Angélique Stéphanou

Publications

Article dans une revue (36)

The Role of Mathematical Models in Epidemic Prediction and the Challenges of COVID-19 Comment on 'Data-driven mathematical modeling approaches for COVID-19: A survey' by E Fanchon,Angélique Stéphanou Physics of Life Reviews, 2025, 52, pp.55-56. ⟨10.1016/j.plrev.2024.12.002⟩ Article dans une revue hal-04766375v1
Modelling the impact of HIF on metabolism and the extracellular matrix: consequences for tumour growth and invasion Kévin Spinicci,Gibin Powathil,Angélique Stéphanou Bulletin of Mathematical Biology, 2025, 87 (27), ⟨10.1007/s11538-024-01391-0⟩ Article dans une revue hal-04754067v1
Beyond the Warburg Effect: Modeling the Dynamic and Context-Dependent Nature of Tumor Metabolism Pierre Jacquet,Angélique Stéphanou Cancers, 2025, 17 (21), pp.3563. ⟨10.3390/cancers17213563⟩ Article dans une revue hal-05348279v1
Spatial organization of mediated-macrophage chemoprotective niches in solid tumors: A mathematical analysis William Dangelser,Angélique Stéphanou,Arnaud Millet Mathematical Modelling of Natural Phenomena, 2025, 20, pp.15. ⟨10.1051/mmnp/2025012⟩ Article dans une revue hal-04798016v1
On the Importance of Acidity in Cancer Cells and Therapy Alaa Tafech,Angélique Stéphanou Biology, 2024, 13 (4), pp.225. ⟨10.3390/biology13040225⟩ Article dans une revue (article de synthèse) hal-04527526v1
A biomechanical model for cell sensing and migration Arnaud Chauvière,Ian Manifacier,Claude Verdier,Grégory Chagnon,Ibrahim Cheddadiet al. Computer Methods in Biomechanics and Biomedical Engineering, 2024, pp.1-19. ⟨10.1080/10255842.2024.2427112⟩ Article dans une revue hal-04727238v1
Is Cancer Metabolism an Atavism? Éric Fanchon,Angélique Stéphanou Cancers, 2024, The Warburg Effect in Cancers, 16 (13), pp.2415. ⟨10.3390/cancers16132415⟩ Article dans une revue hal-04636868v1
A reduced model of cell metabolism to revisit the glycolysis-OXPHOS relationship in the deregulated tumor microenvironment Pierre Jacquet,Angélique Stéphanou Journal of Theoretical Biology, 2023, 562, pp.111434. ⟨10.1016/j.jtbi.2023.111434⟩ Article dans une revue hal-03973607v1
Characterization of the Intracellular Acidity Regulation of Brain Tumor Cells and Consequences for Therapeutic Optimization of Temozolomide Alaa Tafech,Pierre Jacquet,Céline Beaujean,Arnold Fertin,Yves Ussonet al. Biology, 2023, 12 (9), pp.1221. ⟨10.3390/biology12091221⟩ Article dans une revue hal-04208184v1
Generalization of the Ratiometric Method to Extend pH Range Measurements of the BCECF Probe Alaa Tafech,Céline Beaujean,Yves Usson,Angélique Stéphanou Biomolecules, 2023, 13 (3), pp.442. ⟨10.3390/biom13030442⟩ Article dans une revue hal-04287591v1
Modelling the role of HIF in the regulation of metabolic key genes LDH and PDH: Emergence of Warburg Phenotype Kévin Spinicci,Pierre Jacquet,Gibin Powathil,Angélique Stéphanou Computational and Systems Oncology, 2022, 2 (3), ⟨10.1002/cso2.1040⟩ Article dans une revue hal-03759747v1
Can major breakthroughs in cancer be achieved through theoretical models? Comment on “Improving cancer treatments via dynamical biophysical models” by M. Kuznetsov, J. Clairambault and V. Volpert Angélique Stéphanou Physics of Life Reviews, 2022, 40, pp.63-64. ⟨10.1016/j.plrev.2021.11.006⟩ Article dans une revue hal-03470089v1
Searching for the Metabolic Signature of Cancer: A Review from Warburg’s Time to Now Pierre Jacquet,Angélique Stéphanou Biomolecules, 2022, 12 (10), pp.1412. ⟨10.3390/biom12101412⟩ Article dans une revue hal-03813369v1
Metabolic Reprogramming, Questioning, and Implications for Cancer Pierre Jacquet,Angélique Stéphanou Biology, 2021, 10 (2), pp.129. ⟨10.3390/biology10020129⟩ Article dans une revue hal-03151101v1
A minimal biomechanical model for random cell migration Ian Manifacier,Arnaud Chauvière,Claude Verdier,G. Chagnon,Ibrahim Cheddadiet al. Computer Methods in Biomechanics and Biomedical Engineering, 2020, 45th Congress of the Société de Biomécanique, 23 (sup1), pp.S183-S185. ⟨10.1080/10255842.2020.1813420⟩ Article dans une revue hal-03015234v1
On the importance of substrate deformations for cell migration Anais Gagnieu,Grégory Chagnon,Yves Chemisky,Angélique Stephanou,Arnaud Chauvière Computer Methods in Biomechanics and Biomedical Engineering, 2020, 22 suppl 1, pp.S334-S335. ⟨10.1080/10255842.2020.1714933⟩ Article dans une revue hal-02425956v1
Hybrid Modelling in Oncology: Sucesses, Challenges and Hopes Angélique Stéphanou,Pascal Ballet,Gibin Powathil Mathematical Modelling of Natural Phenomena, 2020, 15, ⟨10.1051/mmnp/2019026⟩ Article dans une revue hal-01980757v1
A minimal biomechanical model for random cell migration Ian Manifacier,Arnaud Chauvière,Claude Verdier,Gregory Chagnon,Ibrahim Cheddadiet al. Computer Methods in Biomechanics & Biomedical Engineering, 2020, ⟨10.1080/10255842.2020.1813420⟩ Article dans une revue hal-02985515v1
pH as a potential therapeutic target to improve temozolomide antitumor efficacy : A mechanistic modeling study Angélique Stéphanou,Annabelle Ballesta Pharmacology Research & Perspectives, 2019, 7 (1), pp.e00454. ⟨10.1002/prp2.454⟩ Article dans une revue hal-03015254v1
Systems Biology, Systems Medicine, Systems Pharmacology: The What and The Why Angélique Stéphanou,Eric Fanchon,Pasquale Innominato,Annabelle Ballesta Acta Biotheoretica, 2018, 66 (4), pp.345-365. ⟨10.1007/s10441-018-9330-2⟩ Article dans une revue hal-01975961v1
How tumour-induced vascular changes alter angiogenesis: Insights from a computational model Angélique Stéphanou,Anne-Cécile Lesart,J. Deverchere,A. Juhem,A. Popovet al. Journal of Theoretical Biology, 2017, 419, pp.211-226. ⟨10.1016/j.jtbi.2017.02.018⟩ Article dans une revue hal-01975971v1
Towards the Design of a Patient-Specific Virtual Tumour Flavien Caraguel,Anne-Cécile Lesart,François Estève,Boudewijn Pj van Der Sanden,Angélique Stéphanou Computational and Mathematical Methods in Medicine, 2016, 2016, pp.7851789. ⟨10.1155/2016/7851789⟩ Article dans une revue hal-01975976v1
Hybrid Modelling in Cell Biology Angélique Stéphanou,Vitaly Volpert Mathematical Modelling of Natural Phenomena, 2015, 10 (1), pp.1-3. ⟨10.1051/mmnp/201510100⟩ Article dans une revue hal-01975989v1
Effects of the hypoxia-mimetic agents DFO and CoCl2 on HeLa-FUCCI cells Baptiste Bedessem,Marie-Paule Montmasson,Malika Hamel,Françoise Giroud,Angélique Stéphanou Journal of Cell Biology and Cell Metab, 2015, 2, pp.4-12. ⟨10.24966/cbcm-1943/100004⟩ Article dans une revue hal-01483598v1
A mathematical model of HiF-1α-mediated response to hypoxia on the G1/S transition Baptiste Bedessem,Angélique Stéphanou Mathematical Biosciences, 2014, 248, pp.31-9. ⟨10.1016/j.mbs.2013.11.007⟩ Article dans une revue hal-00977635v1
Proceedings of the XXXIInd Seminar of the French-Speaking Society for Theoretical Biology; Saint-Flour (Cantal), France, 10-13 June, 2012. Nicolas Glade,Angélique Stéphanou Acta Biotheoretica, 2013, 61 (3), pp.289-90. ⟨10.1007/s10441-013-9201-9⟩ Article dans une revue hal-00977696v1
Mathematical modelling and numerical simulations of actin dynamics in the eukaryotic cell. Uduak Z George,Angélique Stéphanou,Anotida Madzvamuse Journal of Mathematical Biology, 2013, 66 (3), pp.547-93. ⟨10.1007/s00285-012-0521-1⟩ Article dans une revue istex hal-00847003v1
A Computational Framework to Assess the Efficacy of Cytotoxic Molecules and Vascular Disrupting Agents against Solid Tumours Margarita Pons-Salort,Boudewijn van Der Sanden,Aurélie Juhem,Andrei Popov,Angélique Stéphanou Mathematical Modelling of Natural Phenomena, 2012, 7 (1), pp.49-77. ⟨10.1051/mmnp/20127104⟩ Article dans une revue hal-00847022v1
On the importance of the submicrovascular network in a computational model of tumour growth. Anne-Cécile Lesart,Boudewijn van Der Sanden,Lauriane Hamard,François Estève,Angélique Stéphanou Microvascular Research, 2012, 84 (2), pp.188-204. ⟨10.1016/j.mvr.2012.06.001⟩ Article dans une revue inserm-00738177v1
On the Influence of Discrete Adhesive Patterns for Cell Shape and Motility: A Computational Approach Céline Franco,Tzvetelina Tzvetkova-Chevolleau,Angélique Stéphanou Mathematical Modelling of Natural Phenomena, 2010, 5 (1), pp.56 - 83. ⟨10.1051/mmnp/20105101⟩ Article dans une revue hal-00847012v1
Modelling the Impact of Pericyte Migration and Coverage of Vessels on the Efficacy of Vascular Disrupting Agents Steven Mcdougall,Mark A.J. Chaplain,Angélique Stéphanou,Alexander R.A. Anderson Mathematical Modelling of Natural Phenomena, 2010, 5 (1), pp.163-202. ⟨10.1051/mmnp/20105108⟩ Article dans une revue hal-00847029v1
The motility of normal and cancer cells in response to the combined influence of substrate rigidity and anisotropic microstructure Tzvetelina Tzvetkova-Chevolleau,Angélique Stéphanou,David Fuard,Jacques Ohayon,Patrick Schiavoneet al. Biomaterials, 2008, 29 (10), pp.1541--1551. ⟨10.1016/j.biomaterials.2007.12.016⟩ Article dans une revue hal-00291559v1
Spatiotemporal dynamics of actin-rich adhesion microdomains: influence of substrate flexibility O. Collin,Angélique Stéphanou Journal of Cell Science, 2006, 119 (9), pp.1914-1925 Article dans une revue hal-01976004v1
Spatiotemporal dynamics of actin-rich adhesion microdomains: influence of substrate flexibility. Olivier Collin,Philippe Tracqui,Angélique Stephanou,Yves Usson,Jocelyne Clément-Lacroixet al. Journal of Cell Science, 2006, 119 (Pt 9), pp.1914-25. ⟨10.1242/jcs.02838⟩ Article dans une revue inserm-00173037v1
The rigidity in fibrin gels as a contributing factor to the dynamics of in vitro vascular cord formation Angélique Stephanou,Ghislaine Meskaoui,Vailhé Bruno,Philippe Tracqui Microvascular Research, 2006, 73 (3), pp.182-190. ⟨10.1016/j.mvr.2006.12.002⟩ Article dans une revue istex hal-00193847v1
A mathematical model for the dynamics of large membrane deformations of isolated fibroblasts Angélique Stéphanou Bulletin of Mathematical Biology, 2004, 66 (5), pp.1119-1154 Article dans une revue hal-01976003v1

Pré-publication, Document de travail (5)

Interplay between biomechanics and morphology drives cell migration features Nicolas Louviaux,Ibrahim Cheddadi,Claude Verdier,Angélique Stéphanou,Arnaud Chauvière 2025 Pré-publication, Document de travail hal-05299667v1
Exploring How Metabolism comes into play with Radiations: A Review Damian Bimbenet,Mathilde Badoual,Gibin Powathil,Angélique Stéphanou 2025 Pré-publication, Document de travail hal-05365150v1
A computational model of the spatiotemporal adaptation of tumor cells metabolism in a growing spheroid Pierre Jacquet,Angélique Stéphanou 2023 Pré-publication, Document de travail hal-04284937v1
A biomechanical model for cell sensing and cell migration Ian Manifacier,Arnaud Chauvière,Claude Verdier,Grégory Chagnon,Ibrahim Cheddadiet al. 2022 Pré-publication, Document de travail hal-03839909v1
Why the tumor cell metabolism is not that abnormal Pierre Jacquet,Angélique Stéphanou 2019 Pré-publication, Document de travail hal-02402051v1

Chapitre d'ouvrage (2)

Development of a Preclinical Tool for Measuring Percutaneous Transfer of Dihydrogen, with a View to Optimizing Medical Devices Adapted to Focal Therapies in Dermatology C. Salomez-Ihl,S. Tanguy,F. Boucher,V. Pascal Mousselard,P. Bedouchet al. Molecular Hydrogen in Health and Disease, 27, Springer Nature Switzerland, pp.401-416, 2024, Advances in Biochemistry in Health and Disease, ⟨10.1007/978-3-031-47375-3_23⟩ Chapitre d'ouvrage hal-04467191v1
A computational framework integrating cytoskeletal and adhesion dynamics for modelling cell motility Angélique Stéphanou Cell mechanics: from single scale-based models to multiscale modeling, Chapman & Hall/CRC Mathematical and Computational Biology, pp.482, 2010, 9781420094541 Chapitre d'ouvrage hal-00977684v1

Brevet (1)

Islet distribution matrix Clovis Chabert,Abdelkader Zebda,Ibrahim Shalayel,Boudewijn van der Sanden,Sandrine Lablancheet al. France, Patent n° : B2024-14-B05366. 2024 Brevet hal-04999953v1

Communication dans un congrès (6)

Modélisation de la motilité cellulaire perturbée par l'interaction cellule-substrat Anais Gagnieu,Arnaud Chauvière,Grégory Chagnon,Yves Chemisky,Angélique Stephanou 38ème Séminaire de la Société Francophone de Biologie Théorique, Jun 2018, Sainf Flour, France Communication dans un congrès hal-01890322v1
Reduced Model For 2D Tumor Growth and Tumor Induced Angiogenesis Mazen Alamir,Mirko Fiacchini,Angélique Stephanou ECC 2015 - 14th European Control Conference, Jul 2015, Linz, Austria Communication dans un congrès hal-01235354v1
Hybrid modelling of mechanical cues in cell migration Angélique Stéphanou,Simon Lefloch,Arnaud Chauvière ITM Conference 2015, Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology, Mar 2015, Paris, France. ⟨10.1051/itmconf/20150500012⟩ Communication dans un congrès hal-01550582v1
Mathematical Modelling of Fibroblast shape Transition on Arrays of Adhesive Micropatterns with Varying Pitch Angélique Stéphanou,Tzvetelina Tzvetkova-Chevolleau,David Fuard,Philippe Tracqui,Patrick Schiavone ECMTB08; European Conference on Mathematical and Theoretical Biology, Jun 2008, Edinburgh, United Kingdom Communication dans un congrès hal-00340399v1
The Motility of Normal and Cancer Cells in Response to the Combined Influence of Substrate Rigidity and Anisotropic Nanostructure Tzvetelina Tzvetkova-Chevolleau,Angélique Stephanou,David Fuard,Jacques Ohayon,Patrick Schiavoneet al. ICBME2008, 13th International Conference on Biomedical Engineering, 2008, Singapore, Singapore Communication dans un congrès hal-00374519v1
Control of cell morphodynamic and displacement orientation by precise tuning between substrate nanopatterning and rigidity Tzvetelina Tzvetkova-Chevolleau,David Fuard,Patrick Schiavone,Sébastien Decossas,Angélique Stéphanouet al. Nanobio Europe 2008, Jun 2008, Barcelona, Spain Communication dans un congrès hal-00340397v1

Ouvrages (2)

Le vivant discret et continu - modes de représentation en biologie théorique Nicolas Glade,Angélique Stéphanou Editions Matériologiques, pp.427, 2013, 978-2-919694-24-2 Ouvrages hal-00977657v1
Spatio-temporal dynamics of the cell - characterization from images and computer-simulations Angélique Stéphanou Lambert Academic Publishing, pp.165, 2010, 9783838337920 Ouvrages hal-00977665v1

HDR (1)

Une Approche Computationnelle pour l'Etude de Processus Morphogénétiques - de la motilité des cellules à la croissance des vaisseaux Angélique Stéphanou Bio-Informatique, Biologie Systémique [q-bio.QM]. Université Joseph-Fourier - Grenoble I, 2011 HDR tel-00749373v1

Thèse (1)

The spatio-temporal dynamics of cell membranes deformations and cell migration Angélique Stéphanou Modeling and Simulation. Université Joseph-Fourier - Grenoble I, 2002. English. ⟨NNT : ⟩ Thèse tel-00004593v1