ALHOSNA BENJDIA Chargée de recherche INRAE, Université PARIS-SACLAY, Unité MicalisCo-cheffe de l'équipe ChemSyBio &quot;Biochimie et Biologie synthétique&quot;

Identifiants chercheurs

IdHAL :

alhosna-benjdia

ORCID :

0000-0002-3544-2541

Présentation

10+ years experience in Biochemistry with a special focus on enzyme maturation, antibiotic, cofactor and natural product biosynthesis. Special emphasis on radical SAM enzymes within the microbiome. Experience in supervision of undergraduate and postgraduate students. Author of 40 publications including high impact journals.

Publications

Article dans une revue (40)

Spectroscopic and Biochemical Characterization of the Noncanonical Radical SAM Enzyme ArsL, Involved in Arsinothricin Biosynthesis Mickaël Mauger,Alain Guillot,Maryam Seif-Eddine,Stéphane Grimaldi,Alhosna Benjdiaet al. Journal of the American Chemical Society, 2025, 147 (24), pp.20381-20393. ⟨10.1021/jacs.5c01006⟩ Article dans une revue hal-05191495v1
SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx Cameron Martino,Benjamin Kellman,Daniel Sandoval,Thomas Mandel Clausen,Robert Cooperet al. mBio, 2025, 16 (4), ⟨10.1128/mbio.04015-24⟩ Article dans une revue hal-05269525v1
Structural and mechanistic basis for RiPP epimerization by a radical SAM enzyme Xavier Kubiak,Ivan Polsinelli,Leonard Chavas,Cameron Fyfe,Alain Guillotet al. Nature Chemical Biology, In press, ⟨10.1038/s41589-023-01493-1⟩ Article dans une revue hal-04371487v1
Radical S -Adenosyl- l -Methionine Enzyme PylB: A C-Centered Radical to Convert l -Lysine into (3 R )-3-Methyl- d -Ornithine Feryel Soualmia,Mickael Cherrier,Timothée Chauviré,Mickaël Mauger,Philip Tathamet al. Journal of the American Chemical Society, 2024, 146 (10), pp.6493-6505. ⟨10.1021/jacs.3c03747⟩ Article dans une revue hal-04496232v1
B12-dependent radical SAM enzymes: Ever expanding structural and mechanistic diversity Alhosna Benjdia,Olivier Berteau Current Opinion in Structural Biology, 2023, 83, pp 102725. ⟨10.1016/j.sbi.2023.102725⟩ Article dans une revue hal-04343304v1
Exploring the biosynthetic capacity of TsrM, a B12‐dependent Radical SAM Enzyme Catalyzing Non‐radical Reactions Feryel Soualmia,Alain Guillot,Nazarii Sabat,Clémence Brewee,Xavier Kubiaket al. Chemistry - A European Journal, 2022, 28 (31), pp.e202200627. ⟨10.1002/chem.202200627⟩ Article dans une revue hal-03620811v1
Crystallographic snapshots of a B12-dependent radical SAM methyltransferase Cameron Fyfe,Noelia Bernardo-García,Laura Fradale,Stéphane Grimaldi,Alain Guillotet al. Nature, 2022, 602 (7896), pp.336-342. ⟨10.1038/s41586-021-04355-9⟩ Article dans une revue hal-03808863v1
Radical SAM Enzymes and Ribosomally‐Synthesized and Post‐translationally Modified Peptides: A Growing Importance in the Microbiomes Alhosna Benjdia,Olivier Berteau Frontiers in Chemistry, 2021, 9, ⟨10.3389/fchem.2021.678068⟩ Article dans une revue hal-03808812v1
The Epipeptide Biosynthesis Locus epeXEPAB Is Widely Distributed in Firmicutes and Triggers Intrinsic Cell Envelope Stress Philipp F Popp,Lena Friebel,Alhosna Benjdia,Alain Guillot,Olivier Berteauet al. Advances in Microbial Physiology, 2021, 31 (3), pp.1-12. ⟨10.1159/000516750⟩ Article dans une revue hal-03817729v1
Gold-Catalyzed Spirocyclization Reactions of N-Propargyl Tryptamines and Tryptophans in Aqueous Media Nazarii Sabat,Feryel Soualmia,Pascal Retailleau,Alhosna Benjdia,Olivier Berteauet al. Organic Letters, 2020, 22 (11), pp.4344-4349. ⟨10.1021/acs.orglett.0c01370⟩ Article dans une revue hal-03004181v1
Biosynthesis of the sactipeptide Ruminococcin C by the human microbiome: Mechanistic insights into thioether bond formation by radical SAM enzymes Clémence Balty,Alain Guillot,Laura Fradale,Clémence Brewee,Benjamin Lefrancet al. Journal of Biological Chemistry, 2020, 295 (49), pp.16665-16677. ⟨10.1074/jbc.RA120.015371⟩ Article dans une revue hal-03332307v1
The Epipeptide YydF Intrinsically Triggers the Cell Envelope Stress Response of Bacillus subtilis and Causes Severe Membrane Perturbations Philipp Popp,Alhosna Benjdia,Henrik Strahl,Olivier Berteau,Thorsten Mascher Frontiers in Microbiology, 2020, 11, ⟨10.3389/fmicb.2020.00151⟩ Article dans une revue hal-02933776v1
Gold-Catalyzed Spirocyclization Reactions of N -Propargyl Tryptamines and Tryptophans in Aqueous Media Nazarii Sabat,Feryel Soualmia,Pascal Retailleau,Alhosna Benjdia,Olivier Berteauet al. Organic Letters, 2020, 22 (14), pp.5714. ⟨10.1021/acs.orglett.0c02206⟩ Article dans une revue hal-02933787v1
Ruminococcin C, an anti-clostridial sactipeptide produced by a prominent member of the human microbiota Ruminococcus gnavus Clémence Balty,Alain Guillot,Laura Fradale,Clémence Brewee,Mylène Boulayet al. Journal of Biological Chemistry, 2019, 294 (40), pp.14512-14525. ⟨10.1074/jbc.RA119.009416⟩ Article dans une revue hal-02868868v1
Mechanistic Investigations of PoyD, a Radical S -Adenosyl- l -methionine Enzyme Catalyzing Iterative and Directional Epimerizations in Polytheonamide A Biosynthesis Aubérie Parent,Alhosna A. Benjdia,Alain A. Guillot,Xavier Kubiak,Clémence Baltyet al. Journal of the American Chemical Society, 2018, 140 (7), pp.2469 - 2477. ⟨10.1021/jacs.7b08402⟩ Article dans une revue hal-01939282v1
DNA repair by the radical SAM enzyme spore Photoproduct Lyase: from biochemistry to structural investigations Olivier Berteau,Alhosna Benjdia Photochemistry and Photobiology, 2017, 93 (1), pp.67-77. ⟨10.1111/php.12702⟩ Article dans une revue hal-01530836v1
Radical SAM enzymes in the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) Alhosna Benjdia,Clémence Balty,Olivier Berteau Frontiers in Chemistry, 2017, 5, ⟨10.3389/fchem.2017.00087⟩ Article dans une revue hal-02627786v1
Post-translational modification of ribosomally synthesized peptides by a radical SAM epimerase in Bacillus subtilis Alhosna Benjdia,Alain Guillot,Pauline Ruffié,Jérôme Leprince,Olivier Berteau Nature Chemistry, 2017, 9 (7), pp.698-707. ⟨10.1038/NCHEM.2714⟩ Article dans une revue hal-01960697v1
Insights into the catalysis of a lysine-tryptophan bond in bacterial peptides by a SPASM domain radical S-adenosylmethionine (SAM) peptide cyclase Alhosna Benjdia,Laure L. Decamps,Alain Guillot,Xavier Kubiak,Pauline Ruffiéet al. Journal of Biological Chemistry, 2017, 292 (26), pp.10835-10844. ⟨10.1074/jbc.M117.783464⟩ Article dans une revue hal-02628401v1
Sulfatases and radical SAM enzymes: emerging themes in glycosaminoglycan metabolism and the human microbiota Alhosna Benjdia,Olivier Berteau Biochemical Society Transactions, 2016, 44 (1), pp.109-115. ⟨10.1042/BST20150191⟩ Article dans une revue hal-01532684v1
Carbon-sulfur bond-forming reaction catalysed by the radical SAM enzyme HydE. Roman Rohac,Patricia Amara,Alhosna Benjdia,Lydie Martin,Pauline Ruffiéet al. Nature Chemistry, 2016, 8 (5), pp.491-500. ⟨10.1038/NCHEM.2490⟩ Article dans une revue hal-01341083v1
The B-12-Radical SAM enzyme PoyC catalyzes valine C-beta-Methylation during Polytheonamide Biosynthesis Auberie Parent,Alain Guillot,Alhosna Benjdia,Gwladys Chartier,Jerome Leprinceet al. Journal of the American Chemical Society, 2016, 138 (48), pp.15515-15518. ⟨10.1021/jacs.6b06697⟩ Article dans une revue hal-01605179v1
Thioether bond formation by SPASM domain radical SAM enzymes: C α H-atom abstraction in subtilosin A biosynthesis Alhosna Benjdia,Alain Guillot,Benjamin Lefranc,Hubert Vaudry,Jérôme Leprinceet al. Chemical Communications, 2016, 52 (37), pp.6249-6252. ⟨10.1039/c6cc01317a⟩ Article dans une revue hal-01960692v1
The thiostrepton A tryptophan methyltransferase TsrM catalyses a cob(II)alamin-dependent methyl transfer reaction. Alhosna Benjdia,Stéphane Pierre,Carmen Gherasim,Alain Guillot,Manon Carmonaet al. Nature Communications, 2015, 6, pp.8377. ⟨10.1038/ncomms9377⟩ Article dans une revue hal-01216185v1
Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase Alhosna A. Benjdia,Korbinian Heil,Andreas Winkler,Thomas Carell,Ilme Schlichting Chemical Communications, 2014, 50 (91), pp.14201-14204. ⟨10.1039/C4CC05158K⟩ Article dans une revue hal-02631377v1
Characterization of Gglycosaminoglycan (GAG) sulfatases from the human gut symbiont bacteroides thetaiotaomicron reveals the first GAG-specific bacterial endosulfatase Jonathan Ulmer,Eric Morssing Vilen,Ramesh Babu Namburi,Alhosna Benjdia,Julie Beneteauet al. Journal of Biological Chemistry, 2014, 289 (35), pp.24289 - 24303. ⟨10.1074/jbc.M114.573303⟩ Article dans une revue hal-01204451v1
A radical transfer pathway in spore photoproduct lyase Linlin Yang,Renae S. Nelson,Alhosna A. Benjdia,Gengjie Lin,Joshua Telseret al. Biochemistry, 2013, 52 (18), pp.3041-3050. ⟨10.1021/bi3016247⟩ Article dans une revue hal-02642679v1
Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme Alhosna A. Benjdia,Korbinian Heil,Thomas R. M. Barends,Thomas R. M. Carell,Ilme Schlichting Nucleic Acids Research, 2012, 40 (18), pp.9308-9318. ⟨10.1093/nar/gks603⟩ Article dans une revue hal-02647062v1
Chondroitin-4-O-sulfatase from Bacteroides thetaiotaomicron: exploration of the substrate specificity Annie Malleron,Alhosna Benjdia,Olivier Berteau,Christine Le Narvor Carbohydrate Research, 2012, 353, pp.96 - 99. ⟨10.1016/j.carres.2012.03.033⟩ Article dans une revue istex hal-01003430v1
Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes Stéphane S. Pierre,Alain A. Guillot,Alhosna A. Benjdia,Corine C. Sandstrom,Philippe P. Langellaet al. Nature Chemical Biology, 2012, 8 (12), pp.957 - 959. ⟨10.1038/NCHEMBIO.1091⟩ Article dans une revue hal-01004114v1
DNA photolyases and SP lyase: structure and mechanism of light-dependent and independent DNA lyases Alhosna A. Benjdia Current Opinion in Structural Biology, 2012, 22 (6), pp.711-720. ⟨10.1016/j.sbi.2012.10.002⟩ Article dans une revue istex hal-02651842v1
Biosynthesis of F-0, Precursor of the F-420 Cofactor, Requires a Unique Two Radical-SAM Domain Enzyme and Tyrosine as Substrate Laure L. Decamps,Benjamin B. Philmus,Alhosna A. Benjdia,Robert R. White,Tadhg P. T. P. Begleyet al. Journal of the American Chemical Society, 2012, 134 (44), pp.18173 - 18176. ⟨10.1021/ja307762b⟩ Article dans une revue hal-01004118v1
Sulfatases and a Radical S-Adenosyl-L-methionine (AdoMet) Enzyme Are Key for Mucosal Foraging and Fitness of the Prominent Human Gut Symbiont, Bacteroides thetaiotaomicron Alhosna A. Benjdia,Eric C. E. C. Martens,Jeffrey I. J. I. Gordon,Olivier Berteau Journal of Biological Chemistry, 2011, 286 (29), pp.25973 - 25982. ⟨10.1074/jbc.M111.228841⟩ Article dans une revue hal-01004563v1
Anaerobic sulfatase-maturating enzyme - A mechanistic link with glycyl radical-activating enzymes? Alhosna Benjdia,Sowmya Subramanian,Jérôme Leprince,Hubert Vaudry,Michael Johnsonet al. FEBS Journal, 2010, 277 (8), pp.1906-1920. ⟨10.1111/j.1742-4658.2010.07613.x⟩ Article dans une revue hal-01960689v1
An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily Bert van Loo,Stefanie Jonas,Ann C. Babtie,Alhosna A. Benjdia,Olivier Berteauet al. Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (7), pp.2740-2745. ⟨10.1073/pnas.0903951107⟩ Article dans une revue hal-02663877v1
Mechanistic Investigations of Anaerobic Sulfatase-Maturating Enzyme: Direct C β H-Atom Abstraction Catalyzed by a Radical AdoMet Enzyme Alhosna Benjdia,Corine C. Sandstrom,Hubert Vaudry,Olivier Berteau,Jérôme Leprinceet al. Journal of the American Chemical Society, 2009, 131 (24), pp.8348-8349. ⟨10.1021/ja901571p⟩ Article dans une revue hal-01960686v1
Anaerobic Sulfatase-maturating Enzymes, First Dual Substrate Radical S -Adenosylmethionine Enzymes Alhosna Benjdia,Sowmya Subramanian,Jérôme Leprince,Hubert Vaudry,Michael Johnsonet al. Journal of Biological Chemistry, 2008, 283 (26), pp.17815-17826. ⟨10.1074/jbc.M710074200⟩ Article dans une revue hal-01960684v1
Anaerobic Sulfatase-Maturating Enzymes: Radical SAM Enzymes Able To Catalyze in Vitro Sulfatase Post-translational Modification Alhosna Benjdia,Jérôme Leprince,Alain Guillot,Hubert Vaudry,Sylvie Rabotet al. Journal of the American Chemical Society, 2007, 129 (12), pp.3462-3463. ⟨10.1021/ja067175e⟩ Article dans une revue istex hal-01960680v1
First evidences for a third sulfatase maturation system in prokaryotes from E. coli aslB and ydeM deletion mutants Alhosna Benjdia,Gianni Dehò,Sylvie Rabot,Olivier Berteau FEBS Letters, 2007, 581 (5), pp.1009-1014. ⟨10.1016/j.febslet.2007.01.076⟩ Article dans une revue istex hal-02659709v1
A new type of bacterial sulfatase reveals a novel maturation pathway in prokaryotes Olivier Berteau,Alain A. Guillot,Alhosna Benjdia,Sylvie S. Rabot Journal of Biological Chemistry, 2006, 281 (32), pp.22464-22470. ⟨10.1074/jbc.M602504200⟩ Article dans une revue hal-02656640v1

Communication dans un congrès (7)

Radically new methylation reactions in antibiotic biosynthesis: Insights into the mechanism of B12-dependent radical SAM enzymes Olivier Berteau,Stéphane Pierre,Alhosna Benjdia,Carmen Gherasim,Ruma Banerjee Experimental Biology Meeting, Mar 2015, Boston, United States Communication dans un congrès hal-01536523v1
Structural perspectives on the mechanism of the radical SAM enzyme, spore photoproduct lyase Alhosna Benjdia,Korbinian Heil,Andreas Winkler,Thomas Carell,Ilme Schlichting Experimental Biology Meeting, Mar 2015, Boston, United States Communication dans un congrès hal-01536522v1
Spore Photoproduct Lyase, a radically different DNA repair enzyme for bacterial spore extreme UV-resistance Alhosna Benjdia,Thomas Barends,Ilme Schlichting,Korbinian Heil,Thomas Carell 16. International Conference on Biological Inorganic Chemistry (ICBIC), IMBG. FRA., Jul 2013, Grenoble, France. 1 p Communication dans un congrès hal-01204366v1
One enzyme for two radical reactions: Deciphering the mechanism of a novel radical SAM enzyme critical for F-420 cofactor biosynthesis Laure Decamps,Alhosna Benjdia,Olivier Berteau,Benjamin Philmus,Tadhg P. Begleyet al. 16. International Conference on Biological Inorganic Chemistry (ICBIC), IMBG. FRA., Jul 2013, Grenoble, France. 1 p Communication dans un congrès hal-01204368v1
Novel methyl transfer reactions: expanding the chemistry of radical SAM enzymes Stéphane Pierre,Alain Guillot,Alhosna Benjdia,Philippe Langella,Olivier Berteau 22. IUBMB Congress, Sep 2012, Seville, Spain. 608 p Communication dans un congrès hal-01189735v1
Insight into a new type of methyltransferase belonging to the radical AdoMet enzyme superfamily: the antibiotic resistance enzyme Cfr from [i]Staphylococcus aureus[/i] Gaëlle Vassiliadis,Alhosna Benjdia,C. Sandström,V. Guerineau,Olivier Berteau 22. IUBMB Congress, Sep 2012, Seville, Spain. 608 p Communication dans un congrès hal-01189736v1
Investigation of a critical radical SAM enzyme involved in co-factor biosynthesis in Actinobacteria Laure Decamps,Alhosna Benjdia,R. H. White,Olivier Berteau 22. IUBMB Congress, Sep 2012, Seville, Spain. 608 p Communication dans un congrès hal-01189734v1

Poster de conférence (2)

B12-Dependant Radical SAM Enzymes: An Emerging Family of Biocatalysts Catalyzing Peptide and Protein Post-Anslational Modifiations Thibaut Bourdin,Alain Guillot,Stéphane Grimaldi,Benjamin Lefranc,Cameron Fyfeet al. 47th FEBS Congress, Jul 2023, Tours, France. 2023 Poster de conférence hal-05168057v1
A radical alternative for methyl transfer reactions: Emergence of the B12-binding/radical SAM-domain enzymes Olivier Berteau,S. Pierre,Alain Guillot,Alhosna Benjdia,Philippe Langellaet al. 16. International Conference on Biological Inorganic Chemistry (ICBIC), Jul 2013, Grenoble, France. Springer, JBIC. Journal of Biological Inorganic Chemistry, 19, 1 p., 2014, XVIth International Conference on Biological Inorganic Chemistry Poster de conférence hal-01204367v1