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Asuncion Carmona

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Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles

Stéphane Roudeau , Asuncion Carmona , Richard Ortega
Current Opinion in Chemical Biology, 2023, 76, pp.102372. ⟨10.1016/j.cbpa.2023.102372⟩
Journal articles hal-04170464v1
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Imaging the structural organization of chemical elements in growth cones of developing hippocampal neurons

Asuncion Carmona , Si Chen , Florelle Domart , Daniel Choquet , Richard Ortega
Metallomics, 2022, 14 (1), pp.mfab073. ⟨10.1093/mtomcs/mfab073⟩
Journal articles hal-03526688v1
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Neurotoxicity of Environmental Metal Toxicants: Special Issue

Richard Ortega , Asuncion Carmona
Toxics, 2022, 10 (7), pp.382. ⟨10.3390/toxics10070382⟩
Journal articles hal-03738833v1
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Altered SOD1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord

Benjamin G. Trist , Sian Genoud , Stéphane Roudeau , Alexander Rookyard , Amr Abdeen
Brain - A Journal of Neurology , 2022, 145 (9), pp.3108-3130. ⟨10.1093/brain/awac165⟩
Journal articles hal-03764277v1
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Correlative nano-imaging of metals and proteins in primary neurons by synchrotron X-ray fluorescence and STED super resolution microscopy: Experimental validation

Richard Ortega , Stéphane Roudeau , Asuncion Carmona
J.Neurosci.Methods, 2022, 381, pp.109702. ⟨10.1016/j.jneumeth.2022.109702⟩
Journal articles hal-03771841v1
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Cytoplasmic aggregation of uranium in human dopaminergic cells after continuous exposure to soluble uranyl at non-cytotoxic concentrations

Asuncion Carmona , Francesco Porcaro , Andrea Somogyi , Stéphane Roudeau , Florelle Domart
NeuroToxicology, 2021, 82, pp.35-44. ⟨10.1016/j.neuro.2020.10.015⟩
Journal articles hal-03066343v1
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How much manganese is safe for infants? A review of the scientific basis of intake guidelines and regulations relevant to the manganese content of infant formulas

Erika J. Mitchell , Seth H. Frisbie , Stéphane Roudeau , Asuncion Carmona , Richard Ortega
J.Trace Elem.Med.Biol., 2021, 65, pp.126710. ⟨10.1016/j.jtemb.2020.126710⟩
Journal articles hal-03115779v1
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Molecular Mechanisms of Environmental Metal Neurotoxicity: A Focus on the Interactions of Metals with Synapse Structure and Function

Asuncion Carmona , Stéphane Roudeau , Richard Ortega
Toxics, 2021, 9 (9), pp.198. ⟨10.3390/toxics9090198⟩
Journal articles hal-03342577v1
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Native Separation and Metallation Analysis of SOD1 Protein from the Human Central Nervous System: a Methodological Workflow

Stéphane Roudeau , Benjamin G. Trist , Asuncion Carmona , Katherine M. Davies , Glenda M. Halliday
Analytical Chemistry, 2021, 93 (32), pp.11108-11115. ⟨10.1021/acs.analchem.1c01128⟩
Journal articles hal-03326181v1
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Correlating STED and synchrotron XRF nano-imaging unveils the cosegregation of metals and cytoskeleton proteins in dendrites

Florelle Domart , Peter Cloetens , Stéphane Roudeau , Asuncion Carmona , Emeline Verdier
eLife, 2020, 9, pp.e62334. ⟨10.7554/eLife.62334⟩
Journal articles hal-03066339v1
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Estimating daily intakes of manganese due to breast milk, infant formulas, or young child nutritional beverages in the United States and France: Comparison to sufficiency and toxicity thresholds

Erika J. Mitchell , Seth H. Frisbie , Stéphane Roudeau , Asuncion Carmona , Richard Ortega
J.Trace Elem.Med.Biol., 2020, 62, pp.126607. ⟨10.1016/j.jtemb.2020.126607⟩
Journal articles hal-03066344v1
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Mapping Chemical Elements and Iron Oxidation States in the Substantia Nigra of 6-Hydroxydopamine Lesioned Rats Using Correlative Immunohistochemistry With Proton and Synchrotron Micro-Analysis

Asuncion Carmona , Stéphane Roudeau , Laura Perrin , Carole Carcenac , Delphine Vantelon
Front.Neurosci., 2019, 13, pp.1014. ⟨10.3389/fnins.2019.01014⟩
Journal articles hal-02327769v1
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Manganese Mapping Using a Fluorescent Mn 2+ Sensor and Nanosynchrotron X-ray Fluorescence Reveals the Role of the Golgi Apparatus as a Manganese Storage Site

Sayani Das , Asuncion Carmona , Kaustav Khatua , Francesco Porcaro , Andrea Somogyi
Inorganic Chemistry, 2019, 58 (20), pp.13724-13732. ⟨10.1021/acs.inorgchem.9b01389⟩
Journal articles hal-02349653v1
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Manganese levels in infant formula and young child nutritional beverages in the United States and France: Comparison to breast milk and regulations

Seth Frisbie , Erika Mitchell , Stéphane Roudeau , Florelle Domart , Asunción Carmona
PLoS ONE, 2019, 14 (11), pp.e0223636. ⟨10.1371/journal.pone.0223636⟩
Journal articles hal-02351030v1

SLC30A10 Mutation Involved in Parkinsonism Results in Manganese Accumulation within Nanovesicles of the Golgi Apparatus

Asuncion Carmona , Charles E. Zogzas , Stéphane Roudeau , Francesco Porcaro , Jan Garrevoet
ACS Chem.Neurosci., 2019, 10 (1), pp.599-609. ⟨10.1021/acschemneuro.8b00451⟩
Journal articles hal-02017059v1

Emerging chemical tools and techniques for tracking biological manganese

Sayani Das , Kaustav Khatua , Ananya Rakshit , Asuncion Carmona , Anindita Sarkar
Dalton Trans., 2019, 48 (21), pp.7047-7061. ⟨10.1039/C9DT00508K⟩
Journal articles hal-02188086v1
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Advances in element speciation analysis of biomedical samples using synchrotron-based techniques

Francesco Porcaro , Stéphane Roudeau , Asunción Carmona , Richard Ortega
Trends in Analytical Chemistry, 2018, 104, pp.22-41. ⟨10.1016/j.trac.2017.09.016⟩
Journal articles hal-01905442v1
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Uranium exposure of human dopaminergic cells results in low cytotoxicity, accumulation within sub-cytoplasmic regions, and down regulation of MAO-B

A. Carmona , Veronique Malard , E. Avazeri , S. Roudeau , F. Porcaro
NeuroToxicology, 2018, 68, pp.177-188. ⟨10.1016/j.neuro.2018.07.019⟩
Journal articles cea-02339669v1

Growth, Duplication and Lateral Mutual Compressive Deformation of Akouemma hemisphaeria on the Seafloor of Okondja Basin at 2.2 Ga (Gabon)

Ambroise Edou- Minko , Mathieu Moussavou , Tomohiko Sato , Yusuke Sawaki , Simplice Ndong Ondo
International Journal of Geosciences, 2017, 08 (09), pp.1172-1191. ⟨10.4236/ijg.2017.89067⟩
Journal articles hal-02900108v1

An Akouemma hemisphaeria Organic Macrofossils Colony Hosting Biodiversity Assemblage on the Seafloor of Okondja Basin (Gabon) dated at 2.2 Ga

A Edou-Minko , M Moussavou , T Sato , C Tchikoundzi , Y Sawaki
New Zealand Journal of Geology and Geophysics, 2017, 06 (02), ⟨10.4172/2381-8719.1000281⟩
Journal articles hal-02900111v1

Zinc and Copper Effects on Stability of Tubulin and Actin Networks in Dendrites and Spines of Hippocampal Neurons

Laura Perrin , Stéphane Roudeau , Asuncion Carmona , Florelle Domart , Jennifer D. Petersen
ACS Chem.Neurosci., 2017, 8 (7), pp.1490-1499. ⟨10.1021/acschemneuro.6b00452⟩
Journal articles hal-01719686v1

Heterogeneous intratumoral distribution of gadolinium nanoparticles within U87 human glioblastoma xenografts unveiled by micro-PIXE imaging

Asuncion Carmona , Stéphane Roudeau , Baptiste L'Homel , Frédéric Pouzoulet , Sarah Bonnet-Boissinot
Anal.Biochem., 2017, 523, pp.50-57. ⟨10.1016/j.ab.2017.02.010⟩
Journal articles hal-01758229v1

Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson’s disease brain

Benjamin G. Trist , Katherine M. Davies , Veronica Cottam , Sian Genoud , Richard Ortega
Acta Neuropathol., 2017, 134 (1), pp.113-127. ⟨10.1007/s00401-017-1726-6⟩
Journal articles hal-01729986v1

α-Synuclein Over-Expression Induces Increased Iron Accumulation and Redistribution in Iron-Exposed Neurons

Richard Ortega , Asuncion Carmona , Stéphane Roudeau , Laura Perrin , Tanja Dučić
Molecular Neurobiology, 2015, 53 (3), pp.1925-1934. ⟨10.1007/s12035-015-9146-x⟩
Journal articles hal-01758781v1

Multicellular Consortia Preserved in Biogenic Ductile-Plastic Nodules of Okondja Basin (Gabon) by 2.1 Ga

Moussavou Edou Minko A , Mathieu Moussavou , Ambroise Edou-Minko , M Mbina Mounguengui , Richard Ortega
Journal of Geology & Geosciences, 2015, 04 (02), ⟨10.4172/2329-6755.1000195⟩
Journal articles hal-02900118v1

Reduced net charge and heterogeneity of pI isoforms in familial amyotrophic lateral sclerosis mutants of copper/zinc superoxide dismutase

Stephane Roudeau , Sylviane Chevreux , Asunción Carmona , Richard Ortega
Electrophoresis, 2015, 36 (19), pp.2482-2488. ⟨10.1002/elps.201500187⟩
Journal articles hal-02899586v1

Analysis of Platinum and Trace Metals in Treated Glioma Rat Cells by X-Ray Fluorescence Emission

Silvia Gil , Asuncion Carmona , Gema Martinez-Criado , Alberto Leon , Yolanda Prezado
Biological Trace Element Research, 2015, 163 (1-2), pp.177-183. ⟨10.1007/s12011-014-0097-2⟩
Journal articles hal-02899952v1

Evaluation of sample preparation methods for single cell quantitative elemental imaging using proton or synchrotron radiation focused beams

Laura Perrin , Asuncion Carmona , Stéphane Roudeau , Richard Ortega
Journal of Analytical Atomic Spectrometry, 2015, 30 (12), pp.2525-2532. ⟨10.1039/C5JA00303B⟩
Journal articles hal-02899701v1
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Low-solubility particles and a Trojan-horse type mechanism of toxicity: the case of cobalt oxide on human lung cells

Richard Ortega , Carole Bresson , Carine Darolles , Celine C. Gautier , Stéphane Roudeau
Particle and Fibre Toxicology, 2014, 11 (1), pp.14. ⟨10.1186/1743-8977-11-14⟩
Journal articles hal-02899990v1

Correlative organelle fluorescence microscopy and synchrotron X-ray chemical element imaging in single cells

Stephane Roudeau , Asuncion Carmona , Laura Perrin , Richard Ortega
Analytical and Bioanalytical Chemistry, 2014, 406 (27), pp.6979-6991. ⟨10.1007/s00216-014-8004-4⟩
Journal articles hal-02899959v1

Environmental manganese compounds accumulate as Mn(II) within the Golgi apparatus of dopamine cells: relationship between speciation, subcellular distribution, and cytotoxicity

A. Carmona , S. Roudeau , L. Perrin , G. Veronesi , R. Ortega
Metallomics, 2014, 6, pp.822-832. ⟨10.1039/C4MT00012A⟩
Journal articles in2p3-01020559v1

Improvement and recent applications of the Tohoku microbeam system

S. Matsuyama , K. Ishii , K. Watanabe , A. Terakawa , Y. Kikuchi
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2014, 318, pp.32-36. ⟨10.1016/j.nimb.2013.06.056⟩
Journal articles in2p3-00977087v1
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Copper pathology in vulnerable brain regions in Parkinson's disease.

Katherine M. Davies , Sylvain Bohic , Asunción Carmona , Richard Ortega , Veronica Cottam
Neurobiol Aging, 2014, 35 (4), pp.858-66. ⟨10.1016/j.neurobiolaging.2013.09.034⟩
Journal articles inserm-00968923v1

Cobalt chloride speciation, mechanisms of cytotoxicity on human pulmonary cells, and synergistic toxicity with zinc

C. Bresson , C. Darolles , A. Carmona , Christian Gautier , N. Sage
Metallomics, 2013, 5, pp.133-143. ⟨10.1039/C3MT20196A⟩
Journal articles in2p3-00823540v1

Cobalt chloride speciation, mechanisms of cytotoxicity on human pulmonary cells, and synergistic toxicity with zinc.

C. Bresson , C. Darolles , A. Carmona , Christian Gautier , N. Sage
Toxicology Letters, 2013, 221, pp.0378-4274. ⟨10.1016/j.toxlet.2013.05.363⟩
Journal articles in2p3-00873216v1

X-ray absorption spectroscopy of biological samples. A tutorial

R. Ortega , A. Carmona , I. Llorens , P- L. Solari
Journal of Analytical Atomic Spectrometry, 2012, 27, pp.2054-2065. ⟨10.1039/c2ja30224a⟩
Journal articles in2p3-00767655v1

Coupling of native IEF and extended X-ray absorption fine structure to characterize zinc-binding sites from pI isoforms of SOD1 and A4V pathogenic mutant

S. Chevreux , I. Llorens , P. Lorenzo Solari , S. Roudeau , Guillaume Devès
Electrophoresis, 2012, 33, pp.1276-1281. ⟨10.1002/elps.201100596⟩
Journal articles in2p3-00699389v1
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Combined use of hard X-ray phase contrast imaging and X-ray fluorescence microscopy for sub-cellular metal quantification.

Ewelina Kosior , Sylvain Bohic , Heikki Suhonen , Richard Ortega , Guillaume Devès
Journal of Structural Biology, 2012, 177 (2), pp.239-47. ⟨10.1016/j.jsb.2011.12.005⟩
Journal articles inserm-00662829v1

High Spatial Resolution Chemical Imaging of Inorganic and Organometallic Pesticides

R. Ortega , A. Carmona
Journal of Environmental & Analytical Toxicology, 2012, 4, pp.005. ⟨10.4172/2161-0525.S4-005⟩
Journal articles in2p3-00776225v1
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Manganese Accumulates within Golgi Apparatus in Dopaminergic Cells as Revealed by Synchrotron X-ray Fluorescence Nanoimaging

Asuncion Carmona , Guillaume Devès , Stéphane Roudeau , Peter Cloetens , Sylvain Bohic
ACS Chemical Neuroscience, 2010, 1 (3), pp.194-203. ⟨10.1021/cn900021z⟩
Journal articles inserm-00522281v1

Fluorine microimaging and quantification using nuclear reaction analysis: A tool for validating tissue distribution of positron emission tomography tracers

G. Devès , S. Roudeau , Asuncion Carmona , S. Lavielle , K. Gionnet
Applied Physics Letters, 2009, 95 (2), pp.023701. ⟨10.1063/1.3173808⟩
Journal articles hal-02900009v1

Multimodal analysis of metals in copper-zinc superoxide dismutase isoforms separated on electrophoresis gels

S. Chevreux , S. Roudeau , A. Fraysse , A. Carmona , Guillaume Devès
Biochimie, 2009, 91 (10), pp.1324--1327. ⟨10.1016/j.biochi.2009.05.016⟩
Journal articles hal-01560752v1

Bio-metals imaging and speciation in cells using proton and synchrotron radiation X-ray micro-spectroscopy

R. Ortega , Guillaume Devès , A. Carmona
Journal of the Royal Society Interface, 2009, 6, pp.S649-S658. ⟨10.1098/rsif.2009.0166.focus⟩
Journal articles in2p3-00762347v1

Direct speciation of metals in copper-zinc superoxide dismutase isoforms on electrophoresis gels using X-ray absorption near edge structure

Sylviane Chevreux , Stéphane Roudeau , Aurélien Fraysse , Asuncion Carmona , Guillaume Devès
Journal of Analytical Atomic Spectrometry, 2008, 23 (8), pp.1117. ⟨10.1039/B802375A⟩
Journal articles hal-02900050v1

Nano-imaging of trace metals by synchrotron X-ray fluorescence into dopaminergic single cells and neurite-like processes

Asuncion Carmona , Peter Cloetens , Guillaume Devès , Sylvain Bohic , Richard Ortega
Journal of Analytical Atomic Spectrometry, 2008, 23 (8), pp.1083. ⟨10.1039/B802242A⟩
Journal articles hal-02900086v1

Accelerator-based research activities at “Centro Nacional de Aceleradores”, Seville (Spain)

M.A. Respaldiza , F.J. Ager , A. Carmona , J. Ferrer , M. García-León
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2008, 266 (10), pp.2105-2109. ⟨10.1016/j.nimb.2008.02.080⟩
Journal articles hal-02900096v1

Quantitative micro-analysis of metal ions in subcellular compartments of cultured dopaminergic cells by combination of three ion beam techniques

A. Carmona , G. Devès , R. Ortega
Analytical and Bioanalytical Chemistry, 2008, 390 (6), pp.1585-1594. ⟨10.1007/s00216-008-1866-6⟩
Journal articles hal-02900090v1

Iron Storage within Dopamine Neurovesicles Revealed by Chemical Nano-Imaging

Richard Ortega , Peter Cloetens , Guillaume Devès , Asuncion Carmona , Sylvain Bohic
PLoS ONE, 2007, 2(9), pp.e925. ⟨10.1371/journal.pone.0000925⟩
Journal articles hal-00199671v1
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Subcellular speciation analysis of trace element oxidation states using synchrotron radiation micro-X-ray absorption near-edge structure.

Thomas Bacquart , Guillaume Devès , Asunción Carmona , Rémi Tucoulou , Sylvain Bohic
Analytical Chemistry, 2007, 79 (19), pp.7353-9. ⟨10.1021/ac0711135⟩
Journal articles inserm-00383852v1

Subcellular Speciation Analysis of Trace Element Oxidation States Using Synchrotron Radiation Micro-X-ray Absorption Near-Edge Structure

Thomas Bacquart , Guillaume Devès , Asunción Carmona , Rémi Tucoulou , Sylvain Bohic
Analytical Chemistry, 2007, 79 (19), pp.7353 -7359. ⟨10.1021/ac0711135S0003-2700(07)01113-4⟩
Journal articles hal-00199708v1
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Iron storage within dopamine neurovesicles revealed by chemical nano-imaging.

Richard Ortega , Peter Cloetens , Guillaume Devès , Asunción Carmona , Sylvain Bohic
PLoS ONE, 2007, 2 (9), pp.e925. ⟨10.1371/journal.pone.0000925⟩
Journal articles inserm-00383874v1

Identifying elements in rocks from the Dry Valleys desert (Antarctica) by ion beam proton induced X-ray emission

J. Wierzchos , C. Ascaso , F.J. Ager , I. García-Orellana , A. Carmona-Luque
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2006, 249 (1-2), pp.571-574. ⟨10.1016/j.nimb.2006.03.057⟩
Journal articles hal-02900102v1

Nuclear microprobe determination of platinum quantitative distribution in rat brain tumors after cisplatin or carboplatin injection for PAT treatment of glioma

Richard Ortega , Marie-Claude Biston , Guillaume Devès , Sylvain Bohic , Asuncion Carmona
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2005, 231 (1-4), pp.321. ⟨10.1016/j.nimb.2005.01.077⟩
Journal articles hal-00139175v1