Arnaud KLEIN Chargé de Recherche - Inserm - Centre de recherche en Myologie

Identifiants chercheurs

IdHAL :

arnaud-f-klein

ORCID :

0000-0002-3860-7049

Publications

Article dans une revue (19)

The beneficial effect of chronic muscular exercise on muscle fragility is increased by Prox1 gene transfer in dystrophic mdx muscle Alexandra Monceau,Clément Delacroix,Mégane Lemaitre,Gaelle Revet,Denis Furlinget al. PLoS ONE, 2022, 17 (4), pp.e0254274. ⟨10.1371/journal.pone.0254274⟩ Article dans une revue hal-03830867v1
Dystrophin Restoration after Adeno-Associated Virus U7–Mediated Dmd Exon Skipping Is Modulated by Muscular Exercise in the Severe D2-Mdx Duchenne Muscular Dystrophy Murine Model Alexandra Monceau,Dylan Moutachi,Mégane Lemaitre,Luis Garcia,Capucine Trolletet al. American Journal of Pathology, 2022, 192, pp.1604-1618. ⟨10.1016/j.ajpath.2022.07.016⟩ Article dans une revue hal-03830848v1
Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats Ludovic Arandel,Magdalena Matloka,Arnaud F Klein,Frédérique Rau,Alain Sureauet al. Nature Biomedical Engineering, 2022, 6 (2), pp.207-220. ⟨10.1038/s41551-021-00838-2⟩ Article dans une revue hal-03830811v1
Comprehensive transcriptome-wide analysis of spliceopathy correction of myotonic dystrophy using CRISPR-Cas9 in iPSCs-derived cardiomyocytes Sumitava Dastidar,Debanjana Majumdar,Jaitip Tipanee,Kshitiz Singh,Arnaud Kleinet al. Molecular Therapy, 2021, 29 (11), ⟨10.1016/j.ymthe.2021.08.004⟩ Article dans une revue hal-03410645v1
Desmin prevents muscle wasting, exaggerated weakness and fragility, and fatigue in dystrophic mdx mouse Arnaud Ferry,Julien Messéant,Ara Parlakian,Mégane Lemaitre,Pauline Royet al. The Journal of Physiology, 2020, 598 (17), pp.3667-3689. ⟨10.1113/JP279282⟩ Article dans une revue hal-02996889v1
Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice Arnaud F Klein,Miguel A Varela,Ludovic Arandel,Ashling Holland,Naira Naouaret al. Journal of Clinical Investigation, 2019, 129 (11), pp.4739 - 4744. ⟨10.1172/jci128205⟩ Article dans une revue hal-03753531v1
Genome Editing of Expanded CTG Repeats within the Human DMPK Gene Reduces Nuclear RNA Foci in the Muscle of DM1 Mice Mirella Lo Scrudato,Karine Poulard,Célia Sourd,Stéphanie Tomé,Arnaud Kleinet al. Molecular Therapy, 2019, Epub ahead of print. ⟨10.1016/j.ymthe.2019.05.021⟩ Article dans une revue hal-02177548v1
Cells of Matter—In Vitro Models for Myotonic Dystrophy Magdalena Matloka,Arnaud F Klein,Frédérique Rau,Denis Furling Frontiers in Neurology, 2018, 9, ⟨10.3389/fneur.2018.00361⟩ Article dans une revue hal-03830776v1
Improvement of Dystrophic Muscle Fragility by Short-Term Voluntary Exercise through Activation of Calcineurin Pathway in mdx Mice Clement Delacroix,Janek Hyzewicz,Megane Lemaitre,Bertrand Friguet,Zhenlin Liet al. American Journal of Pathology, 2018, 188 (11), pp.2662-2673. ⟨10.1016/j.ajpath.2018.07.015⟩ Article dans une revue hal-02134917v1
Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells Sumitava Dastidar,Simon Ardui,Kshitiz Singh,Debanjana Majumdar,Nisha Nairet al. Nucleic Acids Research, 2018, 46, pp.8275 - 8298. ⟨10.1093/nar/gky548⟩ Article dans une revue hal-02357315v1
Immortalized human myotonic dystrophy muscle cell lines to assess therapeutic compounds Ludovic Arandel,Micaela Polay Espinoza,Magdalena Matloka,Audrey Bazinet,Damily de Dea Dinizet al. Disease Models & Mechanisms, 2017, 10 (4), pp.487-497. ⟨10.1242/dmm.027367⟩ Article dans une revue hal-01519721v1
Two novel COLVI long chains in zebrafish that are essential for muscle development Laetitia Ramanoudjame,Claire Rocancourt,Jeanne Lainé,Arnaud Klein,Lucette Joassardet al. Human Molecular Genetics, 2015, 24 (23), pp.6624-6639. ⟨10.1093/hmg/ddv368⟩ Article dans une revue hal-01594462v1
New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeats François-Xavier Laurent,Alain Sureau,Arnaud F Klein,François Trouslard,Erwan Gasnieret al. Nucleic Acids Research, 2012, 40 (7), pp.3159-3171. ⟨10.1093/nar/gkr1228⟩ Article dans une revue hal-03001690v1
Selective silencing of mutated mRNAs in DM1 by using modified hU7-snRNAs Virginie François,Arnaud F Klein,Cyriaque Beley,Arnaud Jollet,Camille Lemercieret al. Nature Structural and Molecular Biology, 2011, 18 (1), pp.85-87. ⟨10.1038/nsmb.1958⟩ Article dans une revue istex hal-03002664v1
Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy. Charlotte Fugier,Arnaud F Klein,Caroline Hammer,Stéphane Vassilopoulos,Ylva Ivarssonet al. Nature Medicine, 2011, 17 (6), pp.720-5. ⟨10.1038/nm.2374⟩ Article dans une revue hal-00811986v1
PABPN1 polyalanine tract deletion and long expansions modify its aggregation pattern and expression Arnaud F Klein,Mitsuru Ebihara,Christine Alexander,Marie-Josée Dicaire,A. Marie-Josée Sassevilleet al. Experimental Cell Research, 2008, 314 (8), pp.1652-1666. ⟨10.1016/j.yexcr.2008.02.005⟩ Article dans une revue istex hal-03821688v1
The dynamism of PABPN1 nuclear inclusions during the cell cycle A. Marie-Josée Sasseville,Antoine W Caron,Lucie Bourget,Arnaud F Klein,Marie-Josée Dicaireet al. Neurobiology of Disease, 2006, 23 (3), pp.621-629. ⟨10.1016/j.nbd.2006.05.015⟩ Article dans une revue istex hal-03821686v1
PABPN1 overexpression leads to upregulation of genes encoding nuclear proteins that are sequestered in oculopharyngeal muscular dystrophy nuclear inclusions Louis-Philippe Corbeil-Girard,Arnaud F Klein,A. Marie-Josée Sasseville,Hugo Lavoie,Marie-Josée Dicaireet al. Neurobiology of Disease, 2005, 18 (3), pp.551-567. ⟨10.1016/j.nbd.2004.10.019⟩ Article dans une revue istex hal-03821678v1
PABPN1 overexpression leads to upregulation of genes encoding nuclear proteins that are sequestered in oculopharyngeal muscular dystrophy nuclear inclusions Louis-Philippe Corbeil-Girard,Arnaud F Klein,A. Marie-Josée Sasseville,Hugo Lavoie,Anik Saint-Deniset al. Neurobiology of Disease, 2005, 18 (3), pp.551-567. ⟨10.1016/j.nbd.2004.10.019⟩ Article dans une revue istex hal-03832516v1

Chapitre d'ouvrage (1)

FISH protocol for Myotonic Dystrophy type 1 cells Arnaud F. Klein,Ludovic Arandel,Joëlle Marie,Denis Furling Trinucleotide Repeats Methods and Protocols, 2056, pp.203 - 215, 2019, ⟨10.1007/978-1-4939-9784-8⟩ Chapitre d'ouvrage hal-02996909v1

Communication dans un congrès (3)

Myotonic dystrophy type 1: from DNA repeat expansion and toxic RNA to the development of new therapeutic approaches Mário Gomes-Pereira,Arnaud F Klein European reference network for rare and low prevalence complex diseases, Jul 2022, Webinar, France Communication dans un congrès hal-04007414v1
Decoy gene therapy to reverse RNA toxicity in DM1 Ludovic Arandel,Arnaud F Klein,Frédérique Rau,Alain Sureau,Aurélien Cordieret al. International Myotonic Dystrophy Consortium Meeting IDMC-13, International Myotonic Dystrophy Consortium, May 2022, Osaka, Japan Communication dans un congrès hal-03999213v1
Dystrophie myotonique: de la pathophysiologie aux approaches thérapeutiques Mário Gomes-Pereira,Arnaud F Klein Société Française de Thérapie Cellulaire et Génique, Apr 2022, Webinar, France Communication dans un congrès hal-04007420v1