Cyril Bourgeois

Publications

Article dans une revue (32)

Monoallelic de novo variants in DDX17 cause a neurodevelopmental disorder Eleanor Seaby,Annie Godwin,Géraldine Meyer-Dilhet,Valentine Clerc,Xavier Grandet al. Brain - A Journal of Neurology , 2025, 148 (4), pp.1155-1168. ⟨10.1093/brain/awae320⟩ Article dans une revue hal-04943083v1
RNA at the crossroads of structure, function, and disease Didier Auboeuf,Cyril Bourgeois,Francesca Fiorini,Virginie Marcel Biochimie, 2025, ⟨10.1016/j.biochi.2025.09.013⟩ Article dans une revue hal-05306217v1
The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions Marine Lanfranchi,Sozerko Yandiev,Géraldine Meyer-Dilhet,Salma Ellouze,Martijn Kerkhofset al. Nature Communications, 2024, 15 (1), pp.2487. ⟨10.1038/s41467-024-46146-6⟩ Article dans une revue hal-04583107v1
Gene-to-gene coordinated regulation of transcription and alternative splicing by 3D chromatin remodeling upon NF-κB activation Paul Marie,Matéo Bazire,Julien Ladet,Lamya Ben Ameur,Sanjay Chaharet al. Nucleic Acids Research, 2024, 52 (4), pp.1527-1543. ⟨10.1093/nar/gkae015⟩ Article dans une revue inserm-04830003v1
Helicases DDX5 and DDX17 promote heterogeneity in HBV transcription termination in infected human hepatocytes Fleur Chapus,Guillaume Giraud,Pélagie Huchon,Mélanie Rodà,Xavier Grandet al. Journal of Hepatology, 2024, 81 (4), pp.609-620. ⟨10.1016/j.jhep.2024.05.016⟩ Article dans une revue inserm-04830013v1
SplicingLore: a web resource for studying the regulation of cassette exons by human splicing factors Hélène Polvèche,Jessica Valat,Nicolas Fontrodona,Audrey Lapendry,Valentine Clercet al. Database - The journal of Biological Databases and Curation, 2023, 2023, pp.baad091. ⟨10.1093/database/baad091⟩ Article dans une revue inserm-04829991v1
Modulatory role of RNA helicases in MBNL-dependent alternative splicing regulation Katarzyna Taylor,Agnieszka Piasecka,Arkadiusz Kajdasz,Aleksandra Brzęk,Micaela Polay Espinozaet al. Cellular and Molecular Life Sciences, 2023, 80 (11), pp.335. ⟨10.1007/s00018-023-04927-0⟩ Article dans une revue inserm-04829975v1
Myotonic dystrophy RNA toxicity alters morphology, adhesion and migration of mouse and human astrocytes Diana Dincã,Louison Lallemant,Anchel González-Barriga,Noémie Cresto,Sandra Brazet al. Nature Communications, 2022, 13 (1), pp.3841. ⟨10.1038/s41467-022-31594-9⟩ Article dans une revue hal-03715682v1
RNA helicase-dependent gene looping impacts messenger RNA processing Sophie Terrone,Jessica Valat,Nicolas Fontrodona,Guillaume Giraud,Jean-Baptiste Claudeet al. Nucleic Acids Research, 2022, 50 (16), pp.9226-9246. ⟨10.1093/nar/gkac717⟩ Article dans une revue hal-03842696v1
Integrative Cell Type-Specific Multi-Omics Approaches Reveal Impaired Programs of Glial Cell Differentiation in Mouse Culture Models of DM1 Anchel González-Barriga,Louison Lallemant,Diana M Dincã,Sandra O Braz,Hélène Polvècheet al. Frontiers in Cellular Neuroscience, 2021, 15, pp.662035. ⟨10.3389/fncel.2021.662035⟩ Article dans une revue hal-03235993v1
Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1 Lamya Ben Ameur,Paul Marie,Morgan Thénoz,Guillaume Giraud,Emmanuel Combeet al. Nature Communications, 2020, 11 (1), pp.3045. ⟨10.1038/s41467-020-16853-x⟩ Article dans une revue inserm-02877333v1
A genome‐wide screen identifies IRF2 as a key regulator of caspase‐4 in human cells Sacha Benaoudia,Amandine Martin,Marta Puig Gamez,Gabrielle Gay,Brice Lagrangeet al. EMBO Reports, 2019, 20 (9), ⟨10.15252/embr.201948235⟩ Article dans une revue hal-02337614v1
Interplay between coding and exonic splicing regulatory sequences Nicolas Fontrodona,Fabien Aubé,Jean-Baptiste Claude,Hélène Polvèche,Sébastien Lemaireet al. Genome Research, 2019, 29 (5), pp.711-722. ⟨10.1101/gr.241315.118⟩ Article dans une revue inserm-04887117v1
Characterizing the interplay between gene nucleotide composition bias and splicing Sébastien Lemaire,Nicolas Fontrodona,Fabien Aubé,Jean-Baptiste Claude,Hélène Polvècheet al. Genome Biology, 2019, 20 (1), pp.259. ⟨10.1186/s13059-019-1869-y⟩ Article dans une revue inserm-04887130v1
The RNA helicase DDX17 controls the transcriptional activity of REST and the expression of proneural microRNAs in neuronal differentiation Marie-Pierre Lambert,Sophie Terrone,Guillaume Giraud,Clara Benoit-Pilven,David Cluetet al. Nucleic Acids Research, 2018, 46 (15), pp.7686-7700. ⟨10.1093/nar/gky545⟩ Article dans une revue (data paper) hal-04897064v1
Complementarity of assembly-first and mapping-first approaches for alternative splicing annotation and differential analysis from RNAseq data Clara Benoit-Pilven,Camille Marchet,Emilie Chautard,Leandro Lima,Marie-Pierre Lambertet al. Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-21770-7⟩ Article dans une revue hal-01924204v1
Identification of Splicing Factors Involved in DMD Exon Skipping Events Using an In Vitro RNA Binding Assay Julie Miro,Cyril F. Bourgeois,Mireille Claustres,Michel Koenig,Sylvie Tuffery-Giraud Methods in Molecular Biology, 2018, 1687, pp.157--169. ⟨10.1007/978-1-4939-7374-3_11⟩ Article dans une revue hal-02350943v1
The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival Chiara Naro,Federica Barbagallo,Paolo Chieffi,Cyril Bourgeois,Maria Paola Paronettoet al. Nucleic Acids Research, 2014, 42 (5), pp.3218-3227. ⟨10.1093/nar/gkt1307⟩ Article dans une revue hal-04477050v1
Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development. Sushma Grellscheid,Caroline Dalgliesh,Markus Storbeck,Andrew Best,Yilei Liuet al. PLoS Genetics, 2011, 7 (12), pp.e1002390. ⟨10.1371/journal.pgen.1002390⟩ Article dans une revue inserm-00711527v1
Molecular design of a splicing switch responsive to the RNA binding protein Tra2 Sushma N Grellscheid,Caroline Dalgliesh,Agata Rozanska,David Grellscheid,Cyril F Bourgeoiset al. Nucleic Acids Research, 2011, 39 (18), pp.8092-8104. ⟨10.1093/nar/gkr495⟩ Article dans une revue hal-04967870v1
A conserved splicing mechanism of the LMNA gene controls premature aging Isabel Cristina Lopez-Mejia,Valentin Vautrot,Marion de Toledo,Isabelle Behm-Ansmant,Cyril Bourgeoiset al. Human Molecular Genetics, 2011, 20 (23), pp.4540-4555. ⟨10.1093/hmg/ddr385⟩ Article dans une revue hal-03034380v1
Antagonistic factors control the unproductive splicing of SC35 terminal intron Natacha Dreumont,Sara Hardy,Isabelle Behm-Ansmant,Liliane Kister,Christiane Branlantet al. Nucleic Acids Research, 2010, 38 (4), pp.1353 - 1366. ⟨10.1093/nar/gkp1086⟩ Article dans une revue hal-01738427v1
Human RBMY regulates germline-specific splicing events by modulating the function of the serine/arginine-rich proteins 9G8 and Tra2-{beta} Natacha Dreumont,Cyril F. Bourgeois,Fabrice Lejeune,Yilei Liu,Ingrid E. Ehrmannet al. Journal of Cell Science, 2010, 123 (Pt 1), pp.40-50. ⟨10.1242/jcs.055889⟩ Article dans une revue hal-04042060v1
Role of RNA structure and protein factors in the control of HIV-1 splicing Jean-Michel Saliou,Cyril Bourgeois,L. Ayadi-Ben Mena,Delphine Ropers,S. Jacquenetet al. Frontiers in Bioscience-Landmark, 2009, 14, pp.2714-2729 Article dans une revue hal-00793011v1
The germ cell nuclear proteins hnRNP G-T and RBMY activate a testis-specific exon Yilei Liu,Cyril F. Bourgeois,Shaochen Pang,Marek Kudla,Natacha Dreumontet al. PLoS Genetics, 2009, 5 (11), ⟨10.1371/journal.pgen.1000707⟩ Article dans une revue hal-04127590v1
Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear Bodies. Prabhakar Rajan,Caroline Dalgliesh,Cyril F Bourgeois,Monika Heiner,Kaveh Emamiet al. BMC Cell Biology, 2009, 10 (1), pp.82. ⟨10.1186/1471-2121-10-82⟩ Article dans une revue inserm-00624805v1
Alternative RNA splicing complexes containing the scaffold attachment factor SAFB2. Kate A Sergeant,Cyril F Bourgeois,Caroline Dalgliesh,Julian P Venables,James Steveninet al. Journal of Cell Science, 2007, 120 (Pt 2), pp.309-19. ⟨10.1242/jcs.03344⟩ Article dans une revue hal-00166256v1
Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon. Julian P Venables,Cyril F Bourgeois,Caroline Dalgliesh,Liliane Kister,James Steveninet al. Human Molecular Genetics, 2005, 14 (16), pp.2289-303. ⟨10.1093/hmg/ddi233⟩ Article dans une revue istex hal-00187820v1
Broad specificity of SR (serine/arginine) proteins in the regulation of alternative splicing of pre-messenger RNA Cyril F. Bourgeois,Fabrice Lejeune,James Stevenin Progress in Nucleic Acid Research and Molecular Biology, 2004, 78, pp.37-88. ⟨10.1016/S0079-6603(04)78002-2⟩ Article dans une revue hal-04122986v1
The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5' splice site Fabienne del Gatto-Konczak,Cyril F. Bourgeois,Caroline Le Guiner,Liliane Kister,Marie-Claude Gesnelet al. Molecular and Cellular Biology, 2000, 20 (17), pp.6287-6299. ⟨10.1128/MCB.20.17.6287-6299.2000⟩ Article dans une revue hal-04128951v1
The splicing factors 9G8 and SRp20 transactivate splicing through different and specific enhancers Yvon Cavaloc,Cyril F. Bourgeois,Liliane Kister,James Stevenin RNA, 1999, 5 (3), pp.468-483. ⟨10.1017/s1355838299981967⟩ Article dans une revue hal-04057113v1
Identification of a bidirectional splicing enhancer: differential involvement of SR proteins in 5' or 3' splice site activation Cyril F. Bourgeois,Michel Popielarz,Georges Hildwein,James Stevenin Molecular and Cellular Biology, 1999, 19 (11), pp.7347-7356. ⟨10.1128/MCB.19.11.7347⟩ Article dans une revue hal-04027664v1

Pré-publication, Document de travail (4)

The AMPK-related kinase NUAK1 regulates neuronal morphogenesis through the RNA splicing co-factor SON Martijn Kerkhofs,Géraldine Meyer-Dilhet,Hélène Polvèche,Sozerko Yandiev,Jacqueline Tait-Mulderet al. 2025 Pré-publication, Document de travail hal-05345384v1
The MYCN oncoprotein and helicases DDX17 and DDX5 have opposite effects on the production of chimeric transcripts in neuroblastoma cells Valentine Clerc,Jessica Valat,Xavier Grand,Nicolas Fontrodona,Matéo Bazireet al. 2024 Pré-publication, Document de travail inserm-04830027v1
Myotonic dystrophy RNA toxicity alters morphology, adhesion and migration of mouse and human astrocytes Diana Dincã,Anchel González-Barriga,Geraldine Sicot,Louison Lallemant,Laure-Elise Pilletet al. 2022 Pré-publication, Document de travail hal-03863376v1
Complementarity of assembly-first and mapping-first approaches for alternative splicing annotation and differential analysis from RNAseq data Clara Benoit-Pilven,Camille Marchet,Emilie Chautard,Leandro Lima,Marie-Pierre Lambertet al. 2017 Pré-publication, Document de travail (preprint/prepublication) hal-01643169v1

Poster de conférence (6)

Toxic CUG RNA repeats disrupt developmentally-regulated splicing in oligodendrocytes causing transient hypomyelination in a mouse model of myotonic dystrophy. Louison Lallemant,Sandra Braz,Anchel González-Barriga,Paul Magneron,Aurélien Cordieret al. The European Meeting on Glial Cells in Health and Disease, Jul 2023, Berlin, France Poster de conférence hal-04005524v1
Myotonic dystrophy RNA toxicity alters morphology, adhesion and migration of mouse and human astrocytes Diana Mihaela Dincã,Louison Lallemant,Anchel González-Barriga,Noemie Cresto,Sandra Brazet al. International Myotonic Dystrophy Consortium Meeting, Jun 2022, Osaka, Japan Poster de conférence hal-04006873v1
RNA toxicity in myotonic dystrophy causes pronounced spliceopathy in astrocytes, in association with defective cell adhesion and morphology, erratic migration and impaired polarization Diana Mihaela Dincã,Anchel González-Barriga,Sandra Braz,Laure-Elise Pillet,Noémie Crestoet al. Cold Spring Harbor Laboratory Meeting on Glia in Health and Disease, Jul 2020, Cold Spring Harbor (New York), United States Poster de conférence hal-04009836v1
Toxic RNA affects astrocyte adhesion, spreading and migration in myotonic dystrophy, and impacts neuritogenesis through abnormal glial-neuronal interactions Diana Mihaela Dincã,Anchel González-Barriga,Sandra Braz,Cyril F Bourgeois,Géraldine Sicotet al. The European Meeting on Glial Cells in Health and Disease, Jul 2019, Porto, Portugal Poster de conférence hal-04009975v1
Investigating oligodendrocyte dysfunction in DM1 brain disease Sandra Braz,Raphael Blain,Cyril F Bourgeois,Aline Huguet-Lachon,Alain Schmittet al. The European Meeting on Glial Cells in Health and Disease, Jul 2019, Porto, Portugal Poster de conférence hal-04010005v1
Combination of Omics Approaches to Study Molecular Abnormalities in Individual Brain Cell Types of a DM1 Mouse Model Anchel González-Barriga,Diana Mihaela Dincã,Sandra Braz,Aurélien Cordier,Cerina Chhuonet al. International Myotonic Dystrophy Consortium Meeting (IDMC-12), Jun 2019, Gothenburg, Sweden. Poster de conférence hal-04009963v1