Beatrice DURAND

Présentation

PRÉSENT Sorbonne Université CNRS UMR7622 – Laboratoire de Biologie du Développement, Bureau 714 - Campus Jussieu, Bâtiment C 7ème étage, boîte 24 9 Quai Saint Bernard 75252 Paris Cedex 05 France Email : beatrice.durand@sorbonne-universite.fr Tel 33 01 44 27 32 93 PROGRAMME D'ÉTUDES ET EXPÉRIENCE DE RECHERCHE. 2014-present: Projet Scientifique &quot;Inhibition localisée de la voie Wnt / β-Catenin au cours du développement précoce&quot;. 2007-2014: Recherche Scientifique – Institut de Biologie de l’Ecole Normale Supérieure (IBENS Paris) 2003- 2006: CNRS – Institut Pasteur - Paris FRANCE. 1998-2002: EMBO Fellow (http://embo.org/). Baylor College of Medicine Houston - Texas, USA. 1994-1998: Human Research Frontier Fellow (http://www.hfsp.org/). University College London - London U.K. 1987-1993: Ph. D. Thèse de doctorat sous la supervision de Pr P. Chambon. Université Louis Pasteur à Strasbourg. 1983-1986: Ecole Normale Supérieure. Agrégation de Biochimie Génie Génétique, classée première. RESPONSABLE SCIENTIFIQUE, RESPONSABILITÉS ADMINISTRATIVES ET PÉDAGOGIQUES MISE EN OEUVRE de projets scientifiques, depuis leur conception jusqu'à leur élaboration et leur publication, en passant par la supervision des aspects scientifiques, techniques et de gestion avec les scientifiques, les étudiants et le personnel technique. CONSEILLER des doctorants (3), post-doctorants (2), étudiants/techniciens (16). EXPERTISE pour les revues scientifiques, les organismes de subventions, les rapports de doctorat et d’HDR, les comités de recrutement. ORGANISATION de conférences &quot;European Amphibian Club 2017 and 2019&quot; et de clubs scientifiques: &quot;Xenoparisiens&quot;. EDITEUR pour Journal of Developmental Biology (https://www.mdpi.com/journal/jdb) FINANCEMENTS: LNCC(2019) 22.5K€-FPGG(2013) 160K€ - collaboration ARC (2009-2011) 50K€- ANR Projet Switch 300K€. ENSEIGNEMENTS: Cours de Master 2 de l’Institut Pasteur &quot; Développement et plasticité du système nerveux &quot;. Assistant pour la National School of Biotechnology in Strasbourg (E.N.S.B.S) – Professeur de biochimie pour Education Nationale (France). TECHNICS Embryologie - Histologie - Culture cellulaire sur cellules immortalisées ou cultures primaires – Biologie Moléculaire – Biochimie – Proliferation - Apoptose - Transcription- Signallisation - lentivirus - shRNA – Xenopus Laevis - Mouse. SÉMINAIRES INVITÉS RÉCENTS 2019 European Amphibian Club 2019 Lutherstad GR. 2018 1- VIB-UGent Center for Inflammation Research. Ghent Belgium 2- Institut de Biologie Paris Sorbonne PARIS FR. 2017 1- European Amphibian Club 2017 (28th-30th June 2017), Rennes FR. 2- Museum d'Histoire Naturelle – (12 April 2017) Paris FR. 3- Université Pierre et Marie Curie – (22 Novembre 2017) Paris FR. 2015: University of Hohenheim Institute of Zoology -Stuttgart - Germany 2013: 17th International Congress of Developmental Biology - Cancun MEXICO. 2013: Institut de Génétique et Développement de Rennes - Rennes – FR. 2012: 14th International Xenopus Conference Port Cros FR.

Publications

Article dans une revue (29)

Cerebellar granular neuron progenitors exit their germinative niche via BarH-like1 activity mediated partly by inhibition of T-cell factor Johnny Bou-Rouphael,Mohamed Doulazmi,Alexis Eschstruth,Asna Abdou,Beatrice Claude Durand Development (Cambridge, England), 2024, 151 (13), pp.10.1242/dev.202234. ⟨10.1242/dev.202234⟩ Article dans une revue hal-04692301v1
T-Cell Factors as Transcriptional Inhibitors: Activities and Regulations in Vertebrate Head Development Johnny Bou-Rouphael,Beatrice Claude Durand Frontiers in Cell and Developmental Biology, 2021, ⟨10.3389/fcell.2021.784998⟩ Article dans une revue hal-03445705v1
Mcl1 protein levels and Caspase‐7 executioner protease control axial organizer cells survival Elena Sena,Johnny Bou-Rouphael,Nathalie Rocques,Clémence Carron-Homo,Beatrice Claude Durand Developmental Dynamics, 2020, 249 (7), pp.847-866. ⟨10.1002/dvdy.169⟩ Article dans une revue hal-02562454v1
Barhl2 maintains T cell factors as repressors and thereby switches off the Wnt/β-Catenin response driving Spemann organizer formation Elena Sena,Nathalie Rocques,Caroline Borday,Harem Sabr Muhamad Amin,Karine Parainet al. Development (Cambridge, England), 2019, 146 (10), pp.dev173112. ⟨10.1242/dev.173112⟩ Article dans une revue hal-02376583v1
An Evolutionarily Conserved Network Mediates Development of the zona limitans intrathalamica, a Sonic Hedgehog-Secreting Caudal Forebrain Signaling Center Elena Sena,Kerstin Feistel,Beatrice Claude Durand Journal of Developmental Biology, 2016, 4 (4), pp.31. ⟨10.3390/jdb4040031⟩ Article dans une revue hal-02560909v1
Stem cell-like &lt;em&gt;Xenopus&lt;/em&gt; Embryonic Explants to Study Early Neural Developmental Features Beatrice Claude Durand Journal of visualized experiments : JoVE, 2016, 108, pp.e53474. ⟨10.3791/53474⟩ Article dans une revue hal-02561072v1
Early development of the neural plate: New roles for apoptosis and for one of its main effectors caspase-3 Hugo Juraver-Geslin,Beatrice Claude Durand Genesis - The Journal of Genetics and Development, 2015, 53 (2), pp.203-224. ⟨10.1002/dvg.22844⟩ Article dans une revue hal-02561075v1
The conserved barH-like homeobox-2 gene barhl2 acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog Hugo Juraver-Geslin,José Luis Gomez-Skarmeta,Beatrice Claude Durand Developmental Biology, 2014, 396 (1), pp.107-120. ⟨10.1016/j.ydbio.2014.09.027⟩ Article dans une revue hal-02561077v1
Barhl2 limits growth of the diencephalic primordium through Caspase3 inhibition of beta-catenin activation Hugo Juraver-Geslin,Jérome Ausseil,Marion Wassef,Beatrice Claude Durand Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (6), pp.2288-2293. ⟨10.1073/pnas.1014017108⟩ Article dans une revue hal-02561073v1
The Murine Ortholog of Notchless, a Direct Regulator of the Notch Pathway in Drosophila melanogaster, Is Essential for Survival of Inner Cell Mass Cells Sarah Cormier,Stéphanie Le Bras,Céline Souilhol,Sandrine Vandormael-Pournin,Beatrice Claude Durandet al. Molecular and Cellular Biology, 2006, 26 (9), pp.3541-3549. ⟨10.1128/MCB.26.9.3541-3549.2006⟩ Article dans une revue pasteur-02075508v1
The pro-apoptotic activity of a vertebrate Bar-like homeobox gene plays a key role in patterning the Xenopus neural plate by limiting the number of chordin- and shh-expressing cells Nicolas Offner,Nathalie Duval,Milan Jamrich,Beatrice Claude Durand Development (Cambridge, England), 2005, 132 (8), pp.1807-1818. ⟨10.1242/dev.01712⟩ Article dans une revue hal-02561079v1
The nuclear orphan receptor COUP-TFI is important for differentiation of oligodendrocytes Hideki Yamaguchi,Cheng Zhou,Song-Chang Lin,Beatrice Claude Durand,Sophia Tsaiet al. Developmental Biology, 2004, 266 (2), pp.238-251. ⟨10.1016/j.ydbio.2003.10.038⟩ Article dans une revue hal-02561081v1
A cell-intrinsic timer that operates during oligodendrocyte development Beatrice Claude Durand,Martin Raff BioEssays, 2000, 22 (1), pp.64-71. ⟨10.1002/(SICI)1521-1878⟩ Article dans une revue hal-02561082v1
Altered Expression of Cell Cycle Proteins and Prolonged Duration of Cardiac Myocyte Hyperplasia in p27 KIP1 Knockout Mice Robert Poolman,Jian-Mei Li,Beatrice Claude Durand,Gavin Brooks Circulation Research, 1999, 85 (2), pp.117-127. ⟨10.1161/01.res.85.2.117⟩ Article dans une revue hal-02561090v1
An Analysis of the Early Events When Oligodendrocyte Precursor Cells Are Triggered to Differentiate by Thyroid Hormone, Retinoic Acid, or PDGF Withdrawal Yasuhito Tokumoto,Beatrice Claude Durand,Martin Raff Developmental Biology, 1999, 213 (2), pp.327-339. ⟨10.1006/dbio.1999.9397⟩ Article dans une revue hal-02561083v1
Cell number control and timing in animal development: the oligodendrocyte cell lineage. M Raff,Beatrice Claude Durand,F Gao International Journal of Developmental Biology, 1998, 42 (3), pp.263-7 Article dans une revue hal-02561084v1
p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation Beatrice Claude Durand,Matthew Fero,James Roberts,Martin Raff Current Biology, 1998, 8 (8), pp.431-440. ⟨10.1016/s0960-9822(98)70177-0⟩ Article dans une revue hal-02561085v1
Oligodendrocyte precursor cells count time but not cell divisions before differentiation Beatrice Claude Durand,Fen-Biao Gao,Martin Raff Current Biology, 1997, 7 (2), pp.152-155. ⟨10.1016/s0960-9822(06)00060-1⟩ Article dans une revue hal-02561087v1
Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation Beatrice Claude Durand,F Gao,M Raff EMBO Journal, 1997, 16 (2), pp.306-317. ⟨10.1093/emboj/16.2.306⟩ Article dans une revue hal-02561088v1
Endogenous Retinoic Acid Receptor (RAR)-Retinoid X Receptor (RXR) Heterodimers Are the Major Functional Forms Regulating Retinoid-responsive Elements in Adult Human Keratinocytes Jia-Hao Xiao,Beatrice Claude Durand,Pierre Chambon,John Voorhees Journal of Biological Chemistry, 1995, 270 (7), pp.3001-3011. ⟨10.1074/jbc.270.7.3001⟩ Article dans une revue hal-02561132v1
The cellular retinoic acid binding protein I is dispensable. P. Gorry,T. Lufkin,Andrée Dierich,Cécile Rochette-Egly,D Décimoet al. Proceedings of the National Academy of Sciences of the United States of America, 1994, 91 (19), pp.9032-9036. ⟨10.1073/pnas.91.19.9032⟩ Article dans une revue hal-02561140v1
Pure and functionally homogeneous recombinant retinoid X receptor. Z. Chen,L Shemshedini,Beatrice Claude Durand,N Noy,P. Chambonet al. Journal of Biological Chemistry, 1994, 269 (41), pp.25770-6 Article dans une revue hal-02561137v1
Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. Beatrice Claude Durand,M. Saunders,Céline Gaudon,B. Roy,R. Lossonet al. EMBO Journal, 1994, 13 (22), pp.5370-82. ⟨10.1002/j.1460-2075.1994.tb06872.x⟩ Article dans une revue hal-02561133v1
All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs Beatrice Claude Durand,Michael Saunders,Pierre Leroy,Mark Leid,Pierre Chambon Cell, 1992, 71 (1), pp.73-85. ⟨10.1016/0092-8674(92)90267-g⟩ Article dans une revue istex hal-02561145v1
Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. P Kastner,A. Perez,Y Lutz,C. Rochette-Egly,M Gaubet al. EMBO Journal, 1992, 11 (2), pp.629-42 Article dans une revue hal-02561207v1
Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors Sunil Nagpal,Michael Saunders,Philippe Kastner,Beatrice Claude Durand,Harikrishna Nakshatriet al. Cell, 1992, 70 (6), pp.1007-1019. ⟨10.1016/0092-8674(92)90250-g⟩ Article dans une revue istex hal-02561148v1
Cellular retinoic acid-binding protein type 2 mRNA is overexpressed in human psoriatic skin as shown by in situ hybridization Liliane Didierjean,Beatrice Claude Durand,Jean-Hilaire Saurat Biochemical and Biophysical Research Communications, 1991, 180 (1), pp.204-208. ⟨10.1016/s0006-291x(05)81277-x⟩ Article dans une revue istex hal-02561154v1
Compartmentalization of MHC class II gene expression in transgenic mice Willem van Ewijk,Yacov Ron,John Monaco,John Kappler,Philippa Marracket al. Cell, 1988, 53 (3), pp.357-370. ⟨10.1016/0092-8674(88)90156-0⟩ Article dans une revue istex hal-02561158v1
Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins. A. Dorn,Beatrice Claude Durand,C. Marfing,M. Le Meur,Christophe Benoistet al. Proceedings of the National Academy of Sciences of the United States of America, 1987, 84 (17), pp.6249-6253. ⟨10.1073/pnas.84.17.6249⟩ Article dans une revue hal-02561163v1

Pré-publication, Document de travail (1)

Cerebellar granular neuron progenitors exit their germinative niche via Barhl1 mediated silencing of T-Cell Factor transcriptional activity Johnny Bou-Rouphael,Mohammed Doulazmi,Alexis Eschstruth,Asna Abdou,Beatrice Claude Durand 2023 Pré-publication, Document de travail hal-04306249v1