Alexia Chauzy

Publications

Article dans une revue (18)

A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data Noémie Prébonnaud,Alexia Chauzy,Nicolas Grégoire,Claire Dahyot-Fizelier,Christophe Adieret al. Microbiology Spectrum, 2025, ⟨10.1128/spectrum.00051-25⟩ Article dans une revue hal-05085650v1
&lt;i&gt;In vitro&lt;/i&gt; pharmacokinetic/pharmacodynamic modeling of the effect of mucin on polymyxin B activity against &lt;i&gt;Acinetobacter baumannii&lt;/i&gt; Mathilde Lacroix,Jérémy Moreau,Claudia Zampaloni,Caterina Bissantz,Hélène Mirfendereskiet al. Antimicrobial Agents and Chemotherapy, 2025, 69 (5), pp.112076. ⟨10.1128/aac.01535-24⟩ Article dans une revue hal-05144888v1
PKPD modeling of the inoculum effect of combined ceftazidime/avibactam and colistin against KPC-3 Klebsiella pneumoniae isolate Romain Aubry,Julien Buyck,Alexia Chauzy,Laure Prouvensier,Jean-Winoc Decousseret al. Antimicrobial Agents and Chemotherapy, 2025, 69 (5), ⟨10.1128/aac.01797-24⟩ Article dans une revue hal-05153931v1
A hollow fiber infection model to study intracellular and extracellular antibiotic activity against Staphylococcus aureus Gwenaëlle Mahieu,Laure Elens,Noémie Prébonnaud,Alexia Chauzy,Françoise van Bambeke iScience, 2025, 28 (3), pp.112076. ⟨10.1016/j.isci.2025.112076⟩ Article dans une revue hal-05136030v1
Impact of nutritional factors on in vitro PK/PD modelling of polymyxin B against various strains of Acinetobacter baumannii Mathilde Lacroix,Jérémy Moreau,Claudia Zampaloni,Caterina Bissantz,Hamasseh Shirvaniet al. International Journal of Antimicrobial Agents, 2024, 64 (1), pp.107189. ⟨10.1016/j.ijantimicag.2024.107189⟩ Article dans une revue hal-04643050v1
Targeting lung macrophages for fungal and parasitic pulmonary infections with innovative amphotericin B dry powder inhalers E. de Pablo,P. O'Connell,R. Fernández-García,S. Marchand,A. Chauzyet al. International Journal of Pharmaceutics, 2023, 635, pp.122788. ⟨10.1016/j.ijpharm.2023.122788⟩ Article dans une revue hal-04131635v1
PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo Alexia Chauzy,Grace Akrong,Vincent Aranzana-Climent,Jérémy Moreau,Laure Prouvensieret al. Frontiers in Pharmacology, 2022, 13, pp.842921. ⟨10.3389/fphar.2022.842921⟩ Article dans une revue hal-03615739v1
A New Pharmacokinetic-Pharmacodynamic Model To Characterize the Inoculum Effect of Acinetobacter baumannii on Polymyxin B In Vitro Grace Akrong,Alexia Chauzy,Vincent Aranzana-Climent,Mathilde Lacroix,Luc Derocheet al. Antimicrobial Agents and Chemotherapy, 2022, 66 (1), pp.e0178921. ⟨10.1128/AAC.01789-21⟩ Article dans une revue hal-03615758v1
Improved In Vitro Anti-Mucorales Activity and Cytotoxicity of Amphotericin B with a Pegylated Surfactant Kévin Brunet,Cheikh Diop,Alexia Chauzy,Noémie Prébonnaud,Sandrine Marchandet al. Journal of Fungi, 2022, 8 (2), pp.121. ⟨10.3390/jof8020121⟩ Article dans une revue hal-03615762v1
A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients Alexia Chauzy,Salim Bouchène,Vincent Aranzana-Climent,Jonathan Clarhaut,Christophe Adieret al. Antibiotics, 2022, 11 (10), pp.1293. ⟨10.3390/antibiotics11101293⟩ Article dans une revue hal-03906712v1
Population pharmacokinetic/pharmacodynamic study suggests continuous infusion of ceftaroline daily dose in ventilated critical care patients with early-onset pneumonia and augmented renal clearance Alexia Chauzy,Nicolas Grégoire,Martine Ferrandière,Sigismond Lasocki,Karim Ashenouneet al. Journal of Antimicrobial Chemotherapy, 2022, 77 (11), pp.3173-3179. ⟨10.1093/jac/dkac299⟩ Article dans une revue hal-03906736v1
Sequential time-kill: a simple experimental trick to discriminate between PK/PD models with distinct heterogeneous sub-populations versus homogenous population with adaptive resistance Alexia Chauzy,H Ih,M Jacobs,S Marchand,N Grégoireet al. Antimicrobial Agents and Chemotherapy, 2020, ⟨10.1128/AAC.00788-20⟩ Article dans une revue hal-02888859v1
Clinical Pharmacokinetics of Daptomycin Nicolas Grégoire,Alexia Chauzy,Julien Buyck,Blandine Rammaert,William Couetet al. Clinical Pharmacokinetics, 2020, ⟨10.1007/s40262-020-00968-x⟩ Article dans une revue hal-03071620v1
Pharmacodynamic modelling of β-lactam/β-lactamase inhibitor checkerboard data: illustration with aztreonam–avibactam Alexia Chauzy,Julien Buyck,B.L.M. de Jonge,Sandrine Marchand,N. Grégoireet al. Clinical Microbiology and Infection, 2019, 25 (4), pp.515.e1-515.e4. ⟨10.1016/j.cmi.2018.11.025⟩ Article dans une revue hal-02321069v1
Semimechanistic Pharmacodynamic Modeling of Aztreonam‐Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug‐Resistant Gram‐Negative Bacteria Alexia Chauzy,Bruna Gaelzer Silva Torres,Julien Buyck,Boudewijn Jonge,Christophe Adieret al. CPT: Pharmacometrics and Systems Pharmacology, 2019, ⟨10.1002/psp4.12452⟩ Article dans une revue hal-02320523v1
Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients with an external ventricular drain Alexia Chauzy,Abdelouaïd Nadji,Jean-Christophe Combes,Nadine Defrance,Belaid Bouhemadet al. Journal of Antimicrobial Chemotherapy, 2019, 74 (3), pp.675-681. ⟨10.1093/jac/dky489⟩ Article dans une revue hal-01957116v1
Microdialysis Study of Aztreonam-Avibactam Distribution in Peritoneal Fluid and Muscle of Rats with or without Experimental Peritonitis Alexia Chauzy,Isabelle Lamarche,Christophe Adier,William Couet,Sandrine Marchand Antimicrobial Agents and Chemotherapy, 2018, 62 (10), ⟨10.1128/AAC.01228-18⟩ Article dans une revue hal-02321070v1
Microdialysis as a way to measure antibiotics concentration in tissues Sandrine Marchand,Alexia Chauzy,Claire Dahyot-Fizelier,William Couet Pharmacological Research, 2016, 111, pp.201-207. ⟨10.1016/j.phrs.2016.06.001⟩ Article dans une revue istex hal-02321071v1

Communication dans un congrès (4)

Transcriptomic data to support in vitro semimechanistic PK/PD modelling of Polymyxin B against Acinetobacter baumannii Mathilde Lacroix,Andrej Trauner,Claudia Zampaloni,Caterina Bissantz,Hamasseh Shirvaniet al. 33rd ECCMID, Apr 2023, Copenaghen, Denmark Communication dans un congrès hal-04142283v1
Pkpop-LCR study: Pharmacokinetic and Pharmacodynamic of linezolid in neurointensive care patients with external ventricular drainage Alexia Chauzy,Fanny Bernard,Nicolas Grégoire,Hélène Mirfendereski,Nadia Imziet al. 33rd ECCMID ; European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark Communication dans un congrès hal-04142302v1
Predicting antibacterial efficacy of linezolid on Staphylococcus aureus in cerebral infections using in vitro hollow fiber model and pharmacokinetic-pharmacodynamic modeling Noémie Prebonnaud,Alexia Chauzy,Claire Dahyot-Fizelier,Sandrine Marchand 33rd ECCMID : : European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark Communication dans un congrès hal-04142287v1
Pharmacodynamic modeling of checkerboard data obtained with β-lactam- β-lactamases inhibitor combination: aztreonam-avibactam Alexia Chauzy ISAP/EPASG Scientific Meeting, Apr 2017, Vienne, Austria Communication dans un congrès hal-02512124v1

Poster de conférence (12)

Simulation-based prediction of pharmacokinetic/pharmacodynamic (PK/PD) index for linezolid to treat cerebral infections in critically ill patients Michael Burtin,Noémie Prébonnaud,Sandrine Marchand,Nicolas Grégoire,Claire Dahyot-Fizelieret al. 33rd PAGE meeting, Jun 2025, Thessalokini, Greece. Poster de conférence hal-05240779v1
In vitro evaluation of the inoculum effect of various β-lactamase-producing Klebsiella pneumoniae isolates on ceftazidime-avibactam Alexia Chauzy,William Couet,Isabelle Martin,Hélène Mirfendereski,Sandrine Marchand 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain Poster de conférence hal-04571024v1
Impact of in vitro use of artificial cerebrospinal fluid compared to Mueller-Hinton broth on the efficacy of linezolid against Staphylococcus aureus in a hollow-fiber model Noémie Prébonnaud,Alexia Chauzy,Christophe Adier,Isabelle Martin,Claire Dahyot-Fizelieret al. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain Poster de conférence hal-04571091v1
PK/PD modelling of the CAMHB nutrients concentrations effect on polymyxin B antimicrobial activity against Acinetobacter baumannii Mathilde Lacroix,Jérémy Moreau,Claudia Zampaloni,Caterina Bissantz,Hamasseh Shirvaniet al. 33rd ECCMID : European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark Poster de conférence hal-04141371v1
Comparison between pharmacokinetic-phramcodynamic modeling results of ceftaroline against methicillin-resistant Staphylococcus aureus after Time Kill and Hollow Fiber experiments Alexia Chauzy,Arthur Fourmy,Hélène Mirfendereski,William Couet,Sandrine Marchand 32nd ECCMID, Apr 2022, Lisbonne, Portugal Poster de conférence hal-04014948v1
In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin Mathilde Lacroix,Alexia Chauzy,Claudia Zampaloni,Caterina Bissantz,Hélène Mirfendereskiet al. 32nd ECCMID, Apr 2022, Lisabon, Portugal Poster de conférence hal-04016532v1
A minimal physiologically-based pharmacokinetic model to investigate CNS distribution of metronidazole in ICU patients Alexia Chauzy,Salim Bouchène,Nicolas Grégoire,William Couet,Olivier Mimozet al. 39ème Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse (RICAI), Dec 2019, Paris, France Poster de conférence hal-02528416v1
Semi-mechanistic pharmacodynamics modeling of aztreonam- avibactam combination to understand its antimicrobial activity against multidrug-resistant Gram(-) bacteria Alexia Chauzy,Bruna Gaelzer Silva Torres,Julien Buyck,Boudewijn Jonge,Christophe Adieret al. PAGE meeting, Jun 2019, Stockholm, Sweden Poster de conférence hal-02528382v1
Semi-mechanistic pharmacokinetic/pharmacodynamics modeling of aztreonam-avibactam combination against multidrug resistant Gram(-) organisms Alexia Chauzy,Bruna Gaelzer Silva Torres,Julien Buyck,Emma Marquizeau,Patrice Gobinet al. the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2018, Madrid, Spain Poster de conférence hal-02528294v1
Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients with external ventricular drain Pascal Chavanet,Alexia Chauzy,Nadine Defrance,Abdelouaïd Nadji,Jean-Christophe Combeset al. the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2018, Madrid, Spain Poster de conférence hal-02528340v1
Microdialysis study distribution of aztreonam and avibactam in skeletal muscle and intraperitoneal fluid of rats with or without experimental peritonitis Alexia Chauzy,Nicolas Grégoire,Isabelle Lamarche,Patrice Gobin,William Couetet al. the 27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2017, Vienne, Austria Poster de conférence hal-02512109v1
Appraisal of potential effect of subcutaneous administration on antibiotics pharmacokinetics-pharmacodynamics Alexia Chauzy,Nicolas Grégoire,Sandrine Marchand,Olivier Mimoz,Marc Paccalinet al. the 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2015, Copenhague, Denmark Poster de conférence hal-02512083v1

Pré-publication, Document de travail (1)

A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data Noémie Prébonnaud,Alexia Chauzy,Nicolas Grégoire,Claire Dahyot-Fizelier,Christophe Adieret al. 2025 Pré-publication, Document de travail hal-05030769v1

Thèse (1)

Evaluation pharmacocinétique/pharmacodynamique in vitro et in vivo de l'association aztréonam-avibactam Alexia Chauzy Sciences du Vivant [q-bio]. Université de poitiers, 2018. Français. ⟨NNT : ⟩ Thèse tel-02533170v1