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Alexandre Vasseur



### **Professional experience:** **Since Oct. 2018** **Research assistant professor at CNRS (Chargé de Recherche au CNRS)**. Appointment in the University of Lorraine/Lorraine Laboratory of Molecular Chemistry, CNRS UMR 7053.Research axis: Heterocycles and Functional Materials (HeMaF). **2015-2018 (3 years)** **Teaching and Research Temporary Attaché** at the Institute of Molecular Sciences of Marseille, CNRS UMR 7313/Ecole Centrale de Marseille. Advisors: Dr. D. NUEL, Dr. L. GIORDANO & Prof. Dr. A. MARTINEZ **Topic: Synthesis of chiral supramolecular bisphosphinite palladacycles and applications in organic synthesis.** **2013-2015 (2 years 6 months)** **Post-doctoral associate at Technion – Israel Institute of Technology, Haifa, Israel** (European Research Council financial support). Advisor: Prof. Ilan MAREK,Sir Michael & Lady Sobell Academic Chair. **Topic: Transition metal-assisted remote functionalization of alkenes.** ### **Teaching experience:** ****2015-2018**** **Teaching in the first and second years of engineering school (Ecole Centrale de Marseille) – 558 h ETD** Structure and molecular properties (1st year): tutorials (48 h); Molecular reactivity (1st year): tutorials (70 h) and practical work (416 h); Materials (2nd year): practical work (24 h). ### **Education:** **2012** **PhD degree** **in organic chemistry** with highest honors (CNRS BDI fellowship) at the Reims Institute of Molecular Chemistry – ICMR, CNRS UMR 7312/University of Reims. Advisor: Dr. Jean LE BRAS. **Topic: C-H Functionalization of heterocycles derived from biomass: Pd-catalyzed dehydrogenative Heck reactions.** Committee members: Prof. Jean-Cyrille HIERSO (University of Burgundy), Prof. Jérôme WASER (Federal Polytechnic School of Lausanne), Dr. Nicolas RABASSO (University of Paris XI), Dr. Norbert Hoffmann (University of Reims), Dr. Jacques MUZART (University of Reims), Dr. Jean LE BRAS (University of Reims). **2009** **Master degree** **in molecular chemistry** with distinction - University of Reims (School of pharmacy). Master degree placement: Reims Institute of Molecular Chemistry (ICMR), CNRS UMR 7312/University of Reims Advisor: Prof. Dominique GUILLAUME. **Topic: Synthesis of enantiopure Beyrepel® analogues, repellents for mosquitoes.


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Zincate‐Mediated Remote Functionalisation of p ‐Iodobenzyl Derivatives Through Metallotropy in 2‐Methyltetrahydrofuran as Key Solvent

Alexandre Pierret , Clément Denhez , Philippe Gros , Alexandre Vasseur
Advanced Synthesis and Catalysis, 2022, ⟨10.1002/adsc.202200475⟩
Journal articles hal-03768996v1
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General methodology for the chemoselective N-alkylation of (2,2,6,6)-tetramethylpiperidin-4-ol: Contribution of microwave irradiation

Romain Membrat , Alexandre Vasseur , Laurent Giordano , Alexandre Martinez , Didier Nuel
Tetrahedron Letters, 2019, 60 (3), pp.240-243. ⟨10.1016/j.tetlet.2018.12.020⟩
Journal articles hal-01969189v1

Platinum–(phosphinito–phosphinous acid) complexes as bi-talented catalysts for oxidative fragmentation of piperidinols: an entry to primary amines

Romain Membrat , Alexandre Vasseur , Delphine Moraleda , Sabine Michaud-Chevallier , Alexandre Martinez
RSC Advances, 2019, 9 (65), pp.37825-37829. ⟨10.1039/C9RA08709E⟩
Journal articles hal-02373357v1
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Synthesis of chiral supramolecular bisphosphinite palladacycles through hydrogen transfer-promoted self-assembly process

Alexandre Vasseur , Romain Membrat , Davide Palpacelli , Michel Giorgi , Didier Nuel
Chemical Communications, 2018, 54 (72), pp.10132 - 10135. ⟨10.1039/c8cc06283h⟩
Journal articles hal-01870774v1

Zirconocene-Mediated Selective C–C Bond Cleavage of Strained Carbocycles: Scope and Mechanism

Jeffrey Bruffaerts , Alexandre Vasseur , Sukhdev Singh , Ahmad Masarwa , Dorian Didier
Journal of Organic Chemistry, 2018, 83 (7), pp.3497-3515. ⟨10.1021/acs.joc.7b03115⟩
Journal articles hal-03006430v1
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Phosphinous Acid Platinum Complex as Robust Catalyst for Oxidation: Comparison with Palladium and Mechanistic Investigations

Romain Membrat , Alexandre Vasseur , Alexandre Martinez , Laurent Giordano , Didier Nuel
European Journal of Organic Chemistry, 2018, 2018 (39), pp.5427-5434. ⟨10.1002/ejoc.201801040⟩
Journal articles hal-01905995v1

Alkene-Zipper Catalyzed Selective and Remote Retro-ene Reaction of Alkenyl Cyclopropylcarbinol

Jeffrey Bruffaerts , Alexandre Vasseur , Ilan Marek
Advanced Synthesis and Catalysis, 2018, 360 (7), pp.1389 - 1396. ⟨10.1002/adsc.201701481⟩
Journal articles hal-01780966v1
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Secondary Phosphine Oxides as Multitalented Preligands En Route to the Chemoselective Palladium-Catalyzed Oxidation of Alcohols

Alexandre Vasseur , Romain Membrat , David Gatineau , Alphonse Tenaglia , Didier Nuel
ChemCatChem, 2017, 9 (5), pp.728 - 732. ⟨10.1002/cctc.201601261⟩
Journal articles hal-01682727v1

A unique Pd-catalysed Heck arylation as a remote trigger for cyclopropane selective ring-opening

Sukhdev Singh , Jeffrey Bruffaerts , Alexandre Vasseur , Ilan Marek
Nature Communications, 2017, 8, ⟨10.1038/ncomms14200⟩
Journal articles hal-01780964v1

Merging allylic C–H bond activation and C–C bond cleavage en route to the formation of a quaternary carbon stereocenter in acyclic systems

Alexandre Vasseur , Ilan Marek
Nature Protocols, 2016, 12 (1), pp.74 - 87. ⟨10.1038/nprot.2016.161⟩
Journal articles hal-01780962v1

Remote functionalization through alkene isomerization

Alexandre Vasseur , Jeffrey Bruffaerts , Ilan Marek
Nature Chemistry, 2016, 8 (3), pp.209 - 219. ⟨10.1038/nchem.2445⟩
Journal articles hal-01780960v1

Ligand-Promoted Reactivity of Alkenes in Dehydrogenative Heck Reactions of Furans and Thiophenes

Alexandre Vasseur , Caroline Laugel , Dominique Harakat , Jacques Muzart , Jean Le Bras
European Journal of Organic Chemistry, 2015, 2015 (5), pp.944-948. ⟨10.1002/ejoc.201403475⟩
Journal articles hal-02109118v1

Ubiquitous Benzoquinones, Multitalented Compounds for Palladium-Catalyzed Oxidative Reactions

Alexandre Vasseur , Jacques Muzart , Jean Le Bras
European Journal of Organic Chemistry, 2015, 2015 (19), pp.4053-4069. ⟨10.1002/ejoc.201500080⟩
Journal articles hal-02109108v1
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Remote functionalization of hydrocarbons with reversibility enhanced stereocontrol

Alexandre Vasseur , Lionel Perrin , Odile Eisenstein , Ilan Marek
Chemical Science, 2015, 6 (5), pp.2770-2776. ⟨10.1039/C5SC00445D⟩
Journal articles hal-01152129v1

Aerobic Dehydrogenative Heck Reactions of Heterocycles with Styrenes: A Negative Effect of Metallic Co-Oxidants

Alexandre Vasseur , Dominique Harakat , Jacques Muzart , Jean Le Bras
Advanced Synthesis and Catalysis, 2013, 355 (1), pp.59-67. ⟨10.1002/adsc.201200787⟩
Journal articles hal-02109125v1

ESI-MS Studies of the Dehydrogenative Heck Reaction of Furans with Acrylates Using Benzoquinone as the Reoxidant and DMSO as the Solvent

Alexandre Vasseur , Dominique Harakat , Jacques Muzart , Jean Le Bras
Journal of Organic Chemistry, 2012, 77 (13), pp.5751-5758. ⟨10.1021/jo300921s⟩
Journal articles hal-02109127v1

Dehydrogenative Heck Reaction of Furans and Thiophenes with Styrenes under Mild Conditions and Influence of the Oxidizing Agent on the Reaction Rate

Alexandre Vasseur , Jacques Muzart , Jean Le Bras
Chemistry - A European Journal, 2011, 17 (45), pp.12556-12560. ⟨10.1002/chem.201101992⟩
Journal articles hal-02109134v1