Alexis Viel Researcher in veterinary pharmacology at Anses

Publications

Article dans une revue (20)

Semi-mechanistic PK/PD modelling of enrofloxacin against sensitive Pasteurella multocida : inter-strain variability and prediction of efficacy in pigs Alexis Viel,Anthony Khaled,Mathias Devreese,Mireille Bruneau,Jérôme Henri Journal of Applied Microbiology, 2026, ⟨10.1093/jambio/lxag045⟩ Article dans une revue hal-05510220v1
Population pharmacokinetic modelling of oxytetracycline in rainbow trout (Oncorhynchus mykiss): Effects of route of administration, temperature and ploidy Alexis Viel,Florine Bachelet,Annaëlle Chailleux,Céline David,Lionel Pineauet al. Aquaculture, 2026, 610, pp.742917. ⟨10.1016/j.aquaculture.2025.742917⟩ Article dans une revue hal-05141538v1
Minimum inhibitory concentrations of sulfonamides and trimethoprim for veterinary pathogens: new data for old antibiotics Nadine Ruchti,Aude Ferran,Andrew Mead,Ludovic Pelligand,Alexis Vielet al. Veterinary Microbiology, 2026, 312, pp.110784. ⟨10.1016/j.vetmic.2025.110784⟩ Article dans une revue hal-05355767v1
Pharmacodynamic Interaction Between Trimethoprim and Sulphonamides for A. pleuropneumoniae : Synergistic Ratios, Optimal Potentiation, and Dynamic Responses Assessed via Time-Kill Curves Andrew Mead,Alexis Viel,Marine Boulanger,Gudrun Overesch,Pierre-Louis Toutainet al. Journal of Applied Microbiology, 2026, ⟨10.1093/jambio/lxag106⟩ Article dans une revue hal-05602740v1
Population pharmacokinetic modeling of sulfadimethoxine, sulfadiazine and sulfamethoxazole combined to trimethoprim in pigs Marine Boulanger,Jean-François Taillandier,Jérôme Henri,Mathias Devreese,Siegrid de Baereet al. Veterinary Quarterly, 2025, 45 (1), pp.2565351. ⟨10.1080/01652176.2025.2565351⟩ Article dans une revue hal-05290011v1
Presence of antimicrobial residues in edible pig tissues after exposure to cross-contaminated feed: a case study with sulphadimethoxine/trimethoprim Cristina Santos-Santórum Suárez,Pascal Sanders,Agnès Perrin-Guyomard,Michel Laurentie,Jean-François Taillandieret al. Food additives & contaminants. Part A. Chemistry, analysis, control, exposure & risk assessment, 2025, pp.1-16. ⟨10.1080/19440049.2025.2467627⟩ Article dans une revue hal-04966079v1
Pharmacokinetic modeling of sulfamethoxazole-trimethoprim and sulfadiazine-trimethoprim combinations in broilers Marine Boulanger,Jean-François Taillandier,Jérôme Henri,Mathias Devreese,Siegrid de Baereet al. Poultry Science, 2024, 103 (11), pp.104200. ⟨10.1016/j.psj.2024.104200⟩ Article dans une revue anses-04687626v1
PBPK Model To Predict Marbofloxacin Distribution in Edible Tissues and Intestinal Exposure in Pigs Alexis Viel,Anis Nouichi,Mélanie Le van Suu,Jean-Guy Rolland,Pascal Sanderset al. Journal of Agricultural and Food Chemistry, 2023, 71 (10), pp.4358-4370. ⟨10.1021/acs.jafc.2c06561⟩ Article dans une revue anses-04167240v1
Ionophore coccidiostats – disposition kinetics in laying hens and residues transfer to eggs Abubakar Bello,Jérôme Henri,Alexis Viel,Jonathan Paul Mochel,Błażej Poźniak Poultry Science, 2023, 102 (1), pp.102280. ⟨10.1016/j.psj.2022.102280⟩ Article dans une revue anses-03922139v1
Selection of antibiotic resistance in pigs after exposure to feed cross-contaminated with oxytetracycline Cristina Santos-Santórum Suárez,Pascal Sanders,Murielle Gaugain,Alexis Viel,Frédéric Paboeufet al. Veterinary Microbiology, 2023, 287, pp.109924. ⟨10.1016/j.vetmic.2023.109924⟩ Article dans une revue anses-04311332v1
Estimating the likelihood of ESBL-producing E. coli carriage in slaughter-aged pigs following bacterial introduction onto a farm: A multiscale risk assessment Catherine Mccarthy,Alexis Viel,Chris Gavin,Pascal Sanders,Robin R.L. Simons Microbial Risk Analysis, 2022, 20, pp.100185. ⟨10.1016/j.mran.2021.100185⟩ Article dans une revue anses-03441007v1
Presence and Depletion of Sulfadiazine, Trimethoprim, and Oxytetracycline into Feathers of Treated Broiler Chickens and Impact on Antibiotic-Resistant Bacteria Estelle Dréano,Charlotte Valentin,Jean-François Taillandier,Angélique Travel,Christophe Soumetet al. Journal of Agricultural and Food Chemistry, 2022, 70 (51), pp.16106-16116. ⟨10.1021/acs.jafc.2c05807⟩ Article dans une revue anses-03918835v1
A physiologically based pharmacokinetic (PBPK) model exploring the blood-milk barrier in lactating species - A case study with oxytetracycline administered to dairy cows and goats Jennifer Tardiveau,Lerica Leroux-Pullen,Ronette Gehring,Gaël Touchais,Marie-Pierre Chotardet al. Food and Chemical Toxicology, 2022, 161, pp.112848. ⟨10.1016/j.fct.2022.112848⟩ Article dans une revue hal-03615752v1
Validation of a LC-MS/MS method for the quantitative analysis of four antibiotics in pig tissues and plasma to assess the risk of transfer of residues to edible matrices after exposure to cross-contaminated feed Cristina Santos-Santórum Suárez,Pascal Sanders,Agnès Perrin-Guyomard,Dominique Hurtaud-Pessel,Michel Laurentieet al. Food additives & contaminants. Part A. Chemistry, analysis, control, exposure & risk assessment, 2022, 39 (11), pp.1818-1827. ⟨10.1080/19440049.2022.2126529⟩ Article dans une revue anses-03922498v1
A liquid chromatography coupled to tandem mass spectrometry method for the quantification of spiramycin and its active metabolite neospiramycin in milk of major and minor species: Validation using the accuracy profile Jennifer Tardiveau,Gael Touchais,Marie-Pierre Chotard-Soutif,Marie-Pierre Lagrée,Dominique Hurtaud-Pesselet al. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2021, 1187, pp.123013. ⟨10.1016/j.jchromb.2021.123013⟩ Article dans une revue anses-03461263v1
Tissue distribution, metabolism, and elimination of Victoria Pure Blue BO in rainbow trout: Main metabolite as an appropriate residue marker Estelle Dubreil-Cheneau,Michel Laurentie,Jean-Michel Delmas,Morgane Danion,Thierry Morinet al. Chemosphere, 2021, 262, pp.127636. ⟨10.1016/j.chemosphere.2020.127636⟩ Article dans une revue anses-02958944v1
Population pharmacokinetics/pharmacodynamics modelling of enrofloxacin for the three major trout pathogens Aeromonas salmonicida, Flavobacterium psychrophilum and Yersinia ruckeri Alexis Viel,Antoine Rostang,Marie-Line Morvan,Catherine Fournel,Patrick Danielet al. Aquaculture, 2021, 545, pp.737119. ⟨10.1016/j.aquaculture.2021.737119⟩ Article dans une revue anses-03318243v1
A Population WB-PBPK Model of Colistin and its Prodrug CMS in Pigs: Focus on the Renal Distribution and Excretion Alexis Viel,Jérôme Henri,Salim Bouchène,Julian Laroche,Jean-Guy Rollandet al. Pharmaceutical Research, 2018, 35, pp.92. ⟨10.1007/s11095-018-2379-4⟩ Article dans une revue anses-01743743v1
Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets Alexis Viel,Jérôme Henri,Agnès Perrin-Guyomard,Julian Laroche,William Couetet al. International Journal of Antimicrobial Agents, 2017, 51 (1), pp.128-131. ⟨10.1016/j.ijantimicag.2017.04.013⟩ Article dans une revue anses-01570163v1
MicroRNA-29b Modulates Innate and Antigen-Specific Immune Responses in Mouse Models of Autoimmunity Apolline Salama,Nolwenn Fichou,Marie Allard,Laurence Dubreil,Laurence de Beaurepaireet al. PLoS ONE, 2014, 9 (9), pp.e106153. ⟨10.1371/journal.pone.0106153⟩ Article dans une revue hal-02477587v1

Communication dans un congrès (6)

Semi-mecanistic PKPD modeling of enrofloxacin against sensitive strains of Pasteurella multocida in pigs Anthony Khaled,Jérôme Henri,Alexis Viel Twelfth International Conference on Antimicrobial Agents in Veterinary Medicine (AAVM), Jun 2024, Athènes, Greece Communication dans un congrès hal-04628898v1
Population PK modeling of OTC in rainbow trout : impact of water temperature and routes of administration Alexis Viel,Annaëlle Chailleux,Florine Bachelet,Céline David,Lionel Pineauet al. Twelfth International Conference on Antimicrobial Agents in Veterinary Medicine (AAVM), Jun 2024, Athènes, Greece Communication dans un congrès hal-04628878v1
Pharmacocinétique des antibiotiques dans la mamelle : les concentrations efficaces sont-elles atteintes dans les différents compartiments ? Alexis Viel,Pascal Sanders Journées Nationales des GTV 2023, Poitiers, May 2023, Poitiers (FR), France Communication dans un congrès hal-04531021v1
Réevaluer le schéma posologique des antibiotiques utilisés en pisciculture - exemple de l'enrofloxacine chez la truite Antoine Rostang,Alexis Viel,Daniel Patrick,Sandrine Baron,Ségolène Calvez 7. Journées de la Recherche Filière Piscicole, ITAVI, Jul 2022, Paris, France. pp.1 Communication dans un congrès hal-04482435v1
Population PKPD modelling of enrofloxacin for the three major trout pathogens A. salmonicida, F. psychrophilum and Y. ruckeri according to fish ploidy Alexis Viel Tenth International Conference on Antimicrobial Agents in Veterinary Medicine, Nov 2020, Virtual conference, France Communication dans un congrès hal-04531066v1
A Population WB-PBPK Model of Colistin and its Prodrug CMS in Pigs and extrapolation to humans Alexis Viel Symposium PBPK, Club phase I, Apr 2018, Paris, France. pp.1-38 Communication dans un congrès anses-01985235v1

Poster de conférence (10)

Mechanistic Modeling of Antibiotics Transfer across the Blood-Milk Barrier in Ruminants: Case Study of Marbofloxacin Marc Codaccioni,Jennifer Tardiveau,Jérôme Henri,Nicolas Grégoire,Alexis Viel 59th Congress of the European Societies of Toxicology (EUROTOX 2025) : Toxicology addresses society's real life risks for sustainable health and well being, Sep 2025, Athènes, Greece. Toxicology letters, 411, pp.S195, 2025, ⟨10.1016/j.toxlet.2025.07.468⟩ Poster de conférence hal-05251265v1
Modélisation pharmacocinétique de population de différents sulfamides associés au triméthoprime chez le porc Marine Boulanger,Jean-François Taillandier,Marlène Lacroix,Béatrice Roques,Aude A Ferranet al. 57es Journées de la recherche porcine (JRP), Feb 2025, Saint-Malo, France. Ifip, Journées de la recherche porcine en France, 57, 2025, 57es Journées de la recherche porcine Poster de conférence hal-05206887v1
Semi-mecanistic PK/PD modeling of three Sulfonamides-Trimethoprim combinations with Echerichia Coli Marine Boulanger,Sadate Tchalaou,Celia Lechevretel,Alexis Viel,Aude A. Ferran Twelfth International Conference on Antimicrobial Agents in Veterinary Medicine (AAVM), Jun 2024, Athènes, France. Poster de conférence hal-04692167v1
Impact of quaternary ammoniums on permeability and intestinal microbiota: a study to detect biomarkers of exposure in rats Kahina Slimani,Sophie Mompelat,Cécile Vignal,Tahar Ait-Ali,Jean-François Taillandieret al. 16èmes JS du RFMF, Jun 2024, Saint-Malo, France Poster de conférence hal-05034843v1
Révision des posologies des combinaisons sulfamides/triméthoprime chez les animaux de production : exemple chez le porc et la volaille (Projet Sultan) Marine Boulanger,Sadate Tchalaou,Jean-François Taillandier,Béatrice Roques,Aude A. Ferranet al. Journées Nationales des GTV 2023, May 2023, Poitiers, France Poster de conférence hal-04711893v1
PBPK modeling to explore dairy cows’ exposure to marbofloxacin and estimate milk withdrawal period Abderrahmane Meslouh,Alexis Viel,Nicolas Grégoire GMP 2023 Symposium, Oct 2023, Paris, France. Poster de conférence hal-04533797v1
Assessment of the selective effect of colistin on mcr-1-positive Escherichia coli through in vitro co-culture time-kill experiments Alexis Viel,Charlotte Valentin,Jérôme Henri,Michel Laurentie,Pascal Sanders Tenth International Conference on Antimicrobial Agents in Veterinary Medicine, Nov 2020, Virtual, France Poster de conférence anses-03499578v1
Use of PBPK modeling to explore the pharmacokinetics and renal disposition of CMS/Colistin in piglets as a model for the paediatric population Alexis Viel,Jérôme Henri,William Couet,Michel Laurentie,Pascal Sanderset al. CVPT/ESVNU Symposium (European College of Veterinary Pharmacology and Therapeutics & European Society of Veterinary Nephrology and Urology): Pharmacology and the kidney, Jul 2019, London, United Kingdom Poster de conférence hal-05480054v1
Lack of experimental evidence to support mcr-1-positive Escherichia coli strain selection during oral administration of colistin by gavage in weaned piglets Alexis Viel,Jérôme Henri,Agnès Perrin-Guyomard,Julian Laroche,William Couetet al. 14th international congress of the European association for veterinary pharmacology and toxicology, Jun 2018, Wroclaw, Poland. Poster de conférence anses-01985196v1
The influence of age on colistin methanosulfonate and colistin plasmatic and tissular distribution after intravenous administration of colistin methanosulfonate in pigs background Alexis Viel,Nicolas Grégoire,Jérôme Henri,Patrice Gobin,Julian Larocheet al. 8th International Conference on Antimicrobial Agents in Veterinary Medicine (AAVM 2016), Aug 2016, Budapest, Hungary Poster de conférence hal-05480028v1

Proceedings/Recueil des communications (4)

114. Population pharmacokinetic modelling of different sulphonamides associated with trimethoprim in pigs Marine Boulanger,J.F. Taillandier,Jérôme Henri,Marlène Z Lacroix,Béatrice Roqueset al. 57th Swine Research Days [57es Journées de la Recherche Porcine] (JRP 2025), Feb 2025, Saint-Malo, France. Animal. Science proceedings, 16 (6), pp.896, 2025, ⟨10.1016/j.anscip.2025.08.115⟩ Proceedings/Recueil des communications hal-05406887v1
P19 | Determination of optimal ratios for three sulfonamides/trimethoprim combinations against &lt;i&gt;E. coli&lt;/i&gt; using checkerboard and time‐kill assays Marine Boulanger,Sadate Tchalaou,Béatrice Roques,Aude A. Ferran,Alexis Viel 15th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Journal of Veterinary Pharmacology and Therapeutics, 46 (S1), pp.94-95, 2023, ⟨10.1111/jvp.13298⟩ Proceedings/Recueil des communications hal-04352581v1
O81 | Antibiotic cross‐contamination of feeding stuffs: Assessment of transfer to food of animal origin and risk of antibiotic resistance Cristina Santos-Santórum Suárez,Murielle Gaugain,Agnes Perrin-Guyomard,Michel Laurentie,Alexis Vielet al. 15th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Journal of Veterinary Pharmacology and Therapeutics, 46 (S1), pp.68-68, 2023, ⟨10.1111/jvp.13247⟩ Proceedings/Recueil des communications hal-04661476v1
Population PK modeling of different sulfonamides in association with trimethoprim in pigs Alexis Viel,Marine Boulanger,Jean-François Taillandier,Michel Laurentie,Jérôme Henriet al. 15th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Journal of Veterinary Pharmacology and Therapeutics, 46 (S1), pp.82-83, 2023, ⟨10.1111/jvp.13277⟩ Proceedings/Recueil des communications hal-04352560v1

Autre publication scientifique (3)

Pharmacokinetic data for the manuscript &quot;Population pharmacokinetic modeling of sulfadimethoxine, sulfadizine and sulfamethoxazole combined to trimethoprim in pigs Marine Boulanger,Alexis Viel 2025, ⟨10.57745/Q2H4LQ⟩ Autre publication scientifique hal-05325641v1
Dataset of Pharmacokinetic data of oxytetracycline in rainbow trout Alexis Viel,Antoine Rostang 2025, ⟨10.57745/4TOPUC⟩ Autre publication scientifique hal-05142087v1
Dataset for the manuscript &quot;Pharmacokinetic modeling of Sulfamethoxazole-Trimethoprim and Sulfadiazine-Trimethoprim combinations in broilers Marine Boulanger,Alexis Viel 2024, ⟨10.57745/D0R0Q5⟩ Autre publication scientifique hal-04692626v1

Rapport (1)

OHEJP-RaDAR-D-JRP3-2.1-Pharmacodynamics and transmission models Alexis Viel,Pascal Sanders Anses. 2021 Rapport hal-04507038v1

Thèse (1)

Usages de la colistine en médecine humaine et vétérinaire : exploration pharmacocinétique et problématique d'antibiorésistance Alexis Viel Pharmacologie. Université de Poitiers, 2017. Français. ⟨NNT : ⟩ Thèse tel-02534138v1