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Beatrice DURAND

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Présentation

**PRESENT** Sorbonne Université CNRS UMR7622 – Laboratoire de Biologie du Développement, Bureau 714 - Campus Jussieu, Bâtiment C 7ème étage, boîte 24 9 Quai Saint Bernard 75252 Paris Cedex 05 France Email : beatrice.durand@sorbonne-universite.fr Tel 33 01 44 27 32 93 **CURRICULUM AND RESEARCH EXPERIENCE.** 2014-present: Scientific Research "Local Inhibition of Wnt / β-catenin Signaling in Early Development ". 2007-2014: Scientific Research - IBENS Paris - “Growth and Morphogenesis of the Caudal Forebrain." 2003- 2006: CNRS - Pasteur Institute, Paris. “Growth and Morphogenesis of the Caudal Forebrain." 1998-2002: EMBO Fellow. Baylor College of Medicine Houston - Texas, USA. (Pr. M. Jamrich) "Barhl2: A Diencephalic Determinant ". 1994-1998: Human Research Frontier Fellow. University College London - London U.K. (Pr. Martin Raff) Human Research Frontier Fellowship “An Intrinsic Clock Mechanism that Limits Oligodendrocyte Precursor Cell Proliferation.” 1987-1993: Ph. D. thesis. Supervisor : Pr P. Chambon. “Cellular Analysis of the Molecular Response to Retinoic Acid (RA) (9-cis RA et all-trans RA) via its Nuclear Receptors (RAR et RXR).” 1983-1986: Ecole Normale Supérieure Saint-Cloud. Agrégation de Biochimie Génie Génétique, First Rank. **SCIENTIFIC LEADER, ADMINISTRATIVE AND TEACHING RESPONSIBILITIES** **IMPLEMENTATION** of scientific projects from their conception to their development and publication, together with the supervision of the scientific, technical and management aspects with scientists, students and technical staff. **ADVISOR of PhDs (3), postdoctorates (2), students/technicians (16).** **EXPERTISE** for scientific journals, grant agencies, PhD and HDR reports, recruitment committees. **ORGANIZATION** of the "European Amphibian Club 2017 and 2019" and scientific club: "Xenoparisiens". **EDITOR** for Journal of Developmental Biology **FUNDINGS:** LNCC (2019-2022) 45K€ - FPGG (2013) 150K€ -ARC Project (2009) 50K€- ANR Switch 300K€. **TEACHING:** Neuroscience Course of the Pasteur Institute "Development and Plasticity of the Nervous System". Teaching Assistant in the National School of Biotechnology in Strasbourg (E.N.S.B.S) - French National Education School teacher of Biochemistry and Cell Biology High school level - **RECENT INVITED SEMINARS** 2019 European Amphibian Club 2019 Lutherstad GR. 2018 VIB-UGent Center for Inflammation Research. Ghent Belgium 2017 1- European Amphibian Club 2017 (28th-30th June 2017), Rennes FR. 2- Museum d'Histoire Naturelle – (12 April 2017) Paris FR. 3- Université Pierre et Marie Curie – (22 Novembre 2017) Paris FR. 2016: Mount Sinai Hospital - NYC - New York, USA - European Amphibian Club 2017 Rennes FR – IBPS PARIS FR. 2015: University of Hohenheim Institute of Zoology -Stuttgart - Germany 2013: 17th International Congress of Developmental Biology - Cancun MEXICO.
PRÉSENT Sorbonne Université CNRS UMR7622 – Laboratoire de Biologie du Développement, Bureau 714 - Campus Jussieu, Bâtiment C 7ème étage, boîte 24 9 Quai Saint Bernard 75252 Paris Cedex 05 France Email : beatrice.durand@sorbonne-universite.fr Tel 33 01 44 27 32 93 PROGRAMME D'ÉTUDES ET EXPÉRIENCE DE RECHERCHE. 2014-present: Projet Scientifique "Inhibition localisée de la voie Wnt / β-Catenin au cours du développement précoce". 2007-2014: Recherche Scientifique – Institut de Biologie de l’Ecole Normale Supérieure (IBENS Paris) 2003- 2006: CNRS – Institut Pasteur - Paris FRANCE. 1998-2002: EMBO Fellow (http://embo.org/). Baylor College of Medicine Houston - Texas, USA. 1994-1998: Human Research Frontier Fellow (http://www.hfsp.org/). University College London - London U.K. 1987-1993: Ph. D. Thèse de doctorat sous la supervision de Pr P. Chambon. Université Louis Pasteur à Strasbourg. 1983-1986: Ecole Normale Supérieure. Agrégation de Biochimie Génie Génétique, classée première. RESPONSABLE SCIENTIFIQUE, RESPONSABILITÉS ADMINISTRATIVES ET PÉDAGOGIQUES MISE EN OEUVRE de projets scientifiques, depuis leur conception jusqu'à leur élaboration et leur publication, en passant par la supervision des aspects scientifiques, techniques et de gestion avec les scientifiques, les étudiants et le personnel technique. CONSEILLER des doctorants (3), post-doctorants (2), étudiants/techniciens (16). EXPERTISE pour les revues scientifiques, les organismes de subventions, les rapports de doctorat et d’HDR, les comités de recrutement. ORGANISATION de conférences "European Amphibian Club 2017 and 2019" et de clubs scientifiques: "Xenoparisiens". EDITEUR pour Journal of Developmental Biology (https://www.mdpi.com/journal/jdb) FINANCEMENTS: LNCC(2019) 22.5K€-FPGG(2013) 160K€ - collaboration ARC (2009-2011) 50K€- ANR Projet Switch 300K€. ENSEIGNEMENTS: Cours de Master 2 de l’Institut Pasteur " Développement et plasticité du système nerveux ". Assistant pour la National School of Biotechnology in Strasbourg (E.N.S.B.S) – Professeur de biochimie pour Education Nationale (France). TECHNICS Embryologie - Histologie - Culture cellulaire sur cellules immortalisées ou cultures primaires – Biologie Moléculaire – Biochimie – Proliferation - Apoptose - Transcription- Signallisation - lentivirus - shRNA – Xenopus Laevis - Mouse. SÉMINAIRES INVITÉS RÉCENTS 2019 European Amphibian Club 2019 Lutherstad GR. 2018 1- VIB-UGent Center for Inflammation Research. Ghent Belgium 2- Institut de Biologie Paris Sorbonne PARIS FR. 2017 1- European Amphibian Club 2017 (28th-30th June 2017), Rennes FR. 2- Museum d'Histoire Naturelle – (12 April 2017) Paris FR. 3- Université Pierre et Marie Curie – (22 Novembre 2017) Paris FR. 2015: University of Hohenheim Institute of Zoology -Stuttgart - Germany 2013: 17th International Congress of Developmental Biology - Cancun MEXICO. 2013: Institut de Génétique et Développement de Rennes - Rennes – FR. 2012: 14th International Xenopus Conference Port Cros FR.

Publications

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T-Cell Factors as Transcriptional Inhibitors: Activities and Regulations in Vertebrate Head Development

Johnny Bou-Rouphael , Beatrice Claude Durand
Frontiers in Cell and Developmental Biology, 2021, ⟨10.3389/fcell.2021.784998⟩
Article dans une revue hal-03445705v1
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Mcl1 protein levels and Caspase‐7 executioner protease control axial organizer cells survival

Elena Sena , Johnny Bou-Rouphael , Nathalie Rocques , Clémence Carron-Homo , Beatrice Claude Durand
Developmental Dynamics, 2020, 249 (7), pp.847-866. ⟨10.1002/dvdy.169⟩
Article dans une revue hal-02562454v1
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Barhl2 maintains T cell factors as repressors and thereby switches off the Wnt/β-Catenin response driving Spemann organizer formation

Elena Sena , Nathalie Rocques , Caroline Borday , Harem Sabr Muhamad Amin , Karine Parain
Development (Cambridge, England), 2019, 146 (10), pp.dev173112. ⟨10.1242/dev.173112⟩
Article dans une revue hal-02376583v1
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An Evolutionarily Conserved Network Mediates Development of the zona limitans intrathalamica, a Sonic Hedgehog-Secreting Caudal Forebrain Signaling Center

Elena Sena , Kerstin Feistel , Beatrice Claude Durand
Journal of Developmental Biology, 2016, 4 (4), pp.31. ⟨10.3390/jdb4040031⟩
Article dans une revue hal-02560909v1
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Stem cell-like Xenopus Embryonic Explants to Study Early Neural Developmental Features

Beatrice Claude Durand
Journal of visualized experiments : JoVE, 2016, 108, pp.e53474. ⟨10.3791/53474⟩
Article dans une revue hal-02561072v1
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Early development of the neural plate: New roles for apoptosis and for one of its main effectors caspase-3

Hugo Juraver-Geslin , Beatrice Claude Durand
Genesis, 2015, 53 (2), pp.203-224. ⟨10.1002/dvg.22844⟩
Article dans une revue hal-02561075v1
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The conserved barH-like homeobox-2 gene barhl2 acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog

Hugo Juraver-Geslin , José Luis Gomez-Skarmeta , Beatrice Claude Durand
Developmental Biology, 2014, 396 (1), pp.107-120. ⟨10.1016/j.ydbio.2014.09.027⟩
Article dans une revue hal-02561077v1
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Barhl2 limits growth of the diencephalic primordium through Caspase3 inhibition of beta-catenin activation

Hugo Juraver-Geslin , Jérome Ausseil , Marion Wassef , Beatrice Claude Durand
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (6), pp.2288-2293. ⟨10.1073/pnas.1014017108⟩
Article dans une revue hal-02561073v1

The Murine Ortholog of Notchless, a Direct Regulator of the Notch Pathway in Drosophila melanogaster, Is Essential for Survival of Inner Cell Mass Cells

Sarah Cormier , Stéphanie Le Bras , Céline Souilhol , Sandrine Vandormael-Pournin , Beatrice Claude Durand
Molecular and Cellular Biology, 2006, 26 (9), pp.3541-3549. ⟨10.1128/MCB.26.9.3541-3549.2006⟩
Article dans une revue pasteur-02075508v1
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The pro-apoptotic activity of a vertebrate Bar-like homeobox gene plays a key role in patterning the Xenopus neural plate by limiting the number of chordin- and shh-expressing cells

Nicolas Offner , Nathalie Duval , Milan Jamrich , Beatrice Claude Durand
Development (Cambridge, England), 2005, 132 (8), pp.1807-1818. ⟨10.1242/dev.01712⟩
Article dans une revue hal-02561079v1
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The nuclear orphan receptor COUP-TFI is important for differentiation of oligodendrocytes

Hideki Yamaguchi , Cheng Zhou , Song-Chang Lin , Beatrice Claude Durand , Sophia Tsai
Developmental Biology, 2004, 266 (2), pp.238-251. ⟨10.1016/j.ydbio.2003.10.038⟩
Article dans une revue hal-02561081v1
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A cell-intrinsic timer that operates during oligodendrocyte development

Beatrice Claude Durand , Martin Raff
BioEssays, 2000, 22 (1), pp.64-71. ⟨10.1002/(SICI)1521-1878⟩
Article dans une revue hal-02561082v1

An Analysis of the Early Events When Oligodendrocyte Precursor Cells Are Triggered to Differentiate by Thyroid Hormone, Retinoic Acid, or PDGF Withdrawal

Yasuhito Tokumoto , Beatrice Claude Durand , Martin Raff
Developmental Biology, 1999, 213 (2), pp.327-339. ⟨10.1006/dbio.1999.9397⟩
Article dans une revue hal-02561083v1

Altered Expression of Cell Cycle Proteins and Prolonged Duration of Cardiac Myocyte Hyperplasia in p27 KIP1 Knockout Mice

Robert Poolman , Jian-Mei Li , Beatrice Claude Durand , Gavin Brooks
Circulation Research, 1999, 85 (2), pp.117-127. ⟨10.1161/01.res.85.2.117⟩
Article dans une revue hal-02561090v1
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Cell number control and timing in animal development: the oligodendrocyte cell lineage.

M Raff , Beatrice Claude Durand , F Gao
International Journal of Developmental Biology, 1998, 42 (3), pp.263-7
Article dans une revue hal-02561084v1

p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation

Beatrice Claude Durand , Matthew Fero , James Roberts , Martin Raff
Current Biology - CB, 1998, 8 (8), pp.431-440. ⟨10.1016/s0960-9822(98)70177-0⟩
Article dans une revue hal-02561085v1
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Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation

Beatrice Claude Durand , F Gao , M Raff
EMBO Journal, 1997, 16 (2), pp.306-317. ⟨10.1093/emboj/16.2.306⟩
Article dans une revue hal-02561088v1

Oligodendrocyte precursor cells count time but not cell divisions before differentiation

Beatrice Claude Durand , Fen-Biao Gao , Martin Raff
Current Biology - CB, 1997, 7 (2), pp.152-155. ⟨10.1016/s0960-9822(06)00060-1⟩
Article dans une revue hal-02561087v1
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Endogenous Retinoic Acid Receptor (RAR)-Retinoid X Receptor (RXR) Heterodimers Are the Major Functional Forms Regulating Retinoid-responsive Elements in Adult Human Keratinocytes

Jia-Hao Xiao , Beatrice Claude Durand , Pierre Chambon , John Voorhees
Journal of Biological Chemistry, 1995, 270 (7), pp.3001-3011. ⟨10.1074/jbc.270.7.3001⟩
Article dans une revue hal-02561132v1
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The cellular retinoic acid binding protein I is dispensable.

P. Gorry , T. Lufkin , Andrée Dierich , Cécile Rochette-Egly , D Décimo
Proceedings of the National Academy of Sciences of the United States of America, 1994, 91 (19), pp.9032-9036. ⟨10.1073/pnas.91.19.9032⟩
Article dans une revue hal-02561140v1
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Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity.

Beatrice Claude Durand , M Saunders , C Gaudon , B Roy , R. Losson
EMBO Journal, 1994, 13 (22), pp.5370-82
Article dans une revue hal-02561133v1
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Pure and functionally homogeneous recombinant retinoid X receptor.

Z. Chen , L Shemshedini , Beatrice Claude Durand , N Noy , P. Chambon
Journal of Biological Chemistry, 1994, 269 (41), pp.25770-6
Article dans une revue hal-02561137v1
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All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs

Beatrice Claude Durand , Michael Saunders , Pierre Leroy , Mark Leid , Pierre Chambon
Cell, 1992, 71 (1), pp.73-85. ⟨10.1016/0092-8674(92)90267-g⟩
Article dans une revue hal-02561145v1
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Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors

Sunil Nagpal , Michael Saunders , Philippe Kastner , Beatrice Claude Durand , Harikrishna Nakshatri
Cell, 1992, 70 (6), pp.1007-1019. ⟨10.1016/0092-8674(92)90250-g⟩
Article dans une revue hal-02561148v1
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Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.

P Kastner , A. Perez , Y Lutz , C. Rochette-Egly , M Gaub
EMBO Journal, 1992, 11 (2), pp.629-42
Article dans une revue hal-02561207v1

Cellular retinoic acid-binding protein type 2 mRNA is overexpressed in human psoriatic skin as shown by in situ hybridization

Liliane Didierjean , Beatrice Claude Durand , Jean-Hilaire Saurat
Biochemical and Biophysical Research Communications, 1991, 180 (1), pp.204-208. ⟨10.1016/s0006-291x(05)81277-x⟩
Article dans une revue hal-02561154v1
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Compartmentalization of MHC class II gene expression in transgenic mice

Willem van Ewijk , Yacov Ron , John Monaco , John Kappler , Philippa Marrack
Cell, 1988, 53 (3), pp.357-370. ⟨10.1016/0092-8674(88)90156-0⟩
Article dans une revue hal-02561158v1
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Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins.

A. Dorn , Beatrice Claude Durand , C. Marfing , M. Le Meur , C. Benoist
Proceedings of the National Academy of Sciences of the United States of America, 1987, 84 (17), pp.6249-6253. ⟨10.1073/pnas.84.17.6249⟩
Article dans une revue hal-02561163v1