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Alice Lebreton

Alice Lebreton, Group leader, INRAE research director, HDR
33
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Presentation

### Carrière de recherche *Depuis 2015* [Resonsable d’équipe](https://www.biologie.ens.fr/ida) à l’Institut de Biologie de l’ENS de Paris, DR2 INRAE depuis 2022, HDR. *2008-2014* Chargée de recherche INRA à l’Institut Pasteur, Paris, unité P. Cossart, groupe H. Bierne. *2006-2008* Post-doctorat au Centre de Génétique Moléculaire du CNRS à Gif-sur-Yvette, équipe B. Séraphin. *2002-2006* Doctorat à l’Institut Pasteur, équipe A. Jacquier, supervision M. Fromont-Racine. *2000* Échange Erasmus à l’Institut de Microbiologie de l’ETH de Zürich, laboratoire de Th. Leisinger. *1999* Stage à l’hôpital de la Pitié-Salpêtrière. ### Enseignement *Depuis 2014* Enseignement à l’ENS de Paris (L3), UE [*Biologie moléculaire de la cellule*](http://www.enseignement.biologie.ens.fr/spip.php?article161&lang=fr), et depuis 2021, UE *Génomlique fonctionnelle*. *Depuis 2011* Enseignement à l’ENS Paris-Saclay, M1 [*Biologie et santé*](https://ens-paris-saclay.fr/formations/masters/biologie-sante), UE *Biologie cellulaire des interactions hôte-bactéries invasives*, et depuis 2017 en L3, UE *Grandes découvertes en sciences du vivant*. *2019-2022* Jury de l‘épreuve orale de biologie du concours d‘entrée de l‘ENS de Paris. *2014-2020* Professeure chargée de cours à l’École normale supérieure. Responsable de l’UE [*Biologie moléculaire de la cellule*](http://www.enseignement.biologie.ens.fr/spip.php?article161&lang=fr) (L3 non biologistes). Co-responsable du cours [*Systèmes microbiens*](http://www.enseignement.biologie.ens.fr/spip.php?article158&lang=fr) du [M2 IMaLiS](http://www.enseignement.biologie.ens.fr/?rubrique11&lang=fr). *2017-2018* Responsable de la filière *Biologie fondamentale pour la santé* du [M2 IMaLiS](http://www.enseignement.biologie.ens.fr/?rubrique11&lang=fr). *2002-2005* Monitorat à l’Université Paris 7 : travaux dirigés et pratiques d’immunologie (L2, L3). ### Cursus universitaire *2015* Habilitation à diriger les recherches en microibiologie-virologie (Université Paris 7) *2002-2006* Doctorat de Microbiologie-Virologie de l’Université Paris 7, école doctorale B2M. *1998-2002* Élève à l’École normale supérieure de Cachan, agrégation de Biochimie – Génie Biologique. Licence et Maîtrise de Biochimie Moléculaire et Cellulaire puis cours Pasteur et DEA de Microbiologie-Virologie de l’Université Paris 7.
### Research career Since 2015 [Group leader](https://www.ibens.ens.fr/?rubrique26&lang=en), Institute of Biology of École normale supérieure (IBENS), Paris, HDR. INRAE Research director since 2022. 2008-2014 INRA researcher, Pasteur Institute (lab P. Cossart, group H. Bierne), Paris. 2006-2008 Post-doctoral fellow, Centre de Génétique Moléculaire (lab B. Séraphin), CNRS, Gif-sur-Yvette. 2002-2006 PhD thesis student, Pasteur Institute (lab A. Jacquier, supervision M. Fromont-Racine), Paris. 2000 Intern, Microbiology Institute (lab Th. Leisinger), ETH Zürich. 1999 Summer intern, La Pitié-Salpêtrière hospital, Paris. ### Teaching *Since 2014* Lecturer for the biology department of ENS, Paris, [*Molecular Cell Biology*](http://www.enseignement.biologie.ens.fr/spip.php?article161) course and *Functional Genomics* course since 2021 (bachelor‘s degree). *Since 2011* Lecturer for the biology department of ENS Paris-Saclay, *Cell Biology of Host-Invasive Bacteria* (Master's degree), and *Major discoveries in Life Sciences* course since 2017 (bachelor‘s degree). *2019-2022* Jury for the biology entrance exam of ENS. *2014-2020* Organisation of the [*Molecular Cell Biology*](http://www.enseignement.biologie.ens.fr/spip.php?article161) course for non-biologist students at ENS (Bachelor’s degree). Co-organisation of the [*Microbial Systems*](http://www.enseignement.biologie.ens.fr/spip.php?article158) course, ([IMaLiS](http://www.enseignement.biologie.ens.fr/?rubrique11) Master’s degree). *2017-2018* Head of the *Fundamental Biology for Health* track in the [IMaLiS](http://www.enseignement.biologie.ens.fr/?rubrique11) Master’s program. *2002-2005* Teaching assistant in Immunology (Bachelor’s degree), Paris 7 University. ### Education 2002-2006 PhD in Microbiology-Virology, Paris 7 University. 1998-2002 Studies in Biochemistry and Cell Biology at École normale supérieure de Cachan and Paris 7 University. Undergraduate studies in Biochemistry and Cell Biology, then Master’s degree in Microbiology-Virology (Pasteur Institute). Agrégation (French degree for high-school teaching) in Biochemistry – Biological Engineering.

Publications

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Regulation of cold-inducible RNA-binding protein (CIRBP) in response to cellular stresses

Morgane Corre , Alice Lebreton
Biochimie, In press, The rise of RNA: from fundamental research to therapeutic applications, ⟨10.1016/j.biochi.2023.04.003⟩
Journal articles hal-04077305v1
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Alternative splicing induced by bacterial pore-forming toxins sharpens CIRBP-mediated cell response to Listeria infection

Morgane Corre , Volker Boehm , Vinko Besic , Anna Kurowska , Anouk Viry
Nucleic Acids Research, 2023, 51 (22), pp.12459-12475. ⟨10.1093/nar/gkad1033⟩
Journal articles hal-04342449v1
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Adaptations of intracellular bacteria to vacuolar or cytosolic niches

Thomas J.P. Petit , Alice Lebreton
Trends in Microbiology, 2022, 30 (8), pp.736-748. ⟨10.1016/j.tim.2022.01.015⟩
Journal articles hal-03602380v1
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Visualizing the dynamics of exported bacterial proteins with the chemogenetic fluorescent reporter FAST

Yankel Chekli , Caroline Peron-Cane , Dario Dell’arciprete , Jean-François Allemand , Chenge Li
Scientific Reports, 2020, 10 (1), pp.15791. ⟨10.1038/s41598-020-72498-2⟩
Journal articles hal-03093348v1
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Engineering E. coli for magnetic control and the spatial localization of functions

Mary Aubry , Wei-An Wang , Yohan Guyodo , Eugénia Delacou , Jean-Michel Guignier
ACS Synthetic Biology, 2020, ⟨10.1021/acssynbio.0c00286⟩
Journal articles hal-03038795v1
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Coordination of transcriptional and translational regulations in human cells infected by Listeria monocytogenes

Vinko Besic , Fatemeh Habibolahi , Benoit Noel , Sebastian Rupp , Auguste Genovesio
RNA Biology, 2020, 17 (10), pp.1492-1507. ⟨10.1080/15476286.2020.1777380⟩
Journal articles hal-02308583v2
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Fluorescent secreted bacterial effectors reveal active intravacuolar proliferation of Listeria monocytogenes in epithelial cells

Caroline Peron Cane , José Carlos Fernandez , Julien Leblanc , Laure Wingertsmann , Arnaud Gautier
PLoS Pathogens, 2020, 16 (10), pp.e1009001. ⟨10.1371/journal.ppat.1009001⟩
Journal articles hal-02424854v2
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ALFA: annotation landscape for aligned reads

Mathieu Bahin , Benoit Noel , Valentine Murigneux , Charles Bernard , Leila Bastianelli
BMC Genomics, 2019, 20 (250), pp.1-11. ⟨10.1186/s12864-019-5624-2⟩
Journal articles hal-02084432v1
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An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling

Alessandro Pagliuso , To Nam Tham , Eric Allemand , Stevens Robertin , Bruno Dupuy
Cell Host and Microbe, 2019, 26 (6), pp.823-835.e11. ⟨10.1016/j.chom.2019.10.004⟩
Journal articles pasteur-02390001v1
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Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk

Mélodie Duval , Pascale Cossart , Alice Lebreton
Seminars in Cell and Developmental Biology, 2017, 65, pp.11-19. ⟨10.1016/j.semcdb.2016.06.016⟩
Journal articles hal-01350977v2
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RNA- and protein-mediated control of Listeria monocytogenes virulence gene expression

Alice Lebreton , Pascale Cossart
RNA Biology, 2017, 14 (5), pp.460-470. ⟨10.1080/15476286.2016.1189069⟩
Journal articles hal-01350979v2
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Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism

Goran Lakisic , Alice Lebreton , Renaud Pourpre , Olivia Wendling , Emanuele Libertini
PLoS Genetics, 2016, 12 (3), pp.e1005898. ⟨10.1371/journal.pgen.1005898⟩
Journal articles hal-01350966v1
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1926–2016: 90 Years of listeriology

Alice Lebreton , Fabrizia Stavru , Sylvain Brisse , Pascale Cossart
Microbes and Infection, 2016, 18 (12), pp.711 - 723. ⟨10.1016/j.micinf.2016.10.009⟩
Journal articles hal-01400517v2
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Organelle targeting during bacterial infection: insights from Listeria

Alice Lebreton , Fabrizia Stavru , Pascale Cossart
Trends in Cell Biology, 2015, 25 (6), pp.330-8. ⟨10.1016/j.tcb.2015.01.003⟩
Journal articles pasteur-01162370v2
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A trip in the "New Microbiology" with the bacterial pathogen Listeria monocytogenes

Pascale Cossart , Alice Lebreton
FEBS Letters, 2014, 588 (15), pp.2437-45. ⟨10.1016/j.febslet.2014.05.051⟩
Journal articles pasteur-01161887v2
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Overexpression of the Heterochromatinization Factor BAHD1 in HEK293 Cells Differentially Reshapes the DNA Methylome on Autosomes and X Chromosome

Emanuele Libertini , Alice Lebreton , Goran Lakisic , Marie-Agnès Dillies , Stephan Beck
Frontiers in Genetics, 2014, 6, pp.339. ⟨10.3389/fgene.2015.00339⟩
Journal articles hal-01350961v1
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Structural basis for the inhibition of the chromatin repressor BAHD1 by the bacterial nucleomodulin LntA.

Alice Lebreton , Viviana Job , Marie Ragon , Alban Le Monnier , Andréa Dessen
mBio, 2014, 5 (1), pp.e00775-13. ⟨10.1128/mBio.00775-13⟩
Journal articles hal-01109386v1
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Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta.

Hélène Bierne , Laetitia Travier , Tanel Mahlakõiv , Ludovic Tailleux , Agathe Subtil
PLoS ONE, 2012, 7 (6), pp.e39080. ⟨10.1371/journal.pone.0039080⟩
Journal articles pasteur-00750162v1
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The intestinal microbiota interferes with the microRNA response upon oral Listeria infection.

Cristel Archambaud , Odile Sismeiro , Joern Toedling , Guillaume Soubigou , Christophe Bécavin
mBio, 2012, 4 (6), pp.e00707-13. ⟨10.1128/mBio.00707-13⟩
Journal articles hal-01350904v1
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Bacteria tune interferon responses by playing with chromatin

Alice Lebreton , Pascale Cossart , Hélène Bierne
Virulence, 2012, 3 (1), pp.87-91. ⟨10.4161/viru.3.1.18531⟩
Journal articles hal-01350803v2

Extensive degradation of RNA precursors by the exosome in wild-type cells.

Rajani Kanth Gudipati , Zhenyu Xu , Alice Lebreton , Bertrand Séraphin , Lars M Steinmetz
Molecular Cell, 2012, 48 (3), pp.409-21. ⟨10.1016/j.molcel.2012.08.018⟩
Journal articles hal-01350901v1
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A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response

Alice Lebreton , Goran Lakisic , Viviana Job , Lauriane Fritsch , To Nam Tham
Science, 2011, 331 (6022), pp.1319-21. ⟨10.1126/science.1200120⟩
Journal articles cea-00819299v1
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60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes

Alice Lebreton , Jean-Claude Rousselle , Pascal Lenormand , Abdelkader Namane , Alain Jacquier
Nucleic Acids Research, 2008, 36 (15), pp.4988-4999. ⟨10.1093/nar/gkn469⟩
Journal articles hal-01350774v1
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Exosome-mediated quality control: substrate recruitment and molecular activity

Alice Lebreton , Bertrand Séraphin
BBA - Biochimica et Biophysica Acta, 2008, 1779 (9), pp.558-65. ⟨10.1016/j.bbagrm.2008.02.003⟩
Journal articles hal-01350691v1
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Endonucleolytic RNA cleavage by a eukaryotic exosome

Alice Lebreton , Rafal Tomecki , Andrzej Dziembowski , Bertrand Séraphin
Nature, 2008, 456 (7224), pp.993-6. ⟨10.1038/nature07480⟩
Journal articles hal-01350769v1
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Cytoplasmic recycling of 60S preribosomal factors depends on the AAA protein Drg1

Brigitte Pertschy , Cosmin Saveanu , Gertrude Zisser , Alice Lebreton , Martin Tengg
Molecular and Cellular Biology, 2007, 27 (19), pp.6581-92. ⟨10.1128/MCB.00668-07⟩
Journal articles hal-01350677v1
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A functional network involved in the recycling of nucleocytoplasmic pre-60S factors

Alice Lebreton , Cosmin Saveanu , Laurence Decourty , Jean-Christophe Rain , Alain Jacquier
Journal of Cell Biology, 2006, 173 (3), pp.349-60. ⟨10.1083/jcb.200510080⟩
Journal articles hal-01350674v1
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Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs

Alice Lebreton , Cosmin Saveanu , Laurence Decourty , Alain Jacquier , Micheline Fromont-Racine
Journal of Biological Chemistry, 2006, 281 (37), pp.27099-108. ⟨10.1074/jbc.M602199200⟩
Journal articles hal-01350676v1
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Sequential protein association with nascent 60S ribosomal particles

Cosmin Saveanu , Abdelkader Namane , Pierre-Emmanuel Gleizes , Alice Lebreton , Jean-Claude Rousselle
Molecular and Cellular Biology, 2003, 23 (13), pp.4449-60. ⟨10.1128/MCB.23.13.4449-4460.2003⟩
Journal articles hal-01350680v1
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Transformation of isopropylamine to L-alaninol by Pseudomonas sp. strain KIE171 involves N-glutamylated intermediates

Susana I de Azevedo Wäsch , Jan R van Der Ploeg , Tere Maire , Alice Lebreton , Andreas Kiener
Applied and Environmental Microbiology, 2002, 68 (5), pp.2368-75. ⟨10.1128/AEM.68.5.2368-2375.2002⟩
Journal articles hal-01350667v1
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Régulations post-transcriptionnelles de l'expression génique de la cellule hôte en réponse à l'infection bactérienne

Alice Lebreton
Sciences du Vivant [q-bio]. Université Paris Diderot (Paris 7), 2015
Habilitation à diriger des recherches tel-02471940v2