Béatrice Vallée

Publications

Article dans une revue (36)

Microscale Thermophoresis for Thermodynamic Analysis: A Proof-of-Concept Study on LIMK Inhibitors Solweig Chartier,Bérengère Claude,Rouba Nasreddine,Pierre Soule,Alexandra Launayet al. Journal of Molecular Biology, 2026, 438 (5), pp.169621. ⟨10.1016/j.jmb.2025.169621⟩ Article dans une revue (article de synthèse) hal-05517956v1
LIM kinase/inhibitor binding study in cell lysates using microscale thermophoresis in the red spectrum Solweig Chartier,Mélanie Rapeto,Rouba Nasreddine,Elodie Villalonga-Rosso,Bérengère Claudeet al. Analytica Chimica Acta, 2026, 1382, pp.344837. ⟨10.1016/j.aca.2025.344837⟩ Article dans une revue hal-05347896v1
Using CE to confirm the activity of fluorescent miRFP670-LIMK1 protein produced for MST assays directly in cell lysate Solweig Chartier,Bérengère Claude,Rouba Nasreddine,Alexandra Launay,Marion Martinset al. Analytica Chimica Acta, 2025, 1360, pp.344145. ⟨10.1016/j.aca.2025.344145⟩ Article dans une revue hal-05304644v1
Saccharomyces cerevisiae Mub1, a substrate adaptor of E 3 ubiquitin ligase Ubr2, modulates sensitivity to cell wall stressors through multiple transcription factors Nada Šupljika,Antonia Paić,Ana Novačić,Tea Martinić Cezar,Béatrice Valléeet al. FEBS Journal, 2025, 292 (19), pp.5046-5066. ⟨10.1111/febs.70091⟩ Article dans une revue hal-05359905v1
An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection Mohammed Bergoug,Christine Mosrin-Huaman,Amandine Serrano,Fabienne Godin,Michel Doudeauet al. Journal of Molecular Biology, 2024, 436 (22), pp.168768. ⟨10.1016/j.jmb.2024.168768⟩ Article dans une revue hal-04771131v1
Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization Anthony Champiré,Rayan Berabez,Abdennour Braka,Aurélie Cosson,Justine Corretet al. European Journal of Medicinal Chemistry, 2024, 271, pp.116391-116391. ⟨10.1016/j.ejmech.2024.116391⟩ Article dans une revue hal-04575964v1
Streamlining N-terminally anchored yeast surface display via structural insights into S. cerevisiae Pir proteins Tea Martinić Cezar,Mateja Lozančić,Ana Novačić,Ana Matičević,Dominik Matijevićet al. Microbial Cell Factories, 2023, 22 (1), pp.174. ⟨10.1186/s12934-023-02183-2⟩ Article dans une revue hal-04208410v1
LIM Kinases: From Molecular to Pathological Features Hélène Bénédetti,Béatrice Vallée Cells, 2023, 12 (12), pp.1649. ⟨10.3390/cells12121649⟩ Article dans une revue hal-04208415v1
LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features Elodie Villalonga,Christine Mosrin,Thierry Normand,Caroline Girardin,Amandine Serranoet al. Cells, 2023, 12 (5), pp.805. ⟨10.3390/cells12050805⟩ Article dans une revue (article de synthèse) hal-04208405v1
Re-engineering of CUP1 promoter and Cup2/Ace1 transactivator to convert Saccharomyces cerevisiae into a whole-cell eukaryotic biosensor capable of detecting 10 nM of bioavailable copper Bojan Žunar,Christine Mosrin-Huaman,Hélène Bénédetti,Béatrice Vallée Biosensors and Bioelectronics, 2022, 214, pp.114502. ⟨10.1016/j.bios.2022.114502⟩ Article dans une revue hal-03820214v1
LIM kinases, promising but reluctant therapeutic targets: chemistry and preclinical validation in vivo Rayan Berabez,Sylvain Routier,Hélène Bénédetti,Karen Plé,Béatrice Vallée Cells, 2022, 11 (13), pp.2090. ⟨10.3390/cells11132090⟩ Article dans une revue hal-03721458v1
Confocal imaging of biomarkers at a single-cell resolution: quantifying 'living' in 3D-printable engineered living material based on Pluronic F-127 and yeast Saccharomyces cerevisiae Bojan Žunar,Taiga Ito,Christine Mosrin,Yoshiyuki Sugahara,Hélène Bénédettiet al. Biomaterials Research, 2022, 26, pp.85. ⟨10.1186/s40824-022-00337-8⟩ Article dans une revue hal-03926884v1
Synthesis of Heterospirocycles through Gold‐(I) Catalysis, Useful Building Blocks for Medicinal Chemistry Kossi Efouako Soklou,Hamid Marzag,Béatrice Vallée,Sylvain Routier,Karen Plé Advanced Synthesis and Catalysis, 2021, ⟨10.1002/adsc.202101080⟩ Article dans une revue hal-03411162v1
Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors Frédéric Buron,Nuno Rodrigues,Thibault Saurat,Marie-Aude Hiebel,Stéphane Bourget al. Molecules, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩ Article dans une revue hal-03348966v1
Neurofibromin Structure, Functions and Regulation Mohammed Bergoug,Michel Doudeau,Fabienne Godin,Christine Mosrin-Huaman,Béatrice Valléeet al. Cells, 2020, 9, ⟨10.3390/cells9112365⟩ Article dans une revue hal-03070759v2
LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability Julie Tastet,Hélène Cuberos,Béatrice Vallée,Annick Toutain,Martine Raynaudet al. Neuroscience, 2019, 399, pp.199-210. ⟨10.1016/j.neuroscience.2018.12.017⟩ Article dans une revue istex hal-02067472v1
Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein Béatrice Vallée,Michel Doudeau,Fabienne Godin,Hélène Bénédetti Journal of visualized experiments : JoVE, 2019, 148, pp.e59820. ⟨10.3791/59820⟩ Article dans une revue hal-02282630v1
N6L pseudopeptide interferes with nucleophosmin protein-protein interactions and sensitizes leukemic cells to chemotherapy A. de Cola,M. Franceschini,A. Di Matteo,G. Colotti,R. Celaniet al. Cancer Letters, 2018, 412, pp.272-282. ⟨10.1016/j.canlet.2017.10.038⟩ Article dans une revue hal-02350445v1
LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b Béatrice Vallée,Hélène Cuberos,Michel Doudeau,Fabienne Godin,David Gossetet al. Biochemical Journal, 2018, 475 (23), pp.3745-3761 Article dans une revue hal-01966439v1
Effets à long terme d’une stratégie engageante : augmenter le nombre d’adhésions de l’association sportive d’un collège mahorais B. Vallée,L. Larrède,V. Willaume,A. Pascual,S. Meineri Pratiques Psychologiques, 2016, 22 (4), pp.353-362. ⟨10.1016/j.prps.2016.07.002⟩ Article dans une revue hal-02493232v1
Roles of LIM kinases in central nervous system function and dysfunction H. Cuberos,B. Vallée,Patrick Vourc’h,J. Tastet,Christian R Andreset al. FEBS Letters, 2015, 589 (24PartB), pp.3795-3806. ⟨10.1016/j.febslet.2015.10.032⟩ Article dans une revue hal-02072231v1
A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line. Fabienne Godin,Sandrine Villette,Béatrice Vallée,Michel Doudeau,Séverine Morisset-Lopezet al. Biochemical and Biophysical Research Communications, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩ Article dans une revue istex hal-00721861v1
Interaction Proteomics Suggests a New Role for the Tfs1 Protein in Yeast. Martine Beaufour,Fabienne Godin,Béatrice Vallée,Martine Cadene,Hélène Bénédetti Journal of Proteome Research, 2012, 11 (6), pp.3211-3218. ⟨10.1021/pr201239t⟩ Article dans une revue hal-00721771v1
LIMK2d, a truncated isoform of Lim kinase 2 regulates neurite growth in absence of the LIM kinase domain Julie Tastet,Patrick Vourc’h,Frédéric Laumonnier,Béatrice Vallée,Carole Michelleet al. Biochemical and Biophysical Research Communications, 2012, 420 (2), pp.247-252. ⟨10.1016/j.bbrc.2012.02.134⟩ Article dans une revue istex hal-01136281v1
Nf1 RasGAP Inhibition of LIMK2 Mediates a New Cross-Talk between Ras and Rho Pathways Béatrice Vallée,Michel Doudeau,Fabienne Godin,Aurélie Gombault,Aurélie Tchalikian-Cossonet al. PLoS ONE, 2012, 7 (10), pp.e47283. ⟨10.1371/journal.pone.0047283⟩ Article dans une revue hal-03054185v1
Soumission sans pression, médiatisation d’un tsunami et don d’argent : efficacité comparée de la porte-au-nez et du « vous êtes libre de… » A. Pascual,L. Dagot,B. Vallée,N. Gueguen European Review of Applied Psychology / Revue Européenne de Psychologie Appliquée, 2009, 59 (1), pp.79-84. ⟨10.1016/j.erap.2006.07.003⟩ Article dans une revue istex hal-02493142v1
A phenotypic study of TFS1 mutants differentially altered in the inhibition of Ira2p or CPY Aurélie Gombault,Jonas Warringer,Robert Caesar,Fabienne Godin,Béatrice Valléeet al. FEMS Yeast Research, 2009, 9 (6), pp.867-874. ⟨10.1111/j.1567-1364.2009.00535.x⟩ Article dans une revue hal-00522432v1
Molecular Basis of the Tfs1/Ira2 Interaction: A Combined Protein Engineering and Molecular Modelling Study Aurélie Gombault,Fabienne Godin,Denise Sy,Baptiste Legrand,Hélène Chautardet al. Journal of Molecular Biology, 2007, 374 (3), pp.604-617. ⟨10.1016/j.jmb.2007.09.057⟩ Article dans une revue istex hal-00181161v1
Lip 1p: a novel subunit of acyl-CoA ceramide synthase Béatrice Vallée,H. Riezman EMBO Journal, 2005, 24, pp.730-741 Article dans une revue hal-00088715v1
Peptides corresponding to the N- and C-terminal parts of PEBP are well-structured in solution: new insights into their possible interaction with partners in vivo. Béatrice Vallée,G Coadou,H. Labbé,D. Sy,F. Vovelleet al. Journal of Peptide Research, 2003, 61 (2), pp.47-57 Article dans une revue hal-02118669v1
Lcb4p Is a Key Regulator of Ceramide Synthesis from Exogenous Long Chain Sphingoid Base in Saccharomyces cerevisiae Kouichi Funato,Ruben Lombardi,Béatrice Vallée,Howard Riezman Journal of Biological Chemistry, 2003, 278 (9), pp.7325-7334. ⟨10.1074/jbc.M209925200⟩ Article dans une revue hal-02118660v1
Biosynthesis and Trafficking of Sphingolipids in the Yeast Saccharomyces cerevisiae † Kouichi Funato,Béatrice Vallée,Howard Riezman Biochemistry, 2002, 41 (51), pp.15105-15114. ⟨10.1021/bi026616d⟩ Article dans une revue istex hal-02118664v1
Lag1p and Lac1p Are Essential for the Acyl-CoA–dependent Ceramide Synthase Reaction in Saccharomyces cerevisae D Schorling,Béatrice Vallée,Wolfgang Barz,Howard Riezman,Dieter Oesterhelt Molecular Biology of the Cell, 2001, 12 (11), pp.3417-3427. ⟨10.1091/mbc.12.11.3417⟩ Article dans une revue hal-02118674v1
Behaviour of bovine phosphatidylethanolamine-binding protein with model membranes. Evidence of affinity for negatively charged membranes. Béatrice Vallée,P Tauc,J Brochon,M Maget-Dana,D. Lelièvreet al. European Journal of Biochemistry, 2001, 268 (22), pp.5831-41 Article dans une revue hal-02118681v1
Stability and physicochemical properties of the bovine brain phosphatidylethanolamine-binding protein. Béatrice Vallée,Caroline Teyssier,R. Maget-Dana,J. Ramstein,N. Bureaudet al. European Journal of Biochemistry, 1999, 266 (1), pp.40-52 Article dans une revue hal-02118686v1
Crystal structure of the phosphatidylethanolamine-binding protein from bovine brain: a novel structural class of phospholipid-binding proteins. C. Serre,Béatrice Vallée,N. Bureaud,F. Schoentgen,C. Zelwer Structure, 1998, 6 (10), pp.1255-65 Article dans une revue hal-02118689v1

Communication dans un congrès (16)

Un nouvel inhibiteur des LIMKs, l'AC429, bloque la croissance des tumeurs primaires d'ostéosarcome Karen Plé,Franck Verrecchia,Béatrice Vallée,Régis Brion,Rayan Berabezet al. Cancéropôle Grand Ouest, colloque du réseau Molécules marines, métabolisme et cancer, May 2022, Mansigné, France Communication dans un congrès hal-04820416v1
Les LIM kinases, des cibles thérapeutiques d’intérêt : de la conception de petites molécules inhibitrices aux premiers essais précliniques Karen Plé,Béatrice Vallée Journée scientifique du réseau Cancers des Tissus Hormono-dépendants (CASTHOR), Cancéropôle Grand Ouest, Dec 2022, Nantes, France Communication dans un congrès hal-04823051v1
Synthesis and preclinical validation of LIMKs inhibitors: Promising drugs for osteosarcoma treatment? Anthony Champiré,Margaux Sainjon,Abdennour Braka,Samia Aci-Seche,Pascal Bonnetet al. XXVII EFMC International Symposium on Medicinal Chemistry, Sep 2022, NICE, France Communication dans un congrès hal-04823073v1
Synthesis and preclinical validation of LIMKs inhibitors: Promising drugs for osteosarcoma treatment? Rayan Berabez,Anthony Champiré,Margaux Sainjon,Abdennour Braka,Samia Aci-Secheet al. SCT 29th Young Research Fellow Meeting, Jul 2022, Nantes, France Communication dans un congrès hal-04822252v1
High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells N Laroui,C Delehedde,C Goncalves,F Godin,Federico Percheet al. SFNano 2021, Dec 2021, Angers, France Communication dans un congrès hal-03668422v1
Séminaire invité : Signalisation cellulaire et Neurofibromatose Béatrice Vallée,Hélène Bénédetti Journées NF, Sep 2021, Orléans, France Communication dans un congrès hal-03560050v1
Life in the bioink: Physiology and energetics of Saccharomyces cerevisiae embedded in polymerized Pluronic F127-DMA, a “smart” thermoresponsive hydrogel Béatrice Vallée,Christine Mosrin-Huaman,Hélène Bénédetti,Régis Guégan,Bojan Zunar ICY15 meets 30ICYGMB, The spirit of Yeast, Aug 2021, Vienne, virtual, Austria Communication dans un congrès hal-03559939v1
Development of a bio­active fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action Justine Corret,Sokaina Hammoud,Frédéric Buron,Pierre Daligaux,Christophe Chesnéet al. FEBS 2021, the 45th FEBS Congress, Jul 2021, Virtual, France Communication dans un congrès hal-03668584v1
Détermination et mise en œuvre d’un modèle in vivo pour tester de nouveaux inhibiteurs originaux des LIM kinases, cibles thérapeutiques émergentes dans le cancer Béatrice Vallée,K. Plé,A. Cosson,M. Doudeau,F. Godinet al. Cancéropôle Grand Ouest, Colloque du Réseau Molécules marines, métabolisme et cancer, May 2019, Mansigné, France Communication dans un congrès hal-02928507v1
Les LIM kinases : nouvelles cibles thérapeutiques anti-cancer H. Bénédetti,Béatrice Vallée,A. Cosson,F. Godin,M. Doudeau Journée scientifique du réseau « Cancers hormonaux–dépendants » du Cancéropôle Grand-Ouest, Apr 2019, Nantes, France Communication dans un congrès hal-02928496v1
Neurofibromin, a new SUMO target involved in neurofibromatosis type 1 disease M. Bergoug,A. Cosson,D. Casas,M. Doudeau,F. Godinet al. 6th LIA Workshop on "Biomarkers and mediators of diseases and new approaches in repair/regenerative therapies, Jun 2019, Varsovie, Poland Communication dans un congrès hal-02928511v1
Développement de petites molécules inhibitrices des LIM kinases, nouvelles cibles thérapeutiques pour lutter contre le cancer, les maladies neurologiques et la neurofibromatose Béatrice Vallée,Karen Plé,A. Cosson,M. Doudeau,F. Godinet al. Journée Fédération CBM-ICOA, Jan 2018, Orléans, France Communication dans un congrès hal-02928530v1
Study of the sumoylation of neurofibromin, the protein responsible for neurofibromatosis type 1 M. Bergoug,A. Cosson,M. Doudeau,F. Godin,Béatrice Valléeet al. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France Communication dans un congrès hal-02928220v1
Développement de modulateurs des LIM kinases Béatrice Vallée,S. Routier,A. Cosson,M. Doudeau,F. Godinet al. Cancéropôle Grand Ouest - 14e colloque du Réseau Produits de la mer en cancérologie - 5e colloque du Réseau Canaux ioniques et cancer, May 2018, Mansigné, France Communication dans un congrès hal-02928559v1
Neurofibromatosis type I: from basic to applied research Béatrice Vallée,A. Cosson,M. Doudeau,F Godin,A. Brakaet al. 4th LIA Workshop, Jun 2017, Cracovie, Poland Communication dans un congrès hal-02928517v1
Study of new partners of neurofibromin: an approach to identify novel therapeutic targets for neurofibromatosis type 1 Béatrice Vallée,Hélène Bénédetti,F. Godin,M. Doudeau 17th European Neurofibromatosis meeting, Sep 2016, Albano-Terme, Italy Communication dans un congrès hal-02928226v1

Poster de conférence (25)

Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation Mohammed Bergoug,Christine Mosrin-Huaman,Amandine Serrano,Fabienne Godin,Michel Doudeauet al. 2024 Global NF Conference, Jun 2024, Brussels, Belgium Poster de conférence hal-03679991v1
An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection Hélène Bénédetti,Christine Mosrin,Amandine Serrano,Mohammed Bergoug,Fabienne Godinet al. Ubiquitin and ubiquitin−like proteins in health and disease, Sep 2024, Cavtat, Croatia Poster de conférence hal-05228729v1
Deciphering the Molecular Mechanism of Pathogenicity in Destabilized variants of Neurofibromin mutated in its SecPH domain Hélène Bénédetti,Christine Mosrin-Huaman,Mohammed Bergoug,Amandine Serrano,Fabienne Godinet al. 2024 Global NF Conference, Jun 2024, Brussels (Belgium), Belgium Poster de conférence hal-04779581v1
New insights into the regulation of actin cytoskeleton dynamics via the Rho/ROCK/LIMK2/cofilin signalling pathway: a novel mechanism of regulation of cofilin by LIMK2 Elodie Villalonga,Célina Chalal,Déborah Cassas,Michel Doudeau,Fabienne Godinet al. FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, virtual, Slovenia Poster de conférence hal-03680139v1
High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells N Laroui,C Delehedde,Cristine Gonçalves,F Godin,F Percheet al. 10th mRNA Health Conference, Nov 2021, Berlin, Germany Poster de conférence hal-03668434v1
Sumoylation of Neurofibromin and its SecPH Domain Plays a Role in Their Functions and Implies Unexpected Structural Requirements Christine Mosrin-Huaman,Mohammed Bergoug,Fabienne Godin,Michel Doudeau,Iva Sosicet al. 2021 NF1 virtual conference, Jun 2021, Virtual, France Poster de conférence hal-03680001v1
Stressed by hydrogel? Physiological response of yeast cells embedded in thermoresponsive Pluronic F127: a prerequisite for bioreactor development Bojan Zunar,Christine Mosrin-Huaman,Hélène Bénédetti,Régis Guégan,Béatrice Vallée FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, Slovenia Poster de conférence hal-03679975v1
New molecular insights into the crosstalk between Rho/ROCK/LIMK2/cofilin signalling pathway and Nf1 Mélissa Thomas,Lauren Blot,Kevin Lesage,Fabienne Godin,Michel Doudeauet al. 2021 NF1 virtual conference, Jun 2021, Virtual, France Poster de conférence hal-03679999v1
Development of a bio­active fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action Justine Corret,Sokaina Hammoud,Frédéric Buron,Pierre Daligaux,Christophe Chesnéet al. FEBS 2021, the 45th FEBS Congress, Jul 2021, Lnubljana, virtual, Slovenia Poster de conférence hal-03679980v1
Study of the different forms of sumoylation of the neurofibromin SecPH domain H. Bénédetti,M. Bergoug,I. Sošic,M. Doudeau,F. Godinet al. EMBO Workshop "The ubiquitin system: Biology, mechanisms and roles in disease", Sep 2019, Cavtat, Croatia Poster de conférence hal-02924090v1
Molecular and functional characterization of LIMK2-1, a hominidae-specific isoform of LIMK2 associated with intellectual disability H. Bénédetti,Béatrice Vallée,J. Tastet,H. Cubéros,A. Toutainet al. NeuroFrance 2019, May 2019, Marseille, France Poster de conférence hal-02924881v1
Neurofibromin, a new SUMO target involved in neurofibromatosis type 1 disease M. Bergoug,I. Sošic,M. Doudeau,F. Godin,Béatrice Valléeet al. EMBO Workshop "The ubiquitin system: Biology, mechanisms and roles in disease", Sep 2019, Cavtat, Croatia Poster de conférence hal-02924095v1
LIM kinases, new therapeutic targets to treat cancers, neurological disorders and Neurofibromatosis: development of small molecule inhibitors Béatrice Vallée,A. Cosson,M. Doudeau,F. Godin,A. Champiréet al. FEBS Meeting 2019, Jul 2019, Cracovie, Poland Poster de conférence hal-02924140v1
Yeast biosensors to detect environmental pollutants into effluent waters Christine Mosrin-Huaman,B. Handelaoui,H. Bénédetti,Béatrice Vallée ICYGMB XXIX International Congress on Yeast Genetics and Molecular Biology, Aug 2019, Göteborg, Sweden Poster de conférence hal-02924111v1
Development of small molecule inhibitors of LIM kinases, new therapeutic targets to treat Neurofibromatosis type I Béatrice Vallée,A. Cosson,M. Doudeau,F. Godin,A. Champiréet al. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France Poster de conférence hal-02924077v1
LARP6, a RNA−binding protein involved in translation and stability of collagen mRNA, is a new partner of Neurofibromin: Molecular studies and functional implications H. Bénédetti,M. Doudeau,F. Godin,Béatrice Vallée,A. Cossonet al. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France Poster de conférence hal-02924084v1
LIM Kinases: new anticancer therapeutic targets Béatrice Vallée,A. Cosson,M. Doudeau,F. Godin,Anthony Champiréet al. Breast Cancer Symposium, Jun 2017, Nantes, France Poster de conférence hal-03680148v1
Design, synthesis and biological evaluation of LIMK inhibitors A. Champiré,A. Braka,Béatrice Vallée,M. Doudeau,F. Godinet al. XXIVe Journées Jeunes Chercheurs (SCT), Feb 2017, Châtenay-Malabry, France Poster de conférence hal-02904837v1
Study of the sumoylation of neurofibromin, the protein responsible for neurofibromatosis type 1 M. Bergoug,A. Cosson,M. Doudeau,F. Godin,Béatrice Valléeet al. EMBO Conference "Ubiquitin and SUMO: from molecular mechanisms to system-wide responses, Sep 2017, Cavtat, Croatia Poster de conférence hal-02924070v1
Conception, synthèse et évaluation biologique d’inhibiteurs de LIM kinases A. Champiré,A. Braka,Béatrice Vallée,M. Doudeau,F. Godinet al. 29e colloque de Biotechnocentre, Oct 2016, Seillac, France Poster de conférence hal-02904847v1
The three isoforms of human LIMK2 regulate actin cytoskeleton remodeling via different pathways Béatrice Vallée,Hélène Cuberos,Michel Doudeau,Fabienne Godin,Patrick Vourc’het al. EMBL Symposium, Actin in action: From Molecules to Cellular Functions, Sep 2016, Heidelberg, Germany. Poster de conférence hal-02453489v1
LINGO-1, a protein involved in various neurodevelopmental processes, interacts with neurofibromin (Nf1), the protein responsible for neurofibromatosis type I: molecular studies and functional implications Hélène Bénédetti,Fabienne Godin,Michel Doudeau,Béatrice Vallée,Marie-Ludivine De Tauziaet al. 10 th FENS (Forum of Neuroscience), Jul 2016, Copenhague, Denmark Poster de conférence hal-02453487v1
LIM kinases: new therapeutic targets to treat Neurofibromatosis type I Béatrice Vallée,Michel Doudeau,Fabienne Godin,Anthony Champiré,Karen Pléet al. The 7th EMBO meeting, Sep 2016, Mannheim, Germany. Poster de conférence hal-02453490v1
LIMK2-1, a new primate-specific isoform of LIMK2, is associated with intellectual disability Béatrice Vallée,Hélène Cuberos,Julie Tastet,Michel Doudeau,Fabienne Godinet al. 10 th FENS (Forum of Neurosciences), Jul 2016, Copenhague, Denmark. Poster de conférence hal-02453486v1
Projet Région LiCorNe: LIMK protein inhibitors, new therapeutic agents for treatment of cognitive disorders associated with type I Neurofibromatosis Béatrice Vallée,Michel Doudeau,F. Godin,H. Cubéros,A. Champiréet al. Journée Fédération PCV FR2708, Jan 2016, Orléans, France Poster de conférence hal-02924056v1

Brevet (1)

4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-3,6-dihydropyridine-(2H)-carboxamide derivatives as Limk and/or Rock kinases inhibitors for use in the treatment of cancer Sylvain Routier,Hélène Bénédetti,Béatrice Vallée,Pascal Bonnet,Karen Pléet al. France, Patent n° : WO2021239727 A1. AMV. 2021 Brevet hal-03555349v1

Pré-publication, Document de travail (1)

Noncanonical structural requirements of neurofibromin SUMOylation reveal a folding-deficiency of several pathogenic mutants Mohammed Bergoug,Christine Mosrin,Fabienne Godin,Michel Doudeau,Iva Sosicet al. 2022 Pré-publication, Document de travail hal-03668582v1

HDR (1)

Etudes de différentes voies de transduction du signal afin de mettre à jour de nouveaux mécanismes moléculaires et de nouvelles cibles thérapeutiques Béatrice Vallée Biochimie, Biologie Moléculaire. Université d'Orléans, 2020 HDR tel-03560017v1