Anne Lespine

146
Documents

Publications

Publications

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Studying the Contribution of P-Glycoproteins in Anthelmintic Resistance in the Nematode Model Caenorhabditis elegans

Clara Blancfuney , Eva Guchen , Marie Garcia , Elise Courtot , Roger K. Prichard et al.
ABC2025, Feb 2025, Innsbruck, Austria
Poster de conférence hal-04974223 v1
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Eprinomectin resistance in Haemonchus contortus: Phenotype, Genomic and Transcriptomic

Rémy Bétous , Robin Lioutaud , Julie Petermann , Sophie Jouffroy , Philippe Jacquiet et al.
Journées d'animation scientifique - Département Santé animale - INRAE, Sep 2024, Seignosse, France
Poster de conférence hal-04700611 v1
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Analyse transcriptomique comparative chez C. elegans résistant à l'ivermectine : l'impact du NHR-8

Lucas Barat , Rémy Bétous , Anne Lespine
JAS INRAE 2024, Sep 2024, Seignosse 'Les Tuquets', France
Poster de conférence hal-04702675 v1
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EVOLUTION OF THE NUCLEAR RECEPTOR DAF-12 IN PARASITIC NEMATODES

Rémy Bétous , Anthony Emile , Hua Che , Eva Guchen , Didier Concordet et al.
Nuclear Receptors and Metabolism. The MetNet-NuRCaMeIn-French Liaison, Oct 2023, Barcelona, Spain
Poster de conférence hal-04700573 v1
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P-Glycoproteins 6 and 9 role in ivermectin resistance in the nematode model Caenorhabditis elegans

Clara Blancfuney , Marie Garcia , Anne Lespine , Mélanie Alberich
International Congress of the European Association for Veterinary Pharmacology and Toxicology, Jul 2023, Bruges, Belgium
Poster de conférence hal-04166911 v1
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Effect of sainfoin (Onobrychis viciifolia) on cyathostomin eggs excretion, larval development, larval community structure and efficacy of ivermectin treatment in horses

Joshua Malsa , Elise Courtot , Michel Boisseau , Bertrand Dumont , Pascale Gombault et al.
Journées d’Animation Scientifique du Département Santé Animale (JAS SA), Oct 2022, Anglet, France.
Poster de conférence hal-03847631 v1

Selected resistance to macrocyclic lactone exhibit modulation of amphid structure and function at genetic level

Cécile Menez , Cristina Ballesteros , Ludmel Urdaneta-Marquez , Roger K. Prichard , Anne Lespine
Molecular Anthelmintics: from Discovery to Resistance, Feb 2020, santa monica, United States
Poster de conférence hal-02958028 v1
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Rapid selection of multiple-resistance to eprinomectin and benzimidazole in a dairy goat farm

Léa Bordes , Nicolas Dumont , Anne Lespine , Elise Souil , Jean-Francois Sutra et al.
27th Conference of the World Association for the Advancement of Veterinary Parasitology, Jul 2019, Madison, WI, USA, United States
Poster de conférence hal-04632464 v1

Le récepteur nucléaire NRH-8 : une nouvelle cible pour augmenter l’efficacité de l’ivermectine chez les nématodes

Cécile Ménez , Mélanie Alberich , Elise Courtot , Sylvie Dervins , Fabrice Guégnard et al.
Journées d'Animation Scientifique du Département Santé Animale, Oct 2018, Nantes, France. , 2018, Santé Animale et Santé Publique
Poster de conférence hal-02734278 v1

Resistance to macrocyclic lactones: Is there a fitness cost of acquired tolerance to ivermectin and moxidectin in Caenorhabditis elegans?

Cécile Menez , Dalia Kansoh , Jean-Francois Sutra , Anne Lespine
Molecular Anthelmintics: from Discovery to Resistance, Feb 2016, San Diego, United States
Poster de conférence hal-02958055 v1

In vitro comparison of the effect of flavonoids in anthelmintic resistant and susceptible isolates of Haemonchus contortus: preliminary results

Guillaume Salle Sallé , Cédric Neveu , Herve Hoste , Anne Lespine
BSP Bristol 2013, Apr 2013, Bristol, United Kingdom. 156 p., 2013
Poster de conférence hal-02746557 v1

Modulation des ABC transporteurs par les lactones macrocycliques : implication des récepteurs nucléaires ?

Cécile Menez-Berlioz , Laila Mselli-Lakhal , M Alvinerie , Anne Lespine
Journées d’Animation Scientifique du Département Santé Animale, 2009, Port d'Albret, France. pp.Inconnu, 2009
Poster de conférence hal-02815467 v1

Médicaments antiparasitaires et ABC transporteurs

Solange Kiki-Mvouaka , M Alvinerie , Anne Lespine
Journées d’Animation Scientifique du Département Santé Animale, 2009, Port d'Albret, France. pp.Inconnu, 2009
Poster de conférence hal-02814455 v1

Interaction of the anthelmintic ivermectin with breast-cancer resistant protein (BCRP)

Anne Lespine , E Kis , T Nagy , Jacques Dupuy , S Orlowski et al.
FEBS-ABC2008 Meeting, 2008, Innsbruck, Austria. pp.Inconnu, 2008
Poster de conférence hal-02818058 v1

P-gp interfering agents potentiate ivermectin susceptibility in nematode ivermectin-resistant strains

Anne Lespine , D Bartley , Jacques Dupuy , M Alvinerie , Frank Jackson
21st International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), 2007, Ghent, Belgium. pp.Inconnu, 2007
Poster de conférence hal-02816515 v1

Differences between ivermectin and moxidectin related to their affinities for multidrug resistance proteins (MRP1, 2 and 3)

Anne Lespine , Jacques Dupuy , Peter Krajcsi , M Alvinerie
International Society of the Study of Xenobiotics, 2006, Manchester, United Kingdom. pp.Inconnu, 2006
Poster de conférence hal-02816155 v1

Role of he P-glycoprotein in the cellular efflux of the mocrcyclic lactones (MLs) Influence of interfering agents

Anne Lespine , J Dupuis , Alain Roulet , Thierry Pineau , M Alvinerie
EU-FEBS Conference, 2004, Copenhagen, Denmark. pp.Inconnu, 2004
Poster de conférence hal-02828610 v1

Putative prediction of macrocyclic lactones in vivo-disposition using an original pharmacological parameter (Vp50) obtained from transport experiments in P-glycoprotein-expressing cells

Alain Roulet , Alain Bousquet‐mélou , Didier Concordet , Jacques Dupuy , Anne Lespine et al.
19th International Conference of the World Association for the Advancement of Veterinary Parasitology, 2003, New Orleans, United States. pp.Inconnu, 2003
Poster de conférence hal-02829746 v1

P-glycoproteins in anthelmintic safety, efficacy, and resistance

Anne Lespine , Clara Blancfuney , Roger Prichard , Mélanie Alberich
Trends in Parasitology, 2024, ⟨10.1016/j.pt.2024.07.008⟩
Article dans une revue hal-04680676 v1
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Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy‐coupling factor transporters (ECFTs)

Jörg Haupenthal , Muhammad Rafehi , Andreas M Kany , Anne Lespine , Katja Stefan et al.
Archiv der Pharmazie / Chemistry in Life Sciences, 2024, 357 (9), ⟨10.1002/ardp.202400267⟩
Article dans une revue hal-04986309 v1
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Filarial DAF-12 sense the host serum to resume iL3 development during infection

Rémy Bétous , Anthony Emile , Hua Che , Eva Guchen , Didier Concordet et al.
PLoS Pathogens, 2023, 19 (6), pp.e1011462. ⟨10.1371/journal.ppat.1011462⟩
Article dans une revue hal-04169441 v1
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A device to simulate contaminant transfer and surface and subsurface flow through intact soil monoliths

Nico Hachgenei , Guillaume Nord , Lorenzo Spadini , Henri Mora , François Courvoisier et al.
Vadose Zone Journal, 2022, 21 (2), ⟨10.1002/vzj2.20184⟩
Article dans une revue hal-03715127 v1
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Effect of sainfoin ( Onobrychis viciifolia ) on cyathostomin eggs excretion, larval development, larval community structure and efficacy of ivermectin treatment in horses

Joshua Malsa , Elise Courtot , Michel Boisseau , Bertrand Dumont , Pascale Gombault et al.
Parasitology, 2022, 149 (11), pp.1439-1449. ⟨10.1017/S0031182022000853⟩
Article dans une revue hal-03753744 v1
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Lack of efficacy of topical administration of eprinomectin against gastrointestinal nematode in a French dairy sheep farm: A case of underexposure of worms

Léa Bordes , Denis Ticoulet , Jean-François Sutra , Anne Lespine , Philippe Jacquiet
Veterinary Record Case Reports, 2022, 10, pp.e435. ⟨10.1002/vrc2.435⟩
Article dans une revue hal-03832199 v1
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Genetic polymorphism, constitutive expression and tissue localization of Dirofilaria immitis P-glycoprotein 11: a putative marker of macrocyclic lactone resistance

Emily Curry , Roger Prichard , Anne Lespine
Parasites & Vectors, 2022, 15 (1), pp.482. ⟨10.1186/s13071-022-05571-6⟩
Article dans une revue hal-04019855 v1
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Ivermectin treatment in lactating mares results in suboptimal ivermectin exposure in their suckling foals

Ghismon-De-Kasin Mayinda , Delphine Serreau , Amandine Gesbert , Fabrice Reigner , Jean-François Sutra et al.
Veterinary Parasitology, 2021, 296, 5 p. ⟨10.1016/j.vetpar.2021.109511⟩
Article dans une revue hal-03282424 v1
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Ivermectin as a potential treatment for COVID-19?

Olivier Chosidow , Charlotte Bernigaud , Didier Guillemot , Bruno Giraudeau , Anne Lespine et al.
PLoS Neglected Tropical Diseases, 2021, 15 (6), pp.e0009446. ⟨10.1371/journal.pntd.0009446⟩
Article dans une revue hal-03246642 v1

A Large Impact of Obesity on the Disposition of Ivermectin, Moxidectin and Eprinomectin in a Canine Model: Relevance for COVID-19 Patients

Alain Bousquet-Mélou , Anne Lespine , Jean-François Sutra , Isabelle Bargues , Pierre-Louis Toutain
Frontiers in Pharmacology, 2021, 12, ⟨10.3389/fphar.2021.666348⟩
Article dans une revue hal-03260114 v1

P-glycoprotein (ABCB1) is involved in vitamin K efflux

Marielle Margier , Cedric Le May , Tiffany Antoine , Charlotte Halimi , Marion Nowicki et al.
Food Chemistry, 2021, 343, pp.1-5. ⟨10.1016/j.foodchem.2020.128510⟩
Article dans une revue hal-03012693 v1

Serious Ivermectin Toxicity and Human ABCB1 Nonsense Mutations

Eloise Baudou , Anne Lespine , Geneviève Durrieu , François André , Peggy Gandia et al.
New England Journal of Medicine, 2020, 383 (8), pp.787--789. ⟨10.1056/NEJMc1917344⟩
Article dans une revue hal-02928174 v1
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The development of the dog heartworm is highly sensitive to sterols which activate the orthologue of the nuclear receptor DAF‑12.

Thavy Long , Mélanie Alberich , François André , Cécile Menez , Roger K Prichard et al.
Scientific Reports, 2020, 10 (1), pp.11207. ⟨10.1038/s41598-020-67466-9⟩
Article dans une revue hal-02957764 v1
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First report of multiple resistance to eprinomectin and benzimidazole in Haemonchus contortus on a dairy goat farm in France

Léa Bordes , Nicolas Dumont , Anne Lespine , Elise Souil , Jean-François Sutra et al.
Parasitology International, 2020, 76, pp.102063. ⟨10.1016/j.parint.2020.102063⟩
Article dans une revue hal-03464522 v1

Scabies in an obese patient: How should the ivermectin dosing be adapted?

G Mellon , L Hermet , Pierre-Louis Toutain , A Dulioust , Anne Lespine
Médecine et Maladies Infectieuses, 2019, 49 (4), pp.286-288. ⟨10.1016/j.medmal.2018.09.007⟩
Article dans une revue hal-02618679 v1

Assessment of the long-acting ivermectin formulation in sheep: Further insight into potential pharmacokinetic interactions

Mariana Ballent , Maria Laura Maté , Paula Dominguez , Guillermo Virkel , Mélanie Alberich et al.
Journal of Veterinary Pharmacology and Therapeutics, 2019, 42 (2), pp.189-196. ⟨10.1111/jvp.12739⟩
Article dans une revue hal-02618035 v1
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The transcription factor NHR-8: A new target to increase ivermectin efficacy in nematodes

Cécile Ménez , Mélanie Alberich , Elise Courtot , Fabrice Guégnard , Alexandra Blanchard et al.
PLoS Pathogens, 2019, 15 (2), 31 p. ⟨10.1371/journal.ppat.1007598⟩
Article dans une revue hal-02628877 v1
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ABCB1 (P-glycoprotein) regulates vitamin D absorption and contributes to its transintestinal efflux

Marielle Margier , Xavier Collet , Cedric Le May , Charles Desmarchelier , François André et al.
FASEB Journal, 2019, 33 (2), pp.2084-2094. ⟨10.1096/fj.201800956R⟩
Article dans une revue hal-01986017 v1
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Efficacy and pharmacokinetics evaluation of a single oral dose of afoxolaner against <em>Sarcoptes scabiei</em> in the porcine Scabies model for human infestation

Charlotte Bernigaud , Fang Fang , Katja Fischer , Anne Lespine , Ludwig S. Aho et al.
Antimicrobial Agents and Chemotherapy, 2018, 62 (9), ⟨10.1128/AAC.02334-17⟩
Article dans une revue hal-02627327 v1
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Structural model, functional modulation by ivermectin and tissue localization of Haemonchus contortus P-glycoprotein-13

Marion David , Chantal Lebrun , Thomas Duguet , Franck Talmont , Robin Beech et al.
International journal for parasitology. Drugs and drug resistance, 2018, 8 (1), pp.145--157. ⟨10.1016/j.ijpddr.2018.02.001⟩
Article dans une revue hal-02177610 v1
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P-glycoproteins play a role in ivermectin resistance in cyathostomins

L.E. Peachey , G.L. Pinchbeck , J.B. Matthews , F.A. Burden , Anne Lespine et al.
International journal for parasitology. Drugs and drug resistance, 2017, 7 (3), pp.388-398. ⟨10.1016/j.ijpddr.2017.10.006⟩
Article dans une revue hal-02620683 v1
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Cross-resistance to moxidectin and ivermectin on a meat sheep farm in France

Carine Paraud , T. Marcotty , Anne Lespine , Jean-Francois Sutra , I. Pors et al.
Veterinary Parasitology, 2016, 226, pp.88-92. ⟨10.1016/j.vetpar.2016.06.033⟩
Article dans une revue hal-02633599 v1
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Preclinical study of single-dose moxidectin, a new oral treatment for scabies: Efficacy, safety, and pharmacokinetics compared to two-Ddose Iiermectin in a porcine model

Charlotte Bernigaud , Fang Fang , Katja Fischer , Anne Lespine , Ludwig Serge Aho et al.
PLoS Neglected Tropical Diseases, 2016, 10 (10), ⟨10.1371/journal.pntd.0005030⟩
Article dans une revue hal-01608099 v1

Acquired tolerance to ivermectin and moxidectin after drug selection pressure in the nematode <em>Caenorhabditis elegans</em>

Cécile Menez , Mélanie Alberich , Dalia Kansoh , Alexandra Blanchard , Anne Lespine
Antimicrobial Agents and Chemotherapy, 2016, 60 (8), pp.4809-4819. ⟨10.1128/AAC.00713-16⟩
Article dans une revue hal-02634646 v1

Efficacy of sainfoin (Onobrychis viciifolia) pellets against multi resistant Haemonchus contortus and interaction with oral ivermectin: Implications for on-farm control

Elodie Gaudin , Margaux Simon , Jessica Quijada , Francois F. Schelcher , Jean-Francois Sutra et al.
Veterinary Parasitology, 2016, 227, pp.122-129. ⟨10.1016/j.vetpar.2016.08.002⟩
Article dans une revue hal-02633792 v1
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In silico analysis of the binding of anthelmintics to Caenorhabditis elegansP-glycoprotein 1.

Marion A. David , Stéphane Orlowski , Roger K. Prichard , Shaima Hashem , François André et al.
International journal for parasitology. Drugs and drug resistance, 2016, 6 (3), pp.299-313. ⟨10.1016/j.ijpddr.2016.09.001⟩
Article dans une revue hal-01451654 v1

Kinetics and anthelmintic efficacy of topical eprinomectin when given orally to goats

Chloé Badie , Anne Lespine , Jacques Devos , Jean-Francois Sutra , Christophe Chartier
Veterinary Parasitology, 2015, 209 (1-2), pp.56-61. ⟨10.1016/j.vetpar.2015.02.013⟩
Article dans une revue hal-02637782 v1

Ivermectin exposure leads to up-regulation of detoxification genes in vitro and in vivo in mice

Mélanie Alberich , Cécile Menez , Jean-Francois Sutra , Anne Lespine
European Journal of Pharmacology, 2014, 740, pp.428 - 435. ⟨10.1016/j.ejphar.2014.06.052⟩
Article dans une revue hal-02634112 v1
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Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions

Andrew C. Kotze , Peter W. Hunt , Philip Skuce , Georg von Samson-Himmelstjerna , Richard J. Martin et al.
International Journal for Parasitology, 2014, 4 (3), pp.164-184. ⟨10.1016/j.ijpddr.2014.07.007⟩
Article dans une revue (article de synthèse) hal-02639668 v1

Persistent coma in<em> Strongyloides</em> hyperinfection syndrome associated with persistently increased ivermectin levels

David J. van Westerloo , Gijs W. Landman , Roger Prichard , Anne Lespine , Leo G. Visser
Clinical Infectious Diseases, 2014, 58 (1), pp.143-144. ⟨10.1093/cid/cit656⟩
Article dans une revue hal-02634358 v1
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Exposition alimentaire aux pesticides seuls ou en mélange : caractérisation métabolique et impact sur la barrière intestinale

Métais Benjamin , Edwin Fouché , Anne Lespine , Anne Galinier , Sutra Jean-François et al.
Innovations Agronomiques, 2013, 28, pp.49-57. ⟨10.17180/f0k6-he23⟩
Article dans une revue hal-04537730 v1

Lipid-like properties and pharmacology of the anthelmintic macrocyclic lactones

Anne Lespine
Expert Opinion on Drug Metabolism and Toxicology, 2013, 9 (12), pp.1581-1595. ⟨10.1517/17425255.2013.832200⟩
Article dans une revue hal-02646036 v1

Transintestinal Cholesterol Excretion Is an Active Metabolic Process Modulated by PCSK9 and Statin Involving ABCB1

Cedric Le May , Jean Mathieu Berger , Anne Lespine , Bruno Pillot , Xavier Prieur et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33 (7), pp.1484-1493. ⟨10.1161/ATVBAHA.112.300263⟩
Article dans une revue hal-03013326 v1

Transintestinal Cholesterol Excretion Is an Active Metabolic Process Modulated by PCSK9 and Statin Involving ABCB1

Cedric Le May , Jean Mathieu Berger , Anne Lespine , Bruno Pillot , Xavier Prieur et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33 (7), pp.1484 - 1493. ⟨10.1161/ATVBAHA.112.300263⟩
Article dans une revue hal-02650431 v1
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Relative Neurotoxicity of Ivermectin and Moxidectin in Mdr1ab (-/-) Mice and Effects on Mammalian GABA(A) Channel Activity

Cécile Menez-Berlioz , Jean-Francois Sutra , Roger Prichard , Anne Lespine
PLoS Neglected Tropical Diseases, 2012, 6 (11), ⟨10.1371/journal.pntd.0001883⟩
Article dans une revue hal-02644560 v1

Endectocides in goats: pharmacology, efficacy and use conditions in the context of anthelmintic resistance

Anne Lespine , Christophe Chartier , Herve Hoste , Roger Alvinerie
Small Ruminant Research, 2012, 103 (1), pp.10-17. ⟨10.1016/j.smallrumres.2011.10.013⟩
Article dans une revue istex hal-02651501 v1

Characterisation of macrocyclic lactone resistance in two field-derived isolates of Cooperia oncophora

Dj Bartley , C.L Mcarthur , L.M Devin , Jean-Francois Sutra , A.A Morrison et al.
Veterinary Parasitology, 2012, 190 (3-4), pp.454-460. ⟨10.1016/j.vetpar.2012.07.022⟩
Article dans une revue istex hal-02652074 v1
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P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: Prospects for reversing transport-dependent anthelmintic resistance

Roger K. Prichard , Cécile Menez-Berlioz , Anne Lespine
International journal for parasitology. Drugs and drug resistance, 2012, 2, pp.58 - 75. ⟨10.1016/j.ijpddr.2011.10.001⟩
Article dans une revue hal-02645017 v1
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Influence of Pluronic 85 and ketoconazole on disposition and efficacy of ivermectin in sheep infected with a multiple resistant Haemonchus contortus isolate

Dj Bartley , A.A Morrison , Jacques Dupuy , Y Bartley , Jean-Francois Sutra et al.
Veterinary Parasitology, 2012, 187 (3-4), pp.464-472. ⟨10.1016/j.vetpar.2012.02.011⟩
Article dans une revue hal-01222889 v1
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Moxidectin and the avermectins: Consanguinity but not identity

Roger Prichard , Cécile Menez-Berlioz , Anne Lespine
International journal for parasitology. Drugs and drug resistance, 2012, 2, pp.134 - 153. ⟨10.1016/j.ijpddr.2012.04.001⟩
Article dans une revue hal-02649069 v1
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Ivermectin induces P-glycoprotein expression and function through mRNA stabilization in murine hepatocyte cell line

Cécile Menez-Berlioz , Laila Mselli-Lakhal , Magali Vignault-Foucaud , Patrick Balaguer , Roger Alvinerie et al.
Biochemical Pharmacology, 2012, 83 (2), pp.269-278. ⟨10.1016/j.bcp.2011.10.010⟩
Article dans une revue hal-01191347 v1
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P-glycoprotein Dysfunction Contributes to HepaticSteatosis and Obesity in Mice

Magali Vignault-Foucaud , Zeina Soayfane , Cécile Menez-Berlioz , Justine Bertrand-Michel , Pascal G.P. Martin et al.
PLoS ONE, 2011, 6 (9), pp.e23614
Article dans une revue hal-01137178 v1
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Ivermectin Interacts With Human ABCG2

Marton Jani , Ildiko Makai , Emese Kis , Pal Szabo , Tunde Nagy et al.
Journal of Pharmaceutical Sciences, 2011, 100 (1), pp.94-97. ⟨10.1002/jps.22262⟩
Article dans une revue istex hal-02645949 v1
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P-glycoprotein Dysfunction Contributes to Hepatic Steatosis and Obesity in Mice

Magali Vignault-Foucaud , Zeina Soayfane , Cécile Menez-Berlioz , Justine Bertrand-Michel , Pascal Guy et al.
PLoS ONE, 2011, 6 (9), ⟨10.1371/journal.pone.0023614⟩
Article dans une revue hal-02650319 v1

Interaction of anthelmintic drugs with P-glycoprotein in recombinant LLC-PK1-mdr1a cells

Jacques Dupuy , Michel Alvinerie , Cécile Menez , Anne Lespine
Chemico-Biological Interactions, 2010, 186 (3), pp.280-286. ⟨10.1016/j.cbi.2010.05.013⟩
Article dans une revue istex hal-02663660 v1

Role of P-Glycoprotein in the Disposition of Macrocyclic Lactones: A Comparison between Ivermectin, Eprinomectin, and Moxidectin in Mice

Solange Kiki-Mvouaka , Cécile Menez , Christiane Borin , Faouzi Lyazrhi , Magali Vignault-Foucaud et al.
Drug Metabolism and Disposition, 2010, 38 (4), pp.573-580. ⟨10.1124/dmd.109.030700⟩
Article dans une revue hal-02663207 v1

Interaction of macrocyclic lactones with the multidrug transporters: The bases of the pharmacokinetics of lipid-like drugs

Anne Lespine , Jacques Dupuy , M Alvinerie , Christine Coméra , T Nagy et al.
Current Drug Metabolism, 2009, 10 (3), pp.272-288
Article dans une revue (article de synthèse) hal-02655821 v1

P-glycoprotein interfering agents potentiate ivermectin susceptibility in ivermectin sensitive and resistant isolates of Teladorsagia circumcincta and Haemonchus contortus

D.J. Bartley , H. Mcallister , Y. Bartley , Jacques Dupuy , Cécile Menez-Berlioz et al.
Parasitology, 2009, 136 (9), pp.1081-1088. ⟨10.1017/S0031182009990345⟩
Article dans une revue istex hal-02662392 v1

Influence of obesity on the pharmacokinetics of anthelmintic macrocyclic lactones in dogs

I Bargues , Anne Lespine , Pierre-Louis Toutain , Alain Bousquet‐mélou
Journal of Veterinary Pharmacology and Therapeutics, 2009, 32 (s1), pp.161-162
Article dans une revue hal-02654350 v1

Ketoconazole increases the plasma levels of ivermectin in sheep

Roger Alvinerie , Jacques Dupuy , Solange Kiki-Mvouaka , Jf Sutra , Anne Lespine
Veterinary Parasitology, 2008, 157 (1-2), pp.117-122. ⟨10.1016/j.vetpar.2008.06.017⟩
Article dans une revue istex hal-02658693 v1

Pharmacologie et efficacité des endectocides chez les caprins

C Chartier , Anne Lespine , Herve Hoste , M.A Alvinerie
Bulletin des G.T.V., 2008, 44, pp.119-124
Article dans une revue hal-02654601 v1

ABC transporter modulation: a strategy to enhance the activity of macrocyclic lactone anthelmintics

Anne Lespine , Roger Alvinerie , Jozef Vercruysse , Roger K. Prichard , Peter Geldhof
Trends in Parasitology, 2008, 24 (7), pp.293-298. ⟨10.1016/j.pt.2008.03.011⟩
Article dans une revue istex hal-02662487 v1

Les endectocides chez les caprins : pharmacologie, efficacité et conditions d'utilisation dans le contexte de la résistance aux anthelminthiques

C Chartier , Anne Lespine , Herve Hoste , M Alvinerie
Bulletin des G.T.V., 2008, pp.Inconnu
Article dans une revue hal-02654687 v1
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Multiple oral dosing of ketoconazole increases dog exposure to ivermectin

C Hugnet , Anne Lespine , Roger Alvinerie
Journal of Pharmacy and Pharmaceutical Sciences, 2007, 10 (3), pp.311-318
Article dans une revue hal-02655765 v1

Estimation of absolute oral bioavailability of moxidectin in dogs using a semi-simultaneous method: influence of lipid co-administration.

Elodie Lallemand , Anne Lespine , Michel Alvinerie , Alain Bousquet‐mélou , Pierre-Louis Toutain
Journal of Veterinary Pharmacology and Therapeutics, 2007, 30 (5), pp.375-80. ⟨10.1111/j.1365-2885.2007.00878.x⟩
Article dans une revue istex hal-00517557 v1

Interaction of macrocyclic lactones with P-glycoprotein : Structure - affinity relationship Eur

Anne Lespine , S. Martin , J. Dupuy , A. Roulet , T. Pineau et al.
Journal of Pharmaceutical Sciences, 2007, pp.84-94
Article dans une revue hal-00207662 v1

Interaction of macrocyclic lactones with P-glycoprotein: Structure-affinity relationship

Anne Lespine , Sylvie Martin , Jacques Dupuy , Alain Roulet , Thierry Pineau et al.
European Journal of Pharmaceutical Sciences, 2007, 30 (1), pp.84-94. ⟨10.1016/j.ejps.2006.10.004⟩
Article dans une revue istex hal-02668370 v1

The interaction between moxidectin and MDR transporters in primary cultures of rat hepatocytes

Jacques Dupuy , Anne Lespine , Jf Sutra , M Alvinerie
Journal of Veterinary Pharmacology and Therapeutics, 2006, 29 (2), pp.107-111
Article dans une revue hal-02661548 v1

Contribution of lymphatic transport to the systemic exposure of orally administered moxidectin in conscious lymph duct-cannulated dogs.

Anne Lespine , Guillaume Chanoit , Alain Bousquet‐mélou , Elodie Lallemand , Firas Mohamad Bassissi et al.
European Journal of Pharmaceutical Sciences, 2006, 27 (1), pp.37-43. ⟨10.1016/j.ejps.2005.08.003⟩
Article dans une revue istex hal-00517563 v1

Fumagillin, a new P-glycoprotein-interfering agent able to modulate moxidectin efflux in rat hepatocytes

Jacques Dupuy , Anne Lespine , Jean-Francois Sutra , Roger Alvinerie
Journal of Veterinary Pharmacology and Therapeutics, 2006, 29 (6), pp.489-494
Article dans une revue hal-02655459 v1

Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3)

Anne Lespine , Jacques Dupuy , S Orlowski , T Nagy , H Glavinas et al.
Chemico-Biological Interactions, 2006, 159 (3), pp.169-179. ⟨10.1016/j.cbi.2005.11.002⟩
Article dans une revue istex hal-02661667 v1

Influence of dyslipidemia on moxidectin distribution in plasma lipoproteins and on its pharmacokinetics

Mf Bassissi , Roger Alvinerie , Pgp Martin , B Perret , Anne Lespine
Pharmaceutical Research, 2006, 23 (11), pp.2672-2680. ⟨10.1007/s11095-006-9114-2⟩
Article dans une revue istex hal-02658696 v1

Assessment of a liposomal formulation of ivermectin in rabbit after a single subcutaneous administration

Mohamad Firas Bassissi , Anne Lespine , Roger Alvinerie
Parasitology Research, 2006, 98 (3), pp.244-249. ⟨10.1007/s00436-005-0073-z⟩
Article dans une revue istex hal-02659880 v1

Influence of the route of administration on efficacy and tissue distribution of ivermectin in goat

Anne Lespine , M Alvinerie , Jf Sutra , I Pors , C Chartier
Veterinary Parasitology, 2005, 128 (3-4), pp.251-260. ⟨10.1016/j.vetpar.2004.11.028⟩
Article dans une revue istex hal-02683370 v1

Enhancement of oral moxidectin bioavailability in rabbits by lipid co-administration

Mohamad Firas Bassissi , Anne Lespine , Roger Alvinerie
Parasitology Research, 2004, 94 (3), pp.188-192. ⟨10.1007/s00436-004-1192-7⟩
Article dans une revue istex hal-02679907 v1

Macrocyclic lactones: distribution in plasma lipoproteins of several animal species including humans

Mf Bassissi , Roger Alvinerie , Anne Lespine
Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology, 2004, 138 (4), pp.437-444. ⟨10.1016/j.cca.2004.07.011⟩
Article dans une revue istex hal-02680351 v1

The influence of parasitism on the pharmacokinetics of moxidectin in lambs

Anne Lespine , J.F. Sutra , J. Dupuy , M. Alvinerie , Gilles Aumont
Parasitology Research, 2004, 93, pp.121-126
Article dans une revue hal-02669260 v1

The influence of parasitism on the pharmacokinetics of moxidectin in lambs

Anne Lespine , Jf Sutra , Jacques Dupuy , M Alvinerie , Gilles Aumont
Parasitology Research, 2004, 93 (2), pp.121-126. ⟨10.1007/s00436-004-1084-x⟩
Article dans une revue istex hal-02680452 v1

Efficacy of eprinomectin pour-on against gastrointestinal nematodes and the nasal bot fly (Oestrus ovis) in sheep

Herve Hoste , Anne Lespine , P Lemercier , M Alvinerie , Philippe P. Jacquiet et al.
Veterinary Record, 2004, 154 (25), pp.782-785
Article dans une revue hal-02672817 v1

The comparative serum disposition kinetics of subcutaneous administration of doramectin, ivermectin and moxidectin in the Australian Merino sheep

S Barber , V Bowles , Anne Lespine , Roger Alvinerie
Journal of Veterinary Pharmacology and Therapeutics, 2003, 26 (5), pp.343-348
Article dans une revue hal-02675599 v1

Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin

Jacques Dupuy , G Larrieu , Jf Sutra , Anne Lespine , M Alvinerie
Veterinary Parasitology, 2003, 112 (4), pp.337-347. ⟨10.1016/S0304-4017(03)00008-6⟩
Article dans une revue istex hal-02683396 v1

Pharmacokinetics of ivermectin in the yak (Bos grunniens)

Jacques Dupuy , H. Yin , J.X. Luo , D.Y. Yang , G.Q. Guan et al.
Veterinary Parasitology, 2003, 117, pp.153-157. ⟨10.1016/j.vetpar.2003.07.025⟩
Article dans une revue istex hal-02681891 v1

Eprinomectin in goat: assessment of subcutaneous administration

Anne Lespine , Jean-Francois Sutra , Jacques Dupuy , Roger Alvinerie
Parasitology Research, 2003, 89 (2), pp.120-122. ⟨10.1007/s00436-002-0727-z⟩
Article dans une revue istex hal-02680249 v1

Efficacy of injectable and pour-on microdose ivermectin in the treatment of goat warble fly infestation by Przhevalskiana silenus (Diptera, Oestridae)

A. Giangaspero , M. Alvinerie , D. Traversa , B. Paoletti , Anne Lespine et al.
Veterinary Parasitology, 2003, 116, pp.333-343
Article dans une revue hal-02680122 v1

Comparative Transcriptomic Analysis in Macrocyclic Lactone-Resistant C. elegans: the impact of NHR-8

Lucas Barat , Anne Lespine , Rémy Bétous
24th Drug Design & Development Seminar (DDDS) 2024, German Society for Parasitology; Ludwig-Maximilians University Würzburg, Mar 2024, Würzburg, Germany
Communication dans un congrès hal-04821507 v1

Deciphering Ivermectin Resistance: Contribution of P-Glycoproteins in Loss-of-Function Strains of Ivermectin-Resistant Caenorhabditis elegans

Clara Blancfuney , Marie Garcia , Élise Courtot , Roger Prichard , Anne Lespine et al.
Anti-Helmintics VI, Sep 2024, Toronto, Canada
Communication dans un congrès hal-04712477 v1

Lipid metabolism and resistance to ivermectin in C. elegans

Anne Lespine , Marie Garcia , Hélène Fougère , Cécile Pouzet , Mélia Lacaze et al.
ANTI-HELMINTICS VI (2024): DRUGS AND VACCINES FOR CONTROLLING NEMATODE, CESTODE AND TREMATODE PARASITES, Sep 2024, Toronto, Canada
Communication dans un congrès hal-04700601 v1

Changes in lipid metabolism in C. elegans resistant to ivermectin

Anne Lespine , Marie Garcia , Hélène Fougère , Cécile Pouzet , Mélia Lacaze et al.
The Hydra Helminth conference, Parasitic Helminths New perspectives in Biology and infection, Sep 2024, Hydra, Greece
Communication dans un congrès hal-04700590 v1

Filarial DAF-12 sense the host serum to resume iL3 development during infection

Rémy Bétous , Anthony Emile , Hua Che , Eva Guchen , Didier Concordet et al.
Les Avancées Scientifiques de la Recherche Biomédicale Toulousaine, SFR-Biologie et Biotechnologie pour la Santé (B2S), Nov 2024, Toulouse, France
Communication dans un congrès hal-04734695 v1

Comparative transcriptomic analysis in the Caenorhabditis elegans parasite model: impact of NHR-8

Lucas Barat , Rémy Bétous , Anne Lespine
13èmes journées du CaPF, Consortium Antiparasitaire et Antifongique, May 2024, TOULOUSE, France
Communication dans un congrès hal-04700582 v1

O75 | Pharmacodynamic and phenotypic evaluation of eprinomectin resistant Haemonchus isolates from French dairy sheep farms

Anne Lespine , Sophie Jouffroy , J. Petterman , Marie Garcia , Christelle Grisez et al.
15th International Congress of the European Association for Veterinary Pharmacology and Toxicology, European Association of Veterinary Pharmacology and Toxicology (EAVPT), Jul 2023, Bruges, Belgium. pp.65-65, ⟨10.1111/jvp.13241⟩
Communication dans un congrès hal-04181004 v1

Filarial DAF-12 sense Δ4-dafachronic acid in host serum to resume iL3 development during infection

Rémy Bétous , Anthony Emile , Hua Che , Didier Concordet , Thavy Long et al.
Molecular Helminthology, Makedonka Mitreva; Phil Newmark; Mostafa Zamanian, Jun 2023, Madison (WI), United States
Communication dans un congrès hal-04669372 v1

Filarial DAF-12 sense Δ4-dafachronic acid in host serum to resume iL3 development during infection

Rémy Bétous , Anthony Emile , Hua Che , Roger K. Prichard , Anne Lespine
22nd Drug Design & Development Seminar (DDDS) 2022 of the German Society for Parasitology (DGP), University of Bern, DNDi & LMU Munich, Jul 2022, Munich, Germany
Communication dans un congrès hal-04669362 v1

Filarial DAF-12 sense Δ4-dafachronic acid in host serum to resume iL3 development during infection

Rémy Bétous , Anthony Emile , Hua Che , Roger K. Prichard , Anne Lespine
Journées d’Animation Scientifique du Département Santé Animale de l'INRAE, Oct 2022, Anglet, France
Communication dans un congrès hal-04669352 v1

Anthelmintic Fluorescent drugs, new probes to detect anthelmintic resistance in the nematode Caenorhabditis elegans

Mélanie Alberich , Jean-Francois Sutra , Marlène Z Lacroix , Anne Lespine
WAAVPT 2021, Jul 2021, Dublin (Online), France
Communication dans un congrès hal-04169554 v1

Filarial DAF-12 are activated by host serum steroids belonging to the cholestenoic acid cascade

Rémy Bétous , Anthony Emile , Anne Lespine
28th Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), Jul 2021, Dublin ( virtual ), Ireland
Communication dans un congrès hal-04669336 v1

The transcription factor NHR-8 is involved in ivermectin tolerance in the model nematode Caenorhabditis elegans and in the strongylid nematode Haemonchus contortus

Cécile Menez , Mélanie Alberich , Elise Courtot , Alexandra Blanchard , Hugo Aguilaniu et al.
anthelmintics: Discovery to resistance, Jan 2018, Clearwater, United States
Communication dans un congrès hal-02929481 v1

ABCB1 is involved in vitamin D intestinal efflux

Marielle Margier , Charles Desmarchelier , Alice Bluteau , André Collet , Patrick Borel et al.
16. Fat Soluble Vitamins (FSV) congress, Société Française des Vitamines et Biofacteurs (SFVB). FRA., Mar 2017, Paris, France. 130 p
Communication dans un congrès hal-01517923 v1

Discovery of a new factor involved in ivermectin tolerance in the model nematode Caenorhabditis elegans and in the strongylid nematode Haemonchus contortus.

Cécile Menez , Mélanie Alberich , Elise Courtot , Anne Lespine
Molecular Helminthology: An Integrated Approach, Mar 2017, Cap Cod, United States
Communication dans un congrès hal-02957851 v1

The transcription factor NHR-8 is involved in ivermectin tolerance in the model nematode <em>Caenorhabditis elegans</em> and in the strongylid nematode <em>Haemonchus contortus</em>

Cécile Ménez , Mélanie Alberich , Elise Courtot , Anne Lespine
26. International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP 2017), The Malaysian Society of Parasitology & Tropical Medicine (MSPTM)., Sep 2017, Kuala Lumpur, Malaysia
Communication dans un congrès hal-02736808 v1

Comparison of ivermectin and moxidectin resistance profiles in the nematode Caenorhabditis elegans

Cécile Menez , Dalia Kansoh , Jean-Francois Sutra , Anne Lespine
International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP 2015), Aug 2015, liverpool, United Kingdom
Communication dans un congrès hal-02929510 v1

Chronic administration of ivermectin leads to a decrease of its concentration in the host

Mélanie Alberich , Cécile Menez , Anne Lespine
12. International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT 2012), Jul 2012, Noordwijkerhout, Netherlands. 182 p
Communication dans un congrès hal-02748957 v1

Comparative pharmacodynamics and pharmacokinetics of moxidectin and ivermectin endectocides: a brief update

R. K. Prichard , Anne Lespine , Cécile Menez
12. International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT 2012), Jul 2012, Noordwijkerhout, Netherlands. 182 p
Communication dans un congrès hal-02748125 v1

Differential neurotoxicity of ivermectin and moxidectin in mammals

Cécile Menez , Jean-Francois Sutra , R. K. Prichard , Anne Lespine
12. International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT 2012), Jul 2012, Noordwijkerhout, Netherlands. 182 p
Communication dans un congrès hal-02748121 v1

Interaction of anthelminthics with ABC transporters

Anne Lespine
Symposium on Membrane Ion Channels in Helminth Parasites, Resistance and Site of Action for Anthelmintics, Saisissez le nom du laboratoire, du service ou du département., Ville service., Dec 2011
Communication dans un congrès hal-02803051 v1

Optimizing anthelmintic combinations to counter anthelmintic resistance

Anne Lespine
Conference of the World Association for the Advancement of Veterinary Parasitology, Saisissez le nom du laboratoire, du service ou du département., Ville service., Aug 2011, Buenos Aires, Argentina
Communication dans un congrès hal-02802149 v1

Influence of obesity on the pharmacokinetics of anthelmintic macrocyclic lactones in dogs

I Bargues , Anne Lespine , Pierre-Louis Toutain , Alain Bousquet‐mélou
11th International congress of the European Association for Veterinary Pharmacology and Toxicology, 2009, Leipzig, Germany
Communication dans un congrès hal-02752015 v1

WP6 - Control of P-glycoprotein (Pgp) in both host and parasites for an improvement of anthelmintic treatment.

Dominique Kerboeuf , Fabrice Guégnard , Christine Koch , Yves Le Vern , Roger Alvinerie et al.
PARASOL - Sixth framework programme of the E.U. (Project FOOD-CT-2005-022851) - Novel solutions for the sustainable control of nematodes in ruminants, 2009, Edinburgh, United Kingdom. n.p
Communication dans un congrès hal-02823130 v1

Disposition of eprinomectin in P-gp deficient mice: a comparison with ivermectin and moxidectin

Solange Kiki-Mvouaka , Christiane Borin , Magali Vignault , Cécile Menez , Christine Coméra et al.
22nd World Association for the Advancement of Veterinary Parasitology Conference - WAAVP 2009, 2009, Calgary, Canada. pp.Inconnu
Communication dans un congrès hal-02815515 v1

The anthelmintic ivermectin: a substrate of Breast-Cancer Resistant Protein (BCRP)

E Kis , Sylvaine Lecoeur , Cécile Menez , T Nagy , Jacques Dupuy et al.
22nd World Association for the Advancement of Veterinary Parasitology Conference - WAAVP 2009, 2009, Calgary, Canada. pp.Inconnu
Communication dans un congrès hal-02821732 v1

Pharmacocinétique de l'éprinomectine chez les souris déficientes en P-gp : comparaison avec l'ivermectine et la moxidectine

Solange Kiki-Mvouaka , Christiane Borin , Magali Vignault-Foucaud , Cécile Menez , Christine Coméra et al.
Journées d’Animation Scientifique du Département Santé Animale, 2009, Port d'Albret, France. pp.Inconnu
Communication dans un congrès hal-02822598 v1

Interaction of macrocyclic lactones (MLs) with multidrug resistance transporters

Anne Lespine , M Alvinerie
21st International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), 2007, Ghent, Belgium. pp.Inconnu
Communication dans un congrès hal-02815063 v1

Investigations into the effects of p-glycoprotein and/or cytochrom P450 inhibitors on the phenotype responses of various developmental stages of ovine nematodes

Dj Bartley , Anne Lespine , Jacques Dupuy , M Alvinerie , H Mc Allister et al.
21st International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), 2007, Ghent, Belgium. pp.Inconnu
Communication dans un congrès hal-02814112 v1

Rôle des ABC transporteurs dans le devenir des lactones macrocycliques dans l'organisme

Anne Lespine
Journées francophones sur les transporteurs ABC, 2006, Paris, France. pp.Inconnu
Communication dans un congrès hal-02811820 v1

Interaction of MLs with ABC transporters

Anne Lespine
Invited by SOLVO Biotechnology, 2006, Budapest, Hungary. pp.Inconnu
Communication dans un congrès hal-02811791 v1

Differences between ivermectin and moxidectin related to their affinities for multidrug resistance proteins (MRP1, 2, and 3)

Anne Lespine , Jacques Dupuy , Peter Krajcsi , M Alvinerie
Inconnu, 2006, pp.Inconnu
Communication dans un congrès hal-02814340 v1

Differences between ivermectin and moxidectin related to their affinities for multidrug resistance proteins (MRP1, 2 and 3)

Anne Lespine , Jacques Dupuy , T Nagy , Peter Krajcsi , M Alvinerie
10e Congrès international de l’EAVPT, 2006, Turin, Italy. pp.Inconnu
Communication dans un congrès hal-02816593 v1

Influence of anthelmintic drugs on P-glycoprotein transport activity in mdr1-LLC-PK1 cells

Jacques Dupuy , Anne Lespine , M Alvinerie
EAVPT, 2006, Turin, Italy. pp.Inconnu
Communication dans un congrès hal-02812336 v1

The role of drug transporters in the disposition of milbemycins and avermectins

M Alvinerie , Anne Lespine
EAVPT, 2006, Turin, Italy. pp.Inconnu
Communication dans un congrès hal-02815213 v1

Influence of hypercholesterolemia on disposition of moxidectin in a rabbit model

F Bassissi , M Alvinerie , Anne Lespine
EUFEPS Conferences 3rd World Conference on Drug Absorption Transport and delivery, 2004, Barcelona, Spain. pp.Inconnu
Communication dans un congrès hal-02827470 v1

Influence of the macrocyclic lactones on the P-glycoprotein function on P-gp overexpressing cells

Anne Lespine , Jacques Dupuy , Alain Roulet , Thierry Pineau
European Federation for Pharmaceutical Sciences Conference, 2004, Copenhagen, Denmark. pp.Inconnu
Communication dans un congrès hal-02830010 v1

Hypodermosis control : determination of dose and route of administration of ivermectin microdosis to goat

M Alvinerie , Anne Lespine , Jacques Dupuy
INCO Project nICA42000-30036 meeting, 2004, Shangai, China. pp.Inconnu
Communication dans un congrès hal-02825675 v1

Eprinomectin in dairy goats : assessment of an optimal dosage

Anne Lespine , J Duupuy , Jf Sutra , M Alvinerie , C Chartier
8th International Conference on Goats, 2004, Pretoria, South Africa. pp.Inconnu
Communication dans un congrès hal-02825263 v1

Improvement of ML's treatment by control of P-glycoprotein in the host

M Alvinerie , Anne Lespine
COST - B16, 2004, Paris, France. pp.Inconnu
Communication dans un congrès hal-02825235 v1

Chemotherapy improvement for hypodermosis

M Alvinerie , Anne Lespine , Jacques Dupuy
INCO Project nICA42000-30036 meeting, 2004, Shangai, China. pp.Inconnu
Communication dans un congrès hal-02825185 v1

Intestinal lymphatic transport of moxidectin in conscious lymph duct-cannulated dogs

Anne Lespine , G Chanoit , Alain Bousquet‐mélou , Elodie Lallemand , F Bassissi et al.
EUFEPS Conferences 3rd World Conference on Drug Absorption Transport and delivery, 2004, Barcelona, Spain. pp.Inconnu
Communication dans un congrès hal-02827582 v1

Effect of route of administration and formulation on ivermectin bioavailability in Chinese cattle

M Alvinerie , Anne Lespine , Jacques Dupuy
INCO Project nICA42000-30036 meeting, 2004, Shangai, China. pp.Inconnu
Communication dans un congrès hal-02825390 v1

Role of the P-glycoprotein in the cellular eflux of macrocyclic lactones : influence of interfering agents

Anne Lespine , Alain Roulet , Jacques Dupuy , Thierry Pineau , M Alvinerie
9th EAVPT Congress, 2003, Lisbon, Portugal. pp.Inconnu
Communication dans un congrès hal-02828145 v1

Binding of ivermectin and moxidectin to the plasma lipoproteins

Anne Lespine , F Bree , F Bassissi , Jf Sutra , Jp Tillement et al.
9th EAVPT Congress, 2003, Lisbon, Portugal. pp.Inconnu
Communication dans un congrès hal-02828011 v1

Putative prediction of macrocyclic lactones in vivo-disposition using an original pharmacological parameter [Vp50] obtained from transport experiments in P-glycoprotein-expressing cells

Alain Roulet , Alain Bousquet‐mélou , Didier Concordet , Jacques Dupuy , Anne Lespine et al.
19th International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), 2003, New Orleans, United States. pp.Inconnu
Communication dans un congrès hal-02829726 v1

Use of reversing agents of P-glycoprotein to increase the systematic availability of macrocyclic lactones : a promising tool

M Alvinerie , Jacques Dupuy , Jf Sutra , Anne Lespine
19th International Conference of the World Association for the Advancement of Veterinary Parasitology, 2003, New Orleans, United States. pp.Inconnu
Communication dans un congrès hal-02825262 v1