Benoit BUSSER

Publications

Article dans une revue (50)

Potent Biological Activity by a Synthetic Cu(I) Cationophore Redistributing Intracellular Copper Pools Nathan Renier,Gianluca Weyckmans Mele,Pierre Lelievre,Mélanie Boeckstaens,Roy Lavendommeet al. Journal of the American Chemical Society, 2026, 148 (1), pp.593-604. ⟨10.1021/jacs.5c15335⟩ Article dans une revue hal-05513296v1
In vivo vectorization and delivery systems for gene therapies and RNA-based therapeutics in oncology Julie Schock Vaiani,Mans Broekgaarden,Jean-Luc Coll,Lucie Sancey,Benoit Busser Nanoscale, 2025, 17 (10), pp.5501-5525. ⟨10.1039/d4nr05371k⟩ Article dans une revue inserm-04945753v1
Soluble VE-cadherin as a biomarker of response to immunotherapy by anti-PD1 in metastatic melanoma Clémentine Broche,Khémary Um,Isabelle Vilgrain,Stéphane Mouret,Marie-Thérèse Lecciaet al. British Journal of Cancer, 2025, 132 (10), pp.863-865. ⟨10.1038/s41416-025-03026-0⟩ Article dans une revue hal-05280347v1
Enhancing Diagnostic Capabilities for Occupational Lung Diseases Using LIBS Imaging on Biopsy Tissue Victor H.C. Ferreira,Vincent Gardette,Benoit Busser,Lucie Sancey,Steven Ronsmanset al. Analytical Chemistry, 2024, ⟨10.1021/acs.analchem.4c00237⟩ Article dans une revue hal-04552785v1
WazaGaY: An Innovative Aza-BODIPY-Derived Near-Infrared Fluorescent Probe for Enhanced Tumor Imaging Mohamed Bendellaa,Charlotte Cave,Amélie Godard,Fabien Dalonneau,Annika Sickingeret al. Journal of Medicinal Chemistry, 2024, 67 (18), pp.16635-16648. ⟨10.1021/acs.jmedchem.4c01435⟩ Article dans une revue hal-04739530v1
Quantifying Titanium Exposure in Lung Tissues: A Novel Laser‐Induced Breakdown Spectroscopy Elemental Imaging‐Based Analytical Framework for Biomedical Applications Vincent Gardette,Lucie Sancey,Marine Leprince,Laurent Gaté,Frederic Cosnieret al. Small Science, 2024, ⟨10.1002/smsc.202300307⟩ Article dans une revue hal-04510056v1
Engineering Radiocatalytic Nanoliposomes with Hydrophobic Gold Nanoclusters for Radiotherapy Enhancement Nazareth Milagros Carigga Gutierrez,Tristan Le Clainche,Anne‐laure Bulin,Sofia Leo,Malika Kadriet al. Advanced Materials, 2024, 36 (50), pp.e2404605. ⟨10.1002/adma.202404605⟩ Article dans une revue inserm-04788875v1
Comparison of the In Vitro and In Vivo Behavior of a Series of NIR-II-Emitting Aza-BODIPYs Containing Different Water-Solubilizing Groups and Their Trastuzumab Antibody Conjugates Elisa Chazeau,Christol Fabre,Malorie Privat,Amélie Godard,Cindy Racoeuret al. Journal of Medicinal Chemistry, 2024, 67 (5), pp.3679-3691. ⟨10.1021/acs.jmedchem.3c02139⟩ Article dans une revue hal-04757976v1
Roles of zinc in cancers: From altered metabolism to therapeutic applications Mohamed Bendellaa,Pierre Lelièvre,Jean-Luc Coll,Lucie Sancey,Aurélien Deniaudet al. International Journal of Cancer, 2024, 154 (1), pp.7-20. ⟨10.1002/ijc.34679⟩ Article dans une revue hal-04205230v1
Al(III) and Ga(III) Bisphenolate Azadipyrromethene-Based &quot;N(2)O(2)&quot; Complexes as Efficient NIR-Fluorophores Amélie Godard,Laura Abad Galán,Jean Rouillon,Shaymaa Al Shehimy,Wassima Tajaniet al. Inorganic Chemistry, 2023, 62 (13), pp.5067-5080. ⟨10.1021/acs.inorgchem.2c03918⟩ Article dans une revue hal-03927565v1
NIR-II Aza-BODIPY Dyes Bioconjugated to Monoclonal Antibody Trastuzumab for Selective Imaging of HER2-Positive Ovarian Cancer Amélie Godard,Ghadir Kalot,Malorie Privat,Mohamed Bendellaa,Benoit Busseret al. Journal of Medicinal Chemistry, 2023, 66 (7), pp.5185-5195. ⟨10.1021/acs.jmedchem.3c00100⟩ Article dans une revue hal-04091996v1
Laser-induced breakdown spectroscopy imaging for material and biomedical applications: recent advances and future perspectives Vincent Gardette,Vincent Motto-Ros,César Alvarez Llamas,Lucie Sancey,Ludovic Duponchelet al. Analytical Chemistry, 2023, 95 (1), pp.49-69. ⟨10.1021/acs.analchem.2c04910⟩ Article dans une revue inserm-03933204v1
Visualizing the cerebral distribution of chemical elements: a challenge met with LIBS elemental imaging Benoit Busser,Anne-Laure Bulin,Vincent Gardette,Hélène Elleaume,Frédéric Pelasciniet al. Journal of Neuroscience Methods, 2022, pp.109676. ⟨10.1016/j.jneumeth.2022.109676⟩ Article dans une revue hal-03726566v1
Succinimido–Ferrocidiphenol Complexed with Cyclodextrins Inhibits Glioblastoma Tumor Growth In Vitro and In Vivo without Noticeable Adverse Toxicity Feten Najlaoui,Benoît Busser,Germain Sotoing Taïwe,Pascal Pigeon,Nathalie Sturmet al. Molecules, 2022, 27 (14), pp.4651. ⟨10.3390/molecules27144651⟩ Article dans une revue hal-03736856v1
Lipoprotein interactions with water-soluble NIR-II emitting aza-BODIPYs boost the fluorescence signal and favor selective tumor targeting Ghadir Kalot,Amélie Godard,Benoit Busser,Mohamed Bendellaa,Fabien Dalonneauet al. Biomaterials Science, 2022, 10 (21), pp.6315-6325. ⟨10.1039/d2bm01271e⟩ Article dans une revue hal-04253882v1
Near-infrared emitting fluorescent homobimetallic gold(I) complexes displaying promising in vitro and in vivo therapeutic properties Robin Lescure,Malorie Privat,Jacques Pliquett,Aurélie Massot,Océane Baffroyet al. European Journal of Medicinal Chemistry, 2021, 220 (4), pp.113483. ⟨10.1016/j.ejmech.2021.113483⟩ Article dans une revue hal-03436249v1
Iron Dysregulation in Human Cancer: Altered Metabolism, Biomarkers for Diagnosis, Prognosis, Monitoring and Rationale for Therapy Pierre Lelièvre,Lucie Sancey,Jean-Luc Coll,Aurélien Deniaud,Benoit Busser Cancers, 2020, 12 (12), pp.3524. ⟨10.3390/cancers12123524⟩ Article dans une revue hal-03113973v1
Stapled peptide targeting the CDK4/Cyclin D interface combined with Abemaciclib inhibits KRAS mutant lung cancer growth Céline Bouclier,Matthieu Simon,Guillaume Laconde,Morgan Pellerano,Sebastien Diotet al. Theranostics, 2020, 10 (5), pp.2008-2028. ⟨10.7150/thno.40971⟩ Article dans une revue inserm-02440284v1
Radiation Dose-Enhancement Is a Potent Radiotherapeutic Effect of Rare-Earth Composite Nanoscintillators in Preclinical Models of Glioblastoma Anne-Laure Bulin,Mans Broekgaarden,Fréderic Chaput,Victor Baisamy,Jan Garrevoetet al. Advanced Science, 2020, 7 (20), pp.2001675. ⟨10.1002/advs.202001675⟩ Article dans une revue hal-02939291v1
IMAGERIE LIBS : AUX PORTES DE LA CLINIQUE Vincent Motto-Ros,Marine Leprince,Ludovic Duponchel,Lucie Sancey,Vincent Bonneterreet al. Photoniques, 2020, 103, pp.34-37. ⟨10.1051/photon/202010334⟩ Article dans une revue inserm-02941470v1
Water-Soluble Aza-BODIPYs: Biocompatible Organic Dyes for High Contrast In Vivo NIR-II Imaging Amélie Godard,Ghadir Kalot,Jacques Pliquett,Benoit Busser,Xavier Le Guévelet al. Bioconjugate Chemistry, 2020, 31 (4), pp.1088-1092. ⟨10.1021/acs.bioconjchem.0c00175⟩ Article dans une revue inserm-02941480v1
LIBS-Based Imaging: Recent Advances and Future Directions Vincent Motto-Ros,V Gardette,L Sancey,M Leprince,D Gentyet al. Journal of Spectroscopy, 2020, 35 (2), pp.34-40 Article dans une revue hal-02998713v1
The Multifaceted Roles of Copper in Cancer: A Trace Metal Element with Dysregulated Metabolism, but Also a Target or a Bullet for Therapy Pierre Lelièvre,Lucie Sancey,Jean-Luc Coll,Aurélien Deniaud,Benoit Busser Cancers, 2020, 12 (12), pp.3594. ⟨10.3390/cancers12123594⟩ Article dans une revue hal-03113913v1
Aza-BODIPY: A New Vector for Enhanced Theranostic Boron Neutron Capture Therapy Applications Ghadir Kalot,Amélie Godard,Benoît Busser,Jacques Pliquett,Mans Broekgaardenet al. Cells, 2020, 9 (9), pp.1953. ⟨10.3390/cells9091953⟩ Article dans une revue inserm-02941457v1
Gold nanoclusters as a contrast agent for image-guided surgery of head and neck tumors Cindy Colombé,Xavier Le Guével,Angela Martín-Serrano,Maxime Henry,Estelle Porretet al. Nanomedicine: Nanotechnology, Biology and Medicine, 2019, 20, pp.102011. ⟨10.1016/j.nano.2019.04.014⟩ Article dans une revue hal-02355599v1
L’imagerie élémentaire par spectroscopie LIBS : De nouvelles applications en médecine Marine Leprince,Lucie Sancey,Jean-Luc Coll,Vincent Motto-Ros,Benoît Busser Médecine/Sciences, 2019, 35 (8-9), pp.682-688. ⟨10.1051/medsci/2019132⟩ Article dans une revue hal-02367671v1
Laser-induced breakdown spectroscopy for human and animal health: A review R. Gaudiuso,N. Melikechi,Z. A. Abdel-Salam,M. A. Harith,V. Palleschiet al. Spectrochimica Acta Part B: Atomic Spectroscopy, 2019, 152, pp.123-148. ⟨10.1016/j.sab.2018.11.006⟩ Article dans une revue istex hal-02285880v1
The pyrrolopyrimidine colchicine-binding site agent PP-13 reduces the metastatic dissemination of invasive cancer cells in vitro and in vivo Pauline Gilson,Morgane Couvet,Laetitia Vanwonterghem,Maxime Henry,Julien Vollaireet al. Biochemical Pharmacology, 2019, 160, pp.1-13. ⟨10.1016/j.bcp.2018.12.004⟩ Article dans une revue hal-02347147v1
Development of molecular analyzes by digital PCR for clinical practice: positioning, current applications and perspectives Jérôme Alexandre Denis,Alexandre Perrier,Juliette Nectoux,Pierre-Jean Lamy,Anne-Sophie Alaryet al. Annales de Biologie Clinique, 2019, 77 (6), pp.619-637. ⟨10.1684/abc.2019.1502⟩ Article dans une revue inserm-02992696v1
Sarcoïdoses et fibroses pulmonaires idiopathiques : les analyses minéralogiques par imagerie LIBS et MEB orientent le diagnostic étiologique Benoit Busser,Mickaël Catinon,Marine Leprince,Frédéric Pelascini,Jean-Luc Collet al. Archives des Maladies Professionnelles et de L'Environnement, 2018, 79 (3), pp.420. ⟨10.1016/j.admp.2018.03.475⟩ Article dans une revue hal-02062820v1
Development of digital PCR molecular tests for clinical practice: principles, practical implementation and recommendations. Jérôme Alexandre Denis,Juliette Nectoux,Pierre-Jean Lamy,Christelle Rouillac Le Sciellour,Hélène Guermoucheet al. Annales de Biologie Clinique, 2018, 76 (5), pp.505-523. ⟨10.1684/abc.2018.1372⟩ Article dans une revue hal-02353393v1
Anticancer properties of lipid and poly(ε-caprolactone) nanocapsules loaded with ferrocenyl-tamoxifen derivatives Feten Najlaoui,Pascal Pigeon,Sonia Aroui,Mylène Pezet,Lucie Sanceyet al. Journal of Pharmacy and Pharmacology, 2018, 70 (11), pp.1474-1484. ⟨10.1111/jphp.12998⟩ Article dans une revue hal-01861749v1
Elemental imaging using laser-induced breakdown spectroscopy: A new and promising approach for biological and medical applications B. Busser,S. Moncayo,J. L. Coll,L. Sancey,Vincent Motto-Ros Coordination Chemistry Reviews, 2018, 358, pp.70-79. ⟨10.1016/j.ccr.2017.12.006⟩ Article dans une revue istex hal-02287419v1
Nuclear translocation of IGF1R by intracellular amphiregulin contributes to the resistance of lung tumour cells to EGFR-TKI Marie Guerard,Thomas Robin,Pascal Perron,Anne-Sophie Hatat,Laurence David-Boudetet al. Cancer Letters, 2018, 420, pp.146-155. ⟨10.1016/j.canlet.2018.01.080⟩ Article dans une revue inserm-02337427v1
Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer properties Pauline Gilson,Fernando Josa-Prado,Claire Beauvineau,Delphine Naud-Martin,Laetitia Vanwonterghemet al. Scientific Reports, 2017, 7 (1), pp.10209. ⟨10.1038/s41598-017-09491-9⟩ Article dans une revue inserm-01599698v2
Plasma circulating tumor DNA levels for the monitoring of melanoma patients: landscape of available technologies and clinical applications Benoit Busser,Julien Lupo,Lucie Sancey,Stéphane Mouret,Patrice Faureet al. BioMed Research International , 2017, Part of Special Issue: Cancer Diagnostic and Predictive Biomarkers 2016, 2017, pp.5986129. ⟨10.1155/2017/5986129⟩ Article dans une revue hal-02059900v1
Characterization of foreign materials in paraffin-embedded pathological specimens using in situ multi-elemental imaging with laser spectroscopy Benoit Busser,Samuel Moncayo,Florian Trichard,Vincent Bonneterre,Nicole Pinelet al. Modern Pathology, 2017, 31 (3), pp.378 - 384. ⟨10.1038/modpathol.2017.152⟩ Article dans une revue hal-01927018v1
Multi-elemental imaging of paraffin-embedded human samples by laser-induced breakdown spectroscopy S. Moncayo,F. Trichard,B. Busser,M. Sabatier-Vincent,F. Pelasciniet al. Spectrochimica Acta Part B: Atomic Spectroscopy, 2017, 133, pp.40-44. ⟨10.1016/j.sab.2017.04.013⟩ Article dans une revue istex hal-02317555v1
Efficacy of AKT Inhibitor ARQ 092 Compared with Sorafenib in a Cirrhotic Rat Model with Hepatocellular Carcinoma Gaël S. Roth,Zuzana Jilkova,Ayca Zeybek Kuyucu,Keerthi Kurma,Ahmad Pouret al. Molecular Cancer Therapeutics, 2017, 9, pp.2803. ⟨10.1158/1535-7163.MCT-16-0602-T⟩ Article dans une revue inserm-02333028v1
3D Imaging of Nanoparticle Distribution in Biological Tissue by Laser-Induced Breakdown Spectroscopy Y. Gimenez,B. Busser,F. Trichard,A. Kulesza,J. M. Laurentet al. Scientific Reports, 2016, 6, pp.29936. ⟨10.1038/srep29936⟩ Article dans une revue hal-01405764v1
Synergistic activity of vorinostat combined with gefitinib but not with sorafenib in mutant KRAS human non-small cell lung cancers and hepatocarcinoma Victor Jeannot,Benoît Busser,Laetitia Vanwonterghem,Sophie Michallet,Sana Ferroudjet al. OncoTargets and Therapy, 2016, 9, pp.6843-6855. ⟨10.2147/OTT.S117743⟩ Article dans une revue hal-02347748v1
A Recombinant Fungal Lectin for Labeling Truncated Glycans on Human Cancer Cells Aymeric Audfray,Mona Beldjoudi,Adrien Breiman,Amandine Hurbin,Irene Booset al. PLoS ONE, 2015, 10 (6), pp.e0128190. ⟨10.1371/journal.pone.0128190⟩ Article dans une revue hal-02349425v1
Laser spectrometry for multi-elemental imaging of biological tissues Lucie Sancey,Vincent Motto-Ros,B Busser,S Kotb,Jean-Michel Benoitet al. Scientific Reports, 2014, 4, pp.6065. ⟨10.1038/srep06065⟩ Article dans une revue hal-01071458v1
The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase-dependent mechanism Victor Jeannot,Benoît Busser,Elisabeth Brambilla,Marie Wislez,Blaise Robinet al. International Journal of Cancer, 2014, 134 (11), pp.2560-2571. ⟨10.1002/ijc.28594⟩ Article dans une revue hal-02349444v1
Comparison of COBAS 4800 KRAS, TaqMan PCR and High Resolution Melting PCR assays for the detection of KRAS somatic mutations in formalin-fixed paraffin embedded colorectal carcinomas Alexandre Harlé,Benoît Busser,Marie Rouyer,Valentin Harter,Pascal Geninet al. Virchows Archiv, 2013, 462 (3), pp.329-335. ⟨10.1007/s00428-013-1380-x⟩ Article dans une revue istex hal-00733883v1
The multiple roles of amphiregulin in human cancer. Benoit Busser,Lucie Sancey,Elisabeth Brambilla,Jean-Luc Coll,Amandine Hurbin Biochimica et Biophysica Acta - Molecular Cell Research, 2011, 1816 (2), pp.119-131. ⟨10.1016/j.bbcan.2011.05.003⟩ Article dans une revue inserm-00602082v1
Insulin-like growth factor-1 receptor inhibition overcomes gefitinib resistance in mucinous lung adenocarcinoma. Amandine Hurbin,Marie Wislez,Benoît Busser,Martine Antoine,Corine Tenaudet al. Journal of Pathology, 2011, 225 (1), pp.83-95. ⟨10.1002/path.2897⟩ Article dans une revue istex inserm-00598462v1
Amphiregulin promotes resistance to gefitinib in nonsmall cell lung cancer cells by regulating Ku70 acetylation. Benoît Busser,Lucie Sancey,Véronique Josserand,Carole Niang,Saadi Khochbinet al. Molecular Therapy, 2010, 18 (3), pp.536-43. ⟨10.1038/mt.2009.227⟩ Article dans une revue inserm-00425467v1
Amphiregulin promotes BAX inhibition and resistance to gefitinib in non-small-cell lung cancers. Benoît Busser,Lucie Sancey,Véronique Josserand,Carole Niang,Marie C. Favrotet al. Molecular Therapy, 2010, 18 (3), pp.528-35. ⟨10.1038/mt.2009.226⟩ Article dans une revue inserm-00425468v1
The increasing role of amphiregulin in non-small cell lung cancer. Benoît Busser,Jean-Luc Coll,Amandine Hurbin Pathologie Biologie, 2009, 57 (7-8), pp.511-2. ⟨10.1016/j.patbio.2008.10.002⟩ Article dans une revue inserm-00333661v1

Brevet (3)

NOUVEAUX FLUOROPHORES AZA-BODIPY ET LEURS UTILISATIONS Lucie Sancey,Benoît Busser,Christol Fabre,Amélie Godard,Ewen Bodioet al. France, Patent n° : FR2512339. 2025 Brevet hal-05466084v1
Calix[4]arenes with high anticancer activity. Benoît Busser,Aurélien Deniaud,Pierre Lelièvre,Lucie Sancey,Nathan Renieret al. France, Patent n° : WO2024/156819 A1. 2023 Brevet hal-05466064v1
Utilisation de composés fluorophores de type aza-BODIPY comme agents de contraste dans l'infrarouge très lointain Lucie Sancey,Christine Goze,Ewen Bodio,Benoît Busser,Jacques Pliquettet al. France, N° de brevet: FR19315089.3. 2019 Brevet hal-05466100v1

Pré-publication, Document de travail (1)

Copper transport across cell membranes by calix[4]arene-based cationophores leading to potent biological activity Nathan Renier,Gianluca Weyckmans Mele,Pierre Lelièvre,Mélanie Boeckstaens,Roy Lavendommeet al. 2025 Pré-publication, Document de travail hal-05393679v1

Poster de conférence (2)

Unlocking the anticancer potential of calix[4]arene-based Cu(I) ionophores in vitro and in vivo Pierre Lelièvre,Cyril Nogier,Jean-Luc Coll,Ivan Jabin,Lucie Sanceyet al. Annual Meeting of the American-Association-for-Cancer-Research (AACR), Apr 2024, San Diego, Californie, United States. CANCER RESEARCH, 84 (6_Supplement), pp.4681., 2024, ⟨10.1158/1538-7445.AM2024-4681⟩ Poster de conférence hal-04771974v1
Discovery of phalbinib, a novel anticancer compound targeting copper homeostasis and inducing cell cycle arrest and autophagy Pierre Lelievre,Cyril Nogier,Nathan Renier,Jean-Luc Coll,Ivan Jabinet al. Annual congress of the European Association for Cancer Research (EACR-2023), Jun 2023, Turin, Italy Poster de conférence hal-04959503v1

Chapitre d'ouvrage (1)

LIBS imaging applications V. Motto-Ros,S. Moncayo,C. Fabre,B. Busser Laser-Induced Breakdown Spectroscopy, Elsevier, pp.329-346, 2020, ⟨10.1016/B978-0-12-818829-3.00014-9⟩ Chapitre d'ouvrage hal-03672496v1

Communication dans un congrès (2)

Laser spectroscopy for in situ elemental imaging of lung tissue: a promising technology Benoit Busser,Samuel Moncayo,Mickaël Catinon,Lucie Sancey,Françoise Thivoletet al. European Respiratory Society International Congress, Sep 2018, Milan, Italy. pp.2643, ⟨10.1183/1393003.congress-2017.PA2643⟩ Communication dans un congrès hal-02062828v1
A new method for multi-elemental imaging and quantifications of biological tissues: laser spectrometry Lucie Sancey,Vincent Motto-Ros,S. Kotb,B. Busser,F. Luxet al. 9ème journée scientifique du CLARA, Jun 2014, Lyon, France Communication dans un congrès hal-01054222v1

Thèse (1)

IDENTIFICATION ET CARACTÉRISATION D'UN NOUVEAU MÉCANISME DE RÉSISTANCE AU GEFITINIB DANS LE CANCER DU POUMON NON-À PETITES CELLULES : ROLE DE L'AMPHIRÉGULINE Benoit Busser Biologie cellulaire. Université Joseph-Fourier - Grenoble I, 2009. Français. ⟨NNT : ⟩ Thèse tel-00446892v2

Mémoire d'étudiant (1)

Rôle de l'amphiréguline dans la résistance du cancer du poumon non-à petites cellules au gefitinib Benoît Busser Sciences pharmaceutiques. 2008 Mémoire d'étudiant dumas-01394344v1