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Boris Hejblum



ChatGPT et au-delà avec l’intelligence artificielle en santé : des leçons à tirer

Rodolphe Thiébaut , Boris P. Hejblum , Fleur Mougin , Christophe Tzourio , Laura Richert
Revue du Rhumatisme, 2024, 91 (1), pp.12-15. ⟨10.1016/j.rhum.2023.07.007⟩
Journal articles hal-04466670v1
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Post-clustering difference testing: valid inference and practical considerations

Benjamin Hivert , Denis Agniel , Rodolphe Thiébaut , Boris P. Hejblum
Computational Statistics and Data Analysis, 2024, 193, pp.107916. ⟨10.1016/j.csda.2023.107916⟩
Journal articles hal-03889565v1
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Identification of early gene expression profiles associated with long-lasting antibody responses to the Ebola vaccine Ad26.ZEBOV/MVA-BN-Filo

Fabiola Blengio , Hakim Hocini , Laura Richert , Cécile Lefebvre , Melany Durand
Cell Reports, 2023, 42 (9), pp.113101. ⟨10.1016/j.celrep.2023.113101⟩
Journal articles hal-04273901v1
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Modéliser la COVID-19 : de la population à l’individu

Carole Vignals , Boris P. Hejblum , Mélanie Prague
Interstices, 2023
Journal articles hal-04230705v1
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Doubly-robust evaluation of high-dimensional surrogate markers

Denis Agniel , Boris Hejblum , Rodolphe Thiébaut , Layla Parast
Biostatistics, 2023, 24 (4), pp.985-999. ⟨10.1093/biostatistics/kxac020⟩
Journal articles hal-03100499v1
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ChatGPT and beyond with artificial intelligence (AI) in health: Lessons to be learned.

Rodolphe Thiebaut , Boris P. Hejblum , Fleur Mougin , Christophe Tzourio , Laura Richert
Joint Bone Spine, 2023, 90 (5), pp.105607. ⟨10.1016/j.jbspin.2023.105607⟩
Journal articles hal-04236822v1
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Using Population Based Kalman Estimator to Model COVID-19 Epidemic in France: Estimating the Effects of Non-Pharmaceutical Interventions on the Dynamics of Epidemic

Annabelle Collin , Boris P. Hejblum , Carole Vignals , Laurent Lehot , Rodolphe Thiébaut
The international journal of biostatistics, inPress, ⟨10.1515/ijb-2022-0087⟩
Journal articles hal-04151651v1
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CytOpT: Optimal Transport with Domain Adaptation for Interpreting Flow Cytometry data

Paul Freulon , Jérémie Bigot , Boris Hejblum
Annals of Applied Statistics, 2023, 17 (2), pp.1086-1104. ⟨10.1214/22-AOAS1660⟩
Journal articles hal-03100405v1

High temporal resolution transcriptomic profiling delineates distinct patterns of interferon response following Covid-19 mRNA vaccination and SARS-CoV2 infection

Darawan Rinchai , Sara Deola , Gabriele Zoppoli , Basirudeen Syed Ahamed Kabeer , Sara Taleb
Science Advances , 2022, 8 (45), eabp9961. ⟨10.1126/sciadv.abp9961⟩
Journal articles hal-03530948v1

The benefit of augmenting open data with clinical data-warehouse EHR for forecasting SARS-CoV-2 hospitalizations in Bordeaux area, France

Thomas Ferté , Vianney Jouhet , Romain Griffier , Boris Hejblum , Rodolphe Thiébaut
JAMIA open, 2022, 5 (4), ⟨10.1093/jamiaopen/ooac086⟩
Journal articles hal-03908260v1

T Cell Immunogenicity, Gene Expression Profile, and Safety of Four Heterologous Prime-Boost Combinations of HIV Vaccine Candidates in Healthy Volunteers: Results of the Randomized Multi-Arm Phase I/II ANRS VRI01 Trial

Laura Richert , Jean-Daniel Lelievre , Christine Lacabaratz , Lucile Hardel , Hakim Hocini
Journal of Immunology, 2022, 208 (12), pp.2663-2674. ⟨10.4049/jimmunol.2101076⟩
Journal articles hal-03690137v1
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Bayesian mixture models for cytometry data analysis

Lin Lin , Boris Hejblum
Wiley Interdisciplinary Reviews: Computational Statistics, In press, 13 (4), pp.e1535. ⟨10.1002/wics.1535⟩
Journal articles hal-03100447v1
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Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study

Sophie Lefevre-Arbogast , Boris P. Hejblum , Catherine Helmer , C. Klose , Claudine Manach
EBioMedicine, 2021, 64, pp.103216. ⟨10.1016/j.ebiom.2021.103216⟩
Journal articles hal-03155026v1
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Predicting Progression to Advanced Age-Related Macular Degeneration from Clinical, Genetic, and Lifestyle Factors Using Machine Learning

Soufiane Ajana , Audrey Cougnard-Grégoire , Johanna Colijn , Bénédicte M.J. Merle , Timo Verzijden
Ophthalmology: Journal of The American Academy of Ophthalmology, 2021, 128 (4), pp.587-597. ⟨10.1016/j.ophtha.2020.08.031⟩
Journal articles hal-03100320v1
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Predicting the retinal content in omega‐3 fatty acids for age‐related macular‐degeneration

Niyazi Acar , Bénédicte M. J. Merle , Soufiane Ajana , Zhiguo He , Stéphane Grégoire
Clinical and Translational Medicine, 2021, 11 (7), pp.e404. ⟨10.1002/ctm2.404⟩
Journal articles hal-03293612v1
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CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death

Yves Lévy , Aurélie Wiedemann , Boris P. Hejblum , Mélany Durand , Cécile Lefebvre
iScience, 2021, 24 (7), pp.102711. ⟨10.1016/j.isci.2021.102711⟩
Journal articles hal-03477973v1
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Robust and Efficient Optimization Using a Marquardt-Levenberg Algorithm with R Package marqLevAlg

Viviane Philipps , Boris P. Hejblum , Mélanie Prague , Daniel Commenges , Cécile Proust-Lima
The R Journal, inPress, ⟨10.32614/RJ-2021-089⟩
Journal articles hal-03100489v1

ATLAS: an automated association test using probabilistically linked health records with application to genetic studies

Harrison Zhang , Boris P. Hejblum , Griffin Weber , Nathan Palmer , Susanne Churchill
Journal of the American Medical Informatics Association, 2021, 28 (12), pp.2582-2592. ⟨10.1093/jamia/ocab187⟩
Journal articles hal-03478039v1
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Automatic phenotyping of electronical health record: PheVis algorithm

Thomas Ferté , Sébastien Cossin , Thierry Schaeverbeke , Thomas Barnetche , Vianney Jouhet
Journal of Biomedical Informatics, 2021, 117, pp.103746. ⟨10.1016/j.jbi.2021.103746⟩
Journal articles hal-03100435v1
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EpidemiOptim: a Toolbox for the Optimization of Control Policies in Epidemiological Models

Cédric Colas , Boris P. Hejblum , Sébastien Rouillon , Rodolphe Thiébaut , Pierre-Yves Oudeyer
Journal of Artificial Intelligence Research, 2021, 71, pp.479-515. ⟨10.1613/jair.1.12588⟩
Journal articles hal-03099898v2
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Analyzing cellular immunogenicity in vaccine clinical trials: a new statistical method including non-specific responses for accurate estimation of vaccine effect

Édouard Lhomme , Boris Hejblum , Christine Lacabaratz , Aurélie Wiedemann , Jean-Daniel Lelièvre
Journal of Immunological Methods, 2020, 477, pp.112711. ⟨10.1016/j.jim.2019.112711⟩
Journal articles hal-03161945v2
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Semi-supervised estimation of covariance with application to phenome-wide association studies with electronic medical records data

Stephanie F Chan , Boris P. Hejblum , Abhishek Chakrabortty , Tianxi Cai
Statistical Methods in Medical Research, 2020, 29 (2), pp.455-465. ⟨10.1177/0962280219837676⟩
Journal articles hal-02425459v1
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dearseq: a variance component score test for RNA-Seq differential analysis that effectively controls the false discovery rate

Marine Gauthier , Denis Agniel , Rodolphe Thiébaut , Boris Hejblum
NAR Genomics and Bioinformatics, 2020, 2 (4), pp.lqaa093. ⟨10.1093/nargab/lqaa093⟩
Journal articles hal-02138664v1
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Immune Alterations in a Patient with SARS-CoV-2-Related Acute Respiratory Distress Syndrome

Lila Bouadma , Aurélie Wiedemann , Juliette Patrier , Mathieu Surénaud , Paul-Henri Wicky
Journal of Clinical Immunology, 2020, 40, pp.1082-1092. ⟨10.1007/s10875-020-00839-x⟩
Journal articles hal-03160737v2
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Long-lasting severe immune dysfunction in Ebola virus disease survivors

Aurélie Wiedemann , Emile Foucat , Hakim Hocini , Cécile Lefebvre , Boris Hejblum
Nature Communications, 2020, 11 (1), pp.3730. ⟨10.1038/s41467-020-17489-7⟩
Journal articles hal-03160838v2
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Gene Expression Signatures Associated With Immune and Virological Responses to Therapeutic Vaccination With Dendritic Cells in HIV-Infected Individuals

Rodolphe Thiébaut , Boris P. Hejblum , Hakim Hocini , Henri Bonnabau , Jason Skinner
Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.00874⟩
Journal articles hal-02267014v2
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Sequential Dirichlet Process Mixtures of Multivariate Skew t-distributions for Model-based Clustering of Flow Cytometry Data

Boris P. Hejblum , Chariff Alkhassim , Raphael Gottardo , François Caron , Rodolphe Thiébaut
Annals of Applied Statistics, 2019, 13 (1), pp.638-660. ⟨10.1214/18-AOAS1209⟩
Journal articles hal-01579063v1
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Benefits of dimension reduction in penalized regression methods for high dimensional grouped data: a case study in low sample size

Soufiane Ajana , Niyazi Acar , Lionel Brétillon , Boris Hejblum , Hélène Jacqmin-Gadda
Bioinformatics, 2019, 35, pp.3628-3634. ⟨10.1093/bioinformatics/btz135⟩
Journal articles hal-02425449v1

Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort

Dorrain Low , Sophie Lefèvre-Arbogast , Raúl Dominguez-Gonzalez , Mireia Urpi Sarda , Pierre Micheau
Molecular Nutrition and Food Research, 2019, 63 (18), pp.e1900177. ⟨10.1002/mnfr.201900177⟩
Journal articles hal-02167524v1
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Sequential Dirichlet process mixture of skew $t$-distributions for model-based clustering of flow cytometry data

Boris P. Hejblum , Chariff Alkhassim , Raphael Gottardo , François Caron , Rodolphe Thiébaut
Annals of Applied Statistics, 2019, 13 (1), pp.638-660
Journal articles hal-03161057v1
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Probabilistic record linkage of de-identified research datasets with discrepancies using diagnosis codes

Boris P. Hejblum , Griffin M. Weber , Katherine P. Liao , Nathan P Palmer , Susanne Churchill
Scientific Data , 2019, 6, pp.180298. ⟨10.1038/sdata.2018.298⟩
Journal articles hal-01942279v1
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cytometree: A binary tree algorithm for automatic gating in cytometry analysis

Daniel Commenges , Chariff Alkhassim , Raphael Gottardo , Boris P. Hejblum , Rodolphe Thiébaut
Cytometry Part A, 2018, 93 (11), pp.1132-1140. ⟨10.1002/cyto.a.23601⟩
Journal articles hal-03161874v2
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Pattern of polyphenol intake and the long-term risk of dementia in older persons

Sophie Lefèvre-Arbogast , David Gaudout , Julien Bensalem , Luc Letenneur , Jean-François Dartigues
Neurology, 2018, 90 (22), pp.e1979 - e1988. ⟨10.1212/WNL.0000000000005607⟩
Journal articles hal-01887895v1
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Kernel machine score test for pathway analysis in the presence of semi-competing risks

Matey Neykov , Boris P. Hejblum , Jennifer A Sinnott
Statistical Methods in Medical Research, 2018, Statistical Methods in Medical Research, 27 (4), pp.1099-1114. ⟨10.1177/0962280216653427⟩
Journal articles hal-01395970v1
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PheProb: probabilistic phenotyping using diagnosis codes to improve power for genetic association studies

Jennifer A Sinnott , Fiona Cai , Sheng Yu , Boris P. Hejblum , Chuan Hong
Journal of the American Medical Informatics Association, 2018, ⟨10.1093/jamia/ocy056⟩
Journal articles hal-01887930v1
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Association between anti-citrullinated fibrinogen antibodies and coronary artery disease in rheumatoid arthritis

Boris P. Hejblum , Jing Cui , Lauren J. Lahey , Andrew Cagan , Jeffrey A. Sparks
Arthritis Care & Research = Arthritis Care and Research, 2018, 70 (7), pp.1113-1117. ⟨10.1002/acr.23444⟩
Journal articles hal-01654403v1
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Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV

Anne Rechtien , Laura Richert , Hadrien Lorenzo , Gloria Martrus , Boris P. Hejblum
Cell Reports, 2017, 20 (9), pp.2251 - 2261. ⟨10.1016/j.celrep.2017.08.023⟩
Journal articles hal-01579246v1
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Variance component score test for time-course gene set analysis of longitudinal RNA-seq data

Denis Agniel , Boris P. Hejblum
Biostatistics, 2017, Biostatistics, 18 (4), pp.589-604. ⟨10.1093/biostatistics/kxx005⟩
Journal articles hal-01579077v1
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Phenome-Wide Association Study of Autoantibodies to Citrullinated and Noncitrullinated Epitopes in Rheumatoid Arthritis

Katherine P. Liao , Jeffrey A Sparks , Boris P. Hejblum , I-Hsin Kuo , Jing Cui
Arthritis & rheumatology, 2017, 69 (4), pp.742 - 749. ⟨10.1002/art.39974⟩
Journal articles hal-01654405v1

Group and sparse group partial least square approaches applied in genomics context

Benoit Liquet , Pierre Lafaye de Micheaux , Boris P. Hejblum , Rodolphe Thiébaut
Bioinformatics, 2016, 32 (1), pp.35-42. ⟨10.1093/bioinformatics/btv535⟩
Journal articles hal-01288891v1
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Time-Course Gene Set Analysis for Longitudinal Gene Expression Data

Boris P. Hejblum , Jason Skinner , Rodolphe Thiébaut
PLoS Computational Biology, 2015, 11 (6), pp.e1004310. ⟨10.1371/journal.pcbi.1004310⟩
Journal articles hal-01203446v1

Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination.

David Furman , Boris P. Hejblum , Noah Simon , Vladimir Jojic , Cornelia L. Dekker
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (2), pp.869-74. ⟨10.1073/pnas.1321060111⟩
Journal articles inserm-00933693v1

L’analyse des « Big Data » en recherche clinique

Rodolphe Thiébaut , Boris P. Hejblum , Laura Richert
Epidemiology and Public Health = Revue d'Epidémiologie et de Santé Publique, 2014, 62 (1), pp.1-4. ⟨10.1016/j.respe.2013.12.021⟩
Journal articles inserm-00933691v1
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Evidence synthesis through a degradation model applied to myocardial infarction.

Daniel Commenges , Boris P. Hejblum
Lifetime Data Analysis, 2013, 19 (1), pp.1-18. ⟨10.1007/s10985-012-9227-3⟩
Journal articles inserm-00726036v1

Association of a predictor of retinal omega-3 polyunsaturated fatty acids with advanced age-related macular degeneration: the BLISAR project

Cécile Delcourt , Soufiane Ajana , Bénédicte Merle , Hélène Jacqmin-Gadda , Boris P. Hejblum
Annual meeting of the association-for-research-in-vision-and-ophthalmology (ARVO), Apr 2019, Vancouver, Canada, United States. Association for Research in Vision and Ophthalmology, Investigative Ophthalmology and Visual Science, 60 (9), 1 p., 2019
Conference poster hal-02736092v1

Identification of a circulating biomarker highly associated to retinal omega-3 polyunsaturated fatty acid content: the BLISAR project

Niyazi Acar , Soufiane Ajana , Olivier Berdeaux , Hélène Jacqmin-Gadda , Boris Hejblum
Annual meeting of the association for research in vision and ophthalmology (ARVO), Apr 2019, Vancouver, Canada, United States. Association for Research in Vision and Ophthalmology, Investigative Ophthalmology and Visual Science, 60 (9), 1 p., 2019
Conference poster hal-02737963v1
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Identification of dietary modulators of cognitive function in ageing using metabolomics discovery

Dorrain Low Yanwen , Sophie Lefèvre-Arbogast , Mélanie Pétéra , Pierre Micheau , Delphine Centeno
Journée Scientifique du CRNH Auvergne, Nov 2017, Clermont-Ferrand, Canada. 2017, Journée Scientifique du CRNH Auvergne 2017
Conference poster hal-01644048v1

Identification of dietary modulators of cognitive function in ageing using metabolomics discovery

Dorrain Low Yanwen , Sophie Lefèvre-Arbogast , Mélanie Pétéra , Pierre Micheau , Delphine Centeno
8. International Conference on Polyphenols and Health ICPH 2017, Oct 2017, Québec, Canada. 2017
Conference poster hal-01595015v1
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Vers une recherche reproductible

Loic Desquilbet , Sabrina Granger , Boris Hejblum , Arnaud Legrand , Pascal Pernot
Unité régionale de formation à l'information scientifique et technique de Bordeaux. Unité régionale de formation à l'information scientifique et technique de Bordeaux, pp.1-161, 2019, 979-10-97595-05-0
Books hal-02144142v3