Antoine Rimbert

Identifiants chercheurs

IdHAL :

antoine-rimbert

ORCID :

0000-0002-2971-4926

IdRef :

193066904

Publications

Article dans une revue (48)

Genetic testing in individuals with extreme HDL-C levels: Diagnostic yield and clinical implications from the Tromsø Study Åsa Schawlann Ølnes,Marianne Teigen,Thea Bismo Strøm,Erik Kristoffer Arnesen,Antoine Rimbertet al. PLoS ONE, 2026, 21 (4), pp.e0344627. ⟨10.1371/journal.pone.0344627⟩ Article dans une revue hal-05601152v1
Versatile Functions of Hepatic Lipase in Lipoprotein Metabolism Wieneke Dijk,Antoine Rimbert,Thibaud Sotin,Cedric Le May,Bertrand Cariou Arteriosclerosis, Thrombosis, and Vascular Biology, 2026, 46 (1), pp.105-118. ⟨10.1161/ATVBAHA.125.323051⟩ Article dans une revue hal-05500165v1
Synergic combination of the monogenic ANGPTL3 p.H343R variant and a polygenic predisposition in a family with hypobetalipoproteinemia Manon Levy,Alexandre Janin,Oriane Marmontel,Anthony Fourier,Séverine Nonyet al. Atherosclerosis, 2025, 411, pp.120569. ⟨10.1016/j.atherosclerosis.2025.120569⟩ Article dans une revue hal-05361341v1
KILDA: identifying KIV-2 repeats from kmers Corentin Molitor,Timothy Labidi,Antoine Rimbert,Bertrand Cariou,Mathilde Di Filippoet al. NAR Genomics and Bioinformatics, 2025, 7 (2), pp.lqaf070. ⟨10.1093/nargab/lqaf070⟩ Article dans une revue hal-05361347v1
Loss of GPR146 decreases plasma levels of HDL cholesterol via post-translational up-regulation of SR-B1 protein levels Boyan Zhang,Natalia Loaiza,Antoine Rimbert,Federico Oldoni,Lisanne Blauwet al. Cardiovascular Research, 2025, 121 (18), pp.2860-2872. ⟨10.1093/cvr/cvaf254⟩ Article dans une revue hal-05489608v1
A study into rare GPR146 gene variants in humans and mice Boyan Zhang,Antoine Rimbert,Antoine Lainé,Nicolette Huijkman,Niels Kloosterhuiset al. Atherosclerosis, 2025, 403, ⟨10.1016/j.atherosclerosis.2025.119137⟩ Article dans une revue hal-05361359v1
Casz1 and Znf101/Zfp961 differentially regulate apolipoproteins A1 and B, alter plasma lipoproteins, and reduce atherosclerosis Abulaish Ansari,Pradeep Kumar Yadav,Liye Zhou,Binu Prakash,Laraib Ijazet al. JCI Insight, 2025, 10 (1), pp.e182260. ⟨10.1172/jci.insight.182260.⟩ Article dans une revue hal-05361367v1
From Genetic Findings to new Intestinal Molecular Targets in Lipid Metabolism Cedric Le May,Simon Ducheix,Bertrand Cariou,Antoine Rimbert Current Atherosclerosis Reports, 2025, 27 (1), pp.26. ⟨10.1007/s11883-024-01264-w⟩ Article dans une revue hal-05361443v1
DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in mice Xiaoke Ge,Bram Slütter,Joost Lambooij,Enchen Zhou,Zhixiong Yinget al. iScience, 2024, 27 (6), pp.109830. ⟨10.1016/j.isci.2024.109830⟩ Article dans une revue hal-04751124v1
Variants in LPA are associated with mutation-negative Familial Hypercholesterolaemia: whole genome sequencing analysis in the 100,000 Genomes Project Martin Bird,Antoine Rimbert,Alan Pittman,Steve Humphries,Marta Futema Atherosclerosis Plus, 2024, 57, pp.2. ⟨10.1016/j.athplu.2024.08.015⟩ Article dans une revue hal-05594877v1
Human induced pluripotent stem cells ‐derived liver organoids grown on a Biomimesys® hyaluronic acid‐based hydroscaffold as a new model for studying human lipoprotein metabolism Meryl Roudaut,Amandine Caillaud,Zied Souguir,Lise Bray,Aurore Girardeauet al. Bioengineering & Translational Medicine, 2024, ⟨10.1002/btm2.10659⟩ Article dans une revue (data paper) hal-04509118v1
MicroRNA-615-3p decreases apo B expression in human liver cells Abulaish Ansari,Pradeep Kumar Yadav,Swati Valmiki,Antoine Laine,Antoine Rimbertet al. Journal of Lipid Research, 2024, 65 (10), pp.100659. ⟨10.1016/j.jlr.2024.100659⟩ Article dans une revue hal-04751117v1
Primary hypocholesterolemia is associated with an increased risk of hepatic complications in the general population Matthieu Wargny,Thomas Goronflot,Antoine Rimbert,Jérôme Boursier,Sofiane Kabet al. Journal of Hepatology, 2024, 80 (6), pp.846-857. ⟨10.1016/j.jhep.2024.01.030⟩ Article dans une revue hal-04474613v2
Variants in &lt;i&gt;LPA&lt;/i&gt; are associated with familial hypercholesterolaemia: whole genome sequencing analysis in the 100 000 Genomes Project Martin Bird,Antoine Rimbert,Alan Michael Pittman,Steve Eric Humphries,Marta Futema European Journal of Preventive Cardiology, 2024, 33 (3), pp.352 - 360. ⟨10.1093/eurjpc/zwae371⟩ Article dans une revue hal-05601388v1
PCSK9 inhibition protects mice from food allergy Victoria Lorant,Martin Klein,Damien Garçon,Thibaud Sotin,Samuel Freyet al. Translational Research, The Journal of Laboratory and Clinical Medicine, 2024, 272, pp.151-161. ⟨10.1016/j.trsl.2024.03.001⟩ Article dans une revue hal-04529957v1
Reply to “The association between primary hypobetalipoproteinemia and hepatic diseases: evidence from genetic studies” Antoine Rimbert,Matthieu Wargny,Bertrand Cariou Journal of Hepatology, 2024, 82 (1), pp.e50 - e51. ⟨10.1016/j.jhep.2024.09.009⟩ Article dans une revue hal-05361515v2
G protein-coupled receptor 146: new insights from genetics and model systems Umesh Tharehalli,Antoine Rimbert Current Opinion in Lipidology, 2024, 35 (3), pp.162-169. ⟨10.1097/MOL.0000000000000929⟩ Article dans une revue hal-04529967v2
Advancements in risk stratification and management strategies in primary cardiovascular prevention Fotios Barkas,Yusuf Ziya Sener,Pelin Arabacilar Golforoush,Azin Kheirkhah,Elena Rodriguez-Sanchezet al. Atherosclerosis, 2024, 395, pp.117579. ⟨10.1016/j.atherosclerosis.2024.117579⟩ Article dans une revue hal-04751122v1
LDL lowering effect of PCSK9 inhibition is reduced in women Veronika Myasoedova,Antoine Rimbert,Marina Camera,Cedric Le May,Romain Capouladeet al. European Heart Journal - Cardiovascular Pharmacotherapy, 2023, 9 (4), pp.337-342. ⟨10.1093/ehjcvp/pvad009⟩ Article dans une revue hal-04212334v1
Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans Sebastian Hendrix,Jenina Kingma,Roelof Ottenhoff,Masoud Valiloo,Monika Sveclaet al. Nature Communications, 2023, 14 (1), pp.5181. ⟨10.1038/s41467-023-40943-1⟩ Article dans une revue hal-04208487v1
Germline JAK2 E846D Substitution as the Cause of Erythrocytosis? Nada Maaziz,Céline Garrec,Fabrice Airaud,Victor Bobée,Nathalie Contentinet al. Genes, 2023, 14 (5), pp.1066. ⟨10.3390/genes14051066⟩ Article dans une revue hal-04208496v1
Generation of an induced pluripotent stem cell line (ITXi012-A) from a patient with genetically determined high-lipoprotein(a) plasma levels Amandine Caillaud,Lise Bray,Aurore Girardeau,Zoé Begué-Racapé,Lucie Vinceet al. Stem Cell Research, 2023, 72, ⟨10.1016/j.scr.2023.103205⟩ Article dans une revue hal-04212298v1
A new 165-SNP low-density lipoprotein cholesterol polygenic risk score based on next generation sequencing outperforms previously published scores in routine diagnostics of familial hypercholesterolemia Xavier Vanhoye,Claire Bardel,Antoine Rimbert,Philippe Moulin,Pierre-Antoine Rollat-Farnieret al. Translational Research, The Journal of Laboratory and Clinical Medicine, 2023, 255, pp.119-127. ⟨10.1016/j.trsl.2022.12.002⟩ Article dans une revue hal-04172500v1
Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis Sandrine Morel,Isabel Hostettler,Georg Spinner,Romain Bourcier,Joanna Peraet al. Journal of Personalized Medicine, 2022, 12 (9), pp.1410. ⟨10.3390/jpm12091410⟩ Article dans une revue hal-04060055v1
In silico and Functional Studies for Classification of EPAS1/HIF2A Genetic Variants Identified in Patients with Erythrocytosis Valéna Karaghiannis,Darko Maric,Céline Garrec,Nada Maaziz,Alexandre Buffetet al. Blood, 2022, 140 (Supplement 1), pp.8157-8158. ⟨10.1182/blood-2022-163123⟩ Article dans une revue hal-04031832v1
Generation of a GPR146 knockout human induced pluripotent stem cell line (ITXi001-A-1) Lise Bray,Amandine Caillaud,Aurore Girardeau,Murielle Patitucci,Cédric Le Mayet al. Stem Cell Research, 2022, 60, pp.102721. ⟨10.1016/j.scr.2022.102721⟩ Article dans une revue hal-03869113v1
Large HDL particles negatively associate with leukocyte counts independent of cholesterol efflux capacity : a cross sectional study in the population-based LifeLines DEEP cohort Anouk Groenen,Venetia Bazioti,Isabelle van Zeventer,Lianmin Chen,Hilde Grootet al. Atherosclerosis, 2022, 343, pp.20-27. ⟨10.1016/j.atherosclerosis.2022.01.008⟩ Article dans une revue hal-04060061v1
The Genetic Spectrum of Familial Hypertriglyceridemia in Oman Khalid Al-Waili,Khalid Al-Rasadi,Muna Al-Bulushi,Mohammed Habais,Abdullah Al-Mujainiet al. Frontiers in Genetics, 2022, 13, ⟨10.3389/fgene.2022.886182⟩ Article dans une revue hal-04060049v1
Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia Wieneke Dijk,Mathilde Di-Filippo Charcosset,Sander Kooijman,Robin Van Eenige,Antoine Rimbertet al. Circulation, 2022, 146 (10), pp.724-739. ⟨10.1161/circulationaha.121.057978⟩ Article dans une revue inserm-03831077v1
APOB CRISPR-Cas9 Engineering in Hypobetalipoproteinemia: A Promising Tool for Functional Studies of Novel Variants Xavier Vanhoye,Alexandre Janin,Amandine Caillaud,Antoine Rimbert,Fabienne Venetet al. International Journal of Molecular Sciences, 2022, 23 (8), pp.4281. ⟨10.3390/ijms23084281⟩ Article dans une revue hal-03659209v1
FACS-assisted CRISPR-Cas9 genome editing of human induced pluripotent stem cells Amandine Caillaud,Antoine Lévêque,Aurélie Thédrez,Aurore Girardeau,Robin Canacet al. STAR Protocols, 2022, 3 (4), pp.101680. ⟨10.1016/j.xpro.2022.101680⟩ Article dans une revue hal-04060050v1
Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion Willemien van Zwol,Antoine Antoine Rimbert,Justina C Wolters,Marieke Smit,Vincent W Blokset al. Hepatology, 2022, 23 (8), pp.n/a-n/a. ⟨10.1002/hep.32709⟩ Article dans une revue hal-04060059v1
Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome Paolo Zanoni,Grigorios Panteloglou,Alaa Othman,Joël T. Haas,Roger Meieret al. Circulation Research, 2022, 130 (1), pp.80-95. ⟨10.1161/CIRCRESAHA.120.318141⟩ Article dans une revue hal-03554168v1
A novel role for GalNAc-T2 dependent glycosylation in energy homeostasis Cristy R.C. Verzijl,Federico Oldoni,Natalia Loaiza,Justina Wolters,Antoine Rimbertet al. Molecular metabolism, 2022, 60 (1), pp.101472. ⟨10.1016/j.molmet.2022.101472⟩ Article dans une revue hal-04060053v1
Genetic Inhibition of PCSK9 and Liver Function Antoine Rimbert,Sarra Smati,Wieneke Dijk,Cedric Le May,Bertrand Cariou JAMA Cardiology, 2021, ⟨10.1001/jamacardio.2020.5341⟩ Article dans une revue hal-03100949v1
Phenotypic Differences Between Polygenic and Monogenic Hypobetalipoproteinemia Antoine Rimbert,Xavier Vanhoye,Dramane Coulibaly,Marie Marrec,Matthieu Pichelinet al. Arteriosclerosis, Thrombosis, and Vascular Biology, 2021, 41 (1), pp.e63-e71. ⟨10.1161/ATVBAHA.120.315491⟩ Article dans une revue hal-03105646v1
Routine use of statins and increased COVID-19 related mortality in inpatients with type 2 diabetes: Results from the CORONADO study Bertrand Cariou,Thomas Goronflot,Antoine Rimbert,Sandrine Boullu,Cedric Le Mayet al. Journal of Diabetes & Metabolism, 2021, 47 (2), pp.101202. ⟨10.1016/j.diabet.2020.10.001⟩ Article dans une revue hal-03100948v1
PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs Meryl Roudaut,Salam Idriss,Amandine Caillaud,Aurore Girardeau,Antoine Rimbertet al. Stem Cell Reports, 2021, ⟨10.1016/j.stemcr.2021.10.004⟩ Article dans une revue hal-03451184v1
Comprehensive &lt;i&gt;in silico&lt;/i&gt; and functional studies for classification of &lt;i&gt;EPAS1/HIF2A&lt;/i&gt; genetic variants identified in patients with erythrocytosis Valéna Karaghiannis,Darko Maric,Céline Garrec,Nada Maaziz,Alexandre Buffetet al. Haematologica, 2020, ⟨10.3324/haematol.2022.281698⟩ Article dans une revue hal-04060048v1
Taking One Step Back in Familial Hypercholesterolemia Natalia Loaiza,Merel Hartgers,Laurens Reeskamp,Jan-Willem Balder,Antoine Rimbertet al. Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, 40 (4), pp.973-985. ⟨10.1161/ATVBAHA.119.313470⟩ Article dans une revue hal-02468286v1
Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids Adriaan van Der Graaf,Annique Claringbould,Antoine Rimbert,Harm-Jan Westra,Yang Liet al. Nature Communications, 2020, 11 (1), pp.4930. ⟨10.1038/s41467-020-18716-x⟩ Article dans une revue hal-02970789v1
GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis Haojie Yu,Antoine Rimbert,Alice Palmer,Takafumi Toyohara,Yulei Xiaet al. Cell, 2019, 179 (6), pp.1276-1288.e14. ⟨10.1016/j.cell.2019.10.034⟩ Article dans une revue hal-02422749v1
A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor Antoine Rimbert,Nawar Dalila,Justina Wolters,Nicolette Huijkman,Marieke Smitet al. European Heart Journal, 2019, ⟨10.1093/eurheartj/ehz727⟩ Article dans une revue hal-02422747v1
The Future of Lipid-Lowering Therapy Willemien Van Zwol,Antoine Rimbert,Jan Kuivenhoven Journal of Clinical Medicine, 2019, 8 (7), pp.1085. ⟨10.3390/jcm8071085⟩ Article dans une revue hal-02422745v1
Use of plasma metabolomics to analyze phenotype-genotype relationships in young hypercholesterolemic females Xiang Zhang,Antoine Rimbert,Willem Balder,Aeilko Having Zwinderman,Jan Albert Kuivenhovenet al. Journal of Lipid Research, 2018, 59 (11), pp.2174-2180. ⟨10.1194/jlr.M088930⟩ Article dans une revue hal-02422741v1
Genetics of syndromic and non-syndromic mitral valve prolapse Thierry Le Tourneau,Jean Merot,Antoine Rimbert,Solena Le Scouarnec,Vincent Probstet al. Heart, 2018, 104 (12), pp.978-984. ⟨10.1136/heartjnl-2017-312420⟩ Article dans une revue hal-04754059v1
Identification of novel APOB mutations by targeted next-generation sequencing for the molecular diagnosis of familial hypobetalipoproteinemia Antoine Rimbert,Matthieu Pichelin,Simon Lecointe,Marie Marrec,Solena Le Scouarnecet al. Atherosclerosis, 2016, Equipe 3 Equipe 4 Equipe 5, 250, pp.52--56. ⟨10.1016/j.atherosclerosis.2016.04.010⟩ Article dans une revue hal-01831745v1
Artériopathie et hétérogénéité artérielle Y. Gouëffic,J.-M. Davaine,T. Merlini,Antoine Rimbert,F. Hérissonet al. La Revue de Médecine Interne, 2013, 34 (1), pp.61-65. ⟨10.1016/j.revmed.2012.10.364⟩ Article dans une revue istex hal-05361509v1

Pré-publication, Document de travail (2)

Isolated prolapse of the posterior mitral valve leaflet: phenotypic refinement, heritability and genetic etiology Antoine Rimbert,Damien Duval,Daniel Trujillano,Florence Kyndt,Antoine Jobbé-Duvalet al. 2024 Pré-publication, Document de travail (preprint/prepublication) hal-04751125v1
MicroRNA-541-3p alters lipoproteins to reduce atherosclerosis by degrading Znf101 and Casz1 transcription factors Abulaish Ansari,Pradeep Kumar Yadav,Liye Zhou,Binu Prakash,Bhargavi Gangulaet al. 2024 Pré-publication, Document de travail hal-04759206v1