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Christine Baly
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Documents
Identifiants chercheurs
- cbaly
- IdRef : 159511895
- 0000-0002-8966-9522
Présentation
Christine BALY, is an INRAE senior scientist (Research Director, DR) from the PhASE (Physiologie and Systèmes d'Elevage) department, deputy director of the UR1197 NBO unit (Neurobiologie de l'Olfaction) in Jouy-en-Josas from 2015 to 2019. She has developed an expertise in the study of the genesis and modulation of the olfactory system in relation with food determinants at both mucosa and bulb levels of integration, using molecular and cellular approaches. Since then, she has joined the new INRAE UMR1198 BREED unit (Biologie de la Reproduction, Environnement, Epigénétique et Développement) to develop research on the role of epigenetics on the plasticity of the olfactory system upon environmental challenges.
**Research**
In 1993, she defended her PhD on the expression of the gene encoding the casein alphaS2 in goats, and identified the mechanism responsible for its genetic polymorphism. She was then recruited as a junior scientist in a INSERM-INRA unit in Paris to work on the regulation of the transcription and replication in early embryos in mice. She was the first to demonstrate a transcriptional activity in mice embryos at the one-cell stage using fluorescent imaging and she participated to the characterization of a structural DNA protein involved in the folding of active chromatin in 1-cell embryos, opening a new front in the study of the role of nuclear organization in gene expression in early embryos.
In 2000, CB moved to a new INRA unit at Jouy-en-Josas that was developing a new challenging program on the biology of olfaction in rodents. She contributed to the study on the mechanisms of i) control and coding of an olfactory message by olfactory receptors, ii) odor discrimination and iii) plasticity of the olfactory system (mucosa and bulb) under the influence of various perturbations by cellular, molecular, and behavioral approaches in rodents. After having characterized the role of metabolic hormones, such as leptin and insulin, on the modulation of the olfactory signal, she developped more integrated models to understand the influence of the animal's metabolic status on the perception of odors and passed her Habilitation to Supervise Research in 2013 (HDR). Since then, she has been studying the influence of the perinatal period related to the maternal environment on the olfactory performances in the perspective of understanding the peripheral mechanisms involved, how they shape olfactory-based behaviors, and how to use this neuroplasticity to guide preferences, especially food preferences in animal models, but also in a translational perspective for agronomical purpose. CB preferentially targets the metabolic environment in various physiological situations in adulthood (fasting, states of genetic or dietary obesity, role nutrients), but she is also interested in the effect of other environmental factors on animal behavioral plasticity in order to understand how olfaction-mediated eating habits develop, to use this plasticity to shape food preferences. Currently, her priorities are focused on:
-the influence of an alteration of the energy balance during pregnancy on the development of obesity in adult mice and its consequences on olfaction-mediated eating behavior
-the influence of perinatal odorant exposure on the development of olfactory-based behaviors (food preferences, anxiety, memory).
-the influence of maternal exposure to diesel particles on the neuronatatomical and functional regulation of the olfactory pathways.
Since 2020, she has joined the new INRAE BREED UMR1198 unit in the MeCP2 team (Mécanismes épigénétiques et construction - prédiction des phénotypes) to develop a project entitled: "epigenetic programming of olfactory-based behaviors in rodents". Her challenges are to understand the molecular bases that govern the long-term effects of maternal environments on offspring's behavioral phenotypes by focusing on neuroepigenetics in rodents, with a translational perspective for improving welfare in farm animals.
Publications
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Endothelin increases the proliferation of rat olfactory mucosa cellsNeural Regeneration Research, 2020, 15 (2), pp.1-9. ⟨10.4103/1673-5374.265558⟩
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Olfaction under metabolic influencesChemical Senses, 2012, 37 (9), pp.769-797. ⟨10.1093/chemse/bjs059⟩
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Neuropeptide Y enhances olfactory mucosa responses to odorant in hungry ratsPLoS ONE, 2012, 7 (9), pp.1-10. ⟨10.1371/journal.pone.0045266.g001⟩
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Endothelin evokes distinct calcium transients in neuronal and non-neuronal cells of rat olfactory mucosa primary culturesNeuroscience, 2010, 165 (2), pp.584-600. ⟨10.1016/j.neuroscience.2009.10.046⟩
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Expression of insulin system in the olfactory epithelium: first approaches to its role and regulationJournal of Neuroendocrinology, 2008, 20 (10), pp.1176-1190. ⟨10.1111/j.1365-2826.2008.01777.x⟩
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Bioinspired nose devices and their potential application for non-invasive olfactory detection of pathologies15. International symposium on Olfaction and Electronic Nose, International Society for Olfaction and Chemical Sensing (ISOCS). INT., Jul 2013, Daegu, South Korea
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Bioelectronic odorant detection nanoplatform15. International Biotechnology Symposium and Exhibition, Sep 2012, Daegu, South Korea
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Cerveau et nutrition2. Rencontres INRA-IRBA, Jun 2011, Brétigny, France
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Identification of relevant olfactory receptors to be used as sensing elements of a bioelectronic odorant detection device33. Annual Meeting of the Association for Chemoreception Sciences, Apr 2011, St Pete Beach, Florida, United States
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Identification de récepteurs olfactifs utilisés comme senseurs d'une puce bioélectroniqueColloque de Neurobiologie IFR144, May 2011, Orsay, France
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Identification of relevant olfactory receptors to be used as sensing elements of a bioelectronic odorant detection nano-platformInternational Symposium on Olfaction and Electronic Nose (ISOEN) 2011, May 2011, New-York, United States
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A bioelectronic sensor nanoplatform based on olfactory receptors and electrochemical impedance spectroscopyECRO XXI, Sep 2011, Manchester, United Kingdom
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A bioelectronic sensor nanoplatform based on olfactory receptors and electrochemical impedance spectroscopy6. World Congress on Biomimetics, Artificial Muscles and Nano-Bio, Oct 2011, Cergy-Pontoise, France
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Identification of relevant olfactory receptors to be used as sensing elements of a bioelectronic odorant detection nanoplatformInternational Symposium on Olfaction and Electronic Nose (ISOEN 2011), International Society for Olfaction and Chemical Sensing (ISOCS). INT., May 2011, New York, United States
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Sensory-metabolic neuroendocrine crosstalk in the rat olfactory epithelium and buld7. Forum of European Neuroscience, Jul 2010, Amsterdam, Netherlands
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Modulation des réponses olfactives de la muqueuse de rats à jeun par le NPY7. Journée d'Animation Scientifique, Aromagri 2010, Sep 2010, Dijon, France. 1 p
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Informations sensorielles, rassasiement et satiétéEcole chercheur INRA, Jan 2010, Ecully, France
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Neuropeptide Y modulates olfactory mucosa responses to odorant in fasted rat32. Annual Meeting of the Association for Chemoreception Sciences, Apr 2010, St Pete Beach, Florida, United States
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Olfactory epithelium, a tissue under metabolic influences32. Annual Meeting of the Association for Chemoreception Sciences, Apr 2010, St Pete Beach, Florida, United States
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Le système olfactif : une cible pour l'insuline ?3. Journées d’Animation Scientifique du Département de Physiologie Animale et Systèmes d’Elevage, Oct 2009, Tours, France
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Neuroendocrine basis for the cross-talk between nutritional-metabolic status and food odour detectionAcademy Colloquium "Nutrition, Metabolism and the Brain", May 2009, Amsterdam, Netherlands
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Modulation par l'endothéline de la dynamique des populations neuronales et non-neuronales dans la muqueuse olfactive du ratColloque interne des IFR144, 115 & 87, Apr 2009, Gif-sur-Yvette, France. n.p
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Is the internal status able to modify olfactory message at the OM level ?1er Symposium Olfaction de l'IMNC UMR8165 CNRS-Université Paris 7/Paris 11 et l'IFR144 NeuroSud-Paris, Jun 2009, Orsay, France. n.p
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Long term effects of endothelin on rat olfactory mucosa : modulation of neuronal and non neuronal cellular populations dynamics4. Journées de Biologie Cellulaire du Grand Campus, May 2009, Orsay, France. 1p
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Le système olfactif est-il sensible au statut métabolique ? Eventuelles conséquences physio-pathologiquesOlfaction, Mémoire et Apprentissages : Venez Pointer Votre Nez !, Jan 2009, Paris, France
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Endothelin modulates both short-term kinetics of odorant detection and long-term cellular population dynamics in olfactory mucosa31. Annual Meeting of the Association for Chemoreception Sciences, Apr 2009, Sarasota, United States
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Endothelin modulates both short-term detection kinetics of odors and long-term cellular population dynamics in olfactory mucosa31. Annual Meeting of the Association for Chemoreception Sciences, Apr 2009, Sarasota, United States
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Olfactory system as a target for insulinAcademy Colloquium "Nutrition, Metabolism and the Brain", May 2009, Amsterdam, Netherlands
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Mécanismes cellulaires et moléculaires impliqués dans l'empreinte métabolique maternelle au niveau de l'hypothalamus et du système olfactifJournées de Restitution des Projets financés sur Crédits Incitatifs en 2006 et 2007 - Département de Physiologie Animale et Système d'Elevage, Nov 2008, Tours, France
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Olfactory mucosa as a target for insulin18. Congress of European Chemoreception Research Organization, ECRO, Sep 2008, Portoroz, Slovenia
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Endothelin modulates both short-term detection kinetics of odors and long-term cellular population dynamics in olfactory mucosaColloque IFR 144 NeuroSud-Paris, Nov 2008, Gif sur Yvette, France. n.p
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Influence de l'état nutritionnel sur la physiologie du système olfactifJournées scientifiques de l'IFR 144 Neurosud Paris, Jun 2007, Jouy-en-Josas, France. n.p
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Anatomical and functional evidences for a neuromodulatory role of endotheline on olfactory mucosa cells28. Annual Meeting of the Association for Chemoreception Sciences, Apr 2006, Saratosa, United States
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Evidences for a role of endothelin on rat olfactory receptors neurons17. Annual Meeting of the European Chemoreception Research Organization (ECRO), Sep 2006, Granada, Spain
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Régulation de l'olfaction en vue de l'ingestion : le système olfactif comme un "senseur" de l'état nutritionnel72ème congrès de la Société de Physiologie, Jun 2005, Rennes, France. n.p
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Projet AstrOBulb (Unité NBO)Assises du Département AlimH, Jan 2014, Arrêches, France. 2014
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Bioelectronic odor detectionXVI International Symposium on Olfaction and Taste, XXII meeting of ECRO, Jun 2012, Stockholm, Sweden. , 2012
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Bioelectronic odor detectionRencontre Chercheurs et Entreprises sur la recherche en Cosmétologie, 2012, Orléans, France. 2012
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Short-term effects of endothelin in rat olfactory mucosa : modulation of odorant detection and intercellular communicationPoster de conférence hal-02820467v1 |
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Long term effects of endothelin on rat olfactory mucosa : modulation of neuronal and non neuronal cellular populations dynamics9. Colloque de la Société des Neurosciences, May 2009, Bordeaux, France. 1 p., 2009
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Développement, plasticité et neuroendocrinologie des systèmes olfactifs périphériquesOdorat et goût : De la neurobiologie des sens chimiques aux applications agronomiques, Editions Quae, 550 p., 2012, Synthèses (Quae), 978-2-7592-1770-0
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