Accéder directement au contenu

Christine Baly

30
Documents
Identifiants chercheurs

Présentation

Christine BALY, is an INRAE senior scientist (Research Director, DR) from the PhASE (Physiologie and Systèmes d'Elevage) department, deputy director of the UR1197 NBO unit (Neurobiologie de l'Olfaction) in Jouy-en-Josas from 2015 to 2019. She has developed an expertise in the study of the genesis and modulation of the olfactory system in relation with food determinants at both mucosa and bulb levels of integration, using molecular and cellular approaches. Since then, she has joined the new INRAE UMR1198 BREED unit (Biologie de la Reproduction, Environnement, Epigénétique et Développement) to develop research on the role of epigenetics on the plasticity of the olfactory system upon environmental challenges. **Research** In 1993, she defended her PhD on the expression of the gene encoding the casein alphaS2 in goats, and identified the mechanism responsible for its genetic polymorphism. She was then recruited as a junior scientist in a INSERM-INRA unit in Paris to work on the regulation of the transcription and replication in early embryos in mice. She was the first to demonstrate a transcriptional activity in mice embryos at the one-cell stage using fluorescent imaging and she participated to the characterization of a structural DNA protein involved in the folding of active chromatin in 1-cell embryos, opening a new front in the study of the role of nuclear organization in gene expression in early embryos. In 2000, CB moved to a new INRA unit at Jouy-en-Josas that was developing a new challenging program on the biology of olfaction in rodents. She contributed to the study on the mechanisms of i) control and coding of an olfactory message by olfactory receptors, ii) odor discrimination and iii) plasticity of the olfactory system (mucosa and bulb) under the influence of various perturbations by cellular, molecular, and behavioral approaches in rodents. After having characterized the role of metabolic hormones, such as leptin and insulin, on the modulation of the olfactory signal, she developped more integrated models to understand the influence of the animal's metabolic status on the perception of odors and passed her Habilitation to Supervise Research in 2013 (HDR). Since then, she has been studying the influence of the perinatal period related to the maternal environment on the olfactory performances in the perspective of understanding the peripheral mechanisms involved, how they shape olfactory-based behaviors, and how to use this neuroplasticity to guide preferences, especially food preferences in animal models, but also in a translational perspective for agronomical purpose. CB preferentially targets the metabolic environment in various physiological situations in adulthood (fasting, states of genetic or dietary obesity, role nutrients), but she is also interested in the effect of other environmental factors on animal behavioral plasticity in order to understand how olfaction-mediated eating habits develop, to use this plasticity to shape food preferences. Currently, her priorities are focused on: -the influence of an alteration of the energy balance during pregnancy on the development of obesity in adult mice and its consequences on olfaction-mediated eating behavior -the influence of perinatal odorant exposure on the development of olfactory-based behaviors (food preferences, anxiety, memory). -the influence of maternal exposure to diesel particles on the neuronatatomical and functional regulation of the olfactory pathways. Since 2020, she has joined the new INRAE BREED UMR1198 unit in the MeCP2 team (Mécanismes épigénétiques et construction - prédiction des phénotypes) to develop a project entitled: "epigenetic programming of olfactory-based behaviors in rodents". Her challenges are to understand the molecular bases that govern the long-term effects of maternal environments on offspring's behavioral phenotypes by focusing on neuroepigenetics in rodents, with a translational perspective for improving welfare in farm animals.

Publications

"marie-christine-lacroix"
Image document

Repeated gestational exposure to diesel engine exhaust affects the fetal olfactory system and alters olfactory-based behavior in rabbit offspring

Estefanía Bernal-Meléndez , Marie-Christine Lacroix , Pascaline Bouillaud , Jacques Callebert , Benoit Olivier
Particle and Fibre Toxicology, 2019, 16 (1), pp.1-17. ⟨10.1186/s12989-018-0288-7⟩
Article dans une revue hal-02110667v1

Rat strains with different metabolic statuses differ in food olfactory-driven behavior

Karine Badonnel , Marie-Christine Lacroix , Didier Durieux , Regine Monnerie , Monique Caillol
Behavioural Brain Research, 2014, 270, pp.228-239. ⟨10.1016/j.bbr.2014.05.011⟩
Article dans une revue hal-02640828v1

Olfaction under metabolic influences

Brigitte Palouzier-Paulignan , Marie-Christine Lacroix , Pascaline Aime , Christine Baly , Monique Caillol
Chemical Senses, 2012, 37 (9), pp.769-797. ⟨10.1093/chemse/bjs059⟩
Article dans une revue hal-02650925v1

Chronic restricted access to food leading to limited undernutrition affects rat neuroendocrine status and olfactory-driven behaviors

Karine Badonnel , Marie-Christine Lacroix , Regine Monnerie , Didier Durieux , Monique Caillol
Hormones and Behavior, 2012, 62 (2), pp.120-127. ⟨10.1016/j.yhbeh.2012.05.010⟩
Article dans une revue hal-02647018v1

Nutritional status modulates behavioural and olfactory bulb Fos responses to isoamyl acetate or food odour in rats: roles of orexins and leptin

Marie Jeanne Prud'Homme , Marie-Christine Lacroix , Karine Badonnel , Sylvette Gougis , Christine Baly
Neuroscience, 2009, 162 (4), pp.1287-1298. ⟨10.1016/j.neuroscience.2009.05.043⟩
Article dans une revue hal-02664324v1

Expression of insulin system in the olfactory epithelium: first approaches to its role and regulation

Marie-Christine Lacroix , Karine Badonnel , Nicolas Meunier , Fang Tan , Claire Schlegel-Le Poupon
Journal of Neuroendocrinology, 2008, 20 (10), pp.1176-1190. ⟨10.1111/j.1365-2826.2008.01777.x⟩
Article dans une revue hal-02659180v1

Leptin and its receptors are present in the rat olfactory mucosa and modulated by the nutritional status

Christine Baly , Josiane Aioun , Karine Badonnel , Marie-Christine Lacroix , Didier Durieux
Brain Research, 2007, 1129, pp.130-141
Article dans une revue hal-02658203v1

Diet-induced obesity impairs olfactory-driven behaviors concomitantly with alterations of cellular dynamics and homeostasis in olfactory tissues

Marie-Christine Lacroix , Monique Caillol , Didier Durieux , Regine Monnerie , Denise Grebert
24. International Meeting European Chemoreception Research Organisation (ECRO), Sep 2014, Dijon, France
Communication dans un congrès hal-02741108v1

Cerveau et nutrition

Karine Badonnel , Marie-Christine Lacroix , Patrice Congar , Monique Caillol , Christine Baly
2. Rencontres INRA-IRBA, Jun 2011, Brétigny, France
Communication dans un congrès hal-02809933v1

Informations sensorielles, rassasiement et satiété

Christine Baly , Karine Badonnel , Marie-Christine Lacroix , Patrice Congar , Roland Salesse
Ecole chercheur INRA, Jan 2010, Ecully, France
Communication dans un congrès hal-02814147v1

Olfactory epithelium, a tissue under metabolic influences

Marie-Christine Lacroix , Karine Badonnel , Nicolas Meunier , Didier Durieux , Regine Monnerie
32. Annual Meeting of the Association for Chemoreception Sciences, Apr 2010, St Pete Beach, Florida, United States
Communication dans un congrès hal-02752580v1

Sensory-metabolic neuroendocrine crosstalk in the rat olfactory epithelium and buld

Roland Salesse , Karine Badonnel , Christine Baly , Patrice Congar , Didier Durieux
7. Forum of European Neuroscience, Jul 2010, Amsterdam, Netherlands
Communication dans un congrès hal-02820587v1

Long term effects of endothelin on rat olfactory mucosa : modulation of neuronal and non neuronal cellular populations dynamics

Iman Laziz , Aniya Larbi , Marie-Christine Lacroix , Christine Baly , Denise Grebert
4. Journées de Biologie Cellulaire du Grand Campus, May 2009, Orsay, France. 1p
Communication dans un congrès hal-02815669v1

Is the internal status able to modify olfactory message at the OM level ?

Patrice Congar , Karine Badonnel , Christine Baly , Didier Durieux , Denise Grebert
1er Symposium Olfaction de l'IMNC UMR8165 CNRS-Université Paris 7/Paris 11 et l'IFR144 NeuroSud-Paris, Jun 2009, Orsay, France. n.p
Communication dans un congrès hal-02820731v1

Endothelin modulates both short-term detection kinetics of odors and long-term cellular population dynamics in olfactory mucosa

Nicolas Meunier , Aniya Larbi , Iman Laziz , Elodie Gouadon , Didier Durieux
31. Annual Meeting of the Association for Chemoreception Sciences, Apr 2009, Sarasota, United States
Communication dans un congrès hal-02755323v1

Olfactory system as a target for insulin

Marie-Christine Lacroix , Karine Badonnel , Nicolas Meunier , Didier Durieux , Regine Monnerie
Academy Colloquium "Nutrition, Metabolism and the Brain", May 2009, Amsterdam, Netherlands
Communication dans un congrès hal-02754778v1

Neuroendocrine basis for the cross-talk between nutritional-metabolic status and food odour detection

Monique Caillol , Karine Badonnel , Marie Jeanne Prud'Homme , Nicolas Meunier , Patrice Congar
Academy Colloquium "Nutrition, Metabolism and the Brain", May 2009, Amsterdam, Netherlands
Communication dans un congrès hal-02753077v1

Modulation par l'endothéline de la dynamique des populations neuronales et non-neuronales dans la muqueuse olfactive du rat

Iman Laziz , Aniya Larbi , Marie-Christine Lacroix , Christine Baly , Denise Grebert
Colloque interne des IFR144, 115 & 87, Apr 2009, Gif-sur-Yvette, France. n.p
Communication dans un congrès hal-02814011v1

Le système olfactif : une cible pour l'insuline ?

Marie-Christine Lacroix , Karine Badonnel , Nicolas Meunier , Didier Durieux , Regine Monnerie
3. Journées d’Animation Scientifique du Département de Physiologie Animale et Systèmes d’Elevage, Oct 2009, Tours, France
Communication dans un congrès hal-02758375v1

Le système olfactif est-il sensible au statut métabolique ? Eventuelles conséquences physio-pathologiques

Christine Baly , Karine Badonnel , Marie-Christine Lacroix , Marie Jeanne Prud'Homme , Nicolas Meunier
Olfaction, Mémoire et Apprentissages : Venez Pointer Votre Nez !, Jan 2009, Paris, France
Communication dans un congrès hal-02750826v1

Mécanismes cellulaires et moléculaires impliqués dans l'empreinte métabolique maternelle au niveau de l'hypothalamus et du système olfactif

Jacqueline Ferezou , Odile Couvreur , Daniel Gripois , Claire-Marie Vacher , Alain Aubourg
Journées de Restitution des Projets financés sur Crédits Incitatifs en 2006 et 2007 - Département de Physiologie Animale et Système d'Elevage, Nov 2008, Tours, France
Communication dans un congrès hal-02756776v1

Is the rat olfactory system sensitive to the metabolic status ?

Christine Baly , Karine Badonnel , Marie-Christine Lacroix , Didier Durieux , Roland Salesse
15. International Symposium on Olfaction and Taste (ISOT), Jul 2008, San Francisco, United States
Communication dans un congrès hal-02751103v1

Olfactory mucosa as a target for insulin

Marie-Christine Lacroix , Karine Badonnel , Nicolas Meunier , Fang Tan , Claire Schlegel-Le Poupon
18. Congress of European Chemoreception Research Organization, ECRO, Sep 2008, Portoroz, Slovenia
Communication dans un congrès hal-02756889v1

Une alimentation contrôlée affecte l'expression de la leptine, de l'insuline et des orexines dans la muqueuse olfactive chez le rat

Karine Badonnel , Marie-Christine Lacroix , Monique Caillol , Didier Durieux , Roland Salesse
2. Journées d'Animation Scientifique du Département de Physiologie Animale et Système d'Elevage, Oct 2007, Tours, France
Communication dans un congrès hal-02752882v1

Influence de l'état nutritionnel sur la physiologie du système olfactif

Christine Baly , Karine Badonnel , Marie-Christine Lacroix , Marie Jeanne Prud'Homme , Patrice Congar
Journées scientifiques de l'IFR 144 Neurosud Paris, Jun 2007, Jouy-en-Josas, France. n.p
Communication dans un congrès hal-02814126v1

Food restriction and fasting affect gene expression of leptin, insulin, orexin and their receptors in rat olfactory mucosa

Karine Badonnel , Roland Salesse , Marie-Christine Lacroix , Monique Caillol , Christine Baly
8ème Colloque de la Société des Neurosciences, May 2007, Montpellier, France. 1 p
Communication dans un congrès hal-02820015v1

Expression des systèmes géniques leptine et insuline dans la muqueuse olfactive chez le rat : rôles possibles

Karine Badonnel , Christine Baly , Marie-Christine Lacroix , Denise Grebert , Monique Caillol
2. Journées d'Animation Scientifique du Département de Physiologie Animale et Système d'Elevage, Oct 2007, Tours, France
Communication dans un congrès hal-02750782v1

Evidence for an insulin/insulin-receptor system in the rat olfactory mucosa

Marie-Christine Lacroix , Karine Badonnel , Christine Baly , Monique Caillol
17. Annual Meeting of the European Chemoreception Research Organization (ECRO), Sep 2006, Granada, Spain
Communication dans un congrès hal-02752218v1