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Bertrand Castaing

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Publications

franck-coste
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Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing

Coste Franck , Stéphane Goffinont , Julien Cros , Virginie Gaudon , Guérin Martine
Nucleic Acids Research, 2022, ⟨10.1093/nar/gkac932⟩
Article dans une revue hal-03841526v1
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Structure and Sequence Determinants Governing the Interactions of RNAs with Influenza A Virus Non-Structural Protein NS1

Alan Wacquiez , Franck Coste , Emmanuel Kut , Virginie Gaudon , Sascha Trapp
Viruses, 2020, 12 (9), 25 p. ⟨10.3390/v12090947⟩
Article dans une revue hal-03082436v1
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Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights

Charlotte Rieux , Stéphane Goffinont , Franck Coste , Zahira Tber , Julien Cros
International Journal of Molecular Sciences, 2020, 21 (6), pp.2058. ⟨10.3390/ijms21062058⟩
Article dans une revue hal-03082414v1
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New protein-DNA complexes in archaea: a small monomeric protein induces a sharp V-turn DNA structure

Karine Loth , Justine Largillière , Franck Coste , Françoise Culard , Céline Landon
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-50211-2⟩
Article dans une revue hal-02306224v1

Repair of 8-oxo-7,8-dihydroguanine in prokaryotic and eukaryotic cells: Properties and biological roles of the Fpg and OGG1 DNA N -glycosylases

Serge Boiteux , Franck Coste , Bertrand Castaing
Free Radical Biology and Medicine, 2017, 107, pp.179 - 201. ⟨10.1016/j.freeradbiomed.2016.11.042⟩
Article dans une revue hal-01618166v1
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ATP-dependent motor activity of the transcription termination factor Rho from Mycobacterium tuberculosis

F. d'Heygere , A. Schwartz , F. Coste , B. Castaing , M. Boudvillain
Nucleic Acids Research, 2015, 43 (12), pp.6099-60111. ⟨10.1093/nar/gkv505⟩
Article dans une revue hal-01171219v1

The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase

R. Le Meur , Françoise Culard , V. Nadan , S. Goffinont , F. Coste
Biochemical Journal, 2015, 471 (1), pp.13-23. ⟨10.1042/BJ20150387⟩
Article dans une revue hal-01216639v1
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Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization

A. Biela , F. Coste , F. Culard , M. Guerin , S. Goffinont
Nucleic Acids Research, 2014, 42 (16), pp.doi: 10.1093/nar/gku613. ⟨10.1093/nar/gku613⟩
Article dans une revue hal-01175522v1

Binding of the RamR repressor to wild-type and mutated promoters of the RamA gene involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium.

Sylvie Baucheron , Franck Coste , Sylvie Canepa , Marie-Christine Maurel , Etienne Giraud
Antimicrobial Agents and Chemotherapy, 2012, 56 (2), pp.942-8. ⟨10.1128/AAC.05444-11⟩
Article dans une revue hal-00721770v1

5-Hydroxy-5-methylhydantoin DNA lesion, a molecular trap for DNA glycosylases

Yann Vei Le Bihan , Angeles M. Izquierdo , Franck Coste , Pierre Aller , Françoise Culard
Nucleic Acids Research, 2011, 39 (14), pp.6277-6290. ⟨10.1093/nar/gkr215⟩
Article dans une revue hal-00614943v1

An alternative flexible conformation of the E. coli HU beta(2) protein: structural, dynamics, and functional aspects

Norbert Garnier , Karine Loth , Franck Coste , Rafal Augustyniak , Virginie Nadan
European Biophysics Journal, 2011, 40 (2), pp.117-129. ⟨10.1007/s00249-010-0630-y⟩
Article dans une revue hal-00602370v1

Bacterial base excision repair enzyme Fpg recognizes bulky N7-substituted-FapydG lesion via unproductive binding mode.

Franck Coste , Matthias Ober , Yann-Vaï Le Bihan , Maria Angeles Izquierdo , Nadège Hervouet
Chemistry & Biology / Chemistry and Biology; CHEMISTRY & BIOLOGY, 2008, 15 (7), pp.706-17. ⟨10.1016/j.chembiol.2008.05.014⟩
Article dans une revue hal-00408047v1

Structural basis for the recognition of the FapydG lesion (2,6-diamino-4-hydroxy-5-formamidopyrimidine) by Formamidopyrimidine-DNA glycosylase

F. Coste , M. Ober , T. Carrell , S. Boiteux , C. Zelwer
Journal of Biological Chemistry, 2006, 279 (42), pp.44074-44083. ⟨10.1074/jbc.M405928200⟩
Article dans une revue hal-00114389v1

Evidence of a thermal unfolding dimeric intermediate for the Escherichia coli histone-like HU proteins: thermodynamics and structure.

Charles Ramstein , Nadège Hervouet , Franck Coste , Charles Zelwer , Jacques Oberto
Journal of Molecular Biology, 2003, 331 (1), pp.101-21
Article dans une revue hal-02127656v1

Crystallization and preliminary X-ray diffraction analysis of the homodimeric form alpha2 of the HU protein from Escherichia coli.

Franck Coste , N. Hervouet , J. Oberto , C. Zelwer , Bertrand Castaing
Acta crystallographica Section D : Structural biology [1993-..], 1999, 55 (Pt 11), pp.1952-4
Article dans une revue hal-02127644v1

Discovery and characterization of inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, pertinent therapeutic targets for cancer therapy

J. Cros , F. Coste , S. Goffinont , Virginie Nadan , V. Roy
Laboratoire International Associé, Jun 2019, Varsovie, Poland
Communication dans un congrès hal-02903108v1

Small molecule inhibitors of the human DNA glycosylases hOGG1 and NEIL1, pertinent therapeutic targets in cancer and neurodegenerative disease therapies

J. Cros , F. Coste , Z. Tber , S. Goffinont , Virginie Nadan
25th Young Research Fellows Meeting, Mar 2018, Orléans, France
Communication dans un congrès hal-02903084v1

Des cristaux pour la recherche de nouveaux antiviraux

Daniel Marc , Franck Coste , Bertrand Castaing
Journées d'Animation Scientifique de la Fédération de Recherche d'Infectiologie (FéRI), Oct 2015, Orléans, France. 17 diapositives
Communication dans un congrès hal-02792217v1

Incorporation of trifluoromethylated pseudoproline in an entomotoxic knottin: effects on oxidative folding, 3D structure and biological activity

F. Coste , G. Chaume , J.-B. Madinier , I. Rahioui , B. Castaing
21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Poster de conférence hal-02893471v1

Search for small molecule inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, potential therapeutic targets in cancer

J. Cros , F. Coste , S. Goffinont , V. Gaudon , V. Roy
13th French 3R meeting, May 2019, Presqu’île de Giens, France
Poster de conférence hal-02903219v1

Search for small molecule inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, potential therapeutic targets in cancer

J. Cros , F. Coste , S. Goffinont , V. Gaudon , V. Roy
Journée Fédération de recherche “Physique et Chimie du Vivant” FR2708 (CBM/ICOA), Apr 2019, Orléans, France
Poster de conférence hal-02903223v1

Screening, characterization and structural studies of small molecules inhibitors of the DNA glycosylase hNEIL1 and hOGG1, potential therapeutic targets in cancer and neurodegenerative disease

Julien Cros , Franck Coste , Stéphane Goffinont , Virginie Nadan , Norbert Garnier
1st French congress on Integrative Structural Biology (BSI-2019), Oct 2019, Toulouse, France
Poster de conférence hal-03385201v1

Interaction de la protéine NS1 des virus influenza A avec l’ARN : mécanismes impliqués dans la reconnaissance spécifique

Daniel Marc , Alan Wacquiez , Stéphane Goffinont , Virginie Nadan , Franck Coste
XIIes Journées Francophones de Virologie, Mar 2019, Lyon, France. Virologie, 23, 2019
Poster de conférence hal-02737761v1

Recherche d’inhibiteurs des enzymes de réparation de l’ADN hNeil1 et hOGG1, de nouvelles cibles pertinentes pour le développement de thérapies anticancéreuses

J. Cros , F. Coste , S. Goffinont , V. Gaudon , V. Roy
31e colloque Biotechnocentre, Oct 2018, Seillac, France
Poster de conférence hal-02904682v1

NS1 des virus Influenza A : approches structurales et fonctionnelles pour de nouvelles stratégies anti-virales

Alan Wacquiez , Franck Coste , Caroline Blondeau , Emmanuel Kut , Virginie Nadan
20. Journées Francophones de Virologie 2018, Mar 2018, Paris, France. John Libbey Eurotext, Virologie, 22, 148 p., 2018
Poster de conférence hal-02736544v1

Search for small molecule inhibitors of DNA glycosylases, pertinent therapeutic targets in cancer and neurodegenerative disease therapies

J. Cros , F. Coste , Z. Tber , S. Goffinont , V. Nadan
5e Colloque annuel du Laboratoire International Associé (LIA) MiR-TANGo, May 2018, Orléans, France
Poster de conférence hal-02904701v1

New protein-DNA complexes in archaea: a small monomeric protein induces a sharp V-turn DNA structure.

Karine Loth , Justine Largillière , Franck Coste , Françoise Culard , Celine Landon
EuroMar 2018, Jul 2018, Nantes, France
Poster de conférence hal-02362581v1

Incorporation of trifluoromethylated pseudoproline in an entomotoxic knottin: effects on oxidative folding, 3D structure and biological activity

F. Coste , G. Chaume , J.-B. Madinier , I. Rahioui , B. Castaing
35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland
Poster de conférence hal-02894161v1

Structures et fonctions de la protéine NS1 des virus influenza pour la recherche de nouvelles cibles thérapeutiques

Alan Wacquiez , Stéphane Goffinont , Virginie Nadan , Franck Coste , Emmanuel Kut
31e Colloque Biotechnocentre, Oct 2018, Seillac, France. , 2018
Poster de conférence hal-02736195v1

New protein-DNA complexes in archaea: a small monomeric protein induces a V-turn structure.

Karine Loth , Justine Largillière , Franck Coste , Françoise Culard , Bertrand Castaing
28th ICMRBS - International Council on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland
Poster de conférence hal-02362584v1

NS1 des virus influenza : relations structure-fonction pour la recherche de nouveaux anti-viraux

A. Wacquiez , S. Goffinont , V. Nadan , F. Coste , E. Kut
30e colloque Biotechnocentre, Oct 2017, Seillac, France
Poster de conférence hal-02904785v1

NS1 of Influenza viruses: structural and functional approaches towards the discovery of novel anti-influenza drugs

A. Wacquiez , F. Coste , V. Nadan , E. Kut , S. Goffinont
Le Studium Conférence “Structural Biology and biophysics of RNA-protein complexes”, Nov 2017, Orléans, France
Poster de conférence hal-02904778v1

New protein-DNA complexes in archaea: a monomeric protein induces a U-turn structure.

Karine Loth , Justine Largillière , Franck Coste , A.F. Delmas , Bertrand Castaing
Le Studium Confenrence: Structural biology and biophysics of RNA-protein complexes, Nov 2017, Orléans, France
Poster de conférence hal-02362576v1

NS1 des virus Influenza A : approches structurales et fonctionnelles pour de nouvelles stratégies anti-virales

A. Wacquiez , F. Coste , C. Blondeau , E. Kut , V. Nadan
Le Studium Conférence « Messenger RNA therapeutics : advances and perspectives », Mar 2017, Orléans, France
Poster de conférence hal-02904828v1

Small-molecule inhibitors of Fpg/Nei DNA glycosylases, enzymes initiating the base excision repair pathway, new targets for cancer therapy

C. Rieux , F. Coste , F. Culard , S. Goffinont , S. Bourg
XXII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids, Jul 2016, Paris, France
Poster de conférence hal-02919151v1

Improvement of the chemical production of β-defensins including straightforward attribution of disulfide bridges

Mathieu Galibert , Chrystelle Derache , Franck Coste , Hervé Meudal , Anne-Christine Lalmanach
18. Réunion du GFPP, May 2013, Sète, France. 1 p., 2013
Poster de conférence hal-02805308v1

Monitoring RNA Unwinding by the Transcription Termination Factor Rho from Mycobacterium tuberculosis

F. d'Heygère , A. Schwartz , F. Coste , B. Castaing , M. Boudvillain
Methods in Mecular Biology, 1259, Springer, pp.293-311, 2015, RNA remodelling proteins (Boudvillain, ed), 978-1-4939-2213-0. ⟨10.1007/978-1-4939-2214-7_18⟩
Chapitre d'ouvrage hal-01174055v1