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Christine Baly

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Documents
Identifiants chercheurs

Présentation

Christine BALY, is an INRAE senior scientist (Research Director, DR) from the PhASE (Physiologie and Systèmes d'Elevage) department, deputy director of the UR1197 NBO unit (Neurobiologie de l'Olfaction) in Jouy-en-Josas from 2015 to 2019. She has developed an expertise in the study of the genesis and modulation of the olfactory system in relation with food determinants at both mucosa and bulb levels of integration, using molecular and cellular approaches. Since then, she has joined the new INRAE UMR1198 BREED unit (Biologie de la Reproduction, Environnement, Epigénétique et Développement) to develop research on the role of epigenetics on the plasticity of the olfactory system upon environmental challenges. **Research** In 1993, she defended her PhD on the expression of the gene encoding the casein alphaS2 in goats, and identified the mechanism responsible for its genetic polymorphism. She was then recruited as a junior scientist in a INSERM-INRA unit in Paris to work on the regulation of the transcription and replication in early embryos in mice. She was the first to demonstrate a transcriptional activity in mice embryos at the one-cell stage using fluorescent imaging and she participated to the characterization of a structural DNA protein involved in the folding of active chromatin in 1-cell embryos, opening a new front in the study of the role of nuclear organization in gene expression in early embryos. In 2000, CB moved to a new INRA unit at Jouy-en-Josas that was developing a new challenging program on the biology of olfaction in rodents. She contributed to the study on the mechanisms of i) control and coding of an olfactory message by olfactory receptors, ii) odor discrimination and iii) plasticity of the olfactory system (mucosa and bulb) under the influence of various perturbations by cellular, molecular, and behavioral approaches in rodents. After having characterized the role of metabolic hormones, such as leptin and insulin, on the modulation of the olfactory signal, she developped more integrated models to understand the influence of the animal's metabolic status on the perception of odors and passed her Habilitation to Supervise Research in 2013 (HDR). Since then, she has been studying the influence of the perinatal period related to the maternal environment on the olfactory performances in the perspective of understanding the peripheral mechanisms involved, how they shape olfactory-based behaviors, and how to use this neuroplasticity to guide preferences, especially food preferences in animal models, but also in a translational perspective for agronomical purpose. CB preferentially targets the metabolic environment in various physiological situations in adulthood (fasting, states of genetic or dietary obesity, role nutrients), but she is also interested in the effect of other environmental factors on animal behavioral plasticity in order to understand how olfaction-mediated eating habits develop, to use this plasticity to shape food preferences. Currently, her priorities are focused on: -the influence of an alteration of the energy balance during pregnancy on the development of obesity in adult mice and its consequences on olfaction-mediated eating behavior -the influence of perinatal odorant exposure on the development of olfactory-based behaviors (food preferences, anxiety, memory). -the influence of maternal exposure to diesel particles on the neuronatatomical and functional regulation of the olfactory pathways. Since 2020, she has joined the new INRAE BREED UMR1198 unit in the MeCP2 team (Mécanismes épigénétiques et construction - prédiction des phénotypes) to develop a project entitled: "epigenetic programming of olfactory-based behaviors in rodents". Her challenges are to understand the molecular bases that govern the long-term effects of maternal environments on offspring's behavioral phenotypes by focusing on neuroepigenetics in rodents, with a translational perspective for improving welfare in farm animals.

Publications

"patrice-congar"

Bioinspired nose devices and their potential application for non-invasive olfactory detection of pathologies

Edith Pajot , Julien Daligault , Karine Badonnel , Aurélie Dewaele , Marie-Annick Persuy
15. International symposium on Olfaction and Electronic Nose, International Society for Olfaction and Chemical Sensing (ISOCS). INT., Jul 2013, Daegu, South Korea
Communication dans un congrès hal-01344430v1

Bioelectronic odorant detection nanoplatform

Edith Pajot , Julien Daligault , Karine Badonnel , Aurélie Dewaele , Marie-Annick Persuy
15. International Biotechnology Symposium and Exhibition, Sep 2012, Daegu, South Korea
Communication dans un congrès hal-02810974v1

Cerveau et nutrition

Karine Badonnel , Marie-Christine Lacroix , Patrice Congar , Monique Caillol , Christine Baly
2. Rencontres INRA-IRBA, Jun 2011, Brétigny, France
Communication dans un congrès hal-02809933v1

Identification of relevant olfactory receptors to be used as sensing elements of a bioelectronic odorant detection device

Julien Daligault , Aurélie Dewaele , Marie-Annick Persuy , Patrice Congar , Christine Baly
33. Annual Meeting of the Association for Chemoreception Sciences, Apr 2011, St Pete Beach, Florida, United States
Communication dans un congrès hal-02747619v1

Identification de récepteurs olfactifs utilisés comme senseurs d'une puce bioélectronique

Julien Daligault , Aurélie Dewaele , Marie-Annick Persuy , Patrice Congar , Karine Badonnel
Colloque de Neurobiologie IFR144, May 2011, Orsay, France
Communication dans un congrès hal-02748698v1

Identification of relevant olfactory receptors to be used as sensing elements of a bioelectronic odorant detection nano-platform

Edith Pajot , Julien Daligault , Aurélie Dewaele , Patrice Congar , Christine Baly
International Symposium on Olfaction and Electronic Nose (ISOEN) 2011, May 2011, New-York, United States
Communication dans un congrès hal-02744618v1

A bioelectronic sensor nanoplatform based on olfactory receptors and electrochemical impedance spectroscopy

Julien Daligault , Karine Badonnel , Aurélie Dewaele , Marie-Annick Persuy , Patrice Congar
ECRO XXI, Sep 2011, Manchester, United Kingdom
Communication dans un congrès hal-02747726v1

A bioelectronic sensor nanoplatform based on olfactory receptors and electrochemical impedance spectroscopy

Julien Daligault , Aurélie Dewaele , Marie-Annick Persuy , Patrice Congar , Christine Baly
6. World Congress on Biomimetics, Artificial Muscles and Nano-Bio, Oct 2011, Cergy-Pontoise, France
Communication dans un congrès hal-02807785v1

Identification of relevant olfactory receptors to be used as sensing elements of a bioelectronic odorant detection nanoplatform

Aurélie Dewaele , Julien Daligault , Patrice Congar , Christine Baly , Roland Salesse
International Symposium on Olfaction and Electronic Nose (ISOEN 2011), International Society for Olfaction and Chemical Sensing (ISOCS). INT., May 2011, New York, United States
Communication dans un congrès hal-02747786v1

Sensory-metabolic neuroendocrine crosstalk in the rat olfactory epithelium and buld

Roland Salesse , Karine Badonnel , Christine Baly , Patrice Congar , Didier Durieux
7. Forum of European Neuroscience, Jul 2010, Amsterdam, Netherlands
Communication dans un congrès hal-02820587v1

Modulation des réponses olfactives de la muqueuse de rats à jeun par le NPY

Julia Negroni , Nicolas Meunier , Regine Monnerie , Christine Baly , Roland Salesse
7. Journée d'Animation Scientifique, Aromagri 2010, Sep 2010, Dijon, France. 1 p
Communication dans un congrès hal-02821755v1

Informations sensorielles, rassasiement et satiété

Christine Baly , Karine Badonnel , Marie-Christine Lacroix , Patrice Congar , Roland Salesse
Ecole chercheur INRA, Jan 2010, Ecully, France
Communication dans un congrès hal-02814147v1

Neuropeptide Y modulates olfactory mucosa responses to odorant in fasted rat

Patrice Congar , Julia Negroni , Nicolas Meunier , Christine Baly , Roland Salesse
32. Annual Meeting of the Association for Chemoreception Sciences, Apr 2010, St Pete Beach, Florida, United States
Communication dans un congrès hal-02755449v1

Olfactory epithelium, a tissue under metabolic influences

Marie-Christine Lacroix , Karine Badonnel , Nicolas Meunier , Didier Durieux , Regine Monnerie
32. Annual Meeting of the Association for Chemoreception Sciences, Apr 2010, St Pete Beach, Florida, United States
Communication dans un congrès hal-02752580v1

Le système olfactif : une cible pour l'insuline ?

Marie-Christine Lacroix , Karine Badonnel , Nicolas Meunier , Didier Durieux , Regine Monnerie
3. Journées d’Animation Scientifique du Département de Physiologie Animale et Systèmes d’Elevage, Oct 2009, Tours, France
Communication dans un congrès hal-02758375v1

Neuroendocrine basis for the cross-talk between nutritional-metabolic status and food odour detection

Monique Caillol , Karine Badonnel , Marie Jeanne Prud'Homme , Nicolas Meunier , Patrice Congar
Academy Colloquium "Nutrition, Metabolism and the Brain", May 2009, Amsterdam, Netherlands
Communication dans un congrès hal-02753077v1

Modulation par l'endothéline de la dynamique des populations neuronales et non-neuronales dans la muqueuse olfactive du rat

Iman Laziz , Aniya Larbi , Marie-Christine Lacroix , Christine Baly , Denise Grebert
Colloque interne des IFR144, 115 & 87, Apr 2009, Gif-sur-Yvette, France. n.p
Communication dans un congrès hal-02814011v1

Is the internal status able to modify olfactory message at the OM level ?

Patrice Congar , Karine Badonnel , Christine Baly , Didier Durieux , Denise Grebert
1er Symposium Olfaction de l'IMNC UMR8165 CNRS-Université Paris 7/Paris 11 et l'IFR144 NeuroSud-Paris, Jun 2009, Orsay, France. n.p
Communication dans un congrès hal-02820731v1

Long term effects of endothelin on rat olfactory mucosa : modulation of neuronal and non neuronal cellular populations dynamics

Iman Laziz , Aniya Larbi , Marie-Christine Lacroix , Christine Baly , Denise Grebert
4. Journées de Biologie Cellulaire du Grand Campus, May 2009, Orsay, France. 1p
Communication dans un congrès hal-02815669v1

Le système olfactif est-il sensible au statut métabolique ? Eventuelles conséquences physio-pathologiques

Christine Baly , Karine Badonnel , Marie-Christine Lacroix , Marie Jeanne Prud'Homme , Nicolas Meunier
Olfaction, Mémoire et Apprentissages : Venez Pointer Votre Nez !, Jan 2009, Paris, France
Communication dans un congrès hal-02750826v1

Endothelin modulates both short-term kinetics of odorant detection and long-term cellular population dynamics in olfactory mucosa

Nicolas Meunier , Elodie Gouadon , Didier Durieux , Denise Grebert , Christine Baly
31. Annual Meeting of the Association for Chemoreception Sciences, Apr 2009, Sarasota, United States
Communication dans un congrès hal-02750448v1

Endothelin modulates both short-term detection kinetics of odors and long-term cellular population dynamics in olfactory mucosa

Nicolas Meunier , Aniya Larbi , Iman Laziz , Elodie Gouadon , Didier Durieux
31. Annual Meeting of the Association for Chemoreception Sciences, Apr 2009, Sarasota, United States
Communication dans un congrès hal-02755323v1

Olfactory system as a target for insulin

Marie-Christine Lacroix , Karine Badonnel , Nicolas Meunier , Didier Durieux , Regine Monnerie
Academy Colloquium "Nutrition, Metabolism and the Brain", May 2009, Amsterdam, Netherlands
Communication dans un congrès hal-02754778v1

Mécanismes cellulaires et moléculaires impliqués dans l'empreinte métabolique maternelle au niveau de l'hypothalamus et du système olfactif

Jacqueline Ferezou , Odile Couvreur , Daniel Gripois , Claire-Marie Vacher , Alain Aubourg
Journées de Restitution des Projets financés sur Crédits Incitatifs en 2006 et 2007 - Département de Physiologie Animale et Système d'Elevage, Nov 2008, Tours, France
Communication dans un congrès hal-02756776v1

Olfactory mucosa as a target for insulin

Marie-Christine Lacroix , Karine Badonnel , Nicolas Meunier , Fang Tan , Claire Schlegel-Le Poupon
18. Congress of European Chemoreception Research Organization, ECRO, Sep 2008, Portoroz, Slovenia
Communication dans un congrès hal-02756889v1

Endothelin modulates both short-term detection kinetics of odors and long-term cellular population dynamics in olfactory mucosa

Nicolas Meunier , Elodie Gouadon , Denise Grebert , Didier Durieux , Christine Baly
Colloque IFR 144 NeuroSud-Paris, Nov 2008, Gif sur Yvette, France. n.p
Communication dans un congrès hal-02823648v1

Influence de l'état nutritionnel sur la physiologie du système olfactif

Christine Baly , Karine Badonnel , Marie-Christine Lacroix , Marie Jeanne Prud'Homme , Patrice Congar
Journées scientifiques de l'IFR 144 Neurosud Paris, Jun 2007, Jouy-en-Josas, France. n.p
Communication dans un congrès hal-02814126v1

Anatomical and functional evidences for a neuromodulatory role of endotheline on olfactory mucosa cells

Patrice Congar , Elodie Gouadon , Nicolas Meunier , Christine Baly , Roland Salesse
28. Annual Meeting of the Association for Chemoreception Sciences, Apr 2006, Saratosa, United States
Communication dans un congrès hal-02755410v1

Evidences for a role of endothelin on rat olfactory receptors neurons

Elodie Gouadon , Patrice Congar , Nicolas Meunier , Tatiana Gorojankina , Christine Baly
17. Annual Meeting of the European Chemoreception Research Organization (ECRO), Sep 2006, Granada, Spain
Communication dans un congrès hal-02751611v1

Régulation de l'olfaction en vue de l'ingestion : le système olfactif comme un "senseur" de l'état nutritionnel

Monique Caillol , Christine Baly , Josiane Aioun , Marie Jeanne Prud'Homme , Tatiana Gorojankina
72ème congrès de la Société de Physiologie, Jun 2005, Rennes, France. n.p
Communication dans un congrès hal-02830324v1
Image document

Projet AstrOBulb (Unité NBO)

Isabelle Denis , Patrice Congar , Gaelle Champeil Potokar , Sacha Muszlak , Christine Baly
Assises du Département AlimH, Jan 2014, Arrêches, France. 2014
Poster de conférence hal-01345500v1

Bioelectronic odor detection

Edith Pajot , Karine Badonnel , Aurélie Dewaele , Julien Daligault , Marie-Annick Persuy
XVI International Symposium on Olfaction and Taste, XXII meeting of ECRO, Jun 2012, Stockholm, Sweden. , 2012
Poster de conférence hal-02747696v1

Bioelectronic odor detection

Edith Pajot , Karine Badonnel , Aurélie Dewaele , Julien Daligault , Marie-Annick Persuy
Rencontre Chercheurs et Entreprises sur la recherche en Cosmétologie, 2012, Orléans, France. 2012
Poster de conférence hal-02746367v1

Short-term effects of endothelin in rat olfactory mucosa : modulation of odorant detection and intercellular communication

Patrice Congar , Nicolas Meunier , Elodie Gouadon , Didier Durieux , Denise Grebert
9. Colloque de la Société des Neurosciences, May 2009, Brdeaux, France. , 2009
Poster de conférence hal-02820467v1

Long term effects of endothelin on rat olfactory mucosa : modulation of neuronal and non neuronal cellular populations dynamics

Iman Laziz , Aniya Larbi , Marie-Christine Lacroix , Christine Baly , Denise Grebert
9. Colloque de la Société des Neurosciences, May 2009, Bordeaux, France. 1 p., 2009
Poster de conférence hal-02816596v1

Développement, plasticité et neuroendocrinologie des systèmes olfactifs périphériques

Christine Baly , Monique Caillol , Patrice Congar , Michel M. Renou
Odorat et goût : De la neurobiologie des sens chimiques aux applications agronomiques, Editions Quae, 550 p., 2012, Synthèses (Quae), 978-2-7592-1770-0
Chapitre d'ouvrage hal-02802569v1