Antoine CLAESSENS Head of équipe FRM 'GATAC-Malaria'.I like everything that is P. falciparum related, but I can't hide my love for var genes.

Identifiants chercheurs

IdHAL :

antoine-claessens

ORCID :

0000-0002-4277-0914

IdRef :

177113758

Présentation

Antoine Claessenshttps://lphi.umontpellier.fr/research-teams/genomic-approaches-to-asymptomatic-chronic-malaria/Chargé de Recherche INSERMHead of équipe FRM GATAC-MalariaLPHI (UMR5294), Bat 24, cc107CNRS/Université MontpellierPlace Eugène Bataillon34095 Montpellier cedex 5France

EDUCATION

2000-2004: **University of Liège, Belgium, 4-year degree (MSc) in biochemistry2004-2004: **University of Cambridge, UK, 6-month undergraduate project in developmental biology of Drosophila, supervised by Steve Russell, Ashburner group2005-2006: **University of Edinburgh, UK. Master in Life Sciences: The molecular basis of disease.

** MALARIA CAREER**2006-2011: Wellcome Trust PhD thesis with Alex Rowe at Edinburgh University, and Zbynek Bozdech at NTU-Singapore2011: Short contract with Pierre Buffet at Pitié-Salpêtrière.2011-2014: Postdoc with Dominic Kwiatkowski at the Sanger Institute and in Oxford University (UK)2014-2017: MRC-Fellowship joint London School of Hygiene and Tropical Medicine / MRC-Gambia, The Gambia2018: Chargé de Recherche INSERM at LPHI, Montpellier, France

**GRANTS**

	2019 - 2021: ATIP-Avenir from CNRS – INSERM	2019 - 2023: ANR-JCJC personal grant: Based in LPHI, Montpellier, France	€ 446,000	2019: CNRS Transverse: Funding for a 3-year PhD student (M-A Guéry)	€ 81,000	2019: InfectioPole Sud / Méditérannée Infection: Funding for a 3-year PhD student	€ 40,000	2020: MUSE-Explore: Collaborative project with Texas BioMed, USA	€ 32,000	2021: LabEx ParaFrap: Selected member of the consortium	€ 10,000	2021: CNRS-Afrique: Initiating a collaboration with Centre Pasteur Cameroun	€ 19,000	2021: ATIP-Avenir renewal: Core funding for 2022 and 2023	€ 60,000	2022: ITMO I3M: Initiating a ‘Projet Amorçage’ in Cameroon (Centre Pasteur)	€ 15,000	2022: Inserm First Step: Initiating a collaboration with Ian Cheeseman, Texas bioMed	€ 10,000	2022: InfectioPole Sud: Funding for a one-year post-doc	€ 50,000	2022: ANR-PRC: project MADBIO, coordinated by S Marquet (Marseille); 693k total.	€ 283,500	2022: Muse Pre-ERC: 18months postdoc + consumables.	€ 132,000	2023: INSB-Structure: Funding for a collaboration with sequencing platform MGX	€ 29,000	2024-2026: Equipe-FRM: Core funding secured for MADBIO-Ghana project	€ 448,500	2022: InfectioPole Sud: Funding for a one-year post-doc (to be recruited)	€ 50,000

** Member of MalariaGEN and ParaFrap consortium.**

Publications

Article dans une revue (26)

Detection of novel Plasmodium falciparum haplotypes under treatment pressure in paediatric severe malaria Balotin Fogang,Emilie Guillochon,Claire Kamaliddin,Gino Agbota,Sem Ezinmegnonet al. Microbial Genomics, 2025, 11 (5), ⟨10.1099/mgen.0.001386⟩ Article dans une revue hal-05247486v1
An acyclic nucleoside phosphonate effectively blocks the egress of the malaria parasite by inhibiting the synthesis of cyclic GMP Marie Ali,Rea Dura,Marc-Antoine Guery,Emma Colard-Itté,Thomas Chevietet al. Science Advances , 2025, 11 (47), pp.eady2859. ⟨10.1126/sciadv.ady2859⟩ Article dans une revue hal-05387607v1
RNA polymerase III is involved in regulating Plasmodium falciparum virulence Gretchen Diffendall,Aurelie Claes,Anna Barcons-Simon,Prince Nyarko,Florent Dingliet al. eLife, 2024, 13, pp.95879. ⟨10.7554/elife.95879⟩ Article dans une revue hal-04652238v1
Asymptomatic Plasmodium falciparum carriage at the end of the dry season is associated with subsequent infection and clinical malaria in Eastern Gambia Balotin Fogang,Lionel Lellouche,Sukai Ceesay,Sainabou Drammeh,Fatou Jaitehet al. Malaria Journal, 2024, 23 (1), 22 [12p.]. ⟨10.1186/s12936-024-04836-y⟩ Article dans une revue hal-04795643v1
Household clustering and seasonal genetic variation of Plasmodium falciparum at the community-level in The Gambia Marc-Antoine Guery,Sukai Ceesay,Sainabou Drammeh,Fatou Jaiteh,Umberto D’alessandroet al. eLife, 2024, ⟨10.7554/eLife.103047.1⟩ Article dans une revue hal-04843159v1
Identification of complex Plasmodium falciparum genetic backgrounds circulating in Africa: a multicountry genomic epidemiology analysis Olivo Miotto,Alfred Amambua-Ngwa,Lucas Amenga-Etego,Muzamil Abdel Hamid,Ishag Adamet al. The Lancet Microbe, 2024, 5 (12), pp.100941. ⟨10.1016/j.lanmic.2024.07.004⟩ Article dans une revue hal-04843190v1
Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples Muzamil Mahdi Abdel Hamid,Mohamed Hassan Abdelraheem,Desmond Omane Acheampong,Ambroise Ahouidi,Mozam Aliet al. Wellcome Open Research, 2023, 8, pp.22. ⟨10.12688/wellcomeopenres.18681.1⟩ Article dans une revue hal-04110334v1
Genomic variation during culture adaptation of genetically complex Plasmodium falciparum clinical isolates Antoine Claessens,Lindsay B Stewart,Eleanor Drury,Ambroise D Ahouidi,Alfred Amambua-Ngwaet al. Microbial Genomics, 2023, 9 (5), ⟨10.1099/mgen.0.001009⟩ Article dans une revue hal-04109945v1
Genetic Diversity of Plasmodium falciparum and Distribution of Antimalarial Drug Resistance Mutations in Symptomatic and Asymptomatic Infections Elangwe Sarah-Matio,Emilie Guillochon,Sandrine Nsango,Luc Abate,Christelle Ngou Maffoet al. Antimicrobial Agents and Chemotherapy, 2022, 66 (8), ⟨10.1128/aac.00188-22⟩ Article dans une revue hal-03873724v1
A Cohort Study on the Duration of &lt;i&gt;Plasmodium falciparum&lt;/i&gt; Infections During the Dry Season in The Gambia Katharine Collins,Sukai Ceesay,Sainabou Drammeh,Fatou Jaiteh,Marc-Antoine Gueryet al. Journal of Infectious Diseases, In press, ⟨10.1093/infdis/jiac116⟩ Article dans une revue hal-03664364v1
Order within chaos: Harnessing Plasmodium falciparum var gene extreme polymorphism for malaria epidemiology Marc-Antoine Guery,Antoine Claessens PLoS Genetics, 2021, 17 (2), pp.e1009344. ⟨10.1371/journal.pgen.1009344⟩ Article dans une revue hal-03228641v1
Understanding Host–Pathogen–Vector Interactions with Chronic Asymptomatic Malaria Infections Prince B Nyarko,Antoine Claessens Trends in Parasitology, 2021, 37 (3), pp.195-204. ⟨10.1016/j.pt.2020.09.017⟩ Article dans une revue hal-02981651v1
An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples Ambroise Ahouidi,Mozam Ali,Jacob Almagro-Garcia,Alfred Amambua-Ngwa,Chanaki Amaratungaet al. Wellcome Open Research, 2021, 6, pp.42. ⟨10.12688/wellcomeopenres.16168.1⟩ Article dans une revue hal-03228653v1
Intrinsic multiplication rate variation and plasticity of human blood stage malaria parasites Lindsay B Stewart,Ofelia Diaz-Ingelmo,Antoine Claessens,James Abugri,Richard D Pearsonet al. Communications Biology, 2020, 3, pp.624. ⟨10.1038/s42003-020-01349-7⟩ Article dans une revue hal-03152246v1
Long read assemblies of geographically dispersed Plasmodium falciparum isolates reveal highly structured subtelomeres Thomas Otto,Ulrike Böhme,Mandy Sanders,Adam Reid,Ellen I Bruskeet al. Wellcome Open Research, 2018, 3, pp.52. ⟨10.12688/wellcomeopenres.14571.1⟩ Article dans une revue hal-01989283v1
RecQ helicases in the malaria parasite Plasmodium falciparum affect genome stability, gene expression patterns and DNA replication dynamics Antoine Claessens,Lynne M Harris,Slavica Stanojcic,Lia Chappell,Adam Stantonet al. PLoS Genetics, 2018, 14 (7), pp.e1007490. ⟨10.1371/journal.pgen.1007490⟩ Article dans une revue hal-01989183v1
Culture adaptation of malaria parasites selects for convergent loss-of-function mutants Antoine Claessens,Muna Affara,Samuel A Assefa,Dominic Kwiatkowski,David J Conway Scientific Reports, 2017, 7, pp.41303. ⟨10.1038/srep41303⟩ Article dans une revue hal-01989281v1
Extreme mutation bias and high AT content in Plasmodium falciparum William L Hamilton,Antoine Claessens,Thomas Otto,Mihir Kekre,Rick M Fairhurstet al. Nucleic Acids Research, 2016, pp.gkw1259. ⟨10.1093/nar/gkw1259⟩ Article dans une revue hal-01989279v1
Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis Antoine Claessens,William L Hamilton,Mihir Kekre,Thomas Otto,Adnan Faizullabhoyet al. PLoS Genetics, 2014, 10 (12), pp.e1004812. ⟨10.1371/journal.pgen.1004812⟩ Article dans une revue hal-01989273v1
Plasmodium falciparum Clearance Is Rapid and Pitting Independent in Immune Malian Children Treated With Artesunate for Malaria Papa Alioune Ndour,Tatiana M Lopera-Mesa,Seidina Diakité,Serena Chiang,Oussama Mouriet al. Journal of Infectious Diseases, 2014, 211 (2), pp.290-297. ⟨10.1093/infdis/jiu427⟩ Article dans une revue hal-01989275v1
Optimized Whole-Genome Amplification Strategy for Extremely AT-Biased Template Samuel Oyola,Magnus Manske,Susana Campino,Antoine Claessens,William L Hamiltonet al. DNA Research, 2014, 21 (6), pp.661-671. ⟨10.1093/dnares/dsu028⟩ Article dans une revue hal-01989274v1
Induction of Strain-Transcending Antibodies Against Group A PfEMP1 Surface Antigens from Virulent Malaria Parasites Ashfaq Ghumra,Jean-Philippe Semblat,Ricardo Ataide,Carolyne Kifude,Yvonne Adamset al. PLoS Pathogens, 2012, 8 (4), pp.e1002665. ⟨10.1371/journal.ppat.1002665⟩ Article dans une revue hal-01989271v1
Selection of &lt;em&gt;Plasmodium falciparum&lt;/em&gt; Parasites for Cytoadhesion to Human Brain Endothelial Cells Antoine Claessens,J. Alexandra Alexandra Rowe Journal of visualized experiments : JoVE, 2012, 59, ⟨10.3791/3122⟩ Article dans une revue hal-01989269v1
Design of a variant surface antigen-supplemented microarray chip for whole transcriptome analysis of multiple Plasmodium falciparum cytoadherent strains, and identification of strain-transcendent rif and stevor genes Antoine Claessens,Ashfaq Ghumra,Archna P Gupta,Sachel Mok,Zbynek Bozdechet al. Malaria Journal, 2011, 10 (1), pp.180. ⟨10.1186/1475-2875-10-180⟩ Article dans une revue hal-04109883v1
Adhesion of Plasmodium falciparum -infected erythrocytes to human cells: molecular mechanisms and therapeutic implications J Alexandra Rowe,Antoine Claessens,Ruth Corrigan,Mònica Arman Expert Reviews in Molecular Medicine, 2009, 11, pp.e16. ⟨10.1017/S1462399409001082⟩ Article dans une revue hal-04208631v1
DISC1, PDE4B, and NDE1 at the centrosome and synapse Nicholas J Bradshaw,Fumiaki Ogawa,Beatriz Antolin-Fontes,Jennifer E Chubb,Becky C Carlyleet al. Biochemical and Biophysical Research Communications, 2008, 377 (4), pp.1091-1096. ⟨10.1016/j.bbrc.2008.10.120⟩ Article dans une revue istex hal-01989255v1

Pré-publication, Document de travail (2)

Detection of novel Plasmodium falciparum haplotypes under treatment pressure in pediatric severe malaria Balotin Fogang,Emilie Guillochon,Claire Kamaliddin,Gino Agbota,Sem Ezinmegnonet al. 2024 Pré-publication, Document de travail (preprint/prepublication) hal-04843179v1
Diverse and weakly immunogenic var gene expression facilitates malaria infection Inayat Bhardwaj,Prince Nyarko,Asrar Ba Ashn,Camille Cohen,Sukai Ceesayet al. 2025 Pré-publication, Document de travail hal-04958548v1