Arnaud Monteil

Présentation

Arnaud Monteil obtained his bachelor’s in biological sciences in 1989 in Montpellier (France). He then studied molecular biology and biochemistry at the University of Montpellier from 1989 to 1996. He started his PhD in 1996 under the supervision of Dr Joël Nargeot (University of Montpellier – Montpellier – France) with the objective to clone and characterize T-type voltage-gated calcium channels, a subtype of calcium channels that was not identified at this time. The thesis was successfully defended in 2000 and led to several publications of importance in the fields of ion channels and cellular excitability. After his thesis defense, Arnaud Monteil joined Prof Richard J. Miller’s laboratory as a post-doctoral fellow at the University of Chicago (Chicago – USA) where he identified and cloned a novel type of four-domain ion channel named NALCN. He went back to France in 2001 as a permanent researcher at the National Center for Scientific Research (CNRS). Since then Arnaud Monteil’s research is concerned with ion channels in Dr Philippe Lory’s team (« *Ion channels in neuronal excitability and diseases » - Institut de Génomique Fonctionnelle – Montpellier ; http://www.igf.cnrs.fr). Dr Philippe Lory’s team is part of the Laboratory of Excellence « Ion Channel Science and Therapeutics » (http://www.labex-icst.fr/en). The overall ambition ofthis laboratory of excellence is to become a world-wide recognized cluster in ion channel studies carrying research and innovation at the interface between biology and medicine. In this context, the research projects headed by Arnaud Monteil focus on the study of ion channels’ mutations involved in complex neurological disorders using molecular and electrophysiological techniques both in vitro (cell lines ; primary cultures) and in vivo (animal models). A special emphasis is to search for new molecules modulating ion channels activity that could be relevant to treat human diseases. Of note, Arnaud Monteil supervised 2-year exchange programs (Hubert-Curien Program 2013-2014 and 2020-2021) with Dr Narawut Pakaprot at Mahidol University (Thailand). In addition to his research activity, Arnaud Monteil is the head of a facility to produce viral vectors for research since 2008 (http://www.biocampus.cnrs.fr), is the president of the « Ion Channel » society since 2014 (http://www.canaux-ioniques.fr/) and leads the scientific committee of the Libellas foundation since 2020 (https://fundacionlibellas.org/). Arnaud Monteil is also an elected member of the National Committee of the CNRS (CoNRS, Sub-committee #24 “Aging, Tumorigenesis, Physiology”) since 2016.

Publications

Article dans une revue (33)

The sodium leak channel NALCN in Drd2+ striatal neurons regulates neuronal excitability, locomotion and food-seeking in a sex-dependent manner Laia Castell,Claire Naon,Angelina Rogliardo,Fabien Ducrocq,Leila Makriniet al. Neuropsychopharmacology, 2026, ⟨10.1038/s41386-026-02363-9⟩ Article dans une revue hal-05517415v1
NALCN/Cch1 channelosome subunits originated in early eukaryotes Adriano Senatore,Tatiana Mayorova,Luis Yañez-Guerra,Wassim Elkhatib,Brian Bejoyet al. Journal of General Physiology, 2025, 157 (6), pp.e202413636. ⟨10.1085/jgp.202413636⟩ Article dans une revue hal-05350556v1
Electrophysiological classification of CACNA1G gene variants associated with neurodevelopmental and neurological disorders Amaël Davakan,Leos Cmarko,Barbara Ribeiro Oliveira-Mendes,Claire Bernat,Najlae Boulaliet al. Frontiers in Pharmacology, 2025, 16, pp.1613072. ⟨10.3389/fphar.2025.1613072⟩ Article dans une revue hal-05326387v1
The background sodium leak channel NALCN is a major controlling factor in pituitary cell excitability Marziyeh Belal,Mariusz Mucha,Arnaud Monteil,Paul G Winyard,Robert Pawlaket al. The Journal of Physiology, 2025, 603 (2), pp.301-317. ⟨10.1113/JP284036⟩ Article dans une revue hal-04819360v1
Generation of two isogenic-corrected control cell lines (IRMBi001-A-1; IRMBi001-A-2) from Autosomal dominant Alzheimer’s disease patient-derived iPSCs carrying a G217D mutation in presenilin 1 gene Coralie Clua Provost,Louise Greetham,Cécile Monzo,Arnaud Monteil,Anne Rovelet-Lecruxet al. Stem Cell Research, 2025, 87, pp.103780. ⟨10.1016/j.scr.2025.103780⟩ Article dans une revue hal-05213438v1
The Cognitive Restoration Effects of Resveratrol: Insight Molecular through Behavioral Studies in Various Cognitive Impairment Models Yingrak Boondam,Chaianan Saefoong,Natjanan Niltup,Arnaud Monteil,Worawan Kitphati ACS Pharmacology & Translational Science, 2024, 7 (11), pp.3334 - 3357. ⟨10.1021/acsptsci.4c00373⟩ Article dans une revue hal-04787206v1
New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN Arnaud Monteil,Nathalie C. Guérineau,Antonio Gil-Nagel,Paloma Parra- Diaz,Philippe Loryet al. Physiological Reviews, 2024, 104 (1), pp.399-472. ⟨10.1152/physrev.00014.2022⟩ Article dans une revue (article de synthèse) hal-04189096v1
Selective blockade of Ca$_V$1.2 (α1C) versus Ca$_V$1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine Pietro Mesirca,Jean Chemin,Christian Barrère,Eleonora Torre,Laura Gallotet al. Nature Communications, 2024, 15 (1), pp.54. ⟨10.1038/s41467-023-43502-w⟩ Article dans une revue hal-04385916v1
Revealing of stomach histology of beta-agonist free, hygienic, and natural swine Saimai Chatree,Nitinart Kongkhwet,Sanfan Inkho,Suthita Jaisamuta,Arnaud Monteilet al. Cogent Food & Agriculture, 2023, 9 (1), pp.2208248. ⟨10.1080/23311932.2023.2208248⟩ Article dans une revue hal-04710696v1
Functional mapping of microRNA promoters with dCas9 fused to transcriptional regulators Pradeep Kumar,Mathilde Courtes,Céline Lemmers,Anne Le Digarcher,Ilda Cokuet al. Frontiers in Genetics, 2023, 14, pp.1147222. ⟨10.3389/fgene.2023.1147222⟩ Article dans une revue hal-04122098v1
NALCN ‐mediated sodium influx confers metastatic prostate cancer cell invasiveness Antoine Folcher,Dmitri Gordienko,Oksana Iamshanova,Alexandre Bokhobza,George Shapovalovet al. EMBO Journal, In press, 42 (13), pp.e112198. ⟨10.15252/embj.2022112198⟩ Article dans une revue hal-04122134v1
Emerging and re-emerging zoonotic viral diseases in Southeast Asia: One Health challenge Paola Mariela Saba Villarroel,Nuttamonpat Gumpangseth,Thanaphon Songhong,Sakda Yainoy,Arnaud Monteilet al. Frontiers in Public Health, 2023, 11, ⟨10.3389/fpubh.2023.1141483⟩ Article dans une revue hal-04234422v1
Effects of Ceftriaxone on Oxidative Stress and Inflammation in a Rat Model of Chronic Cerebral Hypoperfusion Apsorn Sattayakhom,Kosin Kalarat,Thatdao Rakmak,Sompol Tapechum,Arnaud Monteilet al. Behavioral Sciences, 2022, 12 (8), pp.287. ⟨10.3390/bs12080287⟩ Article dans une revue hal-03761404v1
Sodium background currents in endocrine/neuroendocrine cells: towards unraveling channel identity and contribution in hormone secretion Nathalie C. Guérineau,Arnaud Monteil,Philippe Lory Frontiers in Neuroendocrinology, 2021, 63, pp.100947. ⟨10.1016/j.yfrne.2021.100947⟩ Article dans une revue (article de synthèse) hal-03364483v1
A sodium background conductance controls the spiking pattern of mouse adrenal chromaffin cells in situ Alexandre Milman,Stéphanie Venteo,Jean-Louis Bossu,Pierre Fontanaud,Arnaud Monteilet al. The Journal of Physiology, 2021, 599 (6), pp.1855-1883. ⟨10.1113/jp281044⟩ Article dans une revue hal-03138604v1
THE VOLTAGE-GATED SODIUM CHANNEL BETA4 SUBUNIT MAINTAINS EPITHELIAL PHENOTYPE IN MAMMARY CELLS Adélaïde Doray,Roxane Lemoine,Marc Severin,Stéphanie Chadet,Osbaldo Lopez-Charcaset al. Cells, 2021, 10 (7), pp.1624. ⟨10.3390/cells10071624⟩ Article dans une revue hal-03353576v1
The sodium leak channel NALCN regulates cell excitability of pituitary endocrine cells Hathaichanok Impheng,Céline Lemmers,Malik Bouasse,Christian Legros,Narawut Pakaprotet al. FASEB Journal, 2021, 35 (5), pp.e21400. ⟨10.1096/fj.202000841rr⟩ Article dans une revue hal-03188856v1
Neuronal Cav3 channelopathies: recent progress and perspectives Philippe Lory,Sophie Nicole,Arnaud Monteil Pflügers Archiv European Journal of Physiology, 2020, 472 (7), pp.831-844. ⟨10.1007/s00424-020-02429-7⟩ Article dans une revue (article de synthèse) hal-02893632v1
Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons Miriam Candelas,Ana Reynders,Margarita Arango-Lievano,Christoph Neumayer,Antoine Fruquièreet al. Scientific Reports, 2019, 9 (1), pp.3112. ⟨10.1038/s41598-019-39703-3⟩ Article dans une revue hal-02356250v1
Interferon-inducible protein (IFI) 16 regulates Chikungunya and Zika virus infection in human skin fibroblasts. Sineewanlaya Wichit,Rodolphe Hamel,Sakda Yainoy,Nuttamonpat Gumpangseth,Suchawadee Panichet al. EXCLI Journal : Experimental and Clinical Sciences, 2019, 18, pp.467-476. ⟨10.17179/excli2019-1271⟩ Article dans une revue hal-02328306v1
Functional expression of CLIFAHDD and IHPRF pathogenic variants of the NALCN channel in neuronal cells reveals both gain- and loss-of-function properties Malik Bouasse,Hathaichanok Impheng,Zoe Servant,Philippe Lory,Arnaud Monteil Scientific Reports, 2019, 9 (1), pp.11791. ⟨10.1038/s41598-019-48071-x⟩ Article dans une revue hal-02328271v1
Calmodulin regulates Ca v 3 T-type channels at their gating brake Jean Chemin,Valentina Taiakina,Arnaud Monteil,Michael Piazza,Wendy Guanet al. Journal of Biological Chemistry, 2017, 292 (49), pp.20010-20031. ⟨10.1074/jbc.M117.807925⟩ Article dans une revue hal-02328290v1
De novo mutations in NALCN cause a syndrome characterized by congenital contractures of the limbs and face, hypotonia, and developmental delay J. X. Chong,M. J. Mcmillin,K. M. Shively,A. E. Beck,C. T. Marvinet al. American Journal of Human Genetics, 2015, 96 (3), pp.462-73. ⟨10.1016/j.ajhg.2015.01.003⟩ Article dans une revue hal-02064371v1
Inhibition of Cav3.2 T-type Calcium Channels by Its Intracellular I-II Loop Arnaud Monteil,Patrick Chausson,Katia Boutourlinsky,Alexandre Mezghrani,Iulia Blesneacet al. Journal of Biological Chemistry, 2015, 290 (26), pp.16168-16176. ⟨10.1074/jbc.M114.634261⟩ Article dans une revue hal-01348945v1
A Recurrent Mutation in CACNA1G Alters Cav3.1 T-Type Calcium-Channel Conduction and Causes Autosomal-Dominant Cerebellar Ataxia Marie Coutelier,Iulia Blesneac,Arnaud Monteil,Marie-Lorraine Monin,Kunie Andoet al. American Journal of Human Genetics, 2015, 97 (5), pp.726-737. ⟨10.1016/j.ajhg.2015.09.007⟩ Article dans une revue hal-01223815v1
Gd3+ and calcium sensitive, sodium leak currents are features of weak membrane-glass seals in patch clamp recordings Adrienne N. Boone,Adriano Senatore,Jean Chemin,Arnaud Monteil,J. David Spafford PLoS ONE, 2014, 9 (6), pp.e98808. ⟨10.1371/journal.pone.0098808⟩ Article dans une revue hal-01943334v1
The sodium leak channel, NALCN, in health and disease Maud Cochet-Bissuel,Philippe Lory,Arnaud Monteil Frontiers in Cellular Neuroscience, 2014, 8, pp.132. ⟨10.3389/fncel.2014.00132⟩ Article dans une revue hal-01950130v1
A Ca(v)3.2/syntaxin-1A signaling complex controls T-type channel activity and low-threshold exocytosis. Norbert Weiss,Shahid Hameed,José M. Fernández-Fernández,Katell Fablet,Maria Karmazinovaet al. Journal of Biological Chemistry, 2012, 287 (4), pp.2810-8. ⟨10.1074/jbc.M111.290882⟩ Article dans une revue inserm-00757396v1
The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic β‐cell line Leigh Anne Swayne,Alexandre Mezghrani,Annie Varrault,Jean Chemin,Gyslaine Bertrandet al. EMBO Reports, 2009, 10 (8), pp.873 - 880. ⟨10.1038/embor.2009.125⟩ Article dans une revue hal-03760963v1
Regulation of T-type calcium channels: Signalling pathways and functional implications Sylvaine Huc-Brandt,Arnaud Monteil,Isabelle Bidaud,Guillaume Barbara,Jean Cheminet al. Biochimica et Biophysica Acta - Molecular Cell Research, 2009, 1793 (6), pp.947-952. ⟨10.1016/j.bbamcr.2008.11.003⟩ Article dans une revue hal-02282056v1
The multifunctional protein GC1q-R interacts specifically with the i3 loop arginine cluster of the vasopressin V-2 receptor Sebastien Granier,Frederic Jean-Alphonse,Daniel Bacqueville,Arnaud Monteil,Robert Pascalet al. Regulatory Peptides, 2008, 148, pp.76-87. ⟨10.1016/j.regpep.2008.01.007⟩ Article dans une revue istex hal-00493436v1
Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception Emmanuel Bourinet,A. Alloui,Arnaud Monteil,Christian Barrère,Brigitte Couetteet al. EMBO Journal, 2005, 24, pp.315-324. ⟨10.1038/sj.emboj.7600515⟩ Article dans une revue hal-00016908v1
α 1H mRNA in single skeletal muscle fibres accounts for T‐type calcium current transient expression during fetal development in mice Christine Berthier,Arnaud Monteil,Philippe Lory,Caroline Strube The Journal of Physiology, 2002, 539 (3), pp.681-691. ⟨10.1113/jphysiol.2001.013246⟩ Article dans une revue hal-03093134v1

Communication dans un congrès (2)

Calciseptine isolated from the black mamba toxin selectively blocks cardiac Cav1.2 (alpha1C) versus Cav1.3 (alpha1D) L-type calcium channels Pietro Mesirca,Jean Chemin,Christian Barrère,Eleonora Torre,Laura Gallotet al. Meeting of the Southeast Asian section of the International Society for Heart Research World, ISHR-SEA, Oct 2024, Singapour, Singapore. pp.100123, ⟨10.1016/j.jmccpl.2024.100123⟩ Communication dans un congrès hal-05402290v1
Deciphering pathogenic mechanisms underlying human calcium channelopathies Philippe Lory,Jean Chemin,Arnaud Monteil,Nathalie C. Guérineau,Sophie Nicoleet al. 3rd Congress of Physiology and Integrative Biology (CPBI) and 86th Congress of French Physiological Society (SFP), Société Française de Physiologie, Jun 2019, Montpellier, France Communication dans un congrès hal-03020963v1

Poster de conférence (1)

Calciseptine isolated from the black mamba toxin selectively blocks cardiac Cav1.2 (alpha1C) versus Cav1.3 (alpha1D) L-type calcium channels Pietro Mesirca,Jean Chemin,Christian Barrere,Eleonora Torre,Laura Gallotet al. 38th Meeting of the European Section of International Society, Jun 2024, Toulouse, France Poster de conférence hal-04789795v1

Pré-publication, Document de travail (2)

Electrophysiological classification of CACNA1G gene variants associated with neurodevelopmental and neurological disorders Amaël Davakan,Leos Cmarko,Barbara Ribeiro Oliveira-Mendes,Claire Bernat,Najlae Boulaliet al. 2025 Pré-publication, Document de travail hal-05348664v1
Midbrain dopamine D2R regulates the salience of threat-related events Laia Castell,Angelina Rogliardo,Tinaig Le Borgne,Claire Naon,Adeline Cathalaet al. 2025 Pré-publication, Document de travail hal-05343391v1