Alexandre Harlé

Publications

Article dans une revue (74)

Improving Radiation Therapy in Pancreatic Cancer Through Radiosensitization Strategies Julie Dardare,Nicolas Martz,Andréa Witz,Margaux Betz,Cassandra Michelet al. International Journal of Radiation Oncology, Biology, Physics, 2026, 124 (2), pp.395-414. ⟨10.1016/j.ijrobp.2025.09.013⟩ Article dans une revue hal-05335143v1
Radiotherapy in the management of PDAC, from past to present Julie Dardare,Nicolas Martz,Andréa Witz,Margaux Betz,Cassandra Michelet al. Translational Oncology, 2026, 63, pp.102632. ⟨10.1016/j.tranon.2025.102632⟩ Article dans une revue hal-05414832v1
A Novel Droplet Digital PCR Assay for BRCA1 and RAD51C Methylation Cassandra Michel,Alizée Simon,Andréa Witz,Idrissia Hanriot,Julie Dardareet al. Journal of Molecular Diagnostics, 2025, 27 (10), pp.1026-1036. ⟨10.1016/j.jmoldx.2025.07.002⟩ Article dans une revue hal-05335169v1
Homologous recombination deficiency (HRD) testing landscape: clinical applications and technical validation for routine diagnostics Andréa Witz,Julie Dardare,Margaux Betz,Cassandra Michel,Marie Hussonet al. Biomarker Research, 2025, 13 (1), pp.31. ⟨10.1186/s40364-025-00740-y⟩ Article dans une revue hal-05182001v1
Organisation de la réunion de concertation pluridisciplinaire moléculaire à Nancy et en France Alizée Simon,Andréa Witz,Vincent Massard,Aurélien Lambert,Jean-Louis Merlinet al. Innovations & Thérapeutiques en Oncologie, 2025, 11 (2), pp.111-118. ⟨10.1684/ito.2025.512⟩ Article dans une revue hal-05402553v1
Apport de la génomique dans la prise en charge des cancers Étienne Rouleau,Lucie Karayan-Tapon,Marie-Dominique Galibert,Alexandre Harlé,Isabelle Soubeyran Revue Francophone des Laboratoires, 2025, 2025 (568), pp.67-74. ⟨10.1016/S1773-035X(25)76280-2⟩ Article dans une revue hal-05402549v1
Analytical Validation of a Pan-Cancer Next-Generation Sequencing Assay for In-House Liquid Biopsy Testing Gaëlle Lescuyer,Alexandre Harlé,Hari Shankar Kumar,Pantelis Constantoulakis,Nicole Pfarret al. Journal of Molecular Diagnostics, 2025, 75 (5), pp.519-29. ⟨10.1016/j.jmoldx.2025.08.008⟩ Article dans une revue hal-05335439v1
A multicentric national phase II trial assessing TIslelizumab in monotherapy for patients with Hepatocellular Carcinoma Child-Pugh B and ALBI grade 1 or 2 liver function score: The UCGI 41 HESTIA TRIAL DESIGN AND PRELIMINARY SAFETY Data Héloïse Bourien,Xavier Adhoute,Boris Campillo-Gimenez,Mohamed Bouattour,Eric Assenatet al. Digestive and Liver Disease, 2025, 57 (10), pp.2011-2015. ⟨10.1016/j.dld.2025.07.019⟩ Article dans une revue hal-05335471v1
Decoding mutational signatures in breast cancer: Insights from a multi-cohort study Margaux Betz,Andréa Witz,Julie Dardare,Cassandra Michel,Vincent Massardet al. Translational Oncology, 2025, 53, pp.102315. ⟨10.1016/j.tranon.2025.102315⟩ Article dans une revue hal-05182075v1
Sensitive cell‑free DNA assay for accurate detection of RAS and BRAF mutations in liquid biopsies of patients with metastatic colorectal cancer: Final results of the multicentric ColoBEAM study Alexandre Harlé,Céline Gavoille,Olivier Bouché,Meher Ben Abdelghani,Jérôme Plazaet al. Oncology Letters, 2025, 31 (1), pp.1-10. ⟨10.3892/ol.2025.15366⟩ Article dans une revue hal-05368373v1
Characteristics of KRAS WT pancreatic adenocarcinomas: results of a large French multicentric cohort Noémie Trystram,Jérome Cros,Hélène Blons,Simon Garinet,Rémy Nicolleet al. Therapeutic Advances in Medical Oncology, 2025, 17, pp.1-13. ⟨10.1177/17588359251339939⟩ Article dans une revue hal-05402557v1
Les biomarqueurs théranostiques des inhibiteurs de PARP : recommandations et enjeux organisationnels pour les laboratoires français Pauline Gilson,Andréa Witz,Margaux Betz,Julie Dardare,Cassandra Michelet al. Innovations & Thérapeutiques en Oncologie, 2025, 11 (4), pp.270-284. ⟨10.1684/ito.2025.526⟩ Article dans une revue hal-05431335v1
Tumor-derived cell-free DNA and circulating tumor cells: partners or rivals in metastasis formation? Andréa Witz,Julie Dardare,Margaux Betz,Pauline Gilson,Jean-Louis Merlinet al. Clinical and Experimental Medicine, 2024, 24 (1), pp.2. ⟨10.1007/s10238-023-01278-9⟩ Article dans une revue hal-04652495v1
Impact of positive resection margins on recurrence and survival following resection and adjuvant chemotherapy in pancreatic cancer: Results of the PRODIGE 24-CCTG PA-6 randomized controlled trial Aurélien Lambert,Julia Salleron,Alexandre Harlé,James Biagi,Agnès Lerouxet al. Annals of Surgery, 2024, ⟨10.1097/SLA.0000000000006449⟩ Article dans une revue hal-04821542v1
DDB2 expression lights the way for precision radiotherapy response in PDAC cells, with or without olaparib Julie Dardare,Andréa Witz,Margaux Betz,Aurélie François,Laureline Lamyet al. Cell Death Discovery, 2024, 10, pp.411. ⟨10.1038/s41420-024-02188-9⟩ Article dans une revue hal-04821547v1
REGN5093-M114: can an antibody-drug conjugate overcome the challenge of resistance to epidermal growth factor receptor and mesenchymal epithelial transition tyrosine kinase inhibitors in non-small cell lung cancer? Julie Dardare,Andréa Witz,Alexandre Harlé Translational Lung Cancer Research, 2024, 13 (8), pp.2082-2086. ⟨10.21037/tlcr-24-144⟩ Article dans une revue hal-04821538v1
Development and validation of AI-assisted transcriptomic signatures to personalize adjuvant chemotherapy in patients with pancreatic ductal adenocarcinoma Nicolas Fraunhoffer,Pascal Hammel,Thierry Conroy,Rémy Nicolle,Jean-Baptiste Bachetet al. Annals of Oncology, 2024, 35 (9), pp.780-791. ⟨10.1016/j.annonc.2024.06.010⟩ Article dans une revue hal-04821533v1
Integrated molecular characterization of HER2-low breast cancer using next generation sequencing (NGS) Jean-Louis Merlin,Marie Husson,Nassim Sahki,Pauline Gilson,Vincent Massardet al. Biomedicines, 2023, 11 (12), pp.3164. ⟨10.3390/biomedicines11123164⟩ Article dans une revue hal-04821519v1
Prediction of adjuvant gemcitabine sensitivity in resectable pancreatic adenocarcinoma using the GemPred RNA signature: An ancillary study of the PRODIGE-24/CCTG PA6 clinical trial Rémy Nicolle,Jean-Baptiste Bachet,Alexandre Harlé,Juan Iovanna,Pascal Hammelet al. Journal of Clinical Oncology, 2023, 42 (9), pp.1067-1076. ⟨10.1200/JCO.22.02668⟩ Article dans une revue hal-04301719v1
ESR1 gene mutations and liquid biopsy in ER-positive breast cancers: A small step forward, a giant leap for personalization of endocrine therapy? Margaux Betz,Vincent Massard,Pauline Gilson,Andréa Witz,Julie Dardareet al. Cancers, 2023, 15 (21), pp.5169. ⟨10.3390/cancers15215169⟩ Article dans une revue (article de synthèse) hal-04295094v1
CRISPR/Cas9-mediated knock-in of BRCA1/2 mutations restores response to olaparib in pancreatic cancer cell lines Andréa Witz,Julie Dardare,Aurélie Francois,Marie Husson,Marie Rouyeret al. Scientific Reports, 2023, 13 (1), pp.18741. ⟨10.1038/s41598-023-45964-w⟩ Article dans une revue (article de synthèse) hal-04295078v1
GIInger predicts homologous recombination deficiency and patient response to PARPi treatment from shallow genomic profiles Christian Pozzorini,Gregoire Andre,Tommaso Coletta,Adrien Buisson,Jonathan Bieleret al. Cell Reports Medicine, 2023, 4 (12), pp.101344. ⟨10.1016/j.xcrm.2023.101344⟩ Article dans une revue hal-04400735v1
Validation of the Idylla GeneFusion assay to detect fusions and MET exon-skipping in non-small cell lung cancers Pauline Gilson,Celso Pouget,Richard Belmonte,Smahane Fadil,Jessica Demangeet al. Scientific Reports, 2023, 13 (1), pp.12909. ⟨10.1038/s41598-023-39749-4⟩ Article dans une revue hal-04301700v1
Personalized follow-up of circulating DNA in resected stage III/IV melanoma: PERCIMEL multicentric prospective study protocol Lionnel Geoffrois,Alexandre Harlé,Nassim Sahki,Aleksandra Sikanja,Florence Granel-Brocardet al. BMC Cancer, 2023, 23 (1), pp.554. ⟨10.1186/s12885-023-11029-4⟩ Article dans une revue hal-04301664v1
Development of a clinical-biological model to assess tumor progression in metastatic pancreatic cancer: Post hoc analysis of the PRODIGE4/ACCORD11 trial Julie Egea,Julia Salleron,Sophie Gourgou,Ahmet Ayav,Valérie Laurentet al. Cancers, 2022, 14 (20), pp.5068. ⟨10.3390/cancers14205068⟩ Article dans une revue hal-03901662v1
DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy Julie Dardare,Andréa Witz,Margaux Betz,Aurélie Francois,Morgane Meraset al. Frontiers in Oncology, 2022, 12, pp.1052163. ⟨10.3389/fonc.2022.1052163⟩ Article dans une revue hal-03901664v1
Place de l’ADN tumoral circulant dans la prise en charge des cancers : entre défis et nouvelles perspectives Paul Toussaint,Julie Dardare,Alexandre Harlé,Aurélien Lambert,Julien Levyet al. Innovations & Thérapeutiques en Oncologie, 2022, 8 (3), pp.147-156. ⟨10.1684/ito.2022.0318⟩ Article dans une revue hal-03901656v1
Deciphering tumour heterogeneity: From tissue to liquid biopsy Pauline Gilson,Jean-Louis Merlin,Alexandre Harlé Cancers, 2022, 14 (6), pp.1384. ⟨10.3390/cancers14061384⟩ Article dans une revue hal-03893328v1
Intraoperative prediction of non‑sentinel lymph node metastases in breast cancer using cytokeratin 19 mRNA copy number: A retrospective analysis Heloïse Pina,Julia Salleron,Pauline Gilson,Marie Husson,Marie Rouyeret al. Molecular and Clinical Oncology, 2022, 16 (3), pp.58. ⟨10.3892/mco.2022.2491⟩ Article dans une revue hal-03538820v1
Standardisation of pathogenicity classification for somatic alterations in solid tumours and haematologic malignancies Florence Koeppel,Etienne Muller,Alexandre Harlé,Celine Guien,Pierre Sujobertet al. European Journal of Cancer, 2021, 159, pp.1-15. ⟨10.1016/j.ejca.2021.08.047⟩ Article dans une revue hal-03408473v1
A NGS-based blood test for the diagnosis of invasive HPV-associated carcinomas with extensive viral genomic characterization Xavier Sastre-Garau,Mamadou Diop,Fernando Martin,Gilles Dolivet,Frédéric Marchalet al. Clinical Cancer Research, 2021, 27 (19), pp.5307-5316. ⟨10.1158/1078-0432.ccr-21-0293⟩ Article dans une revue hal-04543989v1
Evaluation of the Idylla ctEGFR mutation assay to detect EGFR mutations in plasma from patients with non-small cell lung cancers Alexandre Harlé,Pauline Gilson,Chloé Saurel,Julia Salleron,Marie Hussonet al. Scientific Reports, 2021, 11, pp.10470. ⟨10.1038/s41598-021-90091-z⟩ Article dans une revue hal-03408465v1
Detection of microsatellite instability: State of the art and future applications in circulating tumour DNA (ctDNA) Pauline Gilson,Jean-Louis Merlin,Alexandre Harlé Cancers, 2021, 13 (7), pp.1491. ⟨10.3390/cancers13071491⟩ Article dans une revue hal-03408458v1
Epithelial to mesenchymal transition in patients with pancreatic ductal adenocarcinoma: State-of-the-art and therapeutic opportunities Julie Dardare,Andréa Witz,Jean-Louis Merlin,Agathe Bochnakian,Paul Toussaintet al. Pharmaceuticals, 2021, 14 (8), pp.740. ⟨10.3390/ph14080740⟩ Article dans une revue hal-03408471v1
Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer Claire Franczak,Andréa Witz,Karen Geoffroy,Jessica Demange,Marie Rouyeret al. PLoS ONE, 2020, 15 (1), pp.e0227294. ⟨10.1371/journal.pone.0227294⟩ Article dans une revue hal-02961025v1
Pathology of HPV-associated head and neck carcinomas: Recent data and perspectives for the development of specific tumor markers Xavier Sastre-Garau,Alexandre Harlé Frontiers in Oncology, 2020, 10, pp.528957. ⟨10.3389/fonc.2020.528957⟩ Article dans une revue hal-03079066v1
SMAD4 and the TGFβ pathway in patients with pancreatic ductal adenocarcinoma Julie Dardare,Andréa Witz,Jean-Louis Merlin,Pauline Gilson,Alexandre Harlé International Journal of Molecular Sciences, 2020, 21 (10), pp.3534. ⟨10.3390/ijms21103534⟩ Article dans une revue (article de synthèse) hal-02617115v1
Comparison of pathogenicity prediction tools on somatic variants Voreak Suybeng,Florence Koeppel,Alexandre Harlé,Etienne Rouleau Journal of Molecular Diagnostics, 2020, 22 (12), pp.1383-1392. ⟨10.1016/j.jmoldx.2020.08.007⟩ Article dans une revue hal-02958864v1
Identification of specific tumor markers in vulvar carcinoma through extensive human papillomavirus DNA characterization using next generation sequencing method Jacques Thomas,Léa Leufflen,Virginie Chesnais,Ségolène Diry,Jessica Demangeet al. Journal of Lower Genital Tract Disease, 2020, 24 (1), pp.53-60. ⟨10.1097/LGT.0000000000000498⟩ Article dans une revue hal-02425858v1
Evaluation of 3 molecular-based assays for microsatellite instability detection in formalin-fixed tissues of patients with endometrial and colorectal cancers Pauline Gilson,Julien Levy,Marie Rouyer,Jessica Demange,Marie Hussonet al. Scientific Reports, 2020, 10, pp.16386. ⟨10.1038/s41598-020-73421-5⟩ Article dans une revue hal-02957897v1
Representative sequencing: Unbiased sampling of solid tumor tissue Kevin Litchfield,Stacey Stanislaw,Lavinia Spain,Lisa Gallegos,Andrew Rowanet al. Cell Reports, 2020, 31 (5), pp.107550. ⟨10.1016/j.celrep.2020.107550⟩ Article dans une revue hal-02565183v1
Uncommon mutational profiles of metastatic colorectal cancer detected during routine genotyping using next generation sequencing Claire Franczak,Shaun Kandathil,Pauline Gilson,Marie Husson,Marie Rouyeret al. Scientific Reports, 2019, 9, pp.7083. ⟨10.1038/s41598-019-43646-0⟩ Article dans une revue hal-02125314v1
Evaluation of KRAS, NRAS and BRAF hotspot mutations detection for patients with metastatic colorectal cancer using direct DNA pipetting in a fully-automated platform and Next-Generation Sequencing for laboratory workflow optimisation Pauline Gilson,Claire Franczak,Ludovic Dubouis,Marie Husson,Marie Rouyeret al. PLoS ONE, 2019, 14 (7), pp.e0219204. ⟨10.1371/journal.pone.0219204⟩ Article dans une revue hal-02171684v1
Comparison of three real-time PCR assays for the detection of PIK3CA somatic mutations in formalin-fixed paraffin embedded tissues of patients with breast carcinomas Aurélien Lambert,Julia Salleron,Maëva Lion,Marie Rouyer,Nicolas Lozanoet al. Pathology and Oncology Research, 2019, 25 (3), pp.1117-1123. ⟨10.1007/s12253-018-0538-x⟩ Article dans une revue hal-01930792v1
Integrated routine workflow using next-generation sequencing and a fully-automated platform for the detection of KRAS, NRAS and BRAF mutations in formalin-fixed paraffin embedded samples with poor DNA quality in patients with colorectal carcinoma Claire Franczak,Ludovic Dubouis,Pauline Gilson,Marie Husson,Marie Rouyeret al. PLoS ONE, 2019, 14 (2), pp.e0212801. ⟨10.1371/journal.pone.0212801⟩ Article dans une revue hal-02053754v1
Somatic substitution signature as an innovative tool in lung cancer diagnosis Stéphane Busca,Julia Salleron,Romain Boidot,Jean-Louis Merlin,Alexandre Harlé Scientific Reports, 2019, 9 (1), pp.14561. ⟨10.1038/s41598-019-51155-3⟩ Article dans une revue hal-02325054v1
Emerging roles of DDB2 in cancer Pauline Gilson,Guillaume Drouot,Andréa Witz,Jean-Louis Merlin,Philippe Becuweet al. International Journal of Molecular Sciences, 2019, 20 (20), pp.5168. ⟨10.3390/ijms20205168⟩ Article dans une revue hal-02325073v1
HPV insertional pattern as a personalized tumor marker for the optimized tumor diagnosis and follow-up of patients with HPV-associated carcinomas: a case report Alexandre Harlé,Julie Guillet,Jacques Thomas,Jessica Demange,Gilles Dolivetet al. BMC Cancer, 2019, 19, pp.277. ⟨10.1186/s12885-019-5447-1⟩ Article dans une revue hal-02086012v1
Mutations du gène ESR1 : du fondamental à la clinique Vincent Massard,Alexandre Harlé,Lionel Uwer,Jean-Louis Merlin Oncologie, 2019, 21 (1-4), pp.29-32. ⟨10.3166/onco-2019-0027⟩ Article dans une revue hal-02325099v1
Dual epigenetic regulation of ERα36 expression in breast cancer cells Charlène Thiébaut,Amand Chesnel,Jean-Louis Merlin,Maelle Chesnel,Agnès Lerouxet al. International Journal of Molecular Sciences, 2019, 20 (11), pp.2637. ⟨10.3390/ijms20112637⟩ Article dans une revue hal-02145413v1
Technical considerations for circulating tumor DNA detection in oncology Claire Franczak,Pierre Filhine-Tresarrieu,Pauline Gilson,Jean-Louis Merlin,Lewis Auet al. Expert Review of Molecular Diagnostics, 2019, 19 (2), pp.121-135. ⟨10.1080/14737159.2019.1568873⟩ Article dans une revue hal-01987550v1
Dépistage du déficit en dihydropyrimidine déshydrogénase (DPD) et sécurisation des chimiothérapies à base de fluoropyrimidines : mise au point et recommandations nationales du GPCO-Unicancer et du RNPGx Marie-Anne Loriot,Joseph Ciccolini,Fabienne Thomas,Chantal Barin-Le-Guellec,Bernard Royeret al. Bulletin du Cancer, 2018, 105 (4), pp.397-407. ⟨10.1016/j.bulcan.2018.02.001⟩ Article dans une revue hal-01930855v1
Evaluation and validation of HPV real-time PCR assay for the detection of HPV DNA in oral cytobrush and FFPE samples Alexandre Harlé,Julie Guillet,Jacques Thomas,Xavier Sastre-Garau,Marie Rouyeret al. Scientific Reports, 2018, 8, pp.11313. ⟨10.1038/s41598-018-29790-z⟩ Article dans une revue hal-01930854v1
Clinical interests of circulating tumor DNA in oncology Claire Franczak,Pierre Filhine-Tressarieu,Julien Broséus,Pauline Gilson,Jean-Louis Merlinet al. Archives of Medical Research, 2018, 49 (5), pp.297-305. ⟨10.1016/j.arcmed.2018.10.007⟩ Article dans une revue hal-01930849v1
Accelerated BRAF mutation analysis using a fully automated PCR platform improves the management of patients with metastatic melanoma Delphine Serre,Julia Salleron,Marie Husson,Agnès Leroux,Pauline Gilsonet al. Oncotarget, 2018, 9 (63), pp.32232-32237. ⟨10.18632/oncotarget.25957⟩ Article dans une revue hal-03249247v1
Nuclear factor I X is a recurrent target for HPV16 insertions in anal carcinomas Emmanuelle Jeannot,Alexandre Harlé,Allyson M. Holmes,Xavier Sastre-Garau Genes, Chromosomes & Cancer, 2018, 57 (12), pp.638-644. ⟨10.1002/gcc.22675⟩ Article dans une revue hal-01930850v1
Absence of correlation between radiation-induced CD8 T-lymphocyte apoptosis and sequelae in patients with prostate cancer accidentally overexposed to radiation Guillaume Vogin,Jean-Louis Merlin,Alexandra Rousseau,Didier Peiffert,Alexandre Harléet al. Oncotarget, 2018, 9 (66), pp.32680-32689. ⟨10.18632/oncotarget.26001⟩ Article dans une revue hal-01930852v1
Authors’ Reply to Uguen: “Comparison of five different assays for the detection of BRAF mutations in formalin-fixed paraffin embedded tissues of patients with metastatic melanoma” Alexandre Harlé,Claire Franczak Molecular Diagnosis and Therapy, 2017, 21 (6), pp.695-696. ⟨10.1007/s40291-017-0301-0⟩ Article dans une revue hal-01930856v1
Comparison of five different assays for the detection of BRAF mutations in formalin-fixed paraffin embedded tissues of patients with metastatic melanoma Claire Franczak,Julia Salleron,Cindy Dubois,Pierre Filhine-Tresarrieu,Agnès Lerouxet al. Molecular Diagnosis and Therapy, 2017, 21 (2), pp.209-216. ⟨10.1007/s40291-017-0258-z⟩ Article dans une revue hal-01664623v1
Limited effectiveness of patent blue dye in addition to isotope scanning for identification of sentinel lymph nodes: Cross-sectional real-life study in 1024 breast cancer patients Philippe Rauch,Jean-Louis Merlin,Lea Leufflen,Julia Salleron,Alexandre Harléet al. International Journal of Surgery, 2016, 33, pp.177-181. ⟨10.1016/j.ijsu.2016.08.002⟩ Article dans une revue hal-01418851v1
Detection of BRAF mutations using a fully automated platform and comparison with high resolution melting, real-time allele specific amplification, immunohistochemistry and next generation sequencing assays, for patients with metastatic melanoma Alexandre Harlé,Julia Salleron,Claire Franczak,Cindy Dubois,Pierre Filhine-Tresarrieuet al. PLoS ONE, 2016, 11 (4), pp.e0153576. ⟨10.1371/journal.pone.0153576⟩ Article dans une revue hal-01320598v1
Rare RAS mutations in metastatic colorectal cancer detected during routine RAS genotyping using next generation sequencing Alexandre Harlé,Pierre Filhine-Tresarrieu,Marie Husson,Romain Boidot,Marie Rouyeret al. Targeted Oncology, 2016, 11 (3), pp.363-370. ⟨10.1007/s11523-015-0404-7⟩ Article dans une revue hal-01241768v1
Beside P53 and PTEN: Identification of molecular alterations of the RAS/MAPK and PI3K/AKT signaling pathways in high-grade serous ovarian carcinomas to determine potential novel therapeutic targets Shuhui Chen,Elisa Cavazza,Catherine Barlier,Julia Salleron,Pierre Filhine-Tresarrieuet al. Oncology Letters, 2016, 12 (5), pp.3264-3272. ⟨10.3892/ol.2016.5083⟩ Article dans une revue hal-01418848v1
Trastuzumab as a preoperative monotherapy does not inhibit HER2 downstream signaling in HER2-positive breast cancer Maëva Lion,Alexandre Harlé,Julia Salleron,Carole Ramacci,Mario Camponeet al. Oncology Letters, 2016, 12 (3), pp.2028-2032. ⟨10.3892/ol.2016.4891⟩ Article dans une revue hal-01418865v1
Effect of esomeprazole on the oral absorption of dasatinib in a patient with Philadelphia-positive acute lymphoblastic leukemia Elise Pape,Delphine Michel,Julien Scala-Bertola,Thomas Schiestel,Alexandre Harléet al. British Journal of Clinical Pharmacology, 2016, 81 (6), pp.1195-1196. ⟨10.1111/bcp.12895⟩ Article dans une revue hal-01718101v1
Expression of pEGFR and pAKT as response-predictive biomarkers for RAS wild-type patients to anti-EGFR monoclonal antibodies in metastatic colorectal cancers. Alexandre Harlé,Julia Salleron,Géraldine Perkins,Camilla Pilati,Hélène Blonset al. British Journal of Cancer, 2015, 113 (4), pp.680-685. ⟨10.1038/bjc.2015.250⟩ Article dans une revue hal-01241758v1
Validation de méthode selon la norme ISO 15189 et le SH GTA 04 : application à l'extraction et au dosage quantitatif de l'ADN par méthode spectrophotométrique Alexandre Harlé,Maëva Lion,Marie Husson,Cindy Dubois,Jean-Louis Merlin Annales de Biologie Clinique, 2013, 71 (5), pp.608-614. ⟨10.1684/abc.2013.0891⟩ Article dans une revue hal-00974857v1
Validation de méthode selon la norme ISO 15189 et le SH GTA 04 : application à la détection des mutations KRAS par méthode TaqMan Alexandre Harlé,Cindy Dubois,Marie Rouyer,Jean-Louis Merlin Annales de Biologie Clinique, 2013, 71 (5), pp.603-607. ⟨10.1684/abc.2013.0869⟩ Article dans une revue hal-00974859v1
Signification clinique, diagnostique et intérêt théranostique des mutations du gène PIK3CA dans le cancer du sein Alexandre Harlé,Maëva Lion,Nicolas Lozano,Jean-Louis Merlin Bulletin du Cancer, 2013, 100 (10), pp.947-954. ⟨10.1684/bdc.2013.1827⟩ Article dans une revue hal-00974881v1
Analysis of PIK3CA exon 9 and 20 mutations in breast cancers using PCR-HRM and PCR-ARMS: Correlation with clinicopathological criteria Alexandre Harlé,Maeva Lion,Nicolas Lozano,Marie Husson,Valentin Harteret al. Oncology Reports, 2013, 29 (3), pp.1043-1052. ⟨10.3892/or.2013.2229⟩ Article dans une revue hal-00823892v1
Comparison of COBAS 4800 KRAS, TaqMan PCR and High Resolution Melting PCR assays for the detection of KRAS somatic mutations in formalin-fixed paraffin embedded colorectal carcinomas Alexandre Harlé,Benoît Busser,Marie Rouyer,Valentin Harter,Pascal Geninet al. Virchows Archiv, 2013, 462 (3), pp.329-335. ⟨10.1007/s00428-013-1380-x⟩ Article dans une revue istex hal-00733883v1
Biomarqueurs prédictifs de réponse aux thérapies ciblées en oncologie Alexandre Harlé,Jean-Louis Merlin Annales de Biologie Clinique, 2013, 71 (1), pp.89-97. ⟨10.1684/abc.2013.0906⟩ Article dans une revue hal-00974848v1
Expression and activation of P38 MAP kinase in invasive ductal breast cancers: Correlation with expression of the estrogen receptor, HER2 and downstream signaling phosphorylated proteins. Jean-Louis Merlin,Alexandre Harlé,Maëva Lion,Carole Ramacci,Agnès Leroux Oncology Reports, 2013, 30 (4), pp.1943-1948. ⟨10.3892/or.2013.2645⟩ Article dans une revue hal-00866242v1
Optimization of routine KRAS mutation PCR-based testing procedure for rational individualized first-line-targeted therapy selection in metastatic colorectal cancer Anne-Sophie Chretien,Alexandre Harlé,Magali Meyer-Lefebvre,Marie Rouyer,Marie Hussonet al. Cancer Medicine, 2013, 2 (1), pp.11-20. ⟨10.1002/cam4.47⟩ Article dans une revue hal-00763929v1

Communication dans un congrès (22)

CICLADES: Monitoring of ESR1, PIK3CA and AKT1 ctDNA mutations during real-life follow-up of patients with advanced breast cancer treated with endocrine therapy Vincent Massard,Lionel Uwer,Julia Salleron,Mathilde Deblock,Anne Kiefferet al. San Antonio Breast Cancer Symposium, Dec 2018, San Antonio, TX, United States. pp.OT1-03-02-OT1-03-02, ⟨10.1158/1538-7445.SABCS18-OT1-03-02⟩ Communication dans un congrès hal-03030007v1
From ERα66 to ERα36: a new predictive marker for cancer progression and therapeutic response in breast tumors ? Charlène Thiébaut,Chloé Morel,Alexandre Harlé,Amand Chesnel,Agnès Lerouxet al. Colloque Interrégional Grand-Est de Recherche Translationnelle en Oncologie ONCOTRANS, CGE, Feb 2017, Besançon, France Communication dans un congrès hal-01667636v1
Abstract 2719: Accelerated BRAF mutation analysis using a fully automated PCR platform improves the management of patients with metastatic melanoma : MELFAST trial Alexandre Harlé,Delphine Serre,Julia Salleron,Marie Husson,Agnès Lerouxet al. AACR Annual Meeting 2017, Apr 2017, Washington, DC, United States. pp.2719-2719, ⟨10.1158/1538-7445.AM2017-2719⟩ Communication dans un congrès hal-03029979v1
ERα36 expression: a key breast cancer risk factor? Charlène Thiébaut,Clémence Chamard-Jovenin,Amand Chesnel,Chloé Morel,Isabelle Grillier-Vuissozet al. 2nd EACR-OECI Conference Making it Personal - Cancer Precision Medicine, Mar 2017, Amsterdam, Netherlands Communication dans un congrès hal-01665545v1
L’expression d’ER$\alpha$36: un nouveau marqueur de transformation néoplasique et de progression tumorale mammaire ? Charlène Thiébault,Chloé Morel,Alexandre Harlé,Amand Chesnel,Clémence Chamard-Joveninet al. 18e Journée Scientifique de la Ligue contre le cancer, Nov 2017, Illkirch, France Communication dans un congrès hal-02994508v1
From ERα66 to ERα36: a new predictive marker for cancer progression and therapeutic response in breast tumors ? Charlène Thiébaut,Chloé Morel,Alexandre Harlé,Amand Chesnel,Agnès Lerouxet al. 10e Forum du Cancéropôle du Grand-Est, Nov 2016, Nancy, France Communication dans un congrès hal-01416426v1
Identification of druggable targets in high-grade epithelial ovarian cancer (EOC) using next generation sequencing (NGS)–based molecular diagnostic. Shuhui Chen,Elisa Cavazza,Catherine Barlier,Pierre Filhine-Tresarrieu,Céline Gavoilleet al. ASCO 2016 annual meeting, Jun 2016, Chicago, IL, United States. pp.abstr e17076 Communication dans un congrès hal-01320591v1
From ERα66 to ERα36: a new predictive marker for cancer progression and therapeutic response in breast tumors ? Charlène Thiébaut,Chloé Morel,Alexandre Harlé,Amand Chesnel,Agnès Lerouxet al. 21st World Congress on Advances in Oncology and 19th International Symposium on Molecular Medicine, Oct 2016, Athens, Greece Communication dans un congrès hal-01416456v1
From ERalpha66 to ERalpha36 : a new predcitive marker for cancer progression and therapeutic response in breast tumors Chloé Morel,Alexandre Harlé,Amand Chesnel,Clémence Chamard-Jovenin,Alain Junget al. 9e Forum du Cancéropôle du Grand Est, Nov 2015, Strasbourg, France Communication dans un congrès hal-01241778v1
Detection of rare somatic mutational profiles in metastatic colorectal cancer (mCRC) during routine RAS sequencing using next generation sequencing (NGS) Jean-Louis Merlin,Marie Husson,Marie Rouyer,Agnès Leroux,Alexandre Harlé ASCO 2015 annual meeting, May 2015, Chicago, IL, United States. pp.abstr 11055 Communication dans un congrès hal-01241769v1
Investigation of druggable molecular targets in high grade ovarian tumors using next generation sequencing (NGS) Shuhui Chen,Elisa Cavazza,Catherine Barlier,Pierre Filhine-Tresarrieu,Céline Gavoilleet al. 9e Forum du Cancéropôle du Grand Est, Nov 2015, Strasbourg, France Communication dans un congrès hal-01241780v1
Detection of rare somatic mutational profiles in metastatic colorectal cancer (mCRC) during routine RAS next generation sequencing (NGS) Alexandre Harlé,Marie Husson,Marie Rouyer,Agnès Leroux,Jean-Louis Merlin 4ème Colloque Inter-Régional Grand-Est de Recherche Translationnelle en Oncologie, Oncotrans 2015, Jun 2015, Dijon, France Communication dans un congrès hal-01241773v1
Detection of KRAS, NRAS and BRAF somatic mutations in circulating tumor DNA using two assays of Next Generation Sequencing (NGS) for patients with metastatic colorectal cancer Alexandre Harlé,Romain Boidot,Marie Rouyer,Sandy Chevrier,Vincent Massardet al. 4ème Colloque Inter-Régional Grand-Est de Recherche Translationnelle en Oncologie, Oncotrans 2015, Jun 2015, Dijon, France Communication dans un congrès hal-01241774v1
Testing of KRAS, NRAS, BRAF and PIK3CA somatic mutations on FFPE tumors samples using bidirectionnal ultra-deep pyrosequencing Alexandre Harlé,Marie Husson,Marie Rouyer,Agnès Leroux,Jean-Louis Merlin American Association for Cancer Research Annual meeting, AACR 2014, Apr 2014, San Diego (CA), United States Communication dans un congrès hal-01099669v1
Activation of P38MAP kinase in estrogen-positive invasive breast cancers: Relation with HER2 and downstream signaling phosphorylated proteins expression Jean-Louis Merlin,Alexandre Harlé,Anne-Sophie Chrétien,Carole Rammacci,Agnès Leroux 2013 ASCO Annual Meeting, May 2013, Chicago, Il, United States. pp.CDROM Communication dans un congrès hal-00831927v1
Highly sensitive determination of PIK3CA exon 9 and 20 hotspot mutations in breast tumors Alexandre Harlé,Nicolas Lozano,Cyrielle Nicolaizeau,Maeva Lion,Marie Hussonet al. Annual Meeting of the American Society of Clinical Oncology, ASCO'2012, Jun 2012, Chicago, Illinois, United States. pp.CDROM Communication dans un congrès hal-00747400v1
Comparaison des techniques COBAS KRAS 4800 et PCR TaqMan pour la détection des mutations somatiques du gène KRAS - Application dans le processus d'accréditation des laboratoires de biologie médicale selon la norme ISO 15189 Alexandre Harlé,Jean-Louis Merlin 14e Journées du Groupe de Pharmacologie Clinique Oncologique, Nov 2012, Paris, France Communication dans un congrès hal-00747747v1
PIK3CA exon 9 and 20 mutations analysis in breast cancers using PCR-HRM and PCR-ARMS: relations with clinicopathologic criteria Alexandre Harlé,Maeva Lion,Nicolas Lozano,Marie Husson,Valentin Harteret al. 14e Journées du Groupe de Pharmacologie Clinique Oncologique, Nov 2012, Paris, France Communication dans un congrès hal-00747745v1
Comparison of COBAS 4800 KRAS, PCR TaqMan, and PCR high-resolution melting assays for the detection of KRAS somatic mutations in formalin-fixed paraffin-embedded colorectal tumors Alexandre Harlé,Jean-Louis Merlin Annual Meeting of the American Society of Clinical Oncology, ASCO'2012, Jun 2012, Chicago, Illinois, United States. pp.CDROM Communication dans un congrès hal-00747449v1
Analyse des mutations KRAS dans les cancers colorectaux métastatiques : Optimisation des techniques et des délais pour la sélection rationnelle d'une première ligne thérapeutique Anne-Sophie Chrétien,Alexandre Harlé,Magali Meyer-Lefebvre,Marie Rouyer,Marie Hussonet al. Carrefour Pathologie 2011, Nov 2011, Paris, France. pp.CDROM, ⟨10.1016/j.annpat.2011.09.039⟩ Communication dans un congrès hal-00747865v1
Development of a simple method for the simultaneous determination of imatinib, norimatinib, dasatinib and nilotinib in human plasma by hplc photodiode array detector. Alexandre Harlé,Julien Scala-Bertola,Nicolas Gambier,Jean-Yves Jouzeau,Pierre Gilletet al. 2ème Colloque Inter-régional Grand-Est de Recherche Translationnelle en Oncologie, ONCOTRANS 2011, Sep 2011, Nancy, France Communication dans un congrès hal-00747903v1
Optimization of routine KRAS mutation testing procedure for rational individualized first line targeted therapy selection in metastatic colorectal cancer Anne-Sophie Chrétien,Alexandre Harlé,Magali Meyer-Lefebvre,Marie Rouyer,Marie Hussonet al. 2ème Colloque Inter-régional Grand-Est de Recherche Translationnelle en Oncologie, ONCOTRANS 2011, Sep 2011, Nancy, France Communication dans un congrès hal-00747885v1

Chapitre d'ouvrage (1)

Cell-free DNA in the management of colorectal cancer Alexandre Harlé Florence Schaffner, Jean-Louis Merlin et Nikolas von Bubnoff. Tumor Liquid Biopsies, 215, Springer, pp.253-261, 2020, Recent Results in Cancer Research, 978-3-030-26438-3. ⟨10.1007/978-3-030-26439-0_13⟩ Chapitre d'ouvrage hal-02325084v1

Thèse (1)

Marqueurs de réponse aux thérapies ciblées et personnalisation thérapeutique dans les cancers colorectaux métastatiques Alexandre Harlé Cancer. Université de Lorraine, 2014. Français. ⟨NNT : 2014LORR0267⟩ Thèse tel-01100524v2

HDR (1)

Recherche de biomarqueurs en cancérologie : Recherche préclinique sur le rôle de la protéine DDB2 dans les cancers du pancréas, recherche translationnelle et clinique sur le déploiement des analyses de l’ADN tumoral circulant Alexandre Harlé Cancer. Université de Lorraine, 2021 HDR tel-03111110v1