Anne-Marie François-Bellan

CRHC INSERM
49
Documents

Présentation

Anne-Marie François-Bellan is a specialist in biological rhythms. Graduate  Doctor in Pharmacy at the Faculty of Pharmacy of Marseille in 1984, she  obtained a PhD in Neuroscience in 1988. After a post-doctorate at the  Montreal Neurological Institute in Quebec, she became a researcher in INSERM.  She currently leads a group of chronobiology at the Institute of  NeuroPhysiopathology (UMR 7051) in Marseille whose work focuses on the  molecular mechanisms of circadian clocks, with a particular interest in the  mechanisms controlling the expression of genes by their location in the cell.  This work has identified in recent years, an original mechanism that involves  nuclear subdomains called “paraspeckles” [CNRS INSB website (“Nuclear  subdomains of the cells drive the circadian expression of genes “)].

Publications

Publications

Investigation of a mouse model of Prader-Willi Syndrome with combined disruption of Necdin and Magel2

Pierre-Yves Barelle , Alicia Sicardi , Fabienne Schaller , Julie Buron , Denis Becquet et al.
JCI Insight, 2025, 10 (8), ⟨10.1172/jci.insight.185159⟩
Article dans une revue hal-05172799 v1

Investigation of a mouse model of Prader-Willi Syndrome with combined disruption of Necdin and Magel2

Pierre-Yves Barelle , Alicia Sicardi , Fabienne Schaller , Julie Buron , Denis Becquet et al.
JCI Insight, 2025, 10 (8), ⟨10.1172/jci.insight.185159⟩
Article dans une revue hal-05353839 v1

Nuclear Retention of mRNAs Through Paraspeckle Protein Binding to a Sequence Determinant in 3′UTR

Audrey Jacq , Denis Becquet , Bénédicte Boyer , Séverine Guillen , Maria-Montserrat Bello-Goutierrez et al.
International Journal of Molecular Sciences, 2025, 26 (13), pp.6488. ⟨10.3390/ijms26136488⟩
Article dans une revue hal-05172780 v1
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Direct RNA–RNA interaction between Neat1 and RNA targets, as a mechanism for RNAs paraspeckle retention

Audrey Jacq , Denis Becquet , Séverine Guillen , Bénédicte Boyer , Maria-Montserrat Bello-Goutierrez et al.
RNA Biology, 2021, pp.1-12. ⟨10.1080/15476286.2021.1889253⟩
Article dans une revue hal-03256996 v1
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Genome-wide screening of circadian and non-circadian impact of Neat1 genetic deletion

Audrey Jacq , Denis Becquet , Maria-Montserrat Bello-Goutierrez , Bénédicte Boyer , Séverine Guillen et al.
Computational and Structural Biotechnology Journal, 2021, 19, pp.2121-2132. ⟨10.1016/j.csbj.2021.04.022⟩
Article dans une revue hal-03256941 v1
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Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

Audrey Jacq , Denis Becquet , Séverine Guillen , Bénédicte Boyer , Maria-Montserrat Bello-Goutierrez et al.
Journal of visualized experiments : JoVE, 2021, 173, ⟨10.3791/62475⟩
Article dans une revue hal-03375987 v1

AMPK Activation of PGC-1α/NRF-1-Dependent SELENOT Gene Transcription Promotes PACAP-Induced Neuroendocrine Cell Differentiation Through Tolerance to Oxidative Stress

Houssni Abid , Dorthe Cartier , Abdallah Hamieh , Anne-Marie François-Bellan , Christine Bucharles et al.
Molecular Neurobiology, 2019, 56 (6), pp.4086-4101. ⟨10.1007/s12035-018-1352-x⟩
Article dans une revue hal-02375763 v1
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Manon Torres , Denis Becquet , Séverine Guillen , Bénédicte Boyer , Mathias Moreno et al.
Journal of visualized experiments : JoVE, 2018, 134, ⟨10.3791/57379⟩
Article dans une revue hal-02093065 v1

Circadian processes in the RNA life cycle

Manon Torres , Denis Becquet , Jean-Louis Franc , Anne-Marie François-Bellan
Wiley Interdisciplinary Reviews: RNA, 2018, 9 (3), pp.e1467. ⟨10.1002/wrna.1467⟩
Article dans une revue hal-02093076 v1

Paraspeckles as rhythmic nuclear mRNA anchorages responsible for circadian gene expression

Manon Torres , Denis Becquet , Marie-Pierre Blanchard , Séverine Guillen , Bénédicte Boyer et al.
Nucleus, 2017, pp.1--6. ⟨10.1080/19491034.2016.1277304⟩
Article dans une revue hal-01458094 v1
Image document

Circadian RNA expression elicited by 3’-UTR IRAlu-paraspeckle associated elements

Manon Torres , Denis Becquet , Marie-Pierre Blanchard , Séverine Guillen , Bénédicte Boyer et al.
eLife, 2016, 5, pp.e14837. ⟨10.7554/eLife.14837⟩
Article dans une revue hal-01457643 v1

Remodeling of glial coverage of glutamatergic synapses in the rat nucleus tractus solitarii after ozone inhalation.

Keodavanh Chounlamountry , Bénédicte Boyer , Virginie Penalba , Anne-Marie François-Bellan , Olivier Bosler et al.
Journal of Neurochemistry, 2015, 134 (5), pp.857-64. ⟨10.1111/jnc.13193⟩
Article dans une revue hal-01188602 v1

Structural plasticity of the circadian timing system. An overview from flies to mammals.

Olivier Bosler , Clémence Girardet , Jean-Louis Franc , Denis Becquet , Anne-Marie François-Bellan
Frontiers in Neuroendocrinology, 2015, 38, pp.50-64
Article dans une revue hal-01188628 v1

Evidence for an internal and functional circadian clock in rat pituitary cells.

Denis Becquet , Bénédicte Boyer , Ramahefarizo Rasolonjanahary , Thierry Brue , Séverine Guillen et al.
Molecular and Cellular Endocrinology, 2014, 382 (2), pp.888-98. ⟨10.1016/j.mce.2013.11.004⟩
Article dans une revue istex hal-00966197 v1

POU1F1 (POU class 1 homeobox 1)

Jean-Louis Franc , Denis Becquet , Am François‐bellan
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014, 10, ⟨10.4267/2042/54134⟩
Article dans une revue hal-01671000 v1

Brain-derived neurotrophic factor/TrkB signaling regulates daily ă astroglial plasticity in the suprachiasmatic nucleus: ă Electron-microscopic evidence in mouse

Clémence Girardet , Bruno Lebrun , Marie-Jeanne Cabirol-Pol , Catherine Ă Tardivel , Anne-Marie François-Bellan et al.
Glia, 2013, 61 (7), pp.1172-1177. ⟨10.1002/glia.22509⟩
Article dans une revue istex hal-01471940 v1

DNA microarray analysis and functional profile of pituitary transcriptome under core-clock protein BMAL1 control.

F. Guillaumond , D. Becquet , B. Boyer , O. Bosler , F. Delaunay et al.
Chronobiology International, 2012, 29 (2), pp.103-30. ⟨10.3109/07420528.2011.645707⟩
Article dans une revue hal-00700093 v1

DNA Microarray Analysis and Functional Profile of Pituitary Transcriptome Under Core-Clock Protein BMAL1 Control

Fabienne Guillaumond , D. Becquet , B. Boyer , O. Bosler , Franck Delaunay et al.
Chronobiology International, 2012, 29 (2), pp.103-130. ⟨10.3109/07420528.2011.645707⟩
Article dans une revue hal-02104796 v1

Chromatin remodeling as a mechanism for circadian prolactin transcription: rhythmic NONO and SFPQ recruitment to HLTF.

Fabienne Guillaumond , Benedicte Boyer , Denis Becquet , Severine Guillen , Lauriane Kuhn et al.
FASEB Journal, 2011, 25 (8), pp.2740-56. ⟨10.1096/fj.10-178616⟩
Article dans une revue hal-00625435 v1

Neuroglial and synaptic rearrangements associated with photic entrainment of the circadian clock in the suprachiasmatic nucleus.

Clémence Girardet , Denis Becquet , Marie-Pierre Blanchard , Anne-Marie François-Bellan , Olivier Bosler
European Journal of Neuroscience, 2010, 32 (12), pp.2133-42. ⟨10.1111/j.1460-9568.2010.07520.x⟩
Article dans une revue istex hal-00625331 v1

Daily changes in synaptic innervation of VIP neurons in the rat suprachiasmatic nucleus: contribution of glutamatergic afferents.

Clémence Girardet , Marie-Pierre Blanchard , Géraldine Ferracci , Christian Lévêque , Mathias Moreno et al.
European Journal of Neuroscience, 2010, 31 (2), pp.359-70. ⟨10.1111/j.1460-9568.2009.07071.x⟩
Article dans une revue istex hal-00482298 v1

[Mechanisms of structural plasticity associated with photic synchronization of the circadian clock within the suprachiasmatic nucleus]

Olivier Bosler , Clémence Girardet , Dominique Sage-Ciocca , Hélène Jacomy , Anne-Marie François-Bellan et al.
Journal de la Société de Biologie, 2009, 203 (1), pp.49-63. ⟨10.1051/jbio:2009004⟩
Article dans une revue istex hal-00481513 v1

Ultrastructural plasticity in the rat suprachiasmatic nucleus. Possible involvement in clock entrainment.

Denis Becquet , Clémence Girardet , Fabienne Guillaumond , Anne-Marie François-Bellan , Olivier Bosler
Glia, 2008, 56 (3), pp.294-305. ⟨10.1002/glia.20613⟩
Article dans une revue istex hal-00396981 v1

Nocturnal expression of phosphorylated‐ERK1/2 in gastrin‐releasing peptide neurons of the rat suprachiasmatic nucleus

Fabienne Guillaumond , Denis Becquet , Marie‐pierre Blanchard , Joan Attia , Mathias Moreno et al.
Journal of Neurochemistry, 2007, 101 (5), pp.1224--1235. ⟨10.1111/j.1471-4159.2006.04416.x⟩
Article dans une revue hal-01671001 v1

Vitamin A is a necessary factor for sympathetic-independent rhythmic MAPKinase activation in the rat pineal gland.

F. Guillaumond , F. Giraudet , D. Becquet , D. Sage , G. Laforge-Anglade et al.
European Journal of Neuroscience, 2005, 21, pp.798-802
Article dans une revue hal-00017708 v1

Vitamin A is a necessary factor for sympathetic‐ independent rhythmic activation of mitogen‐activated protein kinase in the rat pineal gland: Vitamin A required in pineal MAPK rhythmicity

D. Sage , G. Laforge‐anglade , O. Bosler , A. M. François‐bellan , F. Guillaumond et al.
European Journal of Neuroscience, 2005, 21 (3), pp.798--802. ⟨10.1111/j.1460-9568.2005.03901.x⟩
Article dans une revue istex hal-01671002 v1

Influence of the Corticosterone Rhythm on Photic Entrainment of Locomotor Activity in Rats

Dominique Sage , Julien Ganem , Fabienne Guillaumond , Geneviève Laforge‐anglade , Anne‐marie François‐bellan et al.
Journal of Biological Rhythms, 2004, 19 (2), pp.144-156. ⟨10.1177/0748730403261894⟩
Article dans une revue hal-01671003 v1

Adrenergic inducibility of AP‐1 binding in the rat pineal gland depends on prior photoperiod

Fabienne Guillaumond , D. Becquet , O. Bosler , A. M. François‐bellan
Journal of Neurochemistry, 2002, 83 (1), pp.157-166. ⟨10.1046/j.1471-4159.2002.01140.x⟩
Article dans une revue hal-01671004 v1

Long‐term variations of AP‐1 composition after CRH stimulation: consequence on POMC gene regulation

D. Becquet , Anne-Marie François-Bellan , O. Bosler , Fabienne Guillaumond
Molecular and Cellular Endocrinology, 2001, 175 (1-2), pp.93--100
Article dans une revue hal-01671005 v1

Circadian Binding Activity of AP‐1, a Regulator of the Arylalkylamine N‐Acetyltransferase Gene in the Rat Pineal Gland, Depends on Circadian Fra‐2, c‐Jun, and Jun‐D Expression and Is Regulated by the Clock's Zeitgebers

F. Guillaumond , D. Sage , P. Deprez , O. Bosler , D. Becquet et al.
Journal of Neurochemistry, 2000, 75 (4), pp.1398--1407
Article dans une revue hal-01671957 v1

Light‐Induced Variations in AP‐1 Binding Activity and Composition in the Rat Suprachiasmatic Nucleus

Anne-Marie François-Bellan , P. Deprez , D. Becquet
Journal of Neurochemistry, 1999, 72 (2), pp.841--847. ⟨10.1046/j.1471-4159.1999.0720841.x⟩
Article dans une revue hal-01671958 v1

Indirect evidence for an association of 5-HT1B binding sites with retinal and geniculate axon terminals in the rat suprachiasmatic nucleus

Anne-Marie François-Bellan , C. Manrique , F. Héry , M. Faudon, , A.M. François-Bellan
Article dans une revue istex hal-03606866 v1

Post‐lesion up‐regulation of 5‐HT1B binding sites in the suprachiasmatic nucleus may be reversed after spontaneous or graft‐induced serotonin reinnervation

C. Manrique , O. Bosler , D. Becquet , F. Héry , M. Faudon et al.
Brain Research, 1998, 788 (1-2), pp.332--336
Article dans une revue hal-01671960 v1

Serotonin directly stimulates luteinizing hormone‐releasing hormone release from GT1 cells via 5‐HT7 receptors

M. Héry , Anne-Marie François-Bellan , F. Héry , P. Deprez , D. Becquet
Endocrine, 1997, 7 (2), pp.261--265
Article dans une revue hal-01671961 v1

8-OH-DPAT regulates the amplitude and the phase of LH surge in ovariectomized steroid-primed rats

M. Héry , Anne-Marie François-Bellan , F. Héry
Endocrine, 1995, 3 (10), pp.751-754. ⟨10.1007/BF03000208⟩
Article dans une revue istex hal-03606867 v1

Evidence for the presence of noradrenergic neurons and their inhibitory action on luteinizing hormone-releasing hormone release in cultured fetal rat hypothalamic cells

Anne-Marie François-Bellan , Micheline Héry , Anne Marie François-Bellan , Paule Deprez , Maxime Faudon et al.
Life Sciences, 1993, 52 (25), pp.2017-2025. ⟨10.1016/0024-3205(93)90686-w⟩
Article dans une revue istex hal-03606864 v1

Increase of central 5-HT1B binding sites following 5,7-dihydroxytryptamine axotomy in the adult rat

Anne-Marie François-Bellan , C. Manrique , L. Segu , M. Héry , M. Faudon et al.
Brain Research, 1993, 623 (2), pp.345-348. ⟨10.1016/0006-8993(93)91452-x⟩
Article dans une revue istex hal-03606893 v1

Glutamate, GABA, glycine and taurine modulate serotonin synthesis and release in rostral and caudal rhombencephalic raphe cells in primary cultures

D. Becquet , M. Hery , Anne-Marie François-Bellan , P. Giraud , P. Deprez et al.
Neurochemistry International, 1993, 23 (3), pp.269--283. ⟨10.1016/0197-0186(93)90118-O⟩
Article dans une revue istex hal-01671965 v1

Convergent serotonin and GABA innervation of VIP neurons in the suprachiasmatic nucleus demonstrated by triple labeling in the rat

Anne-Marie François-Bellan , Olivier Bosler
Brain Research, 1992, 595 (1), pp.149-153. ⟨10.1016/0006-8993(92)91466-r⟩
Article dans une revue istex hal-03606861 v1

Association of neurotensin receptors with VIP-containing neurons and serotonin-containing axons in the suprachiasmatic nucleus of the rat

Anne-Marie François-Bellan , Olivier Bosler , Marie-Christine Tonon , Wei Lin-Tong , Alain Beaudet
Synapse, 1992, 10 (4), pp.282-290. ⟨10.1002/syn.890100403⟩
Article dans une revue istex hal-03606891 v1

Serotonin synthesis from tryptophan by hypothalamic cells in serum‐free medium culture

Denis Becquet , Anne-Marie François-Bellan , Françoise Boudouresque , Maxime Faudon , Francis Hery et al.
Developmental Brain Research, 1990, 54 (1), pp.142--146. ⟨10.1016/0165-3806(90)90075-A⟩
Article dans une revue istex hal-01671974 v1

GABA neurons in the rat suprachiasmatic nucleus: Involvement in chemospecific synaptic circuitry and evidence for GAD-peptide colocalization

Anne-Marie François-Bellan , P. Kachidian , G. Dusticier , M. Tonon , H. Vaudry et al.
Journal of Neurocytology, 1990, 19 (6), pp.937-947. ⟨10.1007/BF01186821⟩
Article dans une revue istex hal-03606860 v1

Analysis of the Inhibitory Effect of Oestradiol on Functional GABA/5-HT Relationship in the Rat Suprachiasmatic Area

Anne-Marie François-Bellan , Micheline Hery , Maxime Faudon , Francis Hery
Journal of Neuroendocrinology, 1989, 1 (6), pp.415-422. ⟨10.1111/j.1365-2826.1989.tb00140.x⟩
Article dans une revue hal-03606859 v1

Regulation by estradiol of GABAA and GABAB binding sites in the diencephalon of the rat: an autoradiographic study

Anne-Marie François-Bellan , Louis Segu , Micheline Héry
Brain Research, 1989, 503 (1), pp.144-147. ⟨10.1016/0006-8993(89)91715-0⟩
Article dans une revue istex hal-03606852 v1

Evidence for GABA control of serotonin metabolism in the rat suprachiasmatic area

Anne-Marie François-Bellan , A.M. François-Bellan , M. Héry , M. Faudon , F. Héry
Neurochemistry International, 1988, 13 (4), pp.455-462. ⟨10.1016/0197-0186(88)90074-5⟩
Article dans une revue istex hal-03606862 v1

The stimulation of GABAB receptors increases serotonin release in the rat suprachiasmatic area

Anne-Marie François-Bellan , A Francoisbellan , M Hery , M Barrit , M Faudon et al.
Neurochemistry International, 1987, 11 (1), pp.55-62. ⟨10.1016/0197-0186(87)90148-3⟩
Article dans une revue istex hal-03606857 v1