cédric lecoutey

Identifiants chercheurs

IdHAL :

cedric-lecoutey

ORCID :

0000-0003-4725-7738

Publications

Pré-publication, Document de travail (1)

Stress-responsive Mycobacterium tuberculosis subpopulations manipulate macrophage polarization and can be targeted to limit inflammation Laura Pokorny,Lalit Kumar Singh,Nicolas Gangneux,Margaux Pillon,Claudia Chicaet al. 2026 Pré-publication, Document de travail pasteur-05573086v1

Article dans une revue (25)

An efficient step-by-step approach to select pleiotropic drug candidates against Alzheimer's disease: The discovery of neocopride Christophe Rochais,Cédric Lecoutey,Georgia Culley,Thomas Curel,Audrey Daviset al. Journal of Alzheimer's Disease, In press, 110 (4), pp.1654-1666. ⟨10.1177/13872877261424925⟩ Article dans une revue hal-05559851v1
Targeting together cholinesterases and serotonin reuptake against Alzheimer’s disease Thomas Guiselin,Cédric Lecoutey,Christophe Rochais,Patrick Dallemagne Journal of Pharmacy and Pharmacology, 2025, 77 (10), pp.1303-1318. ⟨10.1093/jpp/rgaf041⟩ Article dans une revue hal-05297207v1
Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT4 receptors with potential interest in the treatment of Alzheimer's disease Christophe Rochais,Cédric Lecoutey,Julien Lalut,Audrey Davis,Emilie Duvalet al. European Journal of Medicinal Chemistry, 2024, 280, pp.116975. ⟨10.1016/j.ejmech.2024.116975⟩ Article dans une revue hal-04760765v1
Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy Maxime Mistretta,Mena Cimino,Pascal Campagne,Stevenn Volant,Etienne Kornobiset al. Nature Communications, 2024, 15 (1), pp.4175. ⟨10.1038/s41467-024-48269-2⟩ Article dans une revue hal-04578611v1
Conceptual Framework of the Design of Pleiotropic Drugs against Alzheimer’s Disease Thomas Guiselin,Cédric Lecoutey,Christophe Rochais,Patrick Dallemagne Pharmaceutics, 2023, 15 (10), pp.2382. ⟨10.3390/pharmaceutics15102382⟩ Article dans une revue hal-04414828v1
Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer’s disease François-Xavier Toublet,Julien Lalut,Bérénice Hatat,Cédric Lecoutey,Audrey Daviset al. European Journal of Medicinal Chemistry, 2021, 210, pp.113059. ⟨10.1016/j.ejmech.2020.113059⟩ Article dans une revue hal-03082877v1
Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer’s Disease Treatment through Rigidification Strategy Cédric Lecoutey,Rémi Legay,Audrey Davis,Jana Sopková-de Oliveira Santos,Patrick Dallemagneet al. Molecules, 2021, 26 (9), pp.2536. ⟨10.3390/molecules26092536⟩ Article dans une revue hal-03969972v1
Donecopride, a Swiss army knife with potential interest against Alzheimer's disease Christophe Rochais,Cédric Lecoutey,Katia Hamidouche,Patrizia Giannoni,Florence Gavenet al. British Journal of Pharmacology, In press, 177 (9), pp.1988-2005. ⟨10.1111/bph.14964⟩ Article dans une revue hal-02428730v1
Therapeutic modulators of the serotonin 5-HT4 receptor: a patent review (2014-present) Caroline Lanthier,Patrick Dallemagne,Cédric Lecoutey,Sylvie Claeysen,Cédric Lecoutey Expert Opinion on Therapeutic Patents, 2020, 30 (7), pp.495-508. ⟨10.1080/13543776.2020.1767587⟩ Article dans une revue hal-02863879v1
Phenanthrolinic analogs of quinolones show antibacterial activity against M. tuberculosis Songuigama Coulibaly,Mena Cimino,Mahama Ouattara,Cédric Lecoutey,Maria V Buchieriet al. European Journal of Medicinal Chemistry, 2020, 207, pp.112821. ⟨10.1016/j.ejmech.2020.112821⟩ Article dans une revue pasteur-03261309v1
Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer’s disease Julien Lalut,Hugo Payan,Audrey Davis,Cédric Lecoutey,Rémi Legayet al. Scientific Reports, 2020, 10, pp.3014. ⟨10.1038/s41598-020-59805-7⟩ Article dans une revue hal-02485740v1
Impact of T161, Y318 and S363 alanine mutations on regulation of the human delta-opioid receptor (hDOPr) induced by peptidic and alkaloid agonists Elise Camacho,Nicolas Marie,Quentin Dupas,Caroline Martel,Marie Nowoczynet al. Neuropharmacology, In press, 179, ⟨10.1016/j.neuropharm.2020.108286⟩ Article dans une revue hal-03021820v1
A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease Bérénice Hatat,Samir Yahiaoui,Cédric Lecoutey,Audrey Davis,Thomas Freretet al. Frontiers in Aging Neuroscience, 2019, 11, pp.148. ⟨10.3389/fnagi.2019.00148⟩ Article dans une revue hal-02399864v1
Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease François-Xavier Toublet,Cédric Lecoutey,Julien Lalut,Bérénice Hatat,Audrey Daviset al. Molecules, 2019, 24 (15), pp.2786. ⟨10.3390/molecules24152786⟩ Article dans une revue hal-02399906v1
Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase Julien Lalut,Gianluca Santoni,Delphine Karila,Cédric Lecoutey,Audrey Daviset al. European Journal of Medicinal Chemistry, 2019, 162, pp.234-248. ⟨10.1016/j.ejmech.2018.10.064⟩ Article dans une revue hal-01994096v1
Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease Caroline Lanthier,Hugo Payan,Irene Liparulo,Bérénice Hatat,Cédric Lecouteyet al. European Journal of Medicinal Chemistry, 2019, 182, pp.111596. ⟨10.1016/j.ejmech.2019.111596⟩ Article dans une revue hal-02399942v1
Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment Jean-Pierre Jourdan,Marc Since,Laïla El kihel,Cédric Lecoutey,Sophie Corvaisieret al. ChemMedChem, 2017, 12 (12), pp.913-916. ⟨10.1002/cmdc.201700102⟩ Article dans une revue hal-02043731v1
Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment Jean-Pierre Jourdan,Marc Since,Laïla El Kihel,Cédric Lecoutey,Sophie Corvaisieret al. European Journal of Medicinal Chemistry, 2016, 114, pp.365-379. ⟨10.1016/j.ejmech.2016.03.023⟩ Article dans une revue istex hal-02043765v1
Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography Julien Lalut,Benjamin B. Tournier,Thomas Cailly,Cédric Lecoutey,Sophie Corvaisieret al. European Journal of Medicinal Chemistry, 2016, 116, pp.90-101. ⟨10.1016/j.ejmech.2016.03.059⟩ Article dans une revue hal-02011098v1
Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT 4 R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride Cédric Lecoutey,Cédric Lecoutey,Florence Gaven,Patrizia Giannoni,Katia Hamidoucheet al. Journal of Medicinal Chemistry, 2015, 58 (7), pp.3172-3187. ⟨10.1021/acs.jmedchem.5b00115⟩ Article dans une revue hal-02043873v1
Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment Cédric Lecoutey,Damien Hedou,Thomas Freret,Patrizia Giannoni,Florence Gavenet al. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩ Article dans une revue hal-01800439v2
Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease. David Genest,Christophe Rochais,Cédric Lecoutey,Jana Sopkova-de Oliveira Santos,Céline Ballandonneet al. MedChemComm, 2013, 4, pp.925-931 Article dans une revue hal-00840942v1
Synthesis of dual AChE/5-HT4 receptor multi-target directed ligands Cédric Lecoutey,Christophe Rochais,David Genest,Sabrina Butt-Gueulle,Céline Ballandonneet al. MedChemComm, 2012, 3 (5), pp.627. ⟨10.1039/c2md20063e⟩ Article dans une revue hal-05481533v1
Synthesis of dual AChE/5-HT4 receptor multi-target directed ligands. Cédric Lecoutey,Christophe Rochais,David Genest,Sabrina Butt-Gueulle,Céline Ballandonneet al. MedChemComm, 2012, 3, pp.627-634 Article dans une revue hal-00764795v1
Efficient Room-Temperature One-Pot Synthesis of 2-Amino-3-alkyl(3-aryl)quinazolin-4(3H)-ones Cédric Lecoutey,Christine Fossey,Sylvain Rault,Frédéric Fabis European Journal of Organic Chemistry, 2011, 2011 (15), pp.2785-2788 Article dans une revue hal-02018181v1

Poster de conférence (1)

Development of a nasal drug delivery composite nanosystem for Alzheimer’s desease treatment Adnet Thomas,Anne-Claire Groo,Loïc Le Pluart,Celine Picard,A. Daviset al. Journée normande de recherche biomédicale, Nov 2017, caen, France Poster de conférence hal-02295929v1

Brevet (1)

Acetylcholinesterase Inhibitor Compounds and 5ht4 Serotonergic Receptor Agonists, with Promnesia Effect, Methods for the Preparation Thereof and Pharmaceutical Compositions Containing Same Patrick Dallemagne,Christophe Rochais,Cédric Lecoutey,Michel Boulouard,Thomas Freret France, Patent n° : WO2014195593 (A2). 2014 Brevet hal-02042939v1