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Impact of positive resection margins on recurrence and survival following resection and adjuvant chemotherapy in pancreatic cancer: Results of the PRODIGE 24-CCTG PA-6 randomized controlled trial
Aurélien Lambert
,
Julia Salleron
,
Alexandre Harlé
,
James Biagi
,
Agnès Leroux
et al.
Article dans une revue
hal-04821542
v1
|
|
DDB2 expression lights the way for precision radiotherapy response in PDAC cells, with or without olaparib
Julie Dardare
,
Andréa Witz
,
Margaux Betz
,
Aurélie François
,
Laureline Lamy
et al.
Article dans une revue
hal-04821547
v1
|
|
REGN5093-M114: can an antibody-drug conjugate overcome the challenge of resistance to epidermal growth factor receptor and mesenchymal epithelial transition tyrosine kinase inhibitors in non-small cell lung cancer?
Julie Dardare
,
Andréa Witz
,
Alexandre Harlé
Article dans une revue
hal-04821538
v1
|
|
Development and validation of AI-assisted transcriptomic signatures to personalize adjuvant chemotherapy in patients with pancreatic ductal adenocarcinoma
Nicolas Fraunhoffer
,
Pascal Hammel
,
Thierry Conroy
,
Rémy Nicolle
,
Jean-Baptiste Bachet
et al.
Article dans une revue
hal-04821533
v1
|
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Tumor-derived cell-free DNA and circulating tumor cells: partners or rivals in metastasis formation?
Andréa Witz
,
Julie Dardare
,
Margaux Betz
,
Pauline Gilson
,
Jean-Louis Merlin
et al.
Article dans une revue
hal-04652495
v1
|
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Prediction of adjuvant gemcitabine sensitivity in resectable pancreatic adenocarcinoma using the GemPred RNA signature: An ancillary study of the PRODIGE-24/CCTG PA6 clinical trial
Rémy Nicolle
,
Jean-Baptiste Bachet
,
Alexandre Harlé
,
Juan Iovanna
,
Pascal Hammel
et al.
Article dans une revue
hal-04301719
v1
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Integrated molecular characterization of HER2-low breast cancer using next generation sequencing (NGS)
Jean-Louis Merlin
,
Marie Husson
,
Nassim Sahki
,
Pauline Gilson
,
Vincent Massard
et al.
Article dans une revue
hal-04821519
v1
|
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GIInger predicts homologous recombination deficiency and patient response to PARPi treatment from shallow genomic profiles
Christian Pozzorini
,
Gregoire Andre
,
Tommaso Coletta
,
Adrien Buisson
,
Jonathan Bieler
et al.
Article dans une revue
hal-04821524
v1
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CRISPR/Cas9-mediated knock-in of BRCA1/2 mutations restores response to olaparib in pancreatic cancer cell lines
Andréa Witz
,
Julie Dardare
,
Aurélie Francois
,
Marie Husson
,
Marie Rouyer
et al.
Article dans une revue
(article de synthèse)
hal-04295078
v1
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ESR1 gene mutations and liquid biopsy in ER-positive breast cancers: A small step forward, a giant leap for personalization of endocrine therapy?
Margaux Betz
,
Vincent Massard
,
Pauline Gilson
,
Andréa Witz
,
Julie Dardare
et al.
Article dans une revue
(article de synthèse)
hal-04295094
v1
|
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GIInger predicts homologous recombination deficiency and patient response to PARPi treatment from shallow genomic profiles
Christian Pozzorini
,
Gregoire Andre
,
Tommaso Coletta
,
Adrien Buisson
,
Jonathan Bieler
et al.
Article dans une revue
hal-04400735
v1
|
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Validation of the Idylla GeneFusion assay to detect fusions and MET exon-skipping in non-small cell lung cancers
Pauline Gilson
,
Celso Pouget
,
Richard Belmonte
,
Smahane Fadil
,
Jessica Demange
et al.
Article dans une revue
hal-04301700
v1
|
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Personalized follow-up of circulating DNA in resected stage III/IV melanoma: PERCIMEL multicentric prospective study protocol
Lionnel Geoffrois
,
Alexandre Harlé
,
Nassim Sahki
,
Aleksandra Sikanja
,
Florence Granel-Brocard
et al.
Article dans une revue
hal-04301664
v1
|
|
Development of a clinical-biological model to assess tumor progression in metastatic pancreatic cancer: Post hoc analysis of the PRODIGE4/ACCORD11 trial
Julie Egea
,
Julia Salleron
,
Sophie Gourgou
,
Ahmet Ayav
,
Valérie Laurent
et al.
Article dans une revue
hal-03901662
v1
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DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy
Julie Dardare
,
Andréa Witz
,
Margaux Betz
,
Aurélie Francois
,
Morgane Meras
et al.
Article dans une revue
hal-03901664
v1
|
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Place de l’ADN tumoral circulant dans la prise en charge des cancers : entre défis et nouvelles perspectives
Paul Toussaint
,
Julie Dardare
,
Alexandre Harlé
,
Aurélien Lambert
,
Julien Levy
et al.
Article dans une revue
hal-03901656
v1
|
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Deciphering tumour heterogeneity: From tissue to liquid biopsy
Pauline Gilson
,
Jean-Louis Merlin
,
Alexandre Harlé
Article dans une revue
hal-03893328
v1
|
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Intraoperative prediction of non‑sentinel lymph node metastases in breast cancer using cytokeratin 19 mRNA copy number: A retrospective analysis
Heloïse Pina
,
Julia Salleron
,
Pauline Gilson
,
Marie Husson
,
Marie Rouyer
et al.
Article dans une revue
hal-03538820
v1
|
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Standardisation of pathogenicity classification for somatic alterations in solid tumours and haematologic malignancies
Florence Koeppel
,
Etienne Muller
,
Alexandre Harlé
,
Celine Guien
,
Pierre Sujobert
et al.
Article dans une revue
hal-03408473
v1
|
|
A NGS-based blood test for the diagnosis of invasive HPV-associated carcinomas with extensive viral genomic characterization
Xavier Sastre-Garau
,
Mamadou Diop
,
Fernando Martin
,
Gilles Dolivet
,
Frédéric Marchal
et al.
Article dans une revue
hal-04543989
v1
|
|
Evaluation of the Idylla ctEGFR mutation assay to detect EGFR mutations in plasma from patients with non-small cell lung cancers
Alexandre Harlé
,
Pauline Gilson
,
Chloé Saurel
,
Julia Salleron
,
Marie Husson
et al.
Article dans une revue
hal-03408465
v1
|
|
Detection of microsatellite instability: State of the art and future applications in circulating tumour DNA (ctDNA)
Pauline Gilson
,
Jean-Louis Merlin
,
Alexandre Harlé
Article dans une revue
hal-03408458
v1
|
|
Epithelial to mesenchymal transition in patients with pancreatic ductal adenocarcinoma: State-of-the-art and therapeutic opportunities
Julie Dardare
,
Andréa Witz
,
Jean-Louis Merlin
,
Agathe Bochnakian
,
Paul Toussaint
et al.
Article dans une revue
hal-03408471
v1
|
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Representative sequencing: Unbiased sampling of solid tumor tissue
Kevin Litchfield
,
Stacey Stanislaw
,
Lisa Gallegos
,
Andrew Rowan
,
Desiree Schnidrig
et al.
Article dans une revue
hal-02565183
v1
|
|
Comparison of pathogenicity prediction tools on somatic variants
Voreak Suybeng
,
Florence Koeppel
,
Alexandre Harlé
,
Etienne Rouleau
Article dans une revue
hal-02958864
v1
|
|
Identification of specific tumor markers in vulvar carcinoma through extensive human papillomavirus DNA characterization using next generation sequencing method
Jacques Thomas
,
Léa Leufflen
,
Virginie Chesnais
,
Ségolène Diry
,
Jessica Demange
et al.
Article dans une revue
hal-02425858
v1
|
|
Evaluation of 3 molecular-based assays for microsatellite instability detection in formalin-fixed tissues of patients with endometrial and colorectal cancers
Pauline Gilson
,
Julien Levy
,
Marie Rouyer
,
Jessica Demange
,
Marie Husson
et al.
Article dans une revue
hal-02957897
v1
|
|
SMAD4 and the TGFβ pathway in patients with pancreatic ductal adenocarcinoma
Julie Dardare
,
Andréa Witz
,
Jean-Louis Merlin
,
Pauline Gilson
,
Alexandre Harlé
Article dans une revue
(article de synthèse)
hal-02617115
v1
|
|
Pathology of HPV-associated head and neck carcinomas: Recent data and perspectives for the development of specific tumor markers
Xavier Sastre-Garau
,
Alexandre Harlé
Article dans une revue
hal-03079066
v1
|
|
Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer
Claire Franczak
,
Andréa Witz
,
Karen Geoffroy
,
Jessica Demange
,
Marie Rouyer
et al.
Article dans une revue
hal-02961025
v1
|
|
Comparison of three real-time PCR assays for the detection of PIK3CA somatic mutations in formalin-fixed paraffin embedded tissues of patients with breast carcinomas
Aurélien Lambert
,
Julia Salleron
,
Maëva Lion
,
Marie Rouyer
,
Nicolas Lozano
et al.
Article dans une revue
hal-01930792
v1
|
|
Evaluation of KRAS, NRAS and BRAF hotspot mutations detection for patients with metastatic colorectal cancer using direct DNA pipetting in a fully-automated platform and Next-Generation Sequencing for laboratory workflow optimisation
Pauline Gilson
,
Claire Franczak
,
Ludovic Dubouis
,
Marie Husson
,
Marie Rouyer
et al.
Article dans une revue
hal-02171684
v1
|
|
Somatic substitution signature as an innovative tool in lung cancer diagnosis
Stéphane Busca
,
Julia Salleron
,
Romain Boidot
,
Jean-Louis Merlin
,
Alexandre Harlé
Article dans une revue
hal-02325054
v1
|
|
Integrated routine workflow using next-generation sequencing and a fully-automated platform for the detection of KRAS, NRAS and BRAF mutations in formalin-fixed paraffin embedded samples with poor DNA quality in patients with colorectal carcinoma
Claire Franczak
,
Ludovic Dubouis
,
Pauline Gilson
,
Marie Husson
,
Marie Rouyer
et al.
Article dans une revue
hal-02053754
v1
|
|
HPV insertional pattern as a personalized tumor marker for the optimized tumor diagnosis and follow-up of patients with HPV-associated carcinomas: a case report
Alexandre Harlé
,
Julie Guillet
,
Jacques Thomas
,
Jessica Demange
,
Gilles Dolivet
et al.
Article dans une revue
hal-02086012
v1
|
|
Emerging roles of DDB2 in cancer
Pauline Gilson
,
Guillaume Drouot
,
Andréa Witz
,
Jean-Louis Merlin
,
Philippe Becuwe
et al.
Article dans une revue
hal-02325073
v1
|
|
Mutations du gène ESR1 : du fondamental à la clinique
Vincent Massard
,
Alexandre Harlé
,
Lionel Uwer
,
Jean-Louis Merlin
Article dans une revue
hal-02325099
v1
|
|
Dual epigenetic regulation of ERα36 expression in breast cancer cells
Charlène Thiébaut
,
Amand Chesnel
,
Jean-Louis Merlin
,
Maelle Chesnel
,
Agnès Leroux
et al.
Article dans une revue
hal-02145413
v1
|
|
Technical considerations for circulating tumor DNA detection in oncology
Claire Franczak
,
Pierre Filhine-Tresarrieu
,
Pauline Gilson
,
Jean-Louis Merlin
,
Lewis Au
et al.
Article dans une revue
hal-01987550
v1
|
|
Uncommon mutational profiles of metastatic colorectal cancer detected during routine genotyping using next generation sequencing
Claire Franczak
,
Shaun Kandathil
,
Pauline Gilson
,
Marie Husson
,
Marie Rouyer
et al.
Article dans une revue
hal-02125314
v1
|
|
Evaluation and validation of HPV real-time PCR assay for the detection of HPV DNA in oral cytobrush and FFPE samples
Alexandre Harlé
,
Julie Guillet
,
Jacques Thomas
,
Xavier Sastre-Garau
,
Marie Rouyer
et al.
Article dans une revue
hal-01930854
v1
|
|
Clinical interests of circulating tumor DNA in oncology
Claire Franczak
,
Pierre Filhine-Tressarieu
,
Julien Broséus
,
Pauline Gilson
,
Jean-Louis Merlin
et al.
Article dans une revue
hal-01930849
v1
|
|
Accelerated BRAF mutation analysis using a fully automated PCR platform improves the management of patients with metastatic melanoma
Delphine Serre
,
Julia Salleron
,
Marie Husson
,
Agnès Leroux
,
Pauline Gilson
et al.
Article dans une revue
hal-03249247
v1
|
|
Nuclear factor I X is a recurrent target for HPV16 insertions in anal carcinomas
Emmanuelle Jeannot
,
Alexandre Harlé
,
Allyson M. Holmes
,
Xavier Sastre-Garau
Article dans une revue
hal-01930850
v1
|
|
Absence of correlation between radiation-induced CD8 T-lymphocyte apoptosis and sequelae in patients with prostate cancer accidentally overexposed to radiation
Guillaume Vogin
,
Jean-Louis Merlin
,
Alexandra Rousseau
,
Didier Peiffert
,
Alexandre Harlé
et al.
Article dans une revue
hal-01930852
v1
|
|
Dépistage du déficit en dihydropyrimidine déshydrogénase (DPD) et sécurisation des chimiothérapies à base de fluoropyrimidines : mise au point et recommandations nationales du GPCO-Unicancer et du RNPGx
Marie-Anne Loriot
,
Joseph Ciccolini
,
Fabienne Thomas
,
Chantal Barin-Le-Guellec
,
Bernard Royer
et al.
Article dans une revue
hal-01930855
v1
|
|
Authors’ Reply to Uguen: “Comparison of five different assays for the detection of BRAF mutations in formalin-fixed paraffin embedded tissues of patients with metastatic melanoma”
Alexandre Harlé
,
Claire Franczak
Article dans une revue
hal-01930856
v1
|
|
Comparison of five different assays for the detection of BRAF mutations in formalin-fixed paraffin embedded tissues of patients with metastatic melanoma
Claire Franczak
,
Julia Salleron
,
Cindy Dubois
,
Pierre Filhine-Tresarrieu
,
Agnès Leroux
et al.
Article dans une revue
hal-01664623
v1
|
|
Detection of BRAF mutations using a fully automated platform and comparison with high resolution melting, real-time allele specific amplification, immunohistochemistry and next generation sequencing assays, for patients with metastatic melanoma
Alexandre Harlé
,
Julia Salleron
,
Claire Franczak
,
Cindy Dubois
,
Pierre Filhine-Tresarrieu
et al.
Article dans une revue
hal-01320598
v1
|
|
Rare RAS mutations in metastatic colorectal cancer detected during routine RAS genotyping using next generation sequencing
Alexandre Harlé
,
Pierre Filhine-Tresarrieu
,
Marie Husson
,
Romain Boidot
,
Marie Rouyer
et al.
Article dans une revue
hal-01241768
v1
|
|
Beside P53 and PTEN: Identification of molecular alterations of the RAS/MAPK and PI3K/AKT signaling pathways in high-grade serous ovarian carcinomas to determine potential novel therapeutic targets
Shuhui Chen
,
Elisa Cavazza
,
Catherine Barlier
,
Julia Salleron
,
Pierre Filhine-Tresarrieu
et al.
Article dans une revue
hal-01418848
v1
|
|
Trastuzumab as a preoperative monotherapy does not inhibit HER2 downstream signaling in HER2-positive breast cancer
Maëva Lion
,
Alexandre Harlé
,
Julia Salleron
,
Carole Ramacci
,
Mario Campone
et al.
Article dans une revue
hal-01418865
v1
|
|
Effect of esomeprazole on the oral absorption of dasatinib in a patient with Philadelphia-positive acute lymphoblastic leukemia
Elise Pape
,
Delphine Michel
,
Julien Scala-Bertola
,
Thomas Schiestel
,
Alexandre Harlé
et al.
Article dans une revue
hal-01718101
v1
|
|
Limited effectiveness of patent blue dye in addition to isotope scanning for identification of sentinel lymph nodes: Cross-sectional real-life study in 1024 breast cancer patients
Philippe Rauch
,
Jean-Louis Merlin
,
Lea Leufflen
,
Julia Salleron
,
Alexandre Harlé
et al.
Article dans une revue
hal-01418851
v1
|
|
Expression of pEGFR and pAKT as response-predictive biomarkers for RAS wild-type patients to anti-EGFR monoclonal antibodies in metastatic colorectal cancers.
Alexandre Harlé
,
Julia Salleron
,
Géraldine Perkins
,
Camilla Pilati
,
Hélène Blons
et al.
Article dans une revue
hal-01241758
v1
|
|
Analysis of PIK3CA exon 9 and 20 mutations in breast cancers using PCR-HRM and PCR-ARMS: Correlation with clinicopathological criteria
Alexandre Harlé
,
Maeva Lion
,
Nicolas Lozano
,
Marie Husson
,
Valentin Harter
et al.
Article dans une revue
hal-00823892
v1
|
|
Signification clinique, diagnostique et intérêt théranostique des mutations du gène PIK3CA dans le cancer du sein
Alexandre Harlé
,
Maëva Lion
,
Nicolas Lozano
,
Jean-Louis Merlin
Article dans une revue
hal-00974881
v1
|
|
Comparison of COBAS 4800 KRAS, TaqMan PCR and High Resolution Melting PCR assays for the detection of KRAS somatic mutations in formalin-fixed paraffin embedded colorectal carcinomas
Alexandre Harlé
,
Benoît Busser
,
Marie Rouyer
,
Valentin Harter
,
Pascal Genin
et al.
Article dans une revue
istex
hal-00733883
v1
|
|
Expression and activation of P38 MAP kinase in invasive ductal breast cancers: Correlation with expression of the estrogen receptor, HER2 and downstream signaling phosphorylated proteins.
Jean-Louis Merlin
,
Alexandre Harlé
,
Maëva Lion
,
Carole Ramacci
,
Agnès Leroux
Article dans une revue
hal-00866242
v1
|
|
Biomarqueurs prédictifs de réponse aux thérapies ciblées en oncologie
Alexandre Harlé
,
Jean-Louis Merlin
Article dans une revue
hal-00974848
v1
|
|
Optimization of routine KRAS mutation PCR-based testing procedure for rational individualized first-line-targeted therapy selection in metastatic colorectal cancer
Anne-Sophie Chretien
,
Alexandre Harlé
,
Magali Meyer-Lefebvre
,
Marie Rouyer
,
Marie Husson
et al.
Article dans une revue
hal-00763929
v1
|
|
Validation de méthode selon la norme ISO 15189 et le SH GTA 04 : application à l'extraction et au dosage quantitatif de l'ADN par méthode spectrophotométrique
Alexandre Harlé
,
Maëva Lion
,
Marie Husson
,
Cindy Dubois
,
Jean-Louis Merlin
Article dans une revue
hal-00974857
v1
|
|
Validation de méthode selon la norme ISO 15189 et le SH GTA 04 : application à la détection des mutations KRAS par méthode TaqMan
Alexandre Harlé
,
Cindy Dubois
,
Marie Rouyer
,
Jean-Louis Merlin
Article dans une revue
hal-00974859
v1
|