CHAPUT NATHALIE

Publications

Article dans une revue (47)

Nivolumab in Metastatic Clear-cell Renal Cell Carcinoma: An Integrative Biomarker Analysis from the NIVOREN GETUG-AFU 26 Phase 2 Study Ronan Flippot,Yann-Alexandre Vano,Cécile Dalban,Benoit Beuselinck,Aude Fléchonet al. European Urology, 2026, ⟨10.1016/j.eururo.2025.09.4169⟩ Article dans une revue hal-05423521v1
Expanded senescent CD8 T cells in IMID patients are associated with distinct inflammatory cytokines Marie Naigeon,Samuel Bitoun,Matthieu Roulleaux Dugage,Caroline de Oliveira,Caroline Berthotet al. Clinical and Experimental Immunology, 2025, 219 (1), ⟨10.1093/cei/uxaf050⟩ Article dans une revue hal-05521048v1
High circulating IL-6/IL-8 is associated with intratumoral myeloid contexture and poor outcomes in advanced renal cell carcinoma patients treated with PD-1 blockade Lucía Carril-Ajuria,Ronan Flippot,Marie Naigeon,Cécile Dalban,Aude Desnoyeret al. Clinical Cancer Research, 2025, pp.OF1-OF9. ⟨10.1158/1078-0432.CCR-24-0902⟩ Article dans une revue hal-05249577v1
Cancer immunotherapy in elderly patients: the concept of immune senescence challenged by clinical experience Mathilde Guégan,Malvina Bichon,Nathalie Chaput,Roch Houot,Jean Lemoine European Journal of Cancer, 2024, 214, pp.115145-115145. ⟨10.1016/j.ejca.2024.115145⟩ Article dans une revue hal-04891566v1
Metabolic tumor volume assessed by 18F FDG - PET CT scan as a predictive biomarker for immune checkpoint blockers in advanced NSCLC and its biological correlates. Filippo Dall'Olio,Wael Zrafi,Veronique Roelants,Valentina Ambrosini,Aloyse Fourquetet al. Clinical Cancer Research, 2024, ⟨10.1158/1078-0432.CCR-24-1993⟩ Article dans une revue (article de synthèse) hal-04806943v1
B cells and the coordination of immune checkpoint inhibitor response in patients with solid tumors Ronan Flippot,Marcus Teixeira,Macarena Rey-Cardenas,Lucia Carril-Ajuria,Larissa Rainhoet al. Journal for Immunotherapy of Cancer, 2024, 12 (4), pp.e008636. ⟨10.1136/jitc-2023-008636⟩ Article dans une revue inserm-04685443v1
Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8 + T cells in patients with advanced NSCLC Marie Naigeon,Matthieu Roulleaux Dugage,François-Xavier Danlos,Lisa Boselli,Jean-Mehdi Jouniauxet al. Science Advances , 2023, 9 (45), ⟨10.1126/sciadv.adh0708⟩ Article dans une revue hal-04719261v1
Genomic Instability and Pro-Tumoral Inflammation are associated with Primary Resistance to Anti-PD1 + Anti-Angiogenesis in Malignant Pleural Mesothelioma Francois-Xavier Danlos,Matthieu Texier,Bastien Job,Severine Mouraud,Lydie Cassardet al. Cancer Discovery, 2023, 13 (4), pp.858-879. ⟨10.1158/2159-8290.CD-22-0886⟩ Article dans une revue hal-03972355v1
Overcoming resistance to αPD-1 of MMR-deficient tumors with high tumor-induced neutrophils levels by combination of αCTLA-4 and αPD-1 blockers Laetitia Nebot-Bral,Antoine Hollebecque,Andrey Yurchenko,Louise de Forceville,Mathieu Danjouet al. Journal for Immunotherapy of Cancer, 2022, 10 (7), pp.e005059. ⟨10.1136/jitc-2022-005059⟩ Article dans une revue hal-03852523v1
Overcoming resistance to αPD-1 of MMR-deficient tumors with high tumor-induced neutrophils levels by combination of αCTLA-4 and αPD-1 blockers Laetitia Nebot-Bral,Antoine Hollebecque,Andrey A Yurchenko,Louise de Forceville,Mathieu Danjouet al. Journal for Immunotherapy of Cancer, 2022, 10 (7), pp.e005059. ⟨10.1136/jitc-2022-005059⟩ Article dans une revue hal-03853375v1
Plasma CD27, a Surrogate of the Intratumoral CD27–CD70 Interaction, Correlates with Immunotherapy Resistance in Renal Cell Carcinoma Nadine Benhamouda,Ikuan Sam,Nicolas Epaillard,Alain Gey,Letuan Phanet al. Clinical Cancer Research, 2022, 28 (22), pp.4983 - 4994. ⟨10.1158/1078-0432.ccr-22-0905⟩ Article dans une revue pasteur-04142515v1
Association of AXL and PD-L1 Expression with Clinical Outcomes in Patients with Advanced Renal Cell Carcinoma Treated with PD-1 Blockade Stéphane Terry,Cécile Dalban,Nathalie Rioux-Leclercq,Julien Adam,Maxime Meylanet al. Clinical Cancer Research, 2021, 27 (24), pp.6749-60. ⟨10.1158/1078-0432.CCR-21-0972⟩ Article dans une revue hal-03477307v1
Cancer and immunotherapy: a role for microbiota composition Fiona Pham,Fabien Moinard-Butot,Clélia Coutzac,Nathalie Chaput European Journal of Cancer, 2021, 155, pp.145-154. ⟨10.1016/j.ejca.2021.06.051⟩ Article dans une revue hal-04099088v1
Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer Clélia Coutzac,Jean Mehdi Jouniaux,Angelo Paci,Julien Schmidt,Domenico Mallardoet al. Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-16079-x⟩ Article dans une revue hal-03109210v1
Interleukin‐7/Interferon axis drives T‐cell and salivary gland epithelial cell interactions in Sjögren’s syndrome Elodie Rivière,Juliette Pascaud,Alexandre Virone,Anastasia Dupré,Bineta Lyet al. Arthritis & rheumatology, 2020, 73 (4), pp.631-640. ⟨10.1002/art.41558⟩ Article dans une revue pasteur-03036519v1
Why is immunotherapy effective (or not) in patients with MSI/MMRD tumors? Laetitia Nebot-Bral,Clélia Coutzac,Patricia L Kannouche,Nathalie Chaput Bulletin du Cancer, 2019, 106 (2), pp.105-113. ⟨10.1016/j.bulcan.2018.08.007⟩ Article dans une revue hal-02425478v1
IL-15 superagonist RLI has potent immunostimulatory properties on NK cells: implications for antimetastatic treatment Mélanie Desbois,Coralie Béal,Mélinda Charrier,Benjamin Besse,Guillaume Meuriceet al. Journal for Immunotherapy of Cancer, 2019, 8 (1), pp.e000632. ⟨10.1136/jitc-2020-000632⟩ Article dans une revue inserm-03498336v1
Estimating causal effects of time-dependent exposures on a binary endpoint in a high-dimensional setting Vahé Asvatourian,Clélia Coutzac,Nathalie Chaput,Caroline Robert,Stefan Michielset al. BMC Medical Research Methodology, 2018, 18 (1), pp.67. ⟨10.1186/s12874-018-0527-5⟩ Article dans une revue inserm-02310420v1
Enterocolitis due to immune checkpoint inhibitors: a systematic review Emilie Soularue,Patricia Lepage,Jean-Fréderic Colombel,Clelia Coutzac,David Falecket al. Gut, 2018, 67 (11), pp.2056-2067. ⟨10.1136/gutjnl-2018-316948⟩ Article dans une revue hal-02626171v1
Deep phenotyping of immune cell populations by optimized and standardized flow cytometry analyses Fabien Pitoiset,Lydie Cassard,Karim El Soufi,Lisa Boselli,Jonathan Grivelet al. Cytometry Part A, 2018, 93 (8), pp.793-802. ⟨10.1002/cyto.a.23570⟩ Article dans une revue hal-01955310v1
Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab Nathalie Chaput,Patricia Lepage,Clelia Coutzac,E Soularue,Karine Le Rouxet al. Annals of Oncology, 2017, ⟨10.1093/annonc/mdx108⟩ Article dans une revue hal-01604339v1
Colon Immune-Related Adverse Events: Anti-CTLA-4 and Anti-PD-1 Blockade Induce Distinct Immunopathological Entities Clelia Coutzac,Julien Adam,Emilie Soularue,Michael Collins,Antoine Racineet al. Journal of Crohn's and Colitis, 2017, 11 (10), pp.1238-1246. ⟨10.1093/ecco-jcc/jjx081⟩ Article dans une revue hal-02625648v1
Inflammatory bowel disease and cancer response due to anti-CTLA-4: is it in the flora? Franck Carbonnel,Emilie Soularue,Clélia Coutzac,Nathalie Chaput,Christine Mateuset al. Seminars in Immunopathology, 2017, 39 (3), pp.327-331. ⟨10.1007/s00281-016-0613-x⟩ Article dans une revue (article de synthèse) hal-01607061v1
Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC Benjamin Besse,Melinda Charrier,Valerie Lapierre,Eric Dansin,Olivier Lantzet al. OncoImmunology, 2016, 5 (4), ⟨10.1080/2162402X.2015.1071008⟩ Article dans une revue hal-01440237v1
IL-15 Trans-Signaling with the Superagonist RLI Promotes Effector/Memory CD8+ T Cell Responses and Enhances Antitumor Activity of PD-1 Antagonists Mélanie Desbois,Pauline Le Vu,Clélia Coutzac,Elie Marcheteau,Coralie Béalet al. Journal of Immunology, 2016, 197 (1), pp.168 - 178. ⟨10.4049/jimmunol.1600019⟩ Article dans une revue inserm-01823361v1
Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25 Dalil Hannani,Marie Vétizou,David Enot,Sylvie Rusakiewicz,Nathalie Chaputet al. Cell Research, 2015, 25 (2), pp.208-224. ⟨10.1038/cr.2015.3⟩ Article dans une revue hal-02047405v1
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota Marie Vétizou,Jonathan M. Pitt,Romain Daillere,Patricia Lepage,Nadine Waldschmittet al. Science, 2015, 350 (6264), pp.1079-1084. ⟨10.1126/science.aad1329⟩ Article dans une revue hal-02639698v1
Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering Ana I Romero,Nathalie Chaput,Vichnou Poirier-Colame,Sylvie Rusakiewicz,Nicolas Jacquelotet al. Cancer Research, 2014, 74 (1), pp.68. ⟨10.1158/0008-5472.CAN-13-1186⟩ Article dans une revue inserm-02442721v1
Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nicolas F Delahaye,Sylvie Rusakiewicz,Isabelle Martins,Cédric Ménard,Stephan Rouxet al. Nature Medicine, 2011, 17 (6), pp.700-7. ⟨10.1038/nm.2366⟩ Article dans une revue hal-00665651v1
Contribution of IL-17-producing {gamma}{delta} T cells to the efficacy of anticancer chemotherapy. Yuting Ma,Laetitia Aymeric,Clara Locher,Stephen R Mattarollo,Nicolas F Delahayeet al. Journal of Experimental Medicine, 2011, 208 (3), pp.491-503. ⟨10.1084/jem.20100269⟩ Article dans une revue pasteur-00576679v1
Updated Technology to Produce Highly Immunogenic Dendritic Cell-derived Exosomes of Clinical Grade Sophie Viaud,Stéphanie Ploix,Valérie Lapierre,Clotilde Théry,Pierre-Henri Commereet al. Journal of Immunotherapy, 2011, 34 (1), pp.65-75. ⟨10.1097/CJI.0b013e3181fe535b⟩ Article dans une revue hal-03272286v1
Opposing effects of toll-like receptor (TLR3) signaling in tumors can be therapeutically uncoupled to optimize the anticancer efficacy of TLR3 ligands. Rosa Conforti,Yuting Ma,Yannis Morel,Carine Paturel,Magali Termeet al. Cancer Research, 2010, 70 (2), pp.490-500. ⟨10.1158/0008-5472.CAN-09-1890⟩ Article dans une revue hal-00591518v1
Massive expansion of regulatory T-cells following interleukin 2 treatment during a phase I-II dendritic cell-based immunotherapy of metastatic renal cancer. François M Lemoine,Mustapha Cherai,Camille Giverne,Dalia Dimitri,Michelle Rosenzwajget al. International Journal of Oncology, 2009, 35 (3), pp.569-81 Article dans une revue hal-00420217v1
Dendritic Cell-Derived Exosomes Promote Natural Killer Cell Activation and Proliferation: A Role for NKG2D Ligands and IL-15Rα Sophie Viaud,Magali Terme,Caroline Flament,Julien Taieb,Fabrice Andréet al. PLoS ONE, 2009, 4 (3), pp.e4942. ⟨10.1371/journal.pone.0004942⟩ Article dans une revue pasteur-03360096v1
Natural killer cell IFN-gamma levels predict long-term survival with imatinib mesylate therapy in gastrointestinal stromal tumor-bearing patients. Cédric Ménard,Jean-Yves Blay,Christophe Borg,Stefan Michiels,François Ghiringhelliet al. Cancer Research, 2009, 69 (8), pp.3563-9. ⟨10.1158/0008-5472.CAN-08-3807⟩ Article dans une revue inserm-00484764v1
The dendritic cell-like functions of IFN-producing killer dendritic cells reside in the CD11b+ subset and are licensed by tumor cells. Magali Terme,Grégoire Mignot,Evelyn Ullrich,Mathieu Bonmort,Véronique Minard-Colinet al. Cancer Research, 2009, 69 (16), pp.6590-7. ⟨10.1158/0008-5472.CAN-08-4473⟩ Article dans une revue inserm-00451699v1
The critical role of IL-15 in the antitumor effects mediated by the combination therapy imatinib and IL-2. Grégoire Mignot,Evelyn Ullrich,Mathieu Bonmort,Cédric Ménard,Lionel Apetohet al. Journal of Immunology, 2008, 180 (10), pp.6477-83 Article dans une revue hal-00364426v1
Trans-presentation of IL-15 dictates IFN-producing killer dendritic cells effector functions. Evelyn Ullrich,Mathieu Bonmort,Gregoire Mignot,Benedikt Jacobs,Daniela Bosisioet al. Journal of Immunology, 2008, 180 (12), pp.7887-97 Article dans une revue hal-00363902v1
Dendritic cells and innate defense against tumor cells. Evelyn Ullrich,Cédric Ménard,Caroline Flament,Magali Terme,Grégoire Mignotet al. Cytokine & Growth Factor Reviews, 2008, 19 (1), pp.79-92. ⟨10.1016/j.cytogfr.2007.10.009⟩ Article dans une revue istex inserm-00318515v1
Killer dendritic cells: IKDC and the others. Mathieu Bonmort,Marc Dalod,Grégoire Mignot,Evelyn Ullrich,Nathalie Chaputet al. Current Opinion in Immunology, 2008, epub ahead of print. ⟨10.1016/j.coi.2008.04.006⟩ Article dans une revue istex hal-00294468v1
Therapy-induced tumor immunosurveillance involves IFN-producing killer dendritic cells. Evelyn Ullrich,Mathieu Bonmort,Grégoire Mignot,Nathalie Chaput,Julien Taiebet al. Cancer Research, 2007, 67 (3), pp.851-3. ⟨10.1158/0008-5472.CAN-06-3766⟩ Article dans une revue inserm-00451703v1
Chemoimmunotherapy of Tumors: Cyclophosphamide Synergizes with Exosome Based Vaccines Julien Taieb,Nathalie Chaput,Noël Schartz,Stéphan Roux,Sophie Novaultet al. Journal of Immunology, 2006, 176 (5), pp.2722-2729. ⟨10.4049/jimmunol.176.5.2722⟩ Article dans une revue pasteur-03360098v1
CD4&lt;b&gt;+&lt;/b&gt;CD25&lt;b&gt;+&lt;/b&gt; regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner François Ghiringhelli,Cédric Ménard,Magali Terme,Caroline Flament,Julien Taiebet al. Journal of Experimental Medicine, 2005, 202 (8), pp.1075 - 1085. ⟨10.1084/jem.20051511⟩ Article dans une revue inserm-04685415v1
Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death Noelia Casares,Marie O Pequignot,Antoine Tesniere,François Ghiringhelli,Stéphan Rouxet al. Journal of Experimental Medicine, 2005, 202 (12), pp.1691 - 1701. ⟨10.1084/jem.20050915⟩ Article dans une revue inserm-04685411v1
The potential of exosomes in immunotherapy of cancer Nathalie Chaput,Julien Taïeb,Noël Schartz,Caroline Flament,Sophie Novaultet al. Blood Cells, Molecules and Diseases, 2005, 35 (2), pp.111-115. ⟨10.1016/j.bcmd.2005.05.009⟩ Article dans une revue istex pasteur-03360103v1
Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial. Bernard Escudier,Thierry Dorval,Nathalie Chaput,Fabrice André,Marie-Pierre Cabyet al. J Transl Med, 2005, 3, pp.10. ⟨10.1186/1479-5876-3-10⟩ Article dans une revue inserm-00092539v1
Immune response against dying tumor cells. Laurence Zitvogel,Noelia Casares,Marie O Péquignot,Nathalie Chaput,Matthew L Albertet al. Advances in immunology, 2004, pp.131-79. ⟨10.1016/S0065-2776(04)84004-5⟩ Article dans une revue pasteur-01402386v1