Alice Jouneau Alice JOUNEAU

Identifiants chercheurs

IdHAL :

alice-jouneau

ORCID :

0000-0001-5985-9862

IdRef :

136881521

Présentation

CRHC INRAE en Biologie du Développement et cellules souches

né à Paris (France) le 13/02/1968

Addresse : UMR BREED Biologie de la Reproduction, Epigénétique, Environnement et Développement, INRAE

Domaine de Vilvert

78352 Jouy en Josas Cedex, France

E.mail : alice.jouneau@inrae.fr

profil scientifique :

Mon projet principal est de comprendre comment la pluripotence s'établit dans l'embryon de mammifère et comment elle est contrôlée aux niveaux moléculaire et épigénétique. J'ai une expertise reconnue au niveau international et plus de 20 articles sur le développement des embryons de mammifères et la pluripotence chez la souris, le bovin, le lapin. J'ai développé et utilisé plusieurs approches telles que les analyses à haut débit (transcriptome et épigénome), l'imagerie cellulaire, la dérivation in vitro de lignées cellulaires d'épiblastes et de trophoblastes.

Education et Expériences professionnelles :

· 1999 - présent : chercheur INRAE, Biologie du Développement et Reproduction, devenu en 2020 Biologie de la Reproduction, Epigénétique, Environnement et Développement.

· 2005-2007: Associate Professor , Chinese Academy of Sciences, The Sino-French (INRA/CAS) Laboratory LABIOCEM, Institute of Zoology, Beijing China

· 1997-1999: Post-doctoratau Laboratoire de Génétique du Développement des Mélanocytes, dirigé par Lionel Larue, UMR 146, Institut Curie-Orsay, France

· 1992-1996: Doctorat de l'université Paris XI, Laboratoire de Morphogénèse Cellulaire et Progression Tumorale, dirigé par Jean-Paul Thiery, UMR 144, Institut Curie-, France

Publications

Article dans une revue (48)

Transcriptomic profiling reveals similarities between equine IVF and ICSI embryos Klaartje Broothaers,Alice Jouneau,Daniel Angel-Velez,Tine de Coster,Nicola Festucciaet al. Theriogenology, 2026, 251, pp.117749. ⟨10.1016/j.theriogenology.2025.117749⟩ Article dans une revue hal-05374050v1
Establishment and Characterization of Bovine Trophoblast Stem Cells Growing as Adherent Cells or Vesicles Camille Baquerre,Apolline Delahaye,Vincent Brochard,Fabienne Nuttinck,Christian Jeanet al. Molecular Reproduction and Development, 2025, 92 (12), pp.e70073. ⟨10.1002/mrd.70073⟩ Article dans une revue hal-05421401v1
Short‐Term Exposure to Culture Media Used in Human ART Shapes Early Calcium Oscillations in ICSI ‐Fertilized Mouse Oocytes and Impacts Adult Phenotype Bernadette Banrezes,Thierry Sainte‐beuve,Anne Frambourg,Alice Jouneau Reproductive Medicine and Biology, 2025, 24 (1), ⟨10.1002/rmb2.12691⟩ Article dans une revue hal-05387375v1
ZBTB24 is a conserved multifaceted transcription factor at genes and centromeres that governs the DNA methylation state and expression of satellite repeats Giacomo Grillo,Ekaterina Boyarchuk,Seed Mihic,Ivana Ivkovic,Mathilde Bertrandet al. Human Molecular Genetics, 2024, ⟨10.1093/hmg/ddae163⟩ Article dans une revue hal-04815836v1
Ablation of ZC3H11A causes early embryonic lethality and dysregulation of metabolic processes Shady Younis,Alice Jouneau,Mårten Larsson,Jean-Francois Oudin,Jihad Omaret al. Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (23), ⟨10.1073/pnas.2216799120⟩ Article dans une revue hal-04127723v1
Pregnancy bioengineering: getting rid of the uterus? Olivier Sandra,Emmanuelle Motte-Signoret,Alice Jouneau Médecine de la Reproduction, 2022, 24 (2), pp.152-157. ⟨10.1684/mte.2022.0891⟩ Article dans une revue hal-04002423v1
Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development King Hang Tommy Mau,Donja Karimlou,David Barneda,Vincent Brochard,Christophe Royeret al. Nature Communications, 2022, 13 (1), pp.3861. ⟨10.1038/s41467-022-31323-2⟩ Article dans une revue hal-03714680v1
H3K27me3 at pericentromeric heterochromatin is a defining feature of the early mouse blastocyst Mélanie Pailles,Mélanie Hirlemann,Vincent Brochard,Martine Chebrout,Jean-François Oudinet al. Scientific Reports, 2022, 12 (1), pp. 13908. ⟨10.1038/s41598-022-17730-x⟩ Article dans une revue hal-03767167v1
Transcription of rRNA in early mouse embryos promotes chromatin reorganization and expression of major satellite repeats Martine Chebrout,Maïmouna Coura Koné,Habib Jan,Marie Cournut,Martine Letheuleet al. Journal of Cell Science, 2022, 135 (6), ⟨10.1242/jcs.258798⟩ Article dans une revue hal-03642441v1
Progress and challenges in developing organoids in farm animal species for the study of reproduction and their applications to reproductive biotechnologies Guillaume Bourdon,Véronique Cadoret,Gilles Charpigny,Anne Couturier-Tarrade,Rozenn Dalbies-Tranet al. Veterinary Research, 2021, 52 (1), pp.42. ⟨10.1186/s13567-020-00891-w⟩ Article dans une revue hal-03799896v1
Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency Emma Bell,Edward W. Curry,Wout Megchelenbrink,Luc Jouneau,Vincent Brochardet al. Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-14916-7⟩ Article dans une revue hal-02508171v1
Differentiation of derived rabbit trophoblast stem cells under fluid shear stress to mimic the trophoblastic barrier Guenhaël Sanz,Nathalie Daniel,Catherine Archilla,Luc Jouneau,Yan Jaszczyszynet al. Biochimica et Biophysica Acta (BBA) - General Subjects, 2019, 1863 (10), pp.1608-1618. ⟨10.1016/j.bbagen.2019.07.003⟩ Article dans une revue hal-02183790v1
Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states René a M Dirks,Guido van Mierlo,Hindrik H D Kerstens,Andreia S Bernardo,Julianna Kobolaket al. Epigenetics and Chromatin, 2019, 12 (1), pp.1-21. ⟨10.1186/s13072-019-0259-8⟩ Article dans une revue hal-02625883v1
Contrasting epigenetic states of heterochromatin in the different types of mouse pluripotent stem cells Matteo Tosolini,Vincent V. Brochard,Pierre Adenot,Martine M. Chebrout,Giacomo Grilloet al. Scientific Reports, 2018, 8 (1), pp.14. ⟨10.1038/s41598-018-23822-4⟩ Article dans une revue hal-02309000v1
Progressive methylation of POU5F1 regulatory regions during blastocyst development. Eugénie Canon,Luc Jouneau,Thierry Blachère,Nathalie Peynot,Nathalie Danielet al. Reproduction [Cambridge]. Supplement, 2018, 156 (2), pp.145-161. ⟨10.1530/REP-17-0689⟩ Article dans une revue hal-02623175v1
Mammalian embryo comparison identifies novel pluripotency genes associated with the naïve or primed state. Andreia S Bernardo,Alice Jouneau,Hendrik Marks,Philip Kensche,Julianna Kobolaket al. Biology Open, 2018, ⟨10.1242/bio.033282⟩ Article dans une revue hal-02623684v1
Prosurvival effect of cumulus prostaglandin G/H synthase 2/prostaglandin2 signaling on bovine blastocyst: impact on in vivo posthatching development Fabienne Nuttinck,Alice Jouneau,Gilles Charpigny,Isabelle Hue,Christophe Richardet al. Biology of Reproduction, 2017, 96 (3), pp.531-541. ⟨10.1095/biolreprod.116.145367⟩ Article dans une revue hal-01605027v1
Erratum to: Dynamics of gene silencing during X inactivation using allele-specific RNA-seq Hendrik Marks,Hindrik H. D. Kerstens,Tahsin Stefan Barakat,Erik Splinter,René A. M. Dirkset al. Genome Biology, 2016, 17, ⟨10.1186/s13059-016-0885-4⟩ Article dans une revue hal-02630193v1
Dynamic Pattern of HOXB9 Protein Localization during Oocyte Maturation and Early Embryonic Development in Mammals Caroline Sauvegarde,Delphine Paul,Laure Bridoux,Alice Jouneau,Severine S. Degrelleet al. PLoS ONE, 2016, 11 (10), pp.e0165898. ⟨10.1371/journal.pone.0165898⟩ Article dans une revue inserm-02440442v1
Dynamics of gene silencing during X inactivation using allele-specific RNA-seq Hendrik Marks,Hindrik H. D. Kerstens,Tahsin Stefan Barakat,Erik Splinter,René A. M. Dirkset al. Genome Biology, 2015, 16, ⟨10.1186/s13059-015-0698-x⟩ Article dans une revue hal-02632585v1
Stable methylation at promoters distinguishes epiblast stem cells from embryonic stem cells and the in vivo epiblasts Anne-Clémence Veillard,Hendrik Marks,Andreia Sofia Bernardo,Luc Jouneau,Denis Laloëet al. Stem Cells and Development, 2014, 23 (17), pp.2014-2029. ⟨10.1089/scd.2013.0639⟩ Article dans une revue hal-01193858v1
A novel nodal enhancer dependent on pluripotency factors and smad2/3 signaling conditions a regulatory switch during epiblast maturation. Costis Papanayotou,Ataaillah Benhaddou,Anne Camus,Aitana Perea-Gomez,Alice Jouneauet al. PLoS Biology, 2014, 12 (6), pp.e1001890. ⟨10.1371/journal.pbio.1001890⟩ Article dans une revue hal-01060190v1
Contrasting transcriptome landscapes of rabbit pluripotent stem cells [i]in vitro[/i] and [i]in vivo[/i] Barbara Panneau,Luc Jouneau,Pierre Osteil,Yann Tapponnier,Marielle Afanassieffet al. Animal Reproduction Science, 2014, 149 (1-2), pp.67-79. ⟨10.1016/j.anireprosci.2014.05.014⟩ Article dans une revue istex hal-01193859v1
iTRAQ proteome analysis reflects a progressed differentiation state of epiblast derived versus inner cell mass derived murine embryonic stem cells Thomas Fröhlich,Miwako Kösters,Alexander Graf,Eckhard Wolf,Julianna Kobolaket al. Journal of Proteomics, 2013, 90, pp.38-51. ⟨10.1016/j.jprot.2013.03.015⟩ Article dans une revue istex hal-01190583v1
Efficient derivation of bovine embryonic stem cells needs more than active core pluripotency factors Julien J. Maruotti,Marta M. Muñoz,Severine S. Degrelle,Enrique E. Gómez,Claire C. Louetet al. Molecular Reproduction and Development, 2012, 79 (7), pp.461-77. ⟨10.1002/mrd.22051⟩ Article dans une revue hal-01000771v1
Intermediate filaments promote nuclear mechanical constraints during somatic cell nuclear transfer in the mouse Laurence Gall Pouget Gall,Vincent V. Brochard,Sylvie S. Ruffini,Ludivine Laffont,Renaud R. Fleurotet al. CELLULAR REPROGRAMMING, 2012, 14 (6), pp.497-504. ⟨10.1089/cell.2012.0027⟩ Article dans une revue hal-01000765v1
Expression of pluripotency master regulators during two key developmental transitions: EGA and early lineage specification in the bovine embryo Daulat-Raheem D.-R. Khan,Delphine Dube Dubé,Laurence Gall Pouget Gall,Nathalie N. Peynot,Sylvie S. Ruffiniet al. PLoS ONE, 2012, 7 (3), pp.1-12. ⟨10.1371/journal.pone.0034110⟩ Article dans une revue hal-01000766v1
Naive and primed murine pluripotent stem cells have distinct miRNA expression profiles Alice Jouneau,Constance C. Ciaudo,Odile O. Sismeiro,Vincent V. Brochard,Luc Jouneauet al. RNA, 2012, 18 (2), pp.253-264. ⟨10.1261/rna.028878.111⟩ Article dans une revue hal-01001312v1
Pluripotency maintenance in mouse somatic cell nuclear transfer embryos and its improvement by treatment with the histone deacetylase inhibitor TSA Tang T. Hai,Jie J. Hao,Liu L. Wang,Alice Jouneau,Qi Q. Zhou CELLULAR REPROGRAMMING, 2011, 6 (9), pp.1149-1161. ⟨10.1089/cell.2010.0042⟩ Article dans une revue hal-01001201v1
Synergic reprogramming of mammalian cells by combined exposure to mitotic Xenopus egg extracts and transcription factors Olivier Ganier,Stéphane S. Bocquet,Isabelle I. Peiffer,Vincent V. Brochard,Philippe P. Arnaudet al. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (42), pp.17331-17336. ⟨10.1073/pnas.1100733108⟩ Article dans une revue hal-01000287v1
Faithful reprogramming to pluripotency in mammals - what does nuclear transfer teach us? Julien Maruotti,Alice Jouneau,Jean Paul J. P. Renard International Journal of Developmental Biology, 2010, 54 (11-12), pp.1609-1621. ⟨10.1387/ijdb.103195jm⟩ Article dans une revue (article de synthèse) hal-02667213v1
Reprogrammation nucléaire et pluripotence : l’étrange cas des cellules souches d’épiblaste Alice Jouneau Médecine/Sciences, 2010, 26 (10), pp.792-794. ⟨10.1051/medsci/20102610792⟩ Article dans une revue hal-02654341v1
Nuclear transfer-derived epiblast stem cells are transcriptionally and epigenetically distinguishable from their fertilized-derived counterparts Julien Maruotti,Xiang Peng Dai,Vincent V. Brochard,Luc Jouneau,Jun Liuet al. STEM CELLS, 2010, 28 (4), pp.743-752. ⟨10.1002/stem.400⟩ Article dans une revue hal-02664747v1
HSPC117 deficiency in cloned embryos causes placental abnormality and fetal death Yingying Wang,Tang Hai,Zichuan Liu,Shuya Zhou,Zhuo Lvet al. Biochemical and Biophysical Research Communications, 2010, 397 (3), pp.407-412. ⟨10.1016/j.bbrc.2010.05.105⟩ Article dans une revue istex hal-02664699v1
Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide, a histone deacetylase inhibitor Xiangpeng Dai,Jie Hao,Xiao-Jun Hou,Tang Hai,Yong Fanet al. Journal of Biological Chemistry, 2010, 285 (40), pp.31002-31010. ⟨10.1074/jbc.M110.136085⟩ Article dans une revue hal-02664744v1
Early alteration of the self-renewal/differentiation threshold in trophoblast stem cells derived from mouse embryos after nuclear transfer Maite M. Rielland,Vincent V. Brochard,Marie-Christine M.-C. Lacroix,Jean Paul J. P. Renard,Alice Jouneau Developmental Biology, 2009, 334 (2), pp.325-334. ⟨10.1016/j.ydbio.2009.07.022⟩ Article dans une revue hal-00490154v1
Early alteration of the self-renewal/differentiation threshold in trophoblast stem cells derived from mouse embryos after nuclear transfer Maite M. Rielland,Vincent V. Brochard,Marie-Christine M.-C. Lacroix,Jean Paul J. P. Renard,Alice Jouneau 4387, 2009, 334 (2), pp.325-334 Article dans une revue hal-00490600v1
Early alteration of the self-renewal/differentiation threshold in trophoblast stem cells derived from mouse embryos after nuclear transfer Maite M. Rielland,Vincent V. Brochard,Marie-Christine M.-C. Lacroix,Jean Paul J. P. Renard,Alice Jouneau 4387, 2009, 334 (2), pp.325-334 Article dans une revue hal-00489695v1
Trophoblast stem cell derivation, cross-species comparison and use of nuclear transfer: new tools to study trophoblast growth and differentiation Maite M. Rielland,Isabelle Hue,Jean Paul J. P. Renard,Alice Jouneau Developmental Biology, 2008, 322 (1), pp.1-10. ⟨10.1016/j.ydbio.2008.07.017⟩ Article dans une revue hal-02665045v1
Embryonic stem cells in cattle M Munoz,C Diez,Jn Caamano,Alice Jouneau,Isabelle Hueet al. Reproduction in Domestic Animals, 2008, 43, pp.32-37. ⟨10.1111/j.1439-0531.2008.01229.x⟩ Article dans une revue hal-02658497v1
Piezo-assisted nuclear transfer affects cloning efficiency and may cause apoptosis Yang Yu,Chenhui C. Ding,Eryao E. Wang,Xinjie Chen,Xuemei Liet al. Reproduction [Cambridge], 2007, 133 (5), pp.947-954. ⟨10.1530/REP-06-0358⟩ Article dans une revue hal-02610680v1
Establishment of customized mouse stem cell lines by sequential nuclear transfer Chunli Zhao,Ruqiang Yao,Jie Hao,Chenhui Ding,Young Fanet al. Cell Research, 2007, 17 (1), pp.80-87. ⟨10.1038/sj.cr.7310139⟩ Article dans une revue hal-02659115v1
Nuclear reprogramming and pluripotency of embryonic cells: Application to the isolation of embryonic stem cells in farm animals Jean Paul J. P. Renard,Julien Maruotti,Alice Jouneau,Xavier Vignon Theriogenology, 2007, 68, pp.S196-S205. ⟨10.1016/j.theriogenology.2007.05.060⟩ Article dans une revue hal-02654315v1
Developmental abnormalities of NT mouse embryos appear early after implantation Alice Jouneau,Qi Zhou,Anne Camus,Vincent V. Brochard,Linda L. Maulnyet al. Development (Cambridge, England), 2006, 133, pp.1597-1607. ⟨10.1242/dev.02317⟩ Article dans une revue hal-03048850v1
Nuclear transfer : progress and quandaries Xuemei Li,Ziyi Li,Alice Jouneau,Qi Zhou,Jean Paul J. P. Renard Reproductive Biology and Endocrinology, 2003, 1 (84), 6 p. ⟨10.1186/1477-7827-1-84⟩ Article dans une revue hal-02677996v1
Reprogramming in nuclear transfer Alice Jouneau,Jean Paul J. P. Renard Current Opinion in Genetics and Development, 2003, 13, pp.486-491 Article dans une revue hal-02676611v1
Cellules souches embryonnaires et clonage thérapeutique Alice Jouneau,Jean Paul J. P. Renard Médecine/Sciences, 2002, 18, pp.169-180 Article dans une revue hal-02672187v1
Developmental potential of mouse embryos reconstructed from metaphase embryonic stem cell nuclei Qi Zhou,Alice Jouneau,Vincent V. Brochard,Pierre Adenot,Jean Paul J. P. Renard Biology of Reproduction, 2001, 65, pp.412-419 Article dans une revue hal-02674823v1

Chapitre d'ouvrage (5)

Heterogeneity in Epiblast Stem Cells Alice Jouneau Stem Cells Heterogeneity - Novel Concepts, 1123 (chapitre 2), Springer Nature, 225p, 2019, Advances in Experimental Medicine and Biology, ⟨10.1007/978-3-030-11096-3_2⟩ Chapitre d'ouvrage hal-02154640v1
From naive to primed pluripotency: In vitro conversion of mouse embryonic stem cells in epiblast stem cells Matteo Tosolini,Alice Jouneau Embryonic Stem Cell Protocols, 1341, Editions Springer, 449 p., 2016, Methods in Molecular Biology, 978-1-4939-2953-5. ⟨10.1007/7651_2015_208⟩ Chapitre d'ouvrage hal-02797501v1
Acquiring ground state pluripotency: Switching mouse embryonic stem cells from serum/LIF medium to 2i/LIF medium Matteo Tosolini,Alice Jouneau Embryonic Stem Cell Protocols, 1341, Editions Springer, 449 p., 2016, Methods in Molecular Biology, 978-1-4939-2953-5. ⟨10.1007/7651_2015_207⟩ Chapitre d'ouvrage hal-02797617v1
Whole-mount in situ hybridization to assess advancement of development and embryo morphology Bernd Püschel,Alice Jouneau Nuclear reprogramming: Methods and Protocols, 1222 (2 ed.), Editions Springer, 290 p., 2015, Methods in Molecular Biology, 978-1-4939-1593-4. ⟨10.1007/978-1-4939-1594-1_19⟩ Chapitre d'ouvrage hal-02798220v1
Reprogramming and pluripotency of epiblast stem cells Anne-Clémence Veillard,Julien Maruotti,Alice Jouneau Stem cells and cancer stem cells, 8, Springer Science+Business Media, pp.364, 2012, Stem Cells and Cancer Stem Cells, 978-94-007-4798-2. ⟨10.1007/978-94-007-4798-2_13⟩ Chapitre d'ouvrage hal-02807889v1

Ouvrages (1)

Nuclear reprogramming: Methods and Protocols Nathalie Beaujean,Hélène Jammes,Alice Jouneau Editions Springer, 1222 (2 ed.), 290 p., 2015, Methods in Molecular Biology, 978-1-4939-1593-4. ⟨10.1007/978-1-4939-1594-1⟩ Ouvrages (ouvrage de synthèse) hal-02797340v1