Alexandre Boissonnas

Présentation

CURRENT POSITION

Research Director and team leader at the French government Institution Inserm, Institut National de la recherche scientifique et médicale at Centre d’immunologie et des maladies infectieuses CIMI, U1135, Hôpital Pitié-Salpêtrière, Paris, France.

EDUCATION

2014 Official ability to conduct PhD students of the French University UPMC, Paris, France

2000-04 PhD in immunology, Paris VI, Pierre et Marie Curie University, Paris, France

Defended January the 15th 2004

1999-00 Master in Immunology of the Pasteur Institute Paris

VII, Jussieu, Paris, France

PROFESSIONNAL EXPERIENCES

Academic research

2021 Research Director position at Inserm.

2019 Team Leader: “Chemokines, Phagocytes and Inflammation”. Centre d’immunologie et des maladies infectieuses CIMI, CR7, U1135, Hôpital Pitié-Salpêtrière, Paris, France. (HCERES validation).

2018-19 Visiting Scholar in Krummel’s lab, Dept of Pathology UCSF, San Francisco USA.

Immune landscape of human tumors (ImmunoProfiler Consortium).

2014 Group Leader in C. Combadière team, CIMI, CR7, U1135, Hôpital Pitié-Salpêtrière, Paris, France.

Dynamic of the mononuclear phagocytic system.

2009 Principal Investigator INSERM, Laboratoire Immunité et Infection UMR-s945.

Hôpital Pitié-Salpêtrière, Paris, France.

Chemokines implication in T cell and tumor associated macrophages interactions.

2004-09 Post-Doctoral Fellow, Laboratoire immunité et Cancer U932

Institut Curie Paris France (Dr S. Amigorena).

Imaging T cell, Dendritic cell and Tumor cell interactions in vivo.**

1999-04 Master and PhD in Immunology, Laboratoire d’Immunologie Cellulaire U543.

Hôpital Pitié-Salpêtrière, Paris, France. (Dr B.Combadière)

Antigenic variants and T cell homeostasis.

1998 Summer Internship (8 weeks), Laboratoire d’Immunologie Cellulaire U543.

Hopital Pitié-Salpêtrière, Paris, France. (Dr B.Combadière)

Role of TCR altered peptide ligands on T cell apoptosis

1997 Summer internship (4 weeks), Laboratoire d’Immunologie Cellulaire U543.

Hopital Pitié-Salpêtrière, Paris, France. (Pr. B. Autran, PU PH)

Longitudinal study of Tri-therapy-treated HIV patients by flow cytometry**

Pharmaceutical research

1996 Summer internship (7 weeks), Département de Pharmacologie.

Rhône Poulenc Rorer, Maison-Alfort, France (Dr I. Cavero)

In vivo study of hypoglycemic molecules in rats.**

1995 Summer internship (5 weeks), Département de Pharmacologie.

Rhône Poulenc Rorer, Maison-Alfort, France (Dr I. Cavero)

Study on rat explanted organ culture of anticancer and vasoconstrictor drugs side effects**

1994 Summer internship (5 weeks), Département de Pharmacologie.

Rhône Poulenc Rorer, Maison-Alfort, France (Dr I. Cavero)

Technical assistance on explanted organ cultures from rats and guinea pigs**

Publications

Article dans une revue (46)

Combined pharmacological targeting of CD9+ progenitors alleviates obesity-induced adipose tissue fibrosis and metabolic impairment Clémentine Rebière,Ana Letícia Silveira,Amanda Oliveira,Christine Rouault,Solia Adriouchet al. Cell Reports Medicine, 2025, 6 (7), pp.102197. ⟨10.1016/j.xcrm.2025.102197⟩ Article dans une revue hal-05417306v1
Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors Eléonore Weber-Delacroix,Marylou Panouillot,Marie Laviron,François Lanthiez,Tristan Philippeet al. Cancer Immunology Research, 2025, 13 (10), pp.1561 - 1575. ⟨10.1158/2326-6066.cir-25-0103⟩ Article dans une revue hal-05378474v1
Loss of embryonically-derived Kupffer cells during hypercholesterolemia accelerates atherosclerosis development Rebecca Fima,Sébastien Dussaud,Cheïma Benbida,Margault Blanchet,François Lanthiezet al. Nature Communications, 2024, 15 (1), pp.8341. ⟨10.1038/s41467-024-52735-2⟩ Article dans une revue hal-04716830v1
Visualizing the spatial organization of monocytes, interstitial macrophages, and tissue-specific macrophages in situ Maxime Petit,Eléonore Weber-Delacroix,François Lanthiez,Sandrine Barthélémy,Noëlline Guillouet al. Cell Reports, 2024, 43 (10), pp.114847. ⟨10.1016/j.celrep.2024.114847⟩ Article dans une revue (data paper) hal-04889092v1
Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages Nilushi de Silva,Johan Siewiera,Chantal Alkhoury,Guilherme Nader,Francesca Nadalinet al. Nature Aging, 2023, 3 (10), pp.1251-1268. ⟨10.1038/s43587-023-00488-w⟩ Article dans une revue hal-04290463v1
Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages Nilushi de Silva,Johan Siewiera,Chantal Alkhoury,Guilherme Nader,Francesca Nadalinet al. Nature Aging, 2023, 3 (10), pp.1251-1268. ⟨10.1038/s43587-023-00488-w⟩ Article dans une revue hal-04290165v1
Two New Neutrophil Subsets Define a Discriminating Sepsis Signature Aïda Meghraoui-Kheddar,Benjamin Chousterman,Noëlline Guillou,Sierra Barone,Samuel Granjeaudet al. American Journal of Respiratory and Critical Care Medicine, 2022, 205 (1), pp.46-59. ⟨10.1164/rccm.202104-1027OC⟩ Article dans une revue hal-03419725v1
Discovering dominant tumor immune archetypes in a pan-cancer census Alexis Combes,Bushra Samad,Jessica Tsui,Nayvin Chew,Peter Yanet al. Cell, 2022, 185 (1), pp.184-203.e19. ⟨10.1016/j.cell.2021.12.004⟩ Article dans une revue hal-03549512v1
Modulating the tumor-associated macrophage landscape Alexandre Boissonnas,Christophe Combadière Nature Immunology, 2022, 23 (4), pp.481-482. ⟨10.1038/s41590-022-01159-5⟩ Article dans une revue hal-03983376v1
Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer Adriana Mujal,Alexis Combes,Arjun Rao,Mikhail Binnewies,Bushra Samadet al. Cancer Immunology Research, 2022, 10 (4), pp.403-419. ⟨10.1158/2326-6066.CIR-21-0588⟩ Article dans une revue hal-04027478v1
Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer Marie Laviron,Maxime Petit,Eléonore Weber-Delacroix,Alexis J Combes,Arjun Rao Arkalet al. Cell Reports, 2022, 39 (8), pp.110865. ⟨10.1016/j.celrep.2022.110865⟩ Article dans une revue hal-03699958v1
TREM-1 orchestrates angiotensin II–induced monocyte trafficking and promotes experimental abdominal aortic aneurysm Marie Vandestienne,Yujiao Zhang,Icia Santos-Zas,Rida Al-Rifai,Jeremie Joffreet al. Journal of Clinical Investigation, 2021, 131 (2), pp.e142468. ⟨10.1172/JCI142468⟩ Article dans une revue inserm-03833065v1
LOX-1-Expressing Immature Neutrophils Identify Critically-Ill COVID-19 Patients at Risk of Thrombotic Complications Behazine Combadière,Lucille Adam,Noëlline Guillou,Paul Quentric,Pierre Rosenbaumet al. Frontiers in Immunology, 2021, 12, pp.752612. ⟨10.3389/fimmu.2021.752612⟩ Article dans une revue hal-03375967v1
Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure M. Flamant,N. Mougenot,E. Balse,L. Le Fèvre,F. Atassiet al. Scientific Reports, 2021, 11 (1), pp.17982. ⟨10.1038/s41598-021-97493-z⟩ Article dans une revue hal-03354268v1
Ibrutinib induces multiple functional defects in the neutrophil response against Aspergillus fumigatus Damien Blez,Marion Blaize,Carole Soussain,Alexandre Boissonnas,Aïda Meghraoui-Kheddaret al. Haematologica, 2020, 105 (2), pp.478-489. ⟨10.3324/haematol.2019.219220⟩ Article dans une revue hal-02486017v1
Revising CX3CR1 Expression on Murine Classical and Non-classical Monocytes Aïda Meghraoui-Kheddar,Sandrine Barthélémy,Alexandre Boissonnas,Christophe Combadière Frontiers in Immunology, 2020, 11, pp.1117. ⟨10.3389/fimmu.2020.01117⟩ Article dans une revue hal-02898020v1
Imaging resident and recruited macrophage contribution to Wallerian degeneration Alexandre Boissonnas,Floriane Louboutin,Marie Laviron,Pierre-Louis Loyher,Elodie Reboussinet al. Journal of Experimental Medicine, 2020, 217 (11), ⟨10.1084/jem.20200471⟩ Article dans une revue hal-03047020v1
Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing Denise Gay,Giulia Ghinatti,Christian Guerrero-Juarez,Rubén A Ferrer,Federica Ferriet al. Science Advances , 2020, 6 (12), pp.eaay3704. ⟨10.1126/sciadv.aay3704⟩ Article dans une revue hal-02540226v1
Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer Aitziber Buqué,Norma Bloy,Maria Perez-Lanzón,Kristina Iribarren,Juliette Humeauet al. Nature Communications, 2020, 11, pp.3819. ⟨10.1038/s41467-020-17644-0⟩ Article dans une revue hal-03994636v1
Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis Sophie Tran,Ines Baba,Lucie Poupel,Sébastien Dussaud,Martine Moreauet al. Immunity, 2020, 53 (3), pp.627-640.e5. ⟨10.1016/j.immuni.2020.06.003⟩ Article dans une revue hal-02967896v1
Sepsis Triggers a Late Expansion of Functionally Impaired Tissue-Vascular Inflammatory Monocytes During Clinical Recovery Camille Baudesson De Chanville,Benjamin Glenn Chousterman,Pauline Hamon,Marie Laviron,Noelline Guillouet al. Frontiers in Immunology, 2020, 11, pp.675. ⟨10.3389/fimmu.2020.00675⟩ Article dans une revue hal-02798381v1
Publisher Correction: Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer Aitziber Buqué,Norma Bloy,Maria Perez-Lanzón,Kristina Iribarren,Juliette Humeauet al. Nature Communications, 2020, 11 (1), pp.4787. ⟨10.1038/s41467-020-18719-8⟩ Article dans une revue hal-03994694v1
CCR2-Dependent Recruitment of Tregs and Monocytes Following Radiotherapy Is Associated with TNFα-Mediated Resistance Michele Mondini,Pierre-Louis Loyher,Pauline Hamon,Marine Gerbé de Thoré,Marie Lavironet al. Cancer Immunology Research, 2019, 7 (3), pp.376-387. ⟨10.1158/2326-6066.CIR-18-0633⟩ Article dans une revue hal-02339936v1
Ontogeny of Tumor-Associated Macrophages Marie Laviron,Alexandre Boissonnas Frontiers in Immunology, 2019, 10, pp.1799. ⟨10.3389/fimmu.2019.01799⟩ Article dans une revue hal-02279585v1
Tracking Monocytes and Macrophages in Tumors With Live Imaging Marie Laviron,Christophe Combadière,Alexandre Boissonnas Frontiers in Immunology, 2019, 10, pp.1201. ⟨10.3389/fimmu.2019.01201⟩ Article dans une revue hal-02172263v1
CSF1R inhibition prevents radiation pulmonary fibrosis by depletion of interstitial macrophages Lydia Meziani,Michele Mondini,Benoît Petit,Alexandre Boissonnas,Vincent Thomas de Montprevilleet al. European Respiratory Journal, 2018, 51 (3), pp.1702120. ⟨10.1183/13993003.02120-2017⟩ Article dans une revue hal-04003775v1
Macrophages of distinct origins contribute to tumor development in the lung Pierre-Louis Loyher,Pauline Hamon,Marie Laviron,Aïda Meghraoui-Kheddar,Elena Goncalveset al. Journal of Experimental Medicine, 2018, 215 (10), pp.2536 - 2553. ⟨10.1084/jem.20180534⟩ Article dans une revue hal-01913815v1
CSF1R inhibition prevents radiation pulmonary fibrosis by depletion of interstitial macrophages Lydia Meziani,Michele Mondini,Benoît Petit,Alexandre Boissonnas,Vincent Thomas de Montprevilleet al. European Respiratory Journal, 2018, 51 (3), pp.1702120. ⟨10.1183/13993003.02120-2017⟩ Article dans une revue hal-04515426v1
Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota Aurélie Durand,Alexandra Audemard-Verger,Vincent Guichard,Raphaël Mattiuz,Arnaud Delpouxet al. Nature Communications, 2018, 9 (1), pp.68. ⟨10.1038/s41467-017-02458-4⟩ Article dans une revue hal-03863818v1
Unveiling Cerebral Leishmaniasis: parasites and brain inflammation in Leishmania donovani infected mice Guilherme D. Melo,Sophie Goyard,Laurence Fiette,Alexandre Boissonnas,Christophe Combadiereet al. Scientific Reports, 2017, 7, pp.8454. ⟨10.1038/s41598-017-09085-5⟩ Article dans une revue hal-01581802v1
Critical Role for Skin-Derived Migratory DCs and Langerhans Cells in TFH and GC Responses after Intradermal Immunization Clément Levin,Olivia Bonduelle,Charles Nuttens,Charlotte Primard,Bernard Verrieret al. Journal of Investigative Dermatology, 2017, 137 (9), pp.1905-1913. ⟨10.1016/j.jid.2017.04.016⟩ Article dans une revue hal-04002647v1
Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity Marion Duriez,Yassmina Mandouri,Bouchra Lekbaby,Hualin Wang,Aurélie Schnurigeret al. Journal of Hepatology, 2017, 67 (4), pp.687-699. ⟨10.1016/j.jhep.2017.05.025⟩ Article dans une revue inserm-03990705v1
Macrophages Induce Long-Term Trapping of γδ T Cells with Innate-like Properties within Secondary Lymphoid Organs in the Steady State Alexandra Audemard-Verger,Matthieu Rivière,Aurélie Durand,Elisa Peranzoni,Vincent Guichardet al. Journal of Immunology, 2017, 199 (6), pp.1998-2007. ⟨10.4049/jimmunol.1700430⟩ Article dans une revue hal-03863963v1
New insights into experimental visceral leishmaniasis: Real-time in vivo imaging of Leishmania donovani virulence Guilherme Dias de Melo,Sophie Goyard,Hervé Lecoeur,Eline Rouault,Pascale Pescheret al. PLoS Neglected Tropical Diseases, 2017, 11 (9), pp.e0005924. ⟨10.1371/journal.pntd.0005924⟩ Article dans une revue hal-03504212v1
CX3CR1-dependent endothelial margination modulates Ly6Chigh monocyte systemic deployment upon inflammation in mice Pauline Hamon,Pierre-Louis Loyher,Camille Baudesson de Chanville,Fabrice Licata,Christophe Combadièreet al. Blood, 2017, 129 (10), pp.1296-1307. ⟨10.1182/blood-2016-08-732164⟩ Article dans une revue hal-04002521v1
Calcineurin inhibitors impair neutrophil activity against Aspergillus fumigatus in allogenic hematopoietic stem cell transplant recipients Sébastien Imbert,Priscillia Bresler,Alexandre Boissonnas,Lauraine Gauthier,Laëtitia Souchetet al. Journal of Allergy and Clinical Immunology, 2016, 138 (3), pp.860-868. ⟨10.1016/j.jaci.2016.02.026⟩ Article dans une revue hal-01301151v1
CCR2 Influences T Regulatory Cell Migration to Tumors and Serves as a Biomarker of Cyclophosphamide Sensitivity Pierre-Louis Loyher,Juliette Rochefort,Camille Baudesson de Chanville,Pauline Hamon,Géraldine Lescailleet al. Cancer Research, 2016, 76 (22), pp.6483 - 6494. ⟨10.1158/0008-5472.CAN-16-0984⟩ Article dans une revue hal-01397194v1
Ly6Chigh Monocytes Protect against Kidney Damage during Sepsis via a CX3CR1-Dependent Adhesion Mechanism B. G. Chousterman,Alexandre Boissonnas,L. Poupel,C. Baudesson de Chanville,J. Adamet al. Journal of the American Society of Nephrology, 2016, 27 (3), pp.792-803 ⟨10.1681/ASN.2015010009⟩ Article dans une revue hal-01292451v1
Tracking Mouse Bone Marrow Monocytes &lt;em&gt;In Vivo&lt;/em&gt; Pauline Hamon,Mathieu P Rodero,Christophe Combadiere,Alexandre Boissonnas Journal of visualized experiments : JoVE, 2015, 96, ⟨10.3791/52476⟩ Article dans une revue hal-02998291v1
Immune surveillance of the lung by migrating tissue monocytes Mathieu P Rodero,Lucie Poupel,Pierre-Louis Loyher,Pauline Hamon,Fabrice Licataet al. eLife, 2015, 4, pp.e07847. ⟨10.7554/eLife.07847⟩ Article dans une revue hal-01310477v1
CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production Ludovic Arnold,Hélène Perrin,Camille Baudesson de Chanville,Marielle Saclier,Patricia Hermandet al. Nature Communications, 2015, 6, pp.8972. ⟨10.1038/ncomms9972⟩ Article dans une revue hal-01514445v1
In vivo imaging reveals a pioneer wave of monocyte recruitment into mouse skin wounds M.P. Rodero,F. Licata,L. Poupel,P. Hamon,K. Khosrotehraniet al. PLoS ONE, 2014, 9 (10), pp.e108212. ⟨10.1371/journal.pone.0108212⟩ Article dans une revue hal-01369479v1
CD8+ Tumor-Infiltrating T Cells Are Trapped in the Tumor-Dendritic Cell Network Alexandre Boissonnas,Fabrice Licata,Lucie Poupel,Sébastien Jacquelin,Luc Fetleret al. Neoplasia, 2013, 15 (1), pp.85. ⟨10.1593/neo.121572⟩ Article dans une revue hal-01586881v1
Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes. Alexandre Boissonnas,Alix Scholer-Dahirel,Virginie Simon-Blancal,Luigia Pace,Fabien Valetet al. Immunity, 2010, 32 (2), pp.266-78. ⟨10.1016/j.immuni.2009.11.015⟩ Article dans une revue hal-00553080v1
In vivo cellular imaging of lymphocyte tracking by MRI: A tumor model approach to cell-based anticancer therapy P. Smirnov,E. Lavergne,F. Gazeau,M. Lewin,A. Boissonnaset al. Magnetic Resonance in Medicine, 2006, 56(3), pp.498-508 Article dans une revue hal-00098654v1
In vivo cellular imaging of lymphocyte trafficking by MRI : a tumor model approach to cell-based anticancer therapy Pierre Smirnov,Elise Lavergne,Florence Gazeau,Maïté Lewin,Alexandre Boissonnaset al. Magnetic Resonance in Medicine, 2006, 56 (3), pp.498-508. ⟨10.1002/mrm.20996⟩ Article dans une revue hal-00348207v1

Pré-publication, Document de travail (2)

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer Adriana M Mujal,Alexis J Combes,Arjun R Rao,Mikhail Binnewies,Bushra Samadet al. 2021 Pré-publication, Document de travail hal-03451508v3
A Pan-Cancer Census of Dominant Tumor Immune Archetypes Rafael J Argüello,Alexis Combes,Bushra Samad,Jessica Tsui,Nayvin Chewet al. 2021 Pré-publication, Document de travail hal-03407890v1