Boris Hejblum

Publications

Article dans une revue (52)

Reservoir Computing in R: a Tutorial for Using reservoirnet to Predict Complex Time-Series Thomas Ferté,Kalidou Ba,Dan Dutartre,Pierrick Legrand,Vianney Jouhetet al. Computo, 2025, ⟨10.57750/arxn-6z34⟩ Article dans une revue hal-05208084v1
RISE: Two-Stage Rank-Based Identification of High-Dimensional Surrogate Markers Applied to Vaccinology Arthur Hughes,Layla Parast,Rodolphe Thiébaut,Boris P. Hejblum Statistics in Medicine, 2025, 44 (20-22), pp.e70241. ⟨10.1002/sim.70241⟩ Article dans une revue hal-04933460v2
Self-collected finger-prick blood for gene expression profiling: Unveiling early immune responses in mild COVID-19 Rodolphe Thiébaut,Edouard Lhomme,Hakim Hocini,Isabelle Pellegrin,Andrea Boizard-Moracchiniet al. iScience, 2025, 29 (2), pp.114593. ⟨10.1016/j.isci.2025.114593⟩ Article dans une revue hal-05490229v1
A strategy for multimodal integration of transcriptomics, proteomics, and radiomics data for the prediction of recurrence in patients with IDH-mutant gliomas Tiffanie Chouleur,Christèle Etchegaray,Laura Villain,Antoine Lesur,Thomas Fertéet al. International Journal of Cancer, 2025, 157 (3), pp.573-587. ⟨10.1002/ijc.35441⟩ Article dans une revue hal-05069366v1
On the potential benefits of entropic regularization for smoothing Wasserstein estimators Jérémie Bigot,Paul Freulon,Boris P. Hejblum,Arthur Leclaire Electronic Journal of Statistics , 2025, 19 (2), pp.3867-3894. ⟨10.1214/25-EJS2430⟩ Article dans une revue hal-03908229v1
Post-clustering difference testing: valid inference and practical considerations Benjamin Hivert,Denis Agniel,Rodolphe Thiébaut,Boris P. Hejblum Computational Statistics and Data Analysis, 2024, 193, pp.107916. ⟨10.1016/j.csda.2023.107916⟩ Article dans une revue hal-03889565v1
ChatGPT et au-delà avec l’intelligence artificielle en santé : des leçons à tirer Rodolphe Thiébaut,Boris P. Hejblum,Fleur Mougin,Christophe Tzourio,Laura Richert Revue du Rhumatisme, 2024, 91 (1), pp.12-15. ⟨10.1016/j.rhum.2023.07.007⟩ Article dans une revue hal-04466670v1
Neglecting normalization impact in semi-synthetic RNA-seq data simulation generates artificial false positives Boris Hejblum,Kalidou Ba,Rodolphe Thiébaut,Denis Agniel Genome Biology, 2024, 25 (1), pp.281. ⟨10.1101/2022.05.10.490529⟩ Article dans une revue hal-03908246v1
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8&lt;sup&gt;+&lt;/sup&gt; T cell responses against HIV-1 Eoghann White,Laura Papagno,Assia Samri,Kenji Sugata,Boris P. Hejblumet al. Nature Immunology, 2024, 25 (9), pp.1555-1564. ⟨10.1038/s41590-024-01931-9⟩ Article dans une revue hal-04703528v1
Modéliser la COVID-19 : de la population à l’individu Carole Vignals,Boris P. Hejblum,Mélanie Prague Interstices, 2023 Article dans une revue hal-04230705v1
ChatGPT and beyond with artificial intelligence (AI) in health: Lessons to be learned. Rodolphe Thiebaut,Boris P. Hejblum,Fleur Mougin,Christophe Tzourio,Laura Richert Joint Bone Spine, 2023, 90 (5), pp.105607. ⟨10.1016/j.jbspin.2023.105607⟩ Article dans une revue hal-04236822v1
CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death Yves Lévy,Aurélie Wiedemann,Boris Hejblum,Mélany Durand,Cécile Lefebvreet al. iScience, 2023, 26 (1), pp.105715. ⟨10.1016/j.isci.2022.105715⟩ Article dans une revue hal-04374099v1
Doubly-robust evaluation of high-dimensional surrogate markers Denis Agniel,Boris Hejblum,Rodolphe Thiébaut,Layla Parast Biostatistics, 2023, 24 (4), pp.985-999. ⟨10.1093/biostatistics/kxac020⟩ Article dans une revue hal-03100499v1
Using Population Based Kalman Estimator to Model COVID-19 Epidemic in France: Estimating the Effects of Non-Pharmaceutical Interventions on the Dynamics of Epidemic Annabelle Collin,Boris P. Hejblum,Carole Vignals,Laurent Lehot,Rodolphe Thiébautet al. The international journal of biostatistics, In press, ⟨10.1515/ijb-2022-0087⟩ Article dans une revue hal-04151651v1
CytOpT: Optimal Transport with Domain Adaptation for Interpreting Flow Cytometry data Paul Freulon,Jérémie Bigot,Boris Hejblum Annals of Applied Statistics, 2023, 17 (2), pp.1086-1104. ⟨10.1214/22-AOAS1660⟩ Article dans une revue hal-03100405v1
Identification of early gene expression profiles associated with long-lasting antibody responses to the Ebola vaccine Ad26.ZEBOV/MVA-BN-Filo Fabiola Blengio,Hakim Hocini,Laura Richert,Cécile Lefebvre,Melany Durandet al. Cell Reports, 2023, 42 (9), pp.113101. ⟨10.1016/j.celrep.2023.113101⟩ Article dans une revue hal-04273901v1
High temporal resolution transcriptomic profiling delineates distinct patterns of interferon response following Covid-19 mRNA vaccination and SARS-CoV2 infection Darawan Rinchai,Sara Deola,Gabriele Zoppoli,Basirudeen Syed Ahamed Kabeer,Sara Talebet al. Science Advances , 2022, 8 (45), eabp9961. ⟨10.1126/sciadv.abp9961⟩ Article dans une revue hal-03530948v1
The benefit of augmenting open data with clinical data-warehouse EHR for forecasting SARS-CoV-2 hospitalizations in Bordeaux area, France Thomas Ferté,Vianney Jouhet,Romain Griffier,Boris P Hejblum,Rodolphe Thiébautet al. JAMIA open, 2022, 5 (4), ⟨10.1093/jamiaopen/ooac086⟩ Article dans une revue hal-03908260v1
T Cell Immunogenicity, Gene Expression Profile, and Safety of Four Heterologous Prime-Boost Combinations of HIV Vaccine Candidates in Healthy Volunteers: Results of the Randomized Multi-Arm Phase I/II ANRS VRI01 Trial Laura Richert,Jean-Daniel Lelievre,Christine Lacabaratz,Lucile Hardel,Hakim Hociniet al. Journal of Immunology, 2022, 208 (12), pp.2663-2674. ⟨10.4049/jimmunol.2101076⟩ Article dans une revue hal-03690137v1
Predicting Progression to Advanced Age-Related Macular Degeneration from Clinical, Genetic, and Lifestyle Factors Using Machine Learning Soufiane Ajana,Audrey Cougnard-Grégoire,Johanna Colijn,Bénédicte M.J. Merle,Timo Verzijdenet al. Ophthalmology: Journal of The American Academy of Ophthalmology, 2021, 128 (4), pp.587-597. ⟨10.1016/j.ophtha.2020.08.031⟩ Article dans une revue hal-03100320v1
CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death Yves Lévy,Aurélie Wiedemann,Boris P. Hejblum,Mélany Durand,Cécile Lefebvreet al. iScience, 2021, 24 (7), pp.102711. ⟨10.1016/j.isci.2021.102711⟩ Article dans une revue hal-03477973v1
EpidemiOptim: a Toolbox for the Optimization of Control Policies in Epidemiological Models Cédric Colas,Boris P. Hejblum,Sébastien Rouillon,Rodolphe Thiébaut,Pierre-Yves Oudeyeret al. Journal of Artificial Intelligence Research, 2021, 71, pp.479-515. ⟨10.1613/jair.1.12588⟩ Article dans une revue hal-03099898v2
Automatic phenotyping of electronical health record: PheVis algorithm Thomas Ferté,Sébastien Cossin,Thierry Schaeverbeke,Thomas Barnetche,Vianney Jouhetet al. Journal of Biomedical Informatics, 2021, 117, pp.103746. ⟨10.1016/j.jbi.2021.103746⟩ Article dans une revue hal-03100435v1
Bayesian mixture models for cytometry data analysis Lin Lin,Boris Hejblum Wiley Interdisciplinary Reviews: Computational Statistics, In press, 13 (4), pp.e1535. ⟨10.1002/wics.1535⟩ Article dans une revue hal-03100447v1
Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study Sophie Lefevre-Arbogast,Boris P. Hejblum,Catherine Helmer,C. Klose,Claudine Manachet al. EBioMedicine, 2021, 64, pp.103216. ⟨10.1016/j.ebiom.2021.103216⟩ Article dans une revue hal-03155026v1
ATLAS: an automated association test using probabilistically linked health records with application to genetic studies Harrison Zhang,Boris P. Hejblum,Griffin Weber,Nathan Palmer,Susanne Churchillet al. Journal of the American Medical Informatics Association, 2021, 28 (12), pp.2582-2592. ⟨10.1093/jamia/ocab187⟩ Article dans une revue hal-03478039v1
Robust and Efficient Optimization Using a Marquardt-Levenberg Algorithm with R Package marqLevAlg Viviane Philipps,Boris P. Hejblum,Mélanie Prague,Daniel Commenges,Cécile Proust-Lima The R Journal, In press, ⟨10.32614/RJ-2021-089⟩ Article dans une revue hal-03100489v1
Predicting the retinal content in omega‐3 fatty acids for age‐related macular‐degeneration Niyazi Acar,Bénédicte M. J. Merle,Soufiane Ajana,Zhiguo He,Stéphane Grégoireet al. Clinical and Translational Medicine, 2021, 11 (7), pp.e404. ⟨10.1002/ctm2.404⟩ Article dans une revue hal-03293612v1
Long-lasting severe immune dysfunction in Ebola virus disease survivors Aurélie Wiedemann,Emile Foucat,Hakim Hocini,Cécile Lefebvre,Boris Hejblumet al. Nature Communications, 2020, 11 (1), pp.3730. ⟨10.1038/s41467-020-17489-7⟩ Article dans une revue hal-03160838v2
Immune Alterations in a Patient with SARS-CoV-2-Related Acute Respiratory Distress Syndrome Lila Bouadma,Aurélie Wiedemann,Juliette Patrier,Mathieu Surénaud,Paul-Henri Wickyet al. Journal of Clinical Immunology, 2020, 40, pp.1082-1092. ⟨10.1007/s10875-020-00839-x⟩ Article dans une revue hal-03160737v2
Analyzing cellular immunogenicity in vaccine clinical trials: a new statistical method including non-specific responses for accurate estimation of vaccine effect Édouard Lhomme,Boris Hejblum,Christine Lacabaratz,Aurélie Wiedemann,Jean-Daniel Lelièvreet al. Journal of Immunological Methods, 2020, 477, pp.112711. ⟨10.1016/j.jim.2019.112711⟩ Article dans une revue hal-03161945v2
dearseq: a variance component score test for RNA-Seq differential analysis that effectively controls the false discovery rate Marine Gauthier,Denis Agniel,Rodolphe Thiébaut,Boris Hejblum NAR Genomics and Bioinformatics, 2020, 2 (4), pp.lqaa093. ⟨10.1093/nargab/lqaa093⟩ Article dans une revue hal-02138664v1
Semi-supervised estimation of covariance with application to phenome-wide association studies with electronic medical records data Stephanie F Chan,Boris P. Hejblum,Abhishek Chakrabortty,Tianxi Cai Statistical Methods in Medical Research, 2020, 29 (2), pp.455-465. ⟨10.1177/0962280219837676⟩ Article dans une revue hal-02425459v1
Sequential Dirichlet Process Mixtures of Multivariate Skew t-distributions for Model-based Clustering of Flow Cytometry Data Boris P. Hejblum,Chariff Alkhassim,Raphael Gottardo,François Caron,Rodolphe Thiébaut Annals of Applied Statistics, 2019, 13 (1), pp.638-660. ⟨10.1214/18-AOAS1209⟩ Article dans une revue hal-01579063v1
Benefits of dimension reduction in penalized regression methods for high dimensional grouped data: a case study in low sample size Soufiane Ajana,Niyazi Acar,Lionel Brétillon,Boris Hejblum,Hélène Jacqmin-Gaddaet al. Bioinformatics, 2019, 35, pp.3628-3634. ⟨10.1093/bioinformatics/btz135⟩ Article dans une revue hal-02425449v1
Probabilistic record linkage of de-identified research datasets with discrepancies using diagnosis codes Boris P. Hejblum,Griffin M. Weber,Katherine P. Liao,Nathan P Palmer,Susanne Churchillet al. Scientific Data , 2019, 6, pp.180298. ⟨10.1038/sdata.2018.298⟩ Article dans une revue hal-01942279v1
Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort Dorrain Low,Sophie Lefèvre-Arbogast,Raúl Dominguez-Gonzalez,Mireia Urpi Sarda,Pierre Micheauet al. Molecular Nutrition and Food Research, 2019, 63 (18), pp.e1900177. ⟨10.1002/mnfr.201900177⟩ Article dans une revue hal-02167524v1
Sequential Dirichlet process mixture of skew $t$-distributions for model-based clustering of flow cytometry data Boris P. Hejblum,Chariff Alkhassim,Raphael Gottardo,François Caron,Rodolphe Thiébaut Annals of Applied Statistics, 2019, 13 (1), pp.638-660 Article dans une revue hal-03161057v1
Gene Expression Signatures Associated With Immune and Virological Responses to Therapeutic Vaccination With Dendritic Cells in HIV-Infected Individuals Rodolphe Thiébaut,Boris P. Hejblum,Hakim Hocini,Henri Bonnabau,Jason Skinneret al. Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.00874⟩ Article dans une revue hal-02267014v2
Pattern of polyphenol intake and the long-term risk of dementia in older persons Sophie Lefèvre-Arbogast,David Gaudout,Julien Bensalem,Luc Letenneur,Jean-François Dartigueset al. Neurology, 2018, 90 (22), pp.e1979 - e1988. ⟨10.1212/WNL.0000000000005607⟩ Article dans une revue hal-01887895v1
PheProb: probabilistic phenotyping using diagnosis codes to improve power for genetic association studies Jennifer A Sinnott,Fiona Cai,Sheng Yu,Boris P. Hejblum,Chuan Honget al. Journal of the American Medical Informatics Association, 2018, ⟨10.1093/jamia/ocy056⟩ Article dans une revue hal-01887930v1
Association between anti-citrullinated fibrinogen antibodies and coronary artery disease in rheumatoid arthritis Boris P. Hejblum,Jing Cui,Lauren J. Lahey,Andrew Cagan,Jeffrey A. Sparkset al. Arthritis Care & Research = Arthritis Care and Research, 2018, 70 (7), pp.1113-1117. ⟨10.1002/acr.23444⟩ Article dans une revue hal-01654403v1
cytometree: A binary tree algorithm for automatic gating in cytometry analysis Daniel Commenges,Chariff Alkhassim,Raphael Gottardo,Boris P. Hejblum,Rodolphe Thiébaut Cytometry Part A, 2018, 93 (11), pp.1132-1140. ⟨10.1002/cyto.a.23601⟩ Article dans une revue hal-03161874v2
Kernel machine score test for pathway analysis in the presence of semi-competing risks Matey Neykov,Boris P. Hejblum,Jennifer A Sinnott Statistical Methods in Medical Research, 2018, Statistical Methods in Medical Research, 27 (4), pp.1099-1114. ⟨10.1177/0962280216653427⟩ Article dans une revue hal-01395970v1
Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV Anne Rechtien,Laura Richert,Hadrien Lorenzo,Gloria Martrus,Boris P. Hejblumet al. Cell Reports, 2017, 20 (9), pp.2251 - 2261. ⟨10.1016/j.celrep.2017.08.023⟩ Article dans une revue hal-01579246v1
Variance component score test for time-course gene set analysis of longitudinal RNA-seq data Denis Agniel,Boris P. Hejblum Biostatistics, 2017, Biostatistics, 18 (4), pp.589-604. ⟨10.1093/biostatistics/kxx005⟩ Article dans une revue hal-01579077v1
Phenome-Wide Association Study of Autoantibodies to Citrullinated and Noncitrullinated Epitopes in Rheumatoid Arthritis Katherine P. Liao,Jeffrey A Sparks,Boris P. Hejblum,I-Hsin Kuo,Jing Cuiet al. Arthritis & rheumatology, 2017, 69 (4), pp.742 - 749. ⟨10.1002/art.39974⟩ Article dans une revue hal-01654405v1
Group and sparse group partial least square approaches applied in genomics context Benoit Liquet,Pierre Lafaye de Micheaux,Boris P. Hejblum,Rodolphe Thiébaut Bioinformatics, 2016, 32 (1), pp.35-42. ⟨10.1093/bioinformatics/btv535⟩ Article dans une revue hal-01288891v1
Time-Course Gene Set Analysis for Longitudinal Gene Expression Data Boris P. Hejblum,Jason Skinner,Rodolphe Thiébaut PLoS Computational Biology, 2015, 11 (6), pp.e1004310. ⟨10.1371/journal.pcbi.1004310⟩ Article dans une revue hal-01203446v1
L’analyse des « Big Data » en recherche clinique Rodolphe Thiébaut,Boris P. Hejblum,Laura Richert Epidemiology and Public Health = Revue d'Epidémiologie et de Santé Publique, 2014, 62 (1), pp.1-4. ⟨10.1016/j.respe.2013.12.021⟩ Article dans une revue inserm-00933691v1
Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination. David Furman,Boris P. Hejblum,Noah Simon,Vladimir Jojic,Cornelia L. Dekkeret al. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (2), pp.869-74. ⟨10.1073/pnas.1321060111⟩ Article dans une revue inserm-00933693v1
Evidence synthesis through a degradation model applied to myocardial infarction. Daniel Commenges,Boris P. Hejblum Lifetime Data Analysis, 2013, 19 (1), pp.1-18. ⟨10.1007/s10985-012-9227-3⟩ Article dans une revue inserm-00726036v1

Poster de conférence (5)

Untargeted profiling of serum samples revealed diet-related metabolites associated with subsequent cognitive decline in the 3-City cohort Dorrain Y. Low,Sophie Lefèvre-Arbogast,Raúl González-Domínguez,Mireia Urpi-Sarda,Pierre Micheauet al. 13th European Nutrition Conference FENS 2019, Oct 2019, Dublin, Ireland Poster de conférence hal-04823822v1
Identification of a circulating biomarker highly associated to retinal omega-3 polyunsaturated fatty acid content: the BLISAR project Niyazi Acar,Soufiane Ajana,Olivier Berdeaux,Hélène Jacqmin-Gadda,Boris Hejblumet al. Annual meeting of the association for research in vision and ophthalmology (ARVO), Apr 2019, Vancouver, Canada, United States. Association for Research in Vision and Ophthalmology, Investigative Ophthalmology and Visual Science, 60 (9), 1 p., 2019 Poster de conférence hal-02737963v1
Association of a predictor of retinal omega-3 polyunsaturated fatty acids with advanced age-related macular degeneration: the BLISAR project Cécile Delcourt,Soufiane Ajana,Bénédicte Merle,Hélène Jacqmin-Gadda,Boris P. Hejblumet al. Annual meeting of the association-for-research-in-vision-and-ophthalmology (ARVO), Apr 2019, Vancouver, Canada, United States. Association for Research in Vision and Ophthalmology, Investigative Ophthalmology and Visual Science, 60 (9), 1 p., 2019 Poster de conférence hal-02736092v1
Identification of dietary modulators of cognitive function in ageing using metabolomics discovery Dorrain Low Yanwen,Sophie Lefèvre-Arbogast,Mélanie Pétéra,Pierre Micheau,Delphine Centenoet al. Journée Scientifique du CRNH Auvergne, Nov 2017, Clermont-Ferrand, Canada. 2017, Journée Scientifique du CRNH Auvergne 2017 Poster de conférence hal-01644048v1
Identification of dietary modulators of cognitive function in ageing using metabolomics discovery Dorrain Low Yanwen,Sophie Lefèvre-Arbogast,Mélanie Pétéra,Pierre Micheau,Delphine Centenoet al. 8. International Conference on Polyphenols and Health ICPH 2017, Oct 2017, Québec, Canada. 2017 Poster de conférence hal-01595015v1

Pré-publication, Document de travail (8)

Adaptive Dirichlet Process mixture model with unknown concentration parameter and variance: Scaling high dimensional clustering via collapsed variational inference Annesh Pal,Aguirre Mimoun,Rodolphe Thiébaut,Boris P. Hejblum 2026 Pré-publication, Document de travail hal-05490235v1
Representation Learning to Advance Multi-institutional Studies with Electronic Health Record Data Doudou Zhou,Han Tong,Linshanshan Wang,Suqi Liu,Xin Xionget al. 2025 Pré-publication, Document de travail hal-05222545v1
Epidemic Forecasting: Lessons Learned from the SARS-CoV-2 Pandemic to Balance Accuracy, Feasibility, and Impact Thomas Ferté,Vincent Thevenet,Xavier Hinaut,Pierrick Legrand,Dan Dutartreet al. 2025 Pré-publication, Document de travail hal-05392781v1
Practical limitations for real-life application of data fission and data thinning in post-clustering differential analysis Benjamin Hivert,Denis Agniel,Rodolphe Thiébaut,Boris P. Hejblum 2024 Pré-publication, Document de travail hal-04745517v1
Distribution-free complex hypothesis testing for single-cell RNA-seq differential expression analysis Marine Gauthier,Denis Agniel,Rodolphe Thiébaut,Boris P. Hejblum 2021 Pré-publication, Document de travail hal-03478097v1
Gene Set Analysis for time-to-event outcome with the Generalized Berk–Jones statistic Laura Villain,Thomas Ferté,Rodolphe Thiébaut,Boris P. Hejblum 2021 Pré-publication, Document de travail hal-03478102v1
Realistic and Robust Reproducible Research for Biostatistics Boris P. Hejblum,Kevin Kunzmann,Ennio Lavagnini,Anna Hutchinson,David Robertsonet al. 2020 Pré-publication, Document de travail hal-03100421v1
Population modeling of early COVID-19 epidemic dynamics in French regions and estimation of the lockdown impact on infection rate Mélanie Prague,Linda Wittkop,Quentin Clairon,Dan Dutartre,Rodolphe Thiébautet al. 2020 Pré-publication, Document de travail hal-02555100v1

Thèse (1)

Integrative analysis of high-dimensional data applied to vaccine research Boris Hejblum Human health and pathology. Université de Bordeaux, 2015. English. ⟨NNT : 2015BORD0049⟩ Thèse tel-01203547v2

HDR (1)

Statistical methods for leveraging high-dimensional data from high-throughput measurements in vaccine clinical development Boris P. Hejblum Methodology [stat.ME]. Université de Bordeaux, 2024 HDR tel-04633105v1