Bertrand Aigle

Identifiants chercheurs

IdHAL :

bertrand-aigle

ORCID :

0000-0001-5266-5926

IdRef :

120677407

Présentation

Publications

Article dans une revue (50)

Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues Li Su,Yaouba Souaibou,Laurence Hôtel,Christophe Jacob,Peter Grünet al. Chemical Science, 2025, 16 (12), pp.5076-5088. ⟨10.1039/d4sc06976e⟩ Article dans une revue hal-04925676v1
Role of a FAD-dependent monooxygenase in diazo group functionalization of kinamycin in Streptomyces ambofaciens Cláudia M Vicente,Alexis Boutilliat,Laurence Hotel,Cédric Paris,Bertrand Aigle Microbiology, 2025, 171 (6), pp.001576. ⟨10.1099/mic.0.001576⟩ Article dans une revue hal-05238570v1
Membrane-based preparation for mass spectrometry imaging of cultures of bacteria Farès Slimani,Laurence Hotel,Aurélie Deveau,Bertrand Aigle,Patrick Chaimbaultet al. Analytical and Bioanalytical Chemistry, 2024, 416 (29), pp.7161 - 7172. ⟨10.1007/s00216-024-05622-0⟩ Article dans une revue hal-04781473v1
Biosynthesis of novel desferrioxamine derivatives requires unprecedented crosstalk between separate NRPS-independent siderophore pathways Li Su,Yaouba Souaibou,Laurence Hôtel,Cédric Paris,Kira J Weissmanet al. Applied and Environmental Microbiology, 2024, 90 (3), pp.e0211523. ⟨10.1128/aem.02115-23⟩ Article dans une revue hal-04445176v2
Synteruptor : mining genomic islands for non-classical specialized metabolite gene clusters Drago Haas,Matthieu Barba,Cláudia M Vicente,Šarká Nezbedová,Amélie Garénauxet al. NAR Genomics and Bioinformatics, 2024, 6 (2), pp.lqae069. ⟨10.1093/nargab/lqae069⟩ Article dans une revue hal-04628353v1
Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins Li Su,Laurence Hôtel,Cédric Paris,Clara Chepkirui,Alexander Brachmannet al. Nature Communications, 2022, 13 (1), pp.515. ⟨10.1038/s41467-022-27955-z⟩ Article dans une revue hal-03544763v1
Towards the sustainable discovery and development of new antibiotics Marcus Miethke,Marco Pieroni,Tilmann Weber,Mark Brönstrup,Peter Hammannet al. Nature Reviews Chemistry, 2021, 5 (10), pp.726-749. ⟨10.1038/s41570-021-00313-1⟩ Article dans une revue pasteur-03427787v1
Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation Virginia S Lioy,Jean-Noel Lorenzi,Soumaya Najah,Thibault Poinsignon,Herve Lehet al. Nature Communications, 2021, 12, pp.5221. ⟨10.1038/s41467-021-25462-1⟩ Article dans une revue hal-03128776v2
Molecular Dynamics to Elucidate the DNA-Binding Activity of AlpZ, a Member of the Gamma-Butyrolactone Receptor Family in Streptomyces ambofaciens Cláudia M Vicente,Jean-Michel Girardet,Laurence Hôtel,Bertrand Aigle Frontiers in Microbiology, 2020, 11, ⟨10.3389/fmicb.2020.01255⟩ Article dans une revue hal-02935390v1
Inhibitions Dominate but Stimulations and Growth Rescues Are Not Rare Among Bacterial Isolates from Grains of Forest Soil Milena Gonzalo,Aurélie Deveau,Bertrand Aigle Microbial ecology, 2020, 80 (4), pp.872-884. ⟨10.1007/s00248-020-01579-6⟩ Article dans une revue hal-02935408v1
Accompagnement dans l’apprentissage de l’argumentation par une équipe pluridisciplinaire : quels effets sur les acteurs ? Martine Paindorge,Virginie Lang,Virginie Libante,Pascal Reboul,Bertrand Aigle Revue internationale de pédagogie de l’enseignement supérieur, 2020, 36 (2), ⟨10.4000/ripes.2717⟩ Article dans une revue hal-03041936v1
N-acylation of L-amino acids in aqueous media: Evaluation of the catalytic performances of Streptomyces ambofaciens aminoacylases Mohamed Chafik Bourkaib,Stéphane Delaunay,Xavier Framboisier,Laurence Hotel,Bertrand Aigleet al. Enzyme and Microbial Technology, 2020, 137, pp.109536. ⟨10.1016/j.enzmictec.2020.109536⟩ Article dans une revue hal-02868736v1
Draft Whole-Genome Shotgun Sequence of Streptomyces sp. Strain ETH9427 Annabelle Thibessard,Cláudia M Vicente,Claire Bertrand,Bertrand Aigle,Pierre Leblond Microbiology Resource Announcements, 2018, 7 (12), pp.e01197. ⟨10.1128/MRA.01197-18⟩ Article dans une revue hal-01887322v1
Diversité et activités antimicrobiennes de souches de Streptomyces de la Fetzara (Algérie) Mabrouka Benhadj,Djamila Gacemi-Kirane,Maxime Toussaint,Laurence Hotel,Cyril Bontempset al. Annales de Biologie Clinique, 2018, 76 (1), pp.81-95. ⟨10.1684/abc.2017.1316⟩ Article dans une revue hal-01844922v1
Comparative Genomics among Closely Related Streptomyces Strains Revealed Specialized Metabolite Biosynthetic Gene Cluster Diversity Cláudia M Vicente,Annabelle Thibessard,Jean-Noël Lorenzi,Mabrouka Benhadj,Laurence Hotelet al. Antibiotics, 2018, 7 (4), pp.86. ⟨10.3390/antibiotics7040086⟩ Article dans une revue hal-01887213v1
An aminoacylase activity from &lt;i&gt;Streptomyces ambofaciens&lt;/i&gt; catalyzes the acylation of lysine on α-position and peptides on N-terminal position Léna Dettori,Florent Ferrari,Xavier Framboisier,Cédric Paris,Yann Guiavarc’het al. Engineering in Life Sciences, 2018, 18 (8), pp.589-599. ⟨10.1002/elsc.201700173⟩ Article dans une revue hal-01959650v1
Role of secondary metabolites in the interaction between Pseudomonas fluorescensand soil microorganisms under iron-limited conditions Aurélie Deveau,Harald Gross,Béatrice Palin,Samina Mehnaz,Max Schnepfet al. FEMS Microbiology Ecology, 2016, 92 (8), pp.1-11. ⟨10.1093/femsec/fiw107⟩ Article dans une revue hal-01490770v1
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking Mingxun Wang,Jeremy J. Carver,Vanessa V. Phelan,Laura M. Sanchez,Neha Garget al. Nature Biotechnology, 2016, 34 (8), pp.828-837. ⟨10.1038/nbt.3597⟩ Article dans une revue hal-01371824v1
Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the spiramycin producer Annabelle Thibessard,Drago Haas,Claude Gerbaud,Bertrand Aigle,Sylvie Lautruet al. Journal of Biotechnology, 2015, 214, pp.117-118. ⟨10.1016/j.jbiotec.2015.09.020⟩ Article dans une revue hal-01258341v1
Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction Bin Wang,Jinwei Ren,Liyuan Li,Fang Fan,Guohui Panet al. Chemical Communications, 2015, 51 (42), pp.8845 - 8848. ⟨10.1039/c5cc01986a⟩ Article dans une revue hal-01475728v1
Minimum Information about a Biosynthetic Gene cluster. Marnix H Medema,Renzo Kottmann,Yi Yilmaz,Matthew Cummings,John B Bigginset al. Nature Chemical Biology, 2015, 11 (9), pp.625-31. ⟨10.1038/nchembio.1890⟩ Article dans une revue hal-01430728v1
Identification of Alp1U and Lom6 as epoxy hydrolases and implications for kinamycin and lomaiviticin biosynthesis Bin Wang,Fang Fan,Jinwei Ren,Guomin Ai,Bertrand Aigleet al. Nature Communications, 2015, 6, pp.1-5. ⟨10.1038/ncomms8674⟩ Article dans une revue hal-01475795v1
Pseudomonas fluorescens Pirates both Ferrioxamine and Ferricoelichelin Siderophores from Streptomyces ambofaciens. Justine Galet,Aurélie Deveau,Laurence Hotel,Pascale Frey-Klett,Pierre Leblondet al. Applied and Environmental Microbiology, 2015, 81 (9), pp.3132-3141. ⟨10.1128/AEM.03520-14⟩ Article dans une revue hal-01269032v1
Gluconic acid-producing Pseudomonas sp. prevent γ-actinorhodin biosynthesis by Streptomyces coelicolor A3(2) Justine Galet,Aurélie Deveau,Laurence Hotel,Pierre Leblond,Pascale Frey-Klettet al. Archives of Microbiology, 2014, 196 (9), pp.619-627. ⟨10.1007/s00203-014-1000-4⟩ Article dans une revue hal-01268576v1
Genome mining of Streptomyces ambofaciens Bertrand Aigle,Sylvie Lautru,Dieter Spiteller,Jeroen S. Dickschat,Gregory L. Challiset al. Journal of Industrial Microbiology and Biotechnology, 2014, 41 (2), pp.251 - 263. ⟨10.1007/s10295-013-1379-y⟩ Article dans une revue (article de synthèse) hal-01475037v1
A Single Sfp-Type Phosphopantetheinyl Transferase Plays a Major Role in the Biosynthesis of PKS and NRPS Derived Metabolites in &lt;italic&gt;Streptomyces ambofaciens&lt;/italic&gt; ATCC23877 Robert Bunet,Ramona Riclea,Luisa Laureti,Laurence Hotel,Cedric Pariset al. PLoS ONE, 2014, 9 (1), pp.e87607. ⟨10.1371/journal.pone.0087607⟩ Article dans une revue hal-01272916v1
Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis Lijiang Song,Luisa Laureti,Christophe Corre,Pierre Leblond,Bertrand Aigleet al. Journal of Antibiotics, 2014, 67 (1), pp.71 - 76. ⟨10.1038/ja.2013.119⟩ Article dans une revue hal-01474997v1
Actinomycetes: role in biotechnology and medicine Neelu Nawani,Bertrand Aigle,Abul Mandal,Manish Bodas,Sofiane Ghorbelet al. BioMed Research International , 2013, 2013, ⟨10.1155/2013/687190⟩ Article dans une revue hal-02645473v1
Bacterial genome mining for novel natural product discovery S. Song,L Laureti,P Gomez-Escribano,D Fox,V Yeoet al. Planta Medica, 2012, 78 (11), ⟨10.1055/s-0032-1320194⟩ Article dans une revue hal-01667347v1
An Unprecedented 1,2‐Shift in the Biosynthesis of the 3‐Aminosalicylate Moiety of Antimycins Ilka Schoenian,Christian Paetz,Jeroen Dickschat,Bertrand Aigle,Pierre Leblondet al. ChemBioChem, 2012, 13 (6), pp.769-773. ⟨10.1002/cbic.201200033⟩ Article dans une revue istex hal-04443813v1
Volatile Lactones from Streptomycetes Arise via the Antimycin Biosynthetic Pathway Ramona Riclea,Bertrand Aigle,Pierre Leblond,Ilka Schoenian,Dieter Spitelleret al. ChemBioChem, 2012, 13 (11), pp.1635-1644. ⟨10.1002/cbic.201200260⟩ Article dans une revue istex hal-04443796v1
Characterization and manipulation of the pathway-specific late regulator AlpW reveals Streptomyces ambofaciens as a new producer of kinamycins R. Bunet,L. Song,M. Vaz Mendez,C. Corre,L. Hotelet al. Journal of Bacteriology, 2011, 193 ((5)), pp. 1142-1153. ⟨10.1128/JB.01269-10⟩ Article dans une revue hal-00606766v1
Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens Luisa Laureti,Lijiang Song,Sheng Huang,Christophe Corre,Pierre Leblondet al. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (15), pp.6258 - 6263. ⟨10.1073/pnas.1019077108⟩ Article dans une revue hal-02651598v1
A new data mining approach for the detection of bacterial promoters combining stochastic and combinatorial methods Catherine Eng,Charu Asthana,Bertrand Aigle,Sébastien Hergalant,Jean-Francois Mariet al. Journal of Computational Biology, 2009, 16 (9), pp.1211-1225. ⟨10.1089/cmb.2008.0122⟩ Article dans une revue inria-00419969v1
Integrative Gene Cloning and Expression System for Streptomyces sp. US 24 and Streptomyces sp. TN 58 Bioactive Molecule Producing Strains Samiha Sioud,Bertrand Aigle,Ines Karray-Rebai,Slim Smaoui,Samir Bejaret al. Journal of Biomedicine and Biotechnology, 2009, 2009 (Article ID 464986), pp.464986. ⟨10.1155/2009/464986⟩ Article dans une revue hal-01659292v1
Regulation of the Synthesis of the Angucyclinone Antibiotic Alpomycin in Streptomyces ambofaciens by the Autoregulator Receptor AlpZ and Its Specific Ligand Robert Bunet,M. V. V Mendes,Nicolas Rouhier,Xiuhua Pang,L. Hotelet al. Journal of Bacteriology, 2008, 190 (9), pp.3293 - 3305. ⟨10.1128/JB.01989-07⟩ Article dans une revue hal-01659448v1
SIGffRid: A tool to search for sigma factor binding sites in bacterial genomes using comparative approach and biologically driven statistics Fabrice Touzain,Sophie Schbath,Isabelle Debled-Rennesson,Bertrand Aigle,Gregory Kucherovet al. BMC Bioinformatics, 2008, 9 (73), pp.on line. ⟨10.1186/1471-2105-9-73⟩ Article dans une revue inria-00580657v1
Targeted Gene Disruption of the Cyclo (L-Phe, L-Pro) Biosynthetic Pathway in Streptomyces sp. US24 Strain Samiha Sioud,Ines Karray-Rebai,Hedi Aouissaoui,Bertrand Aigle,Samir Bejaret al. Journal of Biomedicine and Biotechnology, 2007, 2007 (Art. No 91409), pp.1 - 9. ⟨10.1155/2007/91409⟩ Article dans une revue hal-01659462v1
Intraspecific variability of the terminal regions of the Streptomyces ambofaciens F. Choulet,A. Gallois,B. Aigle,S. Mangenot,C. Gerbaudet al. Journal of Bacteriology, 2006, 188, p 6599-6610 Article dans une revue hal-00101141v1
Evolution of the terminal regions of the streptomyces linear chromosome Frédéric Choulet,Bertrand Aigle,Alexandre Gallois,Sophie Mangenot,Claude Gerbaudet al. Molecular Biology and Evolution, 2006, 23 (12), pp.2361-2369. ⟨10.1093/molbev/msl108⟩ Article dans une revue hal-02661267v1
Intraspecific Variability of the Terminal Inverted Repeats of the Linear Chromosome of Streptomyces ambofaciens Frédéric Choulet,Alexandre Gallois,B. Aigle,Sophie Mangenot,Claude Gerbaudet al. Journal of Bacteriology, 2006, 188 (18), pp.6599 - 6610. ⟨10.1128/JB.00734-06⟩ Article dans une revue hal-01659064v1
Involvement of AlpV, a New Member of the Streptomyces Antibiotic Regulatory Protein Family, in Regulation of the Duplicated Type II Polyketide Synthase alp Gene Cluster in Streptomyces ambofaciens Bertrand Aigle,Xiuhua Pang,Bernard Decaris,Pierre Leblond Journal of Bacteriology, 2005, 187 (7), pp.2491 - 2500. ⟨10.1128/JB.187.7.2491–2500.2005⟩ Article dans une revue hal-01659049v1
Functional Angucycline-Like Antibiotic Gene Cluster in the Terminal Inverted Repeats of the Streptomyces ambofaciens Linear Chromosome Xiuhua Pang,Bertrand Aigle,Jean-Michel Girardet,Sophie Mangenot,Jean-Luc Pernodetet al. Antimicrobial Agents and Chemotherapy, 2004, 48 (2), pp.575 - 588. ⟨10.1128/AAC.48.2.575-588.2004⟩ Article dans une revue hal-01659031v1
Differential and Cross-Transcriptional Control of Duplicated Genes Encoding Alternative Sigma Factors in Streptomyces ambofaciens Virginie Roth,Bertrand Aigle,Robert Bunet,Thomas Wenner,Céline Fourrieret al. Journal of Bacteriology, 2004, 186 (16), pp.5355 - 5365. ⟨10.1128/JB.186.16.5355–5365.2004⟩ Article dans une revue hal-01659043v1
End-to-end fusion of linear deleted chromosomes initiates a cycle of genome instability in Streptomyces ambofaciens Thomas Wenner,Virginie Roth,Gilles Fischer,Céline Fourrier,Bertrand Aigleet al. Molecular Microbiology, 2003, 50 (2), pp.411-425. ⟨10.1046/j.1365-2958.2003.03698.x⟩ Article dans une revue hal-01659028v1
Characterization of two Streptomyces ambofaciens recA mutants: identification of the RecA protein by immunoblotting B. Aigle,Anne Catherine Holl,Jaime F. Angulo,Pierre Leblond,Bernard Decaris FEMS Microbiology Letters, 1997, 149, pp.181-7. ⟨10.1111/j.1574-6968.1997.tb10326.x⟩ Article dans une revue hal-01658772v1
Isolation and characterization of a mutator strain of Streptomyces ambofaciens ATCC23877 exhibiting an increased level of genetic instability Dominique Vandewiele,Jean-Nicolas Volff,Bertrand Aigle,Jean-Marc Simonet,Bernard Decaris Canadian Journal of Microbiology, 1996, 42 (6), pp.562 - 570. ⟨10.1139/m96-076⟩ Article dans une revue hal-01659581v1
Expression of the Streptomyces coelicolor A3(2) ptpA gene encoding a phosphotyrosine protein phosphatase leads to overproduction of secondary metabolites in S. lividans T Umeyama,Y Tanabe,Bertrand Aigle,Y Horinouchi FEMS Microbiology Letters, 1996, 144 (2-3), pp.177-184. ⟨10.1016/0378-1097(96)00359-X⟩ Article dans une revue hal-03205363v1
An amplifiable and deletable locus of Streptomyces ambofaciens RP181110 contains a very large gene homologous to polyketide synthase genes B. Aigle,Dominique Schneider,Cécile Morilhat,Dominique Vandewiele,Anne Daryet al. Microbiology, 1996, 142 (10), pp.2815 - 2824. ⟨10.1099/13500872-142-10-2815⟩ Article dans une revue hal-01659577v1
Analysis of genome instability in Streptomyces ambofaciens Dominique Schneider,Bertrand Aigle,Pierre Leblond,Jean-Marc Simonet,Bernard Decaris Journal of general microbiology, 1993, 139 (11), pp.2559-2567. ⟨10.1099/00221287-139-11-2559⟩ Article dans une revue hal-01658593v1

Communication dans un congrès (16)

Successes, surprises and pitfalls in modular polyketide synthase engineering Kira J. Weissman,Li Su,Laurence Hôtel,Cédric Paris,Clara Chepkiruiet al. 2nd International Conference on Biomolecules and the Bioeconomy, Nov 2021, Nancy, France Communication dans un congrès hal-03525292v1
Engineering of a polyketide synthase leads to ring-contracted stambomycins Li Su,Laurence Hôtel,Cédric Paris,Clara Chepkirui,Alexander Brachmannet al. VAAM workshop 2021: Biology of Bacterial Producing Natural Products, Sep 2021, Saabrucken, Germany Communication dans un congrès hal-03666909v1
Engineering of a polyketide synthase leads to 'low-fat' stambomycins Li Su,Laurence Hôtel,Cédric Paris,Christophe Jacob,Bertrand Aigleet al. Journées francophones d'actinobactéries (ACTINO 2020), Dec 2020, On-line, France Communication dans un congrès hal-03525244v1
Generation of analogues of stambomycins by genetic engineering and allied approaches Li Su,Laurence Hôtel,Cédric Paris,Christophe Jacob,Bertrand Aigleet al. 15. Congrès National de la SFM (Société Française de Microbiologie), Oct 2019, Paris, France Communication dans un congrès hal-03666910v1
Searching For Specialized Metabolites Gene Clusters By Mining Genomic Islands: A New Comparative Genomics-Based Approach Drago Haas,Matthieu Barba,Cláudia M. Vicente,Géraldine Le Goff,Jamal Ouazzaniet al. International Symposium on the Biology of Actinomycetes, May 2017, Jeju, South Korea Communication dans un congrès hal-01655211v1
Impact of nutrient availability on the diversity, function and functioning of the forest soil bacterial communities: insights from the soil succession of the forest experimental site of Montiers. Stephane Uroz,Marie-Pierre M.-P. Turpault,Océane Nicolitch,Yannick Colin,Marc Buéeet al. Labex ARBRE conference, Oct 2016, Champenoux, France Communication dans un congrès hal-03339707v1
Mining genomic islands with Synteruptor, a new strategy for identifying secondary metabolism gene clusters Drago Haas,Matthieu Barba,Cláudia M Vicente,Amélie Garenaux,Sárka Nezbedováet al. The 13th International Symposium on the Genetics of Industrial Microorganisms, Oct 2016, Wuhan, China Communication dans un congrès hal-03042549v1
Pédagogie renouvelée pour des cursus d'ingénierie à l'université Emmanuelle Jacquet,Bernard Gaume,Yves Gaillard,Eric Descourvières,Pascale Marangeet al. Colloque sur l'Enseignement des Technologies et des Sciences de l'Information et des Systèmes, CETSIS 2014, Oct 2014, Besançon, France Communication dans un congrès hal-01094950v1
Fouille de données du génome à l'aide de modèles de Markov cachés Sébastien Hergalant,Bertrand Aigle,Pierre Leblond,Jean-François Mari Extraction et Gestion de Connaissances - EGC 2005, Jan 2005, Paris/France, France. pp.141 -- 148 Communication dans un congrès inria-00001213v1
SIGffRid : Programme de recherche des sites de fixation des facteurs de transcription par approche comparative Fabrice Touzain,Sophie Schbath,Isabelle Debled-Rennesson,Bertrand Aigle,Pierre Leblondet al. Journées Ouvertes Biologie Informatique Mathématiques - JOBIM'05, Guy Perrière, Alain Guénoche et Christophe Geourjon, Jul 2005, Lyon, France. pp.417-425 Communication dans un congrès inria-00000191v1
Classification non supervisée par HMM de sites de fixation de facteurs de transcription chez les bactéries Sébastien Hergalant,Bertrand Aigle,Bernard Decaris,Jean-François Mari,Pierre Leblond 5èmes Journées Ouvertes : Biologie, Informatique et Mathématiques - JOBIM'04, 2004, Montréal, Canada, 1 p Communication dans un congrès inria-00107788v1
Identification of Transcription Factor Binding Sites in Streptomyces coelicolor A3(2) by Phylogenetic Comparison Fabrice Touzain,Patricia Lavigne,Isabelle Debled-Rennesson,Bertrand Aigle,Pierre Leblondet al. European Conference for Computer Biology - ECCB'2003, 2003, Paris, France Communication dans un congrès inria-00099608v1
HMM, an Efficient Way to Detect Transcriptional Promoters in Bacterial Genomes? Sébastien Hergalant,Bertrand Aigle,Bernard Decaris,Jean-François Mari,Pierre Leblond European Conference on Computational Biology - ECCB'2003, Sep 2003, Paris, France, pp.417--419 Communication dans un congrès inria-00099570v1
Identification of transcription factor binding sites in the genome of Streptomyces coelicolor A3(2) Patricia Lavigne,Isabelle Debled-Rennesson,Bertrand Aigle,Pierre Leblond,Gregory Kucherov 3ème Journées Post-Génomique de la DOUA 2003 - JPGD'03, 2003, Lyon, France Communication dans un congrès inria-00099609v1
Intragenomic reiterations detection using hidden Markov models Sébastien Hergalant,Bertrand Aigle,Bernard Decaris,Pierre Leblond,Jean-François Mari 10th International Conference on Intelligent Systems for Molecular Biology - ISMB 2002, Aug 2002, Edmonton, Canada, 1 p Communication dans un congrès inria-00100914v1
Fouille de données à l'aide de HMM : Application à la détection de réitérations intragénomiques Sébastien Hergalant,Bertrand Aigle,Bernard Decaris,Pierre Leblond,Jean-François Mari Journées Ouvertes Biologie Informatique Mathématiques - JOBIM'02, François Coste - Elisabeth Lebret, 2002, Saint Malo, France, pp.269-273 Communication dans un congrès inria-00100752v1

Poster de conférence (5)

The coelimycin cis-AT polyketide synthase forms macro-complexes in its host Streptomyces coelicolor Magali Tirado,Jean-Malo Massicard,Paula Yagüe,Gemma Fernández-García,Ariane Briegelet al. 20th International Symposium on the Biology of Actinomycetes, Jun 2025, Egmond aan Zee, Netherlands Poster de conférence hal-05144803v1
Creating analogues of the anti-tumor polyketide stambomycins by genetic engineering and allied approaches Li Su,Laurence Hotel,Christophe Jacob,Kira J Weissman,Bertrand Aigle 2018, 2018, Nancy, France Poster de conférence hal-03016980v1
Towards the understanding of molecular dialogues within soil forest microbial communities and their impact on plants Milena Gonzalo,Aurélie Deveau,Bertrand Aigle Actino2017, Oct 2017, Lyon, France Poster de conférence hal-02948434v1
Searching for novel specialized metabolite gene clusters, a new comparative genomics-based approach Cláudia M Vicente,Matthieu Barba,Drago Haas,Sylvie Lautru,Olivier Lespinetet al. Directing Biosynthesis V, Mar 2017, Warwick, United Kingdom Poster de conférence hal-03042555v1
Evidence for a High Heterogeneity Between the Terminal Regions of the Chromosomes of Two Phylogenetically Close Species, Streptomyces ambofaciens and Streptomyces coelicolor by Genome Comparison Frédéric Choulet,Bertrand Aigle,F. X. Francou,Alexandre Gallois,Céline Fourrieret al. Streptomyces dissemination meeting, Jul 2003, Guilford, United Kingdom. 2003, Streptomyces dissemination meeting Poster de conférence hal-01182814v1

Chapitre d'ouvrage (3)

Waking up Streptomyces Secondary Metabolism by Constitutive Expression of Activators or Genetic Disruption of Repressors Bertrand Aigle,Christophe Corre Natural product biosynthesis by microorganisms and plants, part C, 517, Academic Press, 2012, Methods in Enzymology, ⟨10.1016/B978-0-12-404634-4.00017-6⟩ Chapitre d'ouvrage hal-02809379v1
Genome-guided Exploration of Streptomyces ambofaciens Secondary Metabolism Bertrand Aigle,Robert Bunet,Christophe Corre,Amélie Garenaux,S. Huanget al. Paul J Dyson Institute of Life Sciences, School of Medicine, Swansea, UK. Streptomyces: Molecular Biology and Biotechnology, Caister Academic Press, Chapter 10 pp. 179-194, 2011, 978-1-904455-77-6 Chapitre d'ouvrage hal-01667184v1
Fouille de données du génome à l'aide de modèles de Markov cachés Sébastien Hergalant,Bertrand Aigle,Pierre Leblond,Jean-François Mari Extraction et gestion des connaissances. EGC 2005, Cépaduès, 2005, Revue des Nouvelles Technologies de l'Information, 2-85428-677-4 2-85428-682-0 (vol. 1) 2-85428-683-9 (vol. 2) Chapitre d'ouvrage hal-02832934v1

Brevet (1)

Stambomycin and derivatives: their production and their use as drugs Bertrand Aigle,Gregory L Challis,Luisa Laureti,Lijiang Song,Pierre Leblond France, Patent n° : WO2011009938. 2011 Brevet hal-01655316v1

Autre publication scientifique (1)

La folle course aux armements des bactéries contre les antibiotiques Pierre Leblond,Nathalie N. Leblond-Bourget,Sophie Payot,Bertrand Aigle 2018 Autre publication scientifique hal-01889239v1

Thèse (1)

Instabilité génétique chez streptomyces ambofaciens : expression de deux loci amplifiables et délétables, implication possible de RecA dans l'instabilité Bertrand Aigle Génomique, Transcriptomique et Protéomique [q-bio.GN]. Université Henri Poincaré - Nancy 1, 1995. Français. ⟨NNT : 1995NAN10315⟩ Thèse tel-01753746v1