Benoit Joseph

Publications

Brevet (4)

Antibody-drug conjugates based on molecular glue degraders and uses thereof Benoît Joseph,Guy Fournet,Charles Dumontet,Warren Viricel,Louise Conilh France, Patent n° : WO 2025/045758. 2025 Brevet hal-05551016v1
molecular glue degraders and uses thereof Benoît Joseph,Guy Fournet,Charles Dumontet,Warren Viricel,Louise Conilh France, Patent n° : WO 2025/045761. 2025 Brevet hal-05551045v1
Antibody drug conjugate (ADC) targeting Nectin 4 and comprising an exatecan payload Jack Elands,Xavier Préville,Florence Lhospice,Johanna Feris,Daniel Oliveet al. France, Patent n° : JP7594708. 2024 Brevet hal-04931709v1
Enzyme-triggered self-reacting linker having improved physicochemical and pharmacological properties Warren Viricel,Benoît Joseph,Guy Fournet France, Patent n° : WO2022/207699. 2022 Brevet hal-04929242v1

Article dans une revue (26)

Identifying Potent Nonsense-Mediated mRNA Decay Inhibitors with a Novel Screening System Julie Carrard,Fiona Ratajczak,Joséphine Elsens,Catherine Leroy,Rebekah Konget al. Biomedicines, 2023, 11 (10), ⟨10.3390/biomedicines11102801⟩ Article dans une revue hal-04250857v1
Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform Louise Conilh,Guy Fournet,Eric Fourmaux,Angélique Murcia,Eva-Laure Materaet al. Pharmaceuticals, 2021, 14 (3), pp.247. ⟨10.3390/ph14030247⟩ Article dans une revue hal-03215941v1
Monomethyl Auristatin E Grafted-Liposomes to Target Prostate Tumor Cell Lines Ariana Abawi,Xiaoyi Wang,Julien Bompard,Anna Bérot,Valentina Andrettoet al. International Journal of Molecular Sciences, 2021, 22 (8), pp.4103. ⟨10.3390/ijms22084103⟩ Article dans une revue (article de synthèse) hal-04851780v1
Monodisperse polysarcosine-based highly-loaded antibody-drug conjugates Warren Viricel,Guy Fournet,Sabine Beaumel,Emeline Perrial,Sébastien Papotet al. Chemical Science, 2019, 10 (14), pp.4048-4053. ⟨10.1039/C9SC00285E⟩ Article dans une revue hal-02134857v1
Room-Temperature and Transition-Metal-Free Intramolecular α-Arylation of Ketones: A Mild Access to Tetracyclic Indoles and 7-Azaindoles Chérif Adouama,María Budén,Walter Guerra,Marcelo Puiatti,Benoît Josephet al. Organic Letters, 2018, 21 (1), pp.320-324. ⟨10.1021/acs.orglett.8b03831⟩ Article dans une revue hal-02134648v1
Room-Temperature and Transition-Metal-Free Intramolecular α-Arylation of Ketones: A Mild Access to Tetracyclic Indoles and 7-Azaindoles Chérif Adouama,María Budén,Walter Guerra,Marcelo Puiatti,Benoît Josephet al. Organic Letters, 2018, 21 (1), pp.320-324. ⟨10.1021/acs.orglett.8b03831⟩ Article dans une revue hal-03093867v1
Correction: Characterization of Transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis Navina Chrobok,John Bol,Cornelis Jongenelen,John Brevé,Said El Alaouiet al. PLoS ONE, 2018, 13 (12), pp.e0209522. ⟨10.1371/journal.pone.0209522⟩ Article dans une revue hal-02134577v1
Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes Amparo Garcia-Lopez,Francesca Tessaro,Hendrik R A Jonker,Anna Wacker,Christian Richteret al. Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-04110-1⟩ Article dans une revue hal-02115789v1
Impact of meriolins, a new class of cyclin-dependent kinase inhibitors, on malignant glioma proliferation and neo-angiogenesis. Marie Jarry,Céline Lecointre,Céline Malleval,Laurence Desrues,Marie-Thérèse Schouftet al. Neuro-Oncology, 2014, 16 (11), pp.1484-98 Article dans une revue hal-01109355v1
Synthesis and biological evaluation of tetrahydro[1,4]diazepino[1,2-a]indol-1-ones as cyclin-dependent kinase inhibitors Putey Aurelien,Fournet Guy,Olivier Lozach,Lionel Perrin,Meijer Laurentet al. European Journal of Medicinal Chemistry, 2014, 83, pp.617-629 Article dans une revue hal-01147615v1
New 1-arylindoles based serotonin 5-HT7 entagonists. Synthesis and binding evaluation studies Charlène Sagnes,Guy Fournet,Grzegorz Satala,Andrzej J. Bojarski,Benoît Joseph European Journal of Medicinal Chemistry, 2014, 75, pp.159-168 Article dans une revue hal-01147626v1
Recent advances in the synthesis and properties of 4-, 5-, 6- or 7-azaindoles Jean-Yves Mérour,Sylvain Routier,Franck Suzenet,Benoît Joseph Tetrahedron, 2013, 69 (24), pp.4767-4834. ⟨10.1016/j.tet.2013.03.081⟩ Article dans une revue istex hal-04451515v1
Targeting low molecular weight cyclin E (LMW-E) in breast cancer. Angela Nanos-Webb,Natalie A Jabbour,Asha S Multani,Hannah Wingate,Nassima Oumataet al. Breast Cancer Research and Treatment, 2012, 132 (2), pp.575-88. ⟨10.1007/s10549-011-1638-4⟩ Article dans une revue hal-00691433v1
Inhibition of hepatitis C virus NS5B polymerase by S-trityl-L-cysteine derivatives. Daniel B Nichols,Guy Fournet,K. R. Gurukumar,Amartya Basu,Jin-Ching Leeet al. European Journal of Medicinal Chemistry, 2012, 49, pp.191-9. ⟨10.1016/j.ejmech.2012.01.010⟩ Article dans une revue hal-00691431v1
Unexpected matrix interactions in liquid secondary ion mass spectrometry of two pyranosyl mercaptans Christian Gardrat,Benoît Joseph,Christiane Vitry,Alain Castellan,Patrick Rollin Rapid Communications in Mass Spectrometry, 2011, 25 (10), pp.1399-1406. ⟨10.1002/rcm.4998⟩ Article dans une revue istex hal-00677750v1
Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5. Hung Yi Kristal Kaan,Johanna Weiss,Dominik Menger,Venkatasubramanian Ulaganathan,Katarzyna Tkoczet al. Journal of Medicinal Chemistry, 2011, 54 (6), pp.1576-86. ⟨10.1021/jm100991m⟩ Article dans une revue hal-00691439v1
Synthesis of 2-, 3-, and 4-Substituted Pyrido[2,3-b]indoles by C-N, C-O, and C-C(sp) Bond Formation Cédric Schneider,David Goyard,David Gueyrard,Benoît Joseph,Peter Goekjian European Journal of Organic Chemistry, 2010, 2010 (34), pp.6665-6677. ⟨10.1002/ejoc.201000795⟩ Article dans une revue istex hal-02351724v1
New insights into homopiperazine-based 5-HT1A/5-HT7R ligands: synthesis and biological evaluation. Eduard Badarau,Aurélien Putey,Franck Suzenet,Benoit Joseph,Andrzej Bojarskiet al. Journal of Enzyme Inhibition and Medicinal Chemistry, 2010, 25 (3), pp.301-5. ⟨10.3109/14756360903179393⟩ Article dans une revue hal-00691441v1
Synthesis and antiproliferative evaluation of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives. Florence Popowycz,Cédric Schneider,Salvatore Debonis,Dimitrios Skoufias,Frank Kozielskiet al. Bioorganic and Medicinal Chemistry, 2009, 17 (9), pp.3471-8. ⟨10.1016/j.bmc.2009.03.007⟩ Article dans une revue istex hal-00691448v1
Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives as tubulin polymerization inhibitors: synthesis and structure--activity relationship studies. Aurélien Putey,Florence Popowycz,Quoc-Tuan Do,Philippe Bernard,Sandeep K Talapatraet al. Journal of Medicinal Chemistry, 2009, 52 (19), pp.5916-25. ⟨10.1021/jm900476c⟩ Article dans une revue hal-00691446v1
Chemoselective functionalization of α-carbolines at the C-2, C-3, C-4, and C-6 positions using Suzuki–Miyaura reactions Cédric Schneider,David Gueyrard,Benoît Joseph,Peter Goekjian Tetrahedron, 2009, 65 (27), pp.5427-5437. ⟨10.1016/j.tet.2009.04.032⟩ Article dans une revue hal-02351645v1
Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue. Florence Popowycz,Guy Fournet,Cédric Schneider,Karima Bettayeb,Yoan Ferandinet al. Journal of Medicinal Chemistry, 2009, 52 (3), pp.655-63. ⟨10.1021/jm801340z⟩ Article dans une revue hal-00416036v1
Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex. Aude Echalier,Karima Bettayeb,Yoan Ferandin,Olivier Lozach,Monique Clémentet al. Journal of Medicinal Chemistry, 2008, 51 (4), pp.737-51. ⟨10.1021/jm700940h⟩ Article dans une revue hal-00319787v1
Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres François Liger,Florence Popowycz,Thierry Besson,Laurent Picot,Carlos Galmariniet al. Bioorganic and Medicinal Chemistry Letters, 2007, 15 (16), pp.5615-5619. ⟨10.1016/j.bmc.2007.05.033⟩ Article dans une revue istex hal-02357763v1
Synthesis and reactivity of 7-azaindole (1H-pyrrolo[2,3-b]pyridine) Florence Popowycz,Sylvain Routier,Benoît Joseph,Jean-Yves Mérour Tetrahedron, 2007, 63 (5), pp.1031-1064. ⟨10.1016/j.tet.2006.09.067⟩ Article dans une revue istex hal-04451569v1
Synthesis of 6-Substituted Pyrido[2,3- b ]indoles by Electrophilic Substitution Cédric Schneider,David Gueyrard,Florence Popowycz,Benoît Joseph,Peter Goekjian SYNLETT, 2007, 2007 (14), pp.2237-2241. ⟨10.1055/s-2007-985566⟩ Article dans une revue hal-02380611v1

Communication dans un congrès (4)

Récents développements pour la recherche de nouvelles molécules antipaludiques : hétérocycles azotés dérivés d’acides tétramiques et de pyrimidines Maurice Médebielle,Nicolas Chopin,Shinya Iikawa,Claude-Bernard Paultre,Benoît Josephet al. 6. Journées du Consortium antiParasitaire et antiFongique : CaPF-2016 " A la croisée des Mondes !", Consortium Anti-Parasitaire et Fongique (CaPF). FRA., Mar 2016, Tours, France. 49 p Communication dans un congrès hal-02742433v1
Hétérocycles azotés dérivés d’acides tétramiques et de pyrimidines comme nouveaux agents anti-infectieux : activité antipaludique et anti-pneumocystose Maurice Médebielle,Nicolas Chopin,Shinya Iikawa,Claude-Bernard Paultre,Benoît Josephet al. 5. Journée Rhône-Alpes des Biomolécules (JRAB 2016), Centre National de la Recherche Scientifique (CNRS). FRA., Jun 2016, Lyon Villeurbanne, France Communication dans un congrès hal-02743599v1
Chemoselective functionalization of α-carbolines at 2-, 3-, 4- and 6-positions by Suzuki-Miyaura reaction Cédric Schneider,Florence Popowycz,Joseph Benoît,Peter G. Goekjian,Gueyrard David Canadian Chemistry Conference and Exhibition (CSC, 92, 2009), May 2009, Hamilton, Canada Communication dans un congrès hal-02381196v1
Functionnalization of α-carbolines at the C-6 position Cédric Schneider,Gueyrard David,Popowycz Florence,Joseph Benoît,Peter G. Goekjian Symposium de chimie organique Centre-Auvergne-Limousin Poitou-Charente-SYCOCAL PC (52, 2007), May 2007, La Rochelle, France Communication dans un congrès hal-02381215v1