Anne Houdusse

Publications

Article dans une revue (58)

Probing protein–protein interactions with drag flow: a case study of F-actin and tropomyosin Camille Bagès,Morgan Chabanon,Wouter Kools,Thomas Dos Santos,Rebecca Pagèset al. European Physical Journal E: Soft matter and biological physics, 2025, 48 (8-9), pp.49. ⟨10.1140/epje/s10189-025-00509-z⟩ Article dans une revue hal-05253879v1
Coupling between the lever arm and active site via an N-terminal extension tunes force sensitivity in the myosin-1 family Harry W Rathbone,Anne Houdusse Proceedings of the National Academy of Sciences of the United States of America, 2025, 122 (15), ⟨10.1073/pnas.2502977122⟩ Article dans une revue hal-05028939v1
Development of clinically viable non-muscle myosin II small molecule inhibitors Laszlo Radnai,Erica J Young,Carlos Kikuti,Katalin Toth,Minghai Zhouet al. Cell, 2025, 188 (17), pp.4604 - 4621.e15. ⟨10.1016/j.cell.2025.06.006⟩ Article dans une revue hal-05264013v1
Reassessing the unifying hypothesis for hypercontractility caused by myosin mutations in hypertrophic cardiomyopathy James Spudich,Neha Nandwani,Julien Robert-Paganin,Anne Houdusse,Kathleen Ruppel EMBO Journal, 2024, 43 (19), pp.4139-4155. ⟨10.1038/s44318-024-00199-x⟩ Article dans une revue hal-04775427v1
Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite opposite effects in heart contraction Daniel Auguin,Julien Robert-Paganin,Stéphane Réty,Carlos Kikuti,Amandine Davidet al. Nature Communications, 2024, 15 (1), pp.4885. ⟨10.1038/s41467-024-47587-9⟩ Article dans une revue hal-04728659v1
Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy James J Hartman,Darren T Hwee,Julien Robert-Paganin,Chihyuan Chuang,Eva R Chinet al. Nature Cardiovascular Research, 2024, 3 (8), pp.1003-1016. ⟨10.1038/s44161-024-00505-0⟩ Article dans une revue hal-04775429v1
A weak coupling mechanism for the early steps of the recovery stroke of myosin VI: A free energy simulation and string method analysis Florian E C Blanc,Anne Houdusse,Marco Cecchini PLoS Computational Biology, 2024, 20 (4), pp.e1012005. ⟨10.1371/journal.pcbi.1012005⟩ Article dans une revue hal-04775430v1
How myosin VI traps its off-state, is activated and dimerizes Louise Canon,Vicente Planelles-Herrero,Young Il Lee,Franck Mayeux,Tianming Linet al. Nature Communications, 2023, 14 (1), pp.6732. ⟨10.1038/s41467-023-42376-2⟩ Article dans une revue hal-04293608v1
Cryo-EM structure of the folded-back state of human β-cardiac myosin Alessandro Grinzato,Daniel Auguin,Carlos Kikuti,Neha Nandwani,Dihia Moussaouiet al. Nature Communications, 2023, 14 (1), pp.3166. ⟨10.1038/s41467-023-38698-w⟩ Article dans une revue hal-04267665v1
The many roles of myosins in filopodia, microvilli and stereocilia Anne Houdusse,Margaret A Titus Current Biology, 2021, 31 (10), pp.R586-R602. ⟨10.1016/j.cub.2021.04.005⟩ Article dans une revue hal-03281243v1
Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth Lara Katharina Krüger,Matthieu Gélin,Liang Ji,Carlos Kikuti,Anne Houdusseet al. eLife, 2021, 10, pp.e67489. ⟨10.7554/eLife.67489⟩ Article dans une revue hal-03258505v1
Integration of Cardiac Actin Mutants Causing Hypertrophic (p.A295S) and Dilated Cardiomyopathy (p.R312H and p.E361G) into Cellular Structures Constanze Erdmann,Roua Hassoun,Sebastian Schmitt,Carlos Kikuti,Anne Houdusseet al. Antioxidants , 2021, Oxidative Stress in Cardiovascular Diseases, 10 (7), pp.1082. ⟨10.3390/antiox10071082⟩ Article dans une revue hal-03453111v1
VASP-mediated actin dynamics activate and recruit a filopodia myosin Ashley L Arthur,Amy Crawford,Anne Houdusse,Margaret A Titus eLife, 2021, 10, ⟨10.7554/elife.68082⟩ Article dans une revue hal-03395283v1
Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance Catalina Lodillinsky,Laetitia Fuhrmann,Marie Irondelle,Olena Pylypenko,Xiao-Yan Liet al. Oncogene, 2021, 40 (23), pp.4019 - 4032. ⟨10.1038/s41388-021-01826-1⟩ Article dans une revue hal-03453132v1
The actomyosin interface contains an evolutionary conserved core and an ancillary interface involved in specificity Julien Robert-Paganin,Xiao-Ping Xu,Mark Swift,Daniel Auguin,James Robbleeet al. Nature Communications, 2021, 12 (1), pp.1892. ⟨10.1038/s41467-021-22093-4⟩ Article dans une revue hal-03453769v1
Biological nanomotors, driving forces of life Anne Houdusse Comptes Rendus. Biologies, 2021, 343 (4), pp.53-78. ⟨10.5802/crbiol.45>⟩ Article dans une revue hal-03453097v1
Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance Catalina Lodillinsky,Laetitia Fuhrmann,Marie Irondelle,Olena Pylypenko,Xiao-Yan Liet al. Oncogene, In press, ⟨10.1038/s41388-021-01826-1⟩ Article dans une revue hal-03238972v1
Force Generation by Myosin Motors: A Structural Perspective Julien Robert-Paganin,Olena Pylypenko,Carlos Kikuti,H. Lee Sweeney,Anne Houdusse Chemical Reviews, 2020, 120 (1), pp.5-35. ⟨10.1021/acs.chemrev.9b00264⟩ Article dans une revue hal-03238440v1
Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness Máté Gyimesi,Ádám Horváth,Demeter Túrós,Sharad Kumar Suthar,Máté Pénzeset al. Cell, 2020, 183 (2), pp.335-346.e13. ⟨10.1016/j.cell.2020.08.050⟩ Article dans une revue hal-03453772v1
Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets Dihia Moussaoui,James P Robblee,Daniel Auguin,Elena B Krementsova,Silvia Haaseet al. eLife, 2020, 9, pp.e60581. ⟨10.7554/elife.60581⟩ Article dans une revue hal-03059341v1
Optimized filopodia formation requires myosin tail domain cooperation Ashley Arthur,Livia Songster,Helena Sirkia,Akash Bhattacharya,Carlos Kikutiet al. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (44), pp.22196-22204. ⟨10.1073/pnas.1901527116⟩ Article dans une revue hal-02349330v1
2nd PSL Chemical Biology Symposium (2019): At the Crossroads of Chemistry and Biology Marco Lucchino,Anne Billet,Antoine Versini,Harikrishna Bavireddi,Bhanu-Das Dasariet al. ChemBioChem, 2019, 20 (7), pp.968-973. ⟨10.1002/cbic.201900092⟩ Article dans une revue hal-02324665v1
Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism Julien Robert-Paganin,James Robblee,Daniel Auguin,Thomas Blake,Carol Bookwalteret al. Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-11120-0⟩ Article dans une revue hal-02349247v1
An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics Florian Blanc,Tatiana Isabet,Hannah Benisty,H. Lee Sweeney,Marco Cecchiniet al. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (24), pp.6213-6218. ⟨10.1073/pnas.1711512115⟩ Article dans une revue hal-02349286v1
MYO5B , STX3 , and STXBP2 mutations reveal a common disease mechanism that unifies a subset of congenital diarrheal disorders: A mutation update Herschel Dhekne,Olena Pylypenko,Arend Overeem,Rosaria Ferreira,K. Joeri van Der Veldeet al. Human Mutation, 2018, 39 (3), pp.333-344. ⟨10.1002/humu.23386⟩ Article dans une revue hal-02349537v1
Myosin VI and branched actin filaments mediate membrane constriction and fission of melanosomal tubule carriers Léa Ripoll,Xavier Heiligenstein,Ilse Hurbain,Lia Domingues,Florent Figonet al. Journal of Cell Biology, 2018, 217 (8), pp.2709 - 2726. ⟨10.1083/jcb.201709055⟩ Article dans une revue hal-03059386v1
Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity Olena Pylypenko,Hussein Hammich,I-Mei Yu,Anne Houdusse Small GTPases, 2018, 9 (1-2), pp.22-48. ⟨10.1080/21541248.2017.1336191⟩ Article dans une revue hal-02349559v1
Circularly permuted fluorogenic proteins for the design of modular biosensors Alison G Tebo,Frederico M Pimenta,Martha Zoumpoulaki,Carlos Kikuti,Helena Sirkiaet al. ACS Chemical Biology, 2018, 13 (9), pp.2392 - 2397. ⟨10.1021/acschembio.8b00417⟩ Article dans une revue hal-01909679v1
Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition Julien Robert-Paganin,Daniel Auguin,Anne Houdusse Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-06191-4⟩ Article dans une revue hal-02349257v1
The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry Joseph Atherton,I-Mei Yu,Alexander Cook,Joseph M Muretta,Agnel Josephet al. eLife, 2017, 6, ⟨10.7554/eLife.27793⟩ Article dans une revue hal-04015847v1
Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex Sara Bizzotto,Ana Uzquiano,Florent Dingli,Dmitry Ershov,Anne Houllieret al. Scientific Reports, 2017, 7 (1), pp.17308. ⟨10.1038/s41598-017-15253-4⟩ Article dans une revue hal-03825519v1
Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil Vicente J Planelles-Herrero,James J Hartman,Julien Robert-Paganin,Fady I Malik,Anne Houdusse Nature Communications, 2017, 8 (1), ⟨10.1038/s41467-017-00176-5⟩ Article dans une revue hal-03059358v1
Myosin 7 and its adaptors link cadherins to actin I-Mei Yu,Vicente J Planelles-Herrero,Yannick Sourigues,Dihia Moussaoui,Helena Sirkiaet al. Nature Communications, 2017, 8, pp.15864. ⟨10.1038/ncomms15864⟩ Article dans une revue hal-01984704v1
Oxidation of F-actin controls the terminal steps of cytokinesis Stéphane Frémont,Hussein Hammich,Jian Bai,Hugo Wioland,Kerstin Klinkertet al. Nature Communications, 2017, 8, pp.1-16. ⟨10.1038/ncomms14528⟩ Article dans une revue hal-01492528v1
Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions Stephanie Miserey-Lenkei,Hugo Bousquet,Olena Pylypenko,Sabine Bardin,Ariane Dimitrovet al. Nature Communications, 2017, 8 (1), pp.1254. ⟨10.1038/s41467-017-01266-0⟩ Article dans une revue hal-02349571v1
The myosin X motor is optimized for movement on actin bundles Virginie Ropars,Zhaohui Yang,Tatiana Isabet,Florian Blanc,Kaifeng Zhouet al. Nature Communications, 2016, 7, pp.12456. ⟨10.1038/ncomms12456⟩ Article dans une revue hal-01361523v1
Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening. Kerstin Klinkert,Murielle Rocancourt,Anne Houdusse,Arnaud Echard Nature Communications, 2016, 7, pp.11166. ⟨10.1038/ncomms11166⟩ Article dans une revue pasteur-01301777v1
Force-producing ADP state of myosin bound to actin Sarah Wulf,Virginie Ropars,Setsuko Fujita-Becker,Marco Oster,Goetz Hofhauset al. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (13), pp.E1844-E1852. ⟨10.1073/pnas.1516598113⟩ Article dans une revue hal-02349597v1
Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes Olena Pylypenko,Tobias Welz,Janine Tittel,Martin Kollmar,Florian Chardonet al. eLife, 2016, 5, pp.e17523. ⟨10.7554/eLife.17523⟩ Article dans une revue hal-02349587v1
How Actin Initiates the Motor Activity of Myosin Paola Llinas,Tatiana Isabet,Lin Song,Virginie Ropars,Bin Zonget al. Developmental Cell, 2015, 33 (4), pp.401 - 412. ⟨10.1016/j.devcel.2015.03.025⟩ Article dans une revue hal-03059350v1
Myosin VI deafness mutation prevents the initiation of processive runs on actin Olena Pylypenko,Lin Song,Ai Shima,Zhaohui Yang,Anne Houdusseet al. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112, pp.E1201 - E1209. ⟨10.1073/pnas.1420989112⟩ Article dans une revue hal-03059375v1
Myosin VI Must Dimerize and Deploy Its Unusual Lever Arm in Order to Perform Its Cellular Roles Monalisa Mukherjea,M Yusuf Ali,Carlos Kikuti,Daniel Safer,Zhaohui Yanget al. Cell Reports, 2014, 8 (5), ⟨10.1016/j.celrep.2014.07.041⟩ Article dans une revue hal-04775412v1
Structural basis of myosin V Rab GTPase-dependent cargo recognition Olena Pylypenko,Wikayatou Attanda,Charles Gauquelin,Marion Lahmani,Doudouh Coulibalyet al. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (51), pp.20443 - 20448. ⟨10.1073/pnas.1314329110⟩ Article dans une revue pasteur-03525520v1
How myosin motors power cellular functions - an exciting journey from structure to function Paola Llinas,Olena Pylypenko,Tatiana Isabet,Monalisa Mukherjea,H. Lee Sweeneyet al. FEBS Journal, 2012, 279 (4), pp.551-562. ⟨10.1111/j.1742-4658.2011.08449.x⟩ Article dans une revue hal-02349656v1
Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI Julie Ménétrey,Tatiana Isabet,Virginie Ropars,Monalisa Mukherjea,Olena Pylypenkoet al. Molecular Cell, 2012, 48 (1), pp.75 - 86. ⟨10.1016/j.molcel.2012.07.034⟩ Article dans une revue hal-03059379v1
Role of Insert-1 of Myosin VI in Modulating Nucleotide Affinity Olena Pylypenko,Lin Song,Gaelle Squires,Xiaoyan Liu,Alan B Zonget al. Journal of Biological Chemistry, 2011, 286 (13), pp.11716 - 11723. ⟨10.1074/jbc.m110.200626⟩ Article dans une revue hal-03059381v1
Essential &quot;ankle&quot; in the myosin lever arm O. Pylypenko,A. Houdusse Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (1), pp.5-6. ⟨10.1073/pnas.1017676108⟩ Article dans une revue hal-02349672v1
Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids Amel Bahloul,Vincent Michel,Jean-Pierre Hardelin,Sylvie Nouaille,Sylviane Hooset al. Human Molecular Genetics, 2010, 19 (18), pp.3557 - 3565. ⟨10.1093/hmg/ddq271⟩ Article dans une revue pasteur-03525648v1
Structural Basis for Recruitment of Rab6-Interacting Protein 1 to Golgi via a RUN Domain. Rosario Recacha,Annick Boulet,Florence Jollivet,Solange Monier,Anne Houdusseet al. Structure / Struct Fold Des; Structure (Camb ), 2009, 17 (1), pp.21-30. ⟨10.1016/j.str.2008.10.014⟩ Article dans une revue inserm-00355625v1
The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4. Tatiana Isabet,Guillaume Montagnac,Karine Regazzoni,Bertrand Raynal,Fatima El Khadaliet al. EMBO Journal, 2009, 28 (18), pp.2687 - 2858. ⟨10.1038/emboj.2009.209⟩ Article dans une revue hal-00416785v1
Electrospray ionization mass spectrometry studies of noncovalent myosin VI complexes reveal a new specific calmodulin binding site Guillaume Chevreux,Noelle Potier,Alain Dorsselaer,Amel Bahloul,Anne Houdusseet al. Journal of The American Society for Mass Spectrometry, 2005, 16 (8), pp.1367-1376. ⟨10.1016/j.jasms.2005.03.023⟩ Article dans une revue istex hal-02981194v1
The unique insert in myosin VI is a structural calcium-calmodulin binding site A. Bahloul,G. Chevreux,A. Wells,Davy Martin,J. Noltet al. Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (14), pp.4787-4792. ⟨10.1073/pnas.0306892101⟩ Article dans une revue hal-02981195v1
Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1) Gaël Ménasché,Chen Hsuan Ho,Ozden Sanal,Jerome Feldmann,Ilhan Tezcanet al. Journal of Clinical Investigation, 2003, 112 (3), pp.450-456. ⟨10.1172/JCI18264⟩ Article dans une revue inserm-02440362v1
Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients Gaël Ménasché,Jérôme Feldmann,Anne Houdusse,Catherine Desaymard,Alain Fischeret al. Blood, 2003, 101, pp.2736 - 2742. ⟨10.1182/blood-2002-09-2789⟩ Article dans une revue hal-03059374v1
Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients Gaël Ménasché,Jerome Feldmann,Anne Houdusse,Catherine Desaymard,Alain Fischeret al. Blood, 2003, 101 (7), pp.2736-2742. ⟨10.1182/blood-2002-09-2789⟩ Article dans une revue inserm-02440369v1
Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle Batiste Boëda,Aziz El-Amraoui,Amel Bahloul,Richard Goodyear,Laurent Davietet al. EMBO Journal, 2002, 21 (24), pp.6689-6699. ⟨10.1093/emboj/cdf689⟩ Article dans une revue pasteur-05017570v1
Three-dimensional structure of a heteroclitic antigen-antibody cross-reaction complex. Véronique Chitarra,Pedro M. Alzari,Graham A. Bentley,T. Narayana Bhat,Jean-Luc Eiseléet al. Proceedings of the National Academy of Sciences of the United States of America, 1993, 90 (16), pp.7711-7715. ⟨10.1073/pnas.90.16.7711⟩ Article dans une revue pasteur-03136514v1
Three-dimensional structure and antigen binding specificity of antibodies D. Tello,S. Spinelli,H. Souchon,F.A. Saul,M.M. Riottotet al. Biochimie, 1990, 72 (8), pp.507-512. ⟨10.1016/0300-9084(90)90114-v⟩ Article dans une revue istex pasteur-03136462v1

Chapitre d'ouvrage (1)

Myosin Structures. H Lee Sweeney,Anne Houdusse,Julien Robert-Paganin,H. Lee Sweeney Myosins - A Superfamily of Molecular Motors, 1239, pp.7-19, 2020, ⟨10.1007/978-3-030-38062-5_2⟩ Chapitre d'ouvrage hal-03053363v1

Pré-publication, Document de travail (8)

Modulation of Filopodial Myosin Function Amy Crawford,Jessica K Schwartz,Emerson Hall,Anne Houdusse,Margaret A Titus 2025 Pré-publication, Document de travail hal-05264014v1
Ca 2+ regulation of Myosin II and Myosin VI during rupture of the Shigella -containing vacuole Mariette Bonnet,Chun Hui Sun,Jost Enninga,Anne Houdusse,Guy Tran van Nhieu 2024 Pré-publication, Document de travail hal-04775436v1
Development of Clinically Viable Non-Muscle Myosin II Small Molecule Inhibitors with Broad Therapeutic Potential Laszlo Radnai,Erica J Young,Carlos Kikuti,Madalyn Hafenbreidel,Rebecca F Stremelet al. 2024 Pré-publication, Document de travail hal-04775437v1
Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design Dihia Moussaoui,James Robblee,Daniel Auguin,Fabio Fisher,Patricia Fagnantet al. 2022 Pré-publication, Document de travail hal-03811821v1
Nucleotide-free structures of Kif20A illuminate the atypical allostery in this mitotic kinesin-6 Fanomezana Moutse Ranaivoson,Vincent Crozet,Matthieu P.M.H. Benoît,Amna Abdalla Mohammed Khalid,Carlos Kikutiet al. 2022 Pré-publication, Document de travail hal-03872652v1
Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition Julien Robert-Paganin,Daniel Auguin,Anne Houdusse 2020 Pré-publication, Document de travail hal-03059367v1
Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis Dihia Moussaoui,James P Robblee,Daniel Auguin,Elena B Krementsova,Silvia Haaseet al. 2020 Pré-publication, Document de travail hal-03059395v1
Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition Julien Robert-Paganin,Daniel Auguin,Anne Houdusse 2020 Pré-publication, Document de travail hal-03053365v1