
pasteur-02554094
v1
|
|
The trans-sialidase from the African trypanosome Trypanosoma brucei
Georgina Montagna
,
M. Laura Cremona
,
Gastón Paris
,
María Fernanda Amaya
,
Alejandro Buschiazzo
et al.
Article dans une revue
pasteur-02554091
v1
|
|
The Crystal Structure and Mode of Action of Trans-Sialidase, a Key Enzyme in Trypanosoma Cruzi Pathogenesis
Alejandro Buschiazzo
,
María Fernanda Amaya
,
María L Cremona
,
Alberto C Frasch
,
Pedro Alzari
Article dans une revue
pasteur-02554093
v1
|
|
Probing molecular function of trypanosomal sialidases: single point mutations can change substrate specificity and increase hydrolytic activity
Gaston Paris
,
Maria Laura Cremona
,
Maria Fernanda Amaya
,
Alejandro Buschiazzo
,
Susana Giambiagi
et al.
Article dans une revue
pasteur-02554090
v1
|
|
Structural basis of sialyltransferase activity in trypanosomal sialidases
Alejandro Buschiazzo
,
Gisele A Tavares
,
Oscar Campetella
,
Silvia Spinelli
,
Maria L Cremona
et al.
Article dans une revue
pasteur-02554089
v1
|
|
The tyrosine aminotransferase from Trypanosoma rangeli: sequence and genomic characterization
Esteban J Bontempi
,
Gabriela A Garcia
,
Alejandro Buschiazzo
,
Jan Henriksson
,
Carlos A Pravia
et al.
Article dans une revue
pasteur-02554087
v1
|
|
Trypanosoma Rangeli Sialidase: Cloning, Expression and Similarity to T. Cruzi Trans-Sialidase
Alejandro Buschiazzo
,
Oscar Campetella
,
Alberto C Frasch
Article dans une revue
pasteur-02554085
v1
|
|
Medium scale production and purification to homogeneity of a recombinant trans-sialidase from Trypanosoma cruzi
Alberto Carlos C Frasch
,
Alejandro Buschiazzo
,
Oscar Campetella
Cellular and Molecular Biology, 1996, 42 (5), pp.703-10
Article dans une revue
pasteur-02554066
v1
|
|
Sequence of the gene for a Trypanosoma cruzi protein antigenic during the chronic phase of human Chagas disease
Alejandro Buschiazzo
,
Oscar Campetella
,
Roberto A Macina
,
Susana Salceda
,
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Identification of the gene(s) coding for the trans-sialidase of Trypanosoma cruzi
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