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Benoit Arcangioli



**Benoit Arcangioli** 6 March 1959, Age 63 (November 2022), Married two children. Director of the Dynamic of the Genome Unit at the Pasteur Institute, Paris, France. Professor at the Pasteur Institute **EDUCATION** 1984-1986 PhD student, Moshe Yaniv Laboratory, Pasteur Institute, Paris Cité Université. 1988 PhD thesis; Moshe Yaniv Laboratory, Pasteur Institute, Paris Cité Université 1994 HDR, Paris Cité Université. ### ### **RESEARCH and PRofessional EXPERIENCE.** 1980-1982 Chemist Cabot Carbone 1987 Visiting scientist Leonard Guarente MIT, Boston, USA 1987 Roux Foundation fellowship, Pasteur Institute 1988-1991 Research Assistant, Pasteur Institute 1988-1989 Independent Group Leader entitled: Yeast Molecular Genetic Group 1989-1991 EMBO post-doctoral fellowship, Amar Klar, NCI, Frederick, USA 1991-1999 Full Researcher, Pasteur Institute 1999-2021 Laboratory Director, Pasteur Institute 2001-present Director of the Unit entitled: Dynamics of the Genome 2010 Visiting scientist, Robert Martienssen, CSHL, USA 2022-present Professor at the Pasteur Institute **TEACHING AND MENTORING ACTIVITIES** 2005-present Co-director of Pasteur Course entitled: Molecular Genetics and Epigenetics Lecturer in Virology (cell cycle), Microbiology (Genetics of quiescence) courses (Pasteur) Organized two EMBO courses on fission yeast in 2012 and 2014 (2 weeks). Participated to 10 EMBO courses. MOOC E-learning on epigenetics Teaching for ***LSLEAD*** “Life Sciences Leadership School” (2015-2020) Supervised 8 PhD students (1 ongoing), 4 Postdocs (1 ongoing) Invited two professors for sabbatical visit (R. Martienssen (CSHL, USA) and K. Ekwall, Karolinska SWE). **MEETING ORGANIZATION** Co-organized the two following meeting series: **“Levures, Modèles et outils**” (**3** meetings, Brussels, Geneva and Paris 2001-2003-2006 “**3Rs” for: “Replication, recombination and repair**”, (4 meetings, Presqu’Île de Giens 2004-2012 Co-organized the “**Genetics, Epigenetics and Evolution of sex Chromosomes**” Paris 9-10th June 2011 Co-organized the **50th anniversary of the Replicon Theory** (Institut Pasteur, Paris March 25-28, 2013) Co-organized the symposium of Blaise Pascal Chair for Robert Martienssen; entitled « **Lamarck, Landmarks and Landscapes: frontiers in epigenetics** » (Institut Pasteur, Paris February 18th 2014). Co-organized 7 departmental retreats Regularly since 2010, I’m Chairman in the ***S. pombe* international meeting series** Ongoing: Chairman “Aging and Metabolism” Hiroshima (JPN) 28 May-2 June, 2023. **COMMITTEES & ADMINISTRATION** 2009-2012. Secretary of the **Replicon Club**, Société Française de Biochimie et Biologie Moléculaire. 2006-2012. Member of the National Committee (2) of the **Cancer Research Association (ARC)** 2012- Member of the “Comité Colloques, Institut Pasteur” Elected member at the **COMESP** (2012-2016), Head of committee 1 (Genetics and Biochemistry) Member of **HCERES** committee (2018; 2019) 2014-present Twice elected member of the **Assembly of 100** of Pasteur Institute, Member of the “*bureau”* Vice-President of the **ANR agency** committee (2018-2021)**:** “DNA, RNA and epigenetics” Member of the jury of more than 60 PhD theses and 6 HDRs, in France and abroad. Editorial board: Microbial Cell (2017-present). **HONORS & AWARDS** 1986 Prize Jacques Monod (Institut Pasteur) 2007 Prize Pasteur Vallery-Radot 2014 Prize Thérèse Lebrasseur


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The quiescent X, the replicative Y and the Autosomes

Guillaume Achaz , Serge Gangloff , Benoît Arcangioli
Peer Community Journal, 2022, 2, pp.e18. ⟨10.24072/pcjournal.99⟩
Journal articles hal-03771709v1
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Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation

Elie Hammam , Ameya Sinha , Sebastian Baumgarten , Flore Nardella , Jiaqi Liang
mBio, 2021, 12, pp.e02558-21. ⟨10.1128/mBio.02558-21⟩
Journal articles pasteur-03427780v1
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Nitrogen starvation reveals the mitotic potential of mutants in the S/MAPK pathways

Rostyslav Makarenko , Claire Denis , Stefania Francesconi , Serge Gangloff , Benoît Arcangioli
Nature Communications, 2020, 11 (1), pp.1973. ⟨10.1038/s41467-020-15880-y⟩
Journal articles pasteur-02573577v1
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Leo1 is essential for the dynamic regulation of heterochromatin and gene expression during cellular quiescence

Eriko Oya , Mickaël Durand-Dubief , Adiel Cohen , Vladimir Maksimov , Catherine Schurra
Epigenetics & Chromatin, 2019, 12 (1), pp.45. ⟨10.1186/s13072-019-0292-7⟩
Journal articles pasteur-02545917v1
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Molecular signature of the imprintosome complex at the mating-type locus in fission yeast.

Célia Raimondi , Bernd Jagla , Caroline Proux , Hervé Waxin , Serge Gangloff
Microbial Cell , 2018, 5 (4), pp.169 - 183. ⟨10.15698/mic2018.04.623⟩
Journal articles pasteur-01868255v1
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New roles for Dicer in the nucleolus and its relevance to cancer

Benjamin Roche , Benoît Arcangioli , Robert Martienssen
Cell Cycle, 2017, 16 (18), pp.1643-1653. ⟨10.1080/15384101.2017.1361568⟩
Journal articles pasteur-02013965v1
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Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences.

Laetitia Maestroni , Julien Audry , Samah Matmati , Benoît Arcangioli , Vincent Géli
Nature Communications, 2017, ⟨10.1038/s41467-017-01894-6⟩
Journal articles hal-01788868v1
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DNA repair and mutations during quiescence in yeast

Serge Gangloff , Benoît Arcangioli
FEMS Yeast Research, 2017, 17 (1), ⟨10.1093/femsyr/fox002⟩
Journal articles pasteur-01868274v1
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Transcriptional reprogramming in cellular quiescence

Benjamin Roche , Benoît Arcangioli , Robert Martienssen
RNA Biology, 2017, 14 (7), pp.843 - 853. ⟨10.1080/15476286.2017.1327510⟩
Journal articles pasteur-01868271v1
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Quiescence unveils a novel mutational force in fission yeast

Serge Gangloff , Guillaume Achaz , Stefania Francesconi , Adrien Villain , Samia Miled
eLife, 2017, 6, pp.e27469. ⟨10.7554/eLife.27469⟩
Journal articles hal-01678930v1
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RNA interference is essential for cellular quiescence

B. Roche , Benoît Arcangioli , R. Martienssen
Science, 2016, 354 (6313), ⟨10.1126/science.aah5651⟩
Journal articles pasteur-01868276v1
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Regulating retrotransposon activity through the use of alternative transcription start sites

Jenna Persson , Babett Steglich , Agata Smialowska , Mette Boyd , Jette Bornholdt
EMBO Reports, 2016, 17 (5), pp.753 - 768. ⟨10.15252/embr.201541866⟩
Journal articles pasteur-01868286v1
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Activation induced cytidine deaminase mutant (AID-His130Pro) from Hyper IgM 2 patient retained mutagenic activity on SHM artificial substrate

Hanen Ouadani , Imen Benmustapha , Meriem Ben-Ali , Beya Larguèche , Tihana Jovanic
Molecular Immunology, 2016, 79, pp.77 - 82. ⟨10.1016/j.molimm.2016.09.025⟩
Journal articles pasteur-01453058v1
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How to choose the right mate

Benoît Arcangioli
PLoS Genetics, 2013, 9 (10), pp.e1003881. ⟨10.1371/journal.pgen.1003881⟩
Journal articles pasteur-02013959v1
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Lsd1 and lsd2 control programmed replication fork pauses and imprinting in fission yeast

Allyson M. Holmes , Laura Roseaulin , Catherine Schurra , Hervé Waxin , Sarah Lambert
Cell Reports, 2012, 2 (6), pp.1513-1520. ⟨10.1016/j.celrep.2012.10.011⟩
Journal articles pasteur-02013826v1

Lsd1 and Lsd2 Control Programmed Replication Fork Pauses and Imprinting in Fission Yeast

Allyson Holmes , Laura Roseaulin , Catherine Schurra , Herve Waxin , Sarah Lambert
Cell Reports, 2012, 2 (6), pp.1513-1520. ⟨10.1016/j.celrep.2012.10.011⟩
Journal articles hal-03009029v1
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RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II

Mikel Zaratiegui , Stephane E. Castel , Danielle V. Irvine , Anna Kloc , Jie Ren
Nature, 2011, 479 (7371), pp.135-138. ⟨10.1038/nature10501⟩
Journal articles pasteur-02013927v1
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CENP-B preserves genome integrity at replication forks paused by retrotransposon LTR

Mikel Zaratiegui , Matthew W Vaughn , Danielle V. Irvine , Derek Goto , Stephen Watt
Nature, 2011, 469 (7328), pp.112-115. ⟨10.1038/nature09608⟩
Journal articles pasteur-02013953v1
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Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast

Jordan B. Rapp , Chiaki Noguchi , Mukund M. Das , Lisa K. Wong , Alison B. Ansbach
PLoS ONE, 2010, 5 (10), pp.e13379. ⟨10.1371/journal.pone.0013379⟩
Journal articles pasteur-02013890v1

Role of SUMO in the dynamics of telomere maintenance in fission yeast

Blerta Xhemalce , Eva Madi Riising , Peter Baumann , Anne Dejean , Benoît Arcangioli
Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (3), pp.893-898. ⟨10.1073/pnas.0605442104⟩
Journal articles pasteur-03236974v1

Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance

Blerta Xhemalce , Jacob-Sebastian Seeler , Geneviève Thon , Anne Dejean , Benoît Arcangioli
EMBO Journal, 2004, 23 (19), pp.3844-3853. ⟨10.1038/sj.emboj.7600394⟩
Journal articles pasteur-03237018v1

The nucleotide sequence of the PRII gene related to DNA primase in Saccharomyces cerevisiae

Rostyslav Makarenko , Claire Denis , Stefania Francesconi , Serge Gangloff , Benoît Arcangioli
Nucleic Acids Research, 1987, 15 (19), pp.7975-7989. ⟨10.1093/nar/15.19.7975⟩
Journal articles hal-03007979v1