Charles-Adrien RICHARD

Publications

Pré-publication, Document de travail (3)

Can Plitidepsin Be Used as an Antiviral Against RSV? Charlotte Estampes,Jenna Fix,Julien Sourimant,Priscila Sutto-Ortiz,Charles-Adrien Richardet al. 2025 Pré-publication, Document de travail hal-05155899v1
Specific targeting and clustering of Phosphatidylserine lipids by RSV M protein is critical for virus particle production Jitendriya Swain,Maxime Bierre,Laura Veyrié,Charles-Adrien Richard,Jean-François Éléouëtet al. 2024 Pré-publication, Document de travail hal-04684084v1
Hardening of Respiratory Syncytial Virus Inclusion Bodies by Cyclopamine Proceeds through Perturbation of the Interactions between the M2-1 Protein, RNA and the P Protein Cédric Diot,Charles-Adrien Richard,Jennifer Risso-Ballester,Davy Martin,Jenna Fixet al. 2024 Pré-publication, Document de travail hal-04684081v1

Article dans une revue (39)

Regulation of respiratory syncytial virus nucleoprotein oligomerization by phosphorylation Vincent Basse,Yao Wang,Carine Rodrigues-Machado,Céline Henry,Charles-Adrien Richardet al. Journal of Biological Chemistry, 2025, 301 (3), pp.108256. ⟨10.1016/j.jbc.2025.108256⟩ Article dans une revue hal-04952022v1
Intranasal spike and nucleoprotein fusion protein-based vaccine provides cross-protection and reduced transmission against SARS-CoV-2 variants Zineb Lakhrif,Agathe Poupée-Beaugé,Fanny Boursin,Céline Ducournau,Louis Lantieret al. NPJ vaccines, 2025, 10 (1), pp.75. ⟨10.1038/s41541-025-01123-y⟩ Article dans une revue hal-05046705v1
Can plitidepsin be used as an antiviral against RSV? Charlotte Estampes,Jenna Fix,Julien Sourimant,Priscila Sutto-Ortiz,Charles-Adrien Richardet al. MSphere, 2025, 10 (12), ⟨10.1128/msphere.00127-25⟩ Article dans une revue hal-05399147v1
Selective targeting and clustering of phosphatidylserine lipids by RSV M protein is critical for virus particle production Jitendriya Swain,Maxime Bierre,Laura Veyrié,Charles-Adrien Richard,Jean-François Eléouëtet al. Journal of Biological Chemistry, 2023, 299 (11), pp.105323. ⟨10.1016/j.jbc.2023.105323⟩ Article dans une revue hal-04283163v1
Hardening of Respiratory Syncytial Virus Inclusion Bodies by Cyclopamine Proceeds through Perturbation of the Interactions of the M2-1 Protein with RNA and the P Protein Cédric Diot,Charles-Adrien Richard,Jennifer Risso-Ballester,Davy Martin,Jenna Fixet al. International Journal of Molecular Sciences, 2023, 24 (18), pp.13862. ⟨10.3390/ijms241813862⟩ Article dans une revue hal-04239191v1
Investigation of the Fuzzy Complex between RSV Nucleoprotein and Phosphoprotein to Optimize an Inhibition Assay by Fluorescence Polarization Silva Khodjoyan,Deborha Morissette,Fortune Hontonnou,Luis Checa Ruano,Charles-Adrien Richardet al. International Journal of Molecular Sciences, 2023, 24 (1), pp.569. ⟨10.3390/ijms24010569⟩ Article dans une revue hal-04012024v1
Characterization of the Interaction Domains between the Phosphoprotein and the Nucleoprotein of Human Metapneumovirus Hortense Decool,Benjamin Bardiaux,Luis Checa Ruano,Olivier Sperandio,Jenna Fixet al. Journal of Virology, 2022, 96 (2), pp.e0090921. ⟨10.1128/JVI.00909-21⟩ Article dans une revue hal-03579501v2
Importance of RNA length for in vitro encapsidation by the nucleoprotein of human respiratory syncytial virus Lorène Gonnin,Charles-Adrien Richard,Irina Gutsche,Didier Chevret,Joris Troussieret al. Journal of Biological Chemistry, 2022, 298 (9), pp.102337. ⟨10.1016/j.jbc.2022.102337⟩ Article dans une revue hal-03797501v2
Tetramerization of Phosphoprotein Is Essential for Respiratory Syncytial Virus Budding while Its N-Terminal Region Mediates Direct Interactions with the Matrix Protein Monika Bajorek,Marie Galloux,Charles-Adrien Richard,Or Szekely,Rina Rosenzweiget al. Journal of Virology, 2021, 95, ⟨10.1128/jvi.02217-20⟩ Article dans une revue hal-04635668v2
PB1-F2 amyloid-like fibers correlate with proinflammatory signaling and respiratory distress in influenza-infected mice Christophe Chevalier,Olivier Leymarie,Laura Sedano,Bruno da Costa,Charles-Adrien Richardet al. Journal of Biological Chemistry, 2021, 297 (1), ⟨10.1016/j.jbc.2021.100885⟩ Article dans une revue hal-03299147v1
Targeting the Respiratory Syncytial Virus N 0 -P Complex with Constrained α-Helical Peptides in Cells and Mice Marie Galloux,Nadège Gsponer,Vanessa Gaillard,Brice Fenner,Thibaut Larcheret al. Antimicrobial Agents and Chemotherapy, 2020, 64 (10), ⟨10.1128/AAC.00717-20⟩ Article dans une revue hal-03353101v1
De novo protein design enables the precise induction of RSV-neutralizing antibodies Fabian Sesterhenn,Che Yang,Jaume Bonet,Johannes T. Cramer,Xiaolin Wenet al. Science, 2020, 368 (6492), ⟨10.1126/science.aay5051⟩ Article dans une revue hal-02677103v1
Minimal Elements Required for the Formation of Respiratory Syncytial Virus Cytoplasmic Inclusion Bodies In Vivo and In Vitro Marie Galloux,Jennifer Risso-Ballester,Charles-Adrien Richard,Jenna Fix,Marie-Anne Rameix-Weltiet al. mBio, 2020, 11 (5), ⟨10.1128/mBio.01202-20⟩ Article dans une revue hal-02954783v1
Does intrinsic disorder in proteins favor their Interaction with lipids? Evgenia Deryusheva,Ekaterina Nemashkalova,Marie Galloux,Charles-Adrien Richard,Jean Francois Eleouetet al. Proteomics, 2019, 19 (6), pp.1-9. ⟨10.1002/pmic.201800098⟩ Article dans une revue hal-02626958v1
A DNA vaccine encoding the Gn ectodomain of Rift Valley Fever virus protects mice via a humoral response decreased by DEC205 targeting Tiphany Chrun,Sandra Lacote,Celine Urien,Charles-Adrien Richard,Matthias Tenbuschet al. Frontiers in Immunology, 2019, 10, 15 p. ⟨10.3389/fimmu.2019.00860⟩ Article dans une revue hal-02624043v1
The interactome analysis of the Respiratory Syncytial Virus protein M2-1 suggests a new role in viral mRNA metabolism post- transcription Camille Bouillier,Gina Cosentino,Thibaut Leger,Vincent Rincheval,Charles-Adrien Richardet al. Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-51746-0⟩ Article dans une revue hal-02907594v1
Biochemical characterization of the respiratory syncytial virus N0-P complex in solution Camille Esneau,Bertrand Raynal,Pierre Roblin,Sébastien Brûlé,Charles-Adrien Richardet al. Journal of Biological Chemistry, 2019, 294 (10), pp.3647-3660. ⟨10.1074/jbc.RA118.006453⟩ Article dans une revue hal-02276899v1
RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription Charles-Adrien Richard,Vincent Rincheval,Safa Lassoued,Jenna Fix,Christophe Cardoneet al. PLoS Pathogens, 2018, 14 (3), pp.e1006920. ⟨10.1371/journal.ppat.1006920⟩ Article dans une revue hal-01740353v1
First demonstration of the circulation of a pneumovirus in French pigs by detection of anti-swine orthopneumovirus nucleoprotein antibodies Charles-Adrien Richard,Caroline Hervet,Déborah Ménard,Irina Gutsche,Valérie Normandet al. BMC Veterinary Research, 2018, 49 (1), ⟨10.1186/s13567-018-0615-x⟩ Article dans une revue hal-01964289v1
The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex Muniyandi Selvaraj,Kavestri Yegambaram,Eleanor J a A Todd,Charles-Adrien Richard,Rachel L Dodset al. mBio, 2018, 9 (6), ⟨10.1128/mBio.01554-18⟩ Article dans une revue hal-04283277v1
The structure of the human respiratory syncytial virus M2-1 protein bound to the interaction domain of the phosphoprotein P defines the orientation of the complex Muniyandi Selvaraj,Kavestri Yegambaram,Eleanor J. A. A. Todd,Charles-Adrien Richard,Rachel L. Dodset al. mBio, 2018, 9 (6), ⟨10.1128/mBio.01554-18⟩ Article dans une revue hal-02621034v1
Reversible unfolding of infectious prion assemblies reveals the existence of an oligomeric elementary brick Angélique Igel-Egalon,Mohammed Moudjou,Davy Martin,Alexandra Busley,Tina Knäppleet al. PLoS Pathogens, 2017, 13 (9), ⟨10.1371/journal.ppat.1006557⟩ Article dans une revue hal-02619876v1
Corrigendum: A Universal Influenza Vaccine Can Lead to Disease Exacerbation or Viral Control Depending on Delivery Strategies Cindy Bernelin-Cottet,Charlotte Deloizy,Ondrej Stanek,Céline Barc,Edwige Bouguyonet al. Frontiers in Immunology, 2017, 8, pp.831. ⟨10.3389/fimmu.2017.00831⟩ Article dans une revue hal-02618722v1
N-terminal domain of PB1-F2 protein of influenza A virus can fold into amyloid-like oligomers and damage cholesterol and cardiolipid containing membranes Dalila Ajjaji,Charles-Adrien Richard,Sandra Mazerat,Christophe Chevalier,Jasmina Vidic Biochemical and Biophysical Research Communications, 2016, 477 (1), pp.27-32. ⟨10.1016/j.bbrc.2016.06.016⟩ Article dans une revue hal-02636639v1
A Universal Influenza Vaccine Can Lead to Disease Exacerbation or Viral Control Depending on Delivery Strategies Cindy Bernelin-Cottet,Charlotte Deloizy,Ondrej Stanek,Céline Barc,Edwige Bouguyonet al. Frontiers in Immunology, 2016, 8, pp.1-1. ⟨10.3389/fimmu.2016.00641⟩ Article dans une revue hal-01569908v1
Targeting human respiratory syncytial virus transcription anti-termination factor M2-1 to inhibit &lt;em&gt;in vivo&lt;/em&gt; viral replication B. Bailly,Charles-Adrien Richard,G. Sharma,L. Wang,L. Johansenet al. Scientific Reports, 2016, 6, ⟨10.1038/srep25806⟩ Article dans une revue hal-02637632v1
Amyloid assemblies of influenza a virus PB1-F2 protein Damage membrane and induce cytotoxicity Jasmina Vidic,Charles-Adrien Richard,Christine Péchoux,Bruno B. da Costa,Nicolas N. Berthoet al. Journal of Biological Chemistry, 2016, 291 (2), pp.739-751. ⟨10.1074/jbc.M115.652917⟩ Article dans une revue hal-02637618v1
Interaction between Shadoo and PrP Affects the PrP-Folding Pathway Danica Ciric,Charles-Adrien Richard,Mohammed Moudjou,Jérôme Chapuis,Pierre Sibilleet al. Journal of Virology, 2015, 89 (12), pp.6287-6293. ⟨10.1128/JVI.03429-14⟩ Article dans une revue hal-02636090v1
Identification and Characterization of the Binding Site of the Respiratory Syncytial Virus Phosphoprotein to RNA-Free Nucleoprotein Marie Galloux,Gaëlle Gabiane,Julien Sourimant,Charles-Adrien Richard,Patrick Englandet al. Journal of Virology, 2015, 89 (7), pp.3484-3496. ⟨10.1128/jvi.03666-14⟩ Article dans une revue hal-04678676v1
Purification and Refolding to Amyloid Fibrils of (His)-tagged Recombinant Shadoo Protein Expressed as Inclusion Bodies in [i]E. Coli[/i] Qiaojing Li,Charles-Adrien Richard,Mohammed Moudjou,Jasmina Vidic Journal of visualized experiments : JoVE, 2015, 106, ⟨10.3791/53432⟩ Article dans une revue hal-01309645v1
Highly infectious prions generated by a single round of microplate-based protein misfolding cyclic amplification Mohammed M. Moudjou,Pierre Sibille,Guillaume Fichet,Fabienne Reine,Jerome Chapuiset al. mBio, 2014, 5 (1), ⟨10.1128/mBio.00829-13⟩ Article dans une revue hal-02636078v1
Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation Sian J. Tanner,Antonio Ariza,Charles-Adrien Richard,Hannah F. Kyle,Rachel L. Dodset al. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (4), pp.1580-1585. ⟨10.1073/pnas.1317262111⟩ Article dans une revue hal-02631183v1
Electrochemical Detection of the Oligomerization of PB1-F2 Influenza A Virus Protein in Infected Cells Anna Miodek,Jasmina Vidic,Helene Sauriat-Dorizon,Charles-Adrien Richard,Ronan Le Gofficet al. Analytical Chemistry, 2014, 86 (18), pp.9098 - 9105. ⟨10.1021/ac5018056⟩ Article dans une revue hal-02635306v1
Highly Infectious Prions Generated by a Single Round of Microplate-Based Protein Misfolding Cyclic Amplification Mohammed Moudjou,Pierre Sibille,Guillaume Fichet,Fabienne Reine,Jérôme Chapuiset al. mBio, 2014, 5 (1), ⟨10.1128/mBio.00829-13⟩ Article dans une revue hal-03402322v1
Detection of soluble oligomers formed by PB1-F2 influenza A virus protein in vitro Jasmina Vidic,Ronan Le Goffic,Anna Miodek,Christiane Bourdieu,Charles-Adrien Richardet al. Journal of Analytical & Bioanalytical Techniques, 2013, 4 (3), pp.1-2. ⟨10.4172/2155-9872.1000169⟩ Article dans une revue hal-02642907v1
Surface plasmon resonance immunosensor for detection of pb1-f2 influenza a virus protein in infected biological samples Jasmina Vidic,Christophe Chevalier,Ronan Le Goffic,Anna Miodek,Christiane Bourdieuet al. Journal of Analytical & Bioanalytical Techniques, 2013, S7, ⟨10.4172/2155-9872.S7-006⟩ Article dans une revue hal-02642777v1
Shadoo binds lipid membranes and undergoes aggregation and fibrillization Qiaojing Li,Christophe Chevalier,Celine C. Henry,Charles-Adrien Richard,Mohammed M. Moudjouet al. Biochemical and Biophysical Research Communications, 2013, 438 (3), pp.519 - 525. ⟨10.1016/j.bbrc.2013.07.104⟩ Article dans une revue istex hal-02643069v1
Molecular dynamics studies of the nucleoprotein of influenza A virus: role of the protein flexibility in RNA binding Bogdan Tarus,Christophe Chevalier,Charles-Adrien Richard,Bernard B. Delmas,Carmelo Di Primoet al. PLoS ONE, 2012, 7 (1), pp.e30038. ⟨10.1371/journal.pone.0030038⟩ Article dans une revue hal-02647086v1
Development and validation of a method for fipronil residue determination in ovine plasma using 96-well plate solid-phase extraction and gas chromatography-tandem mass spectrometry Emmanuelle Bichon,Charles-Adrien Richard,Bruno Le Bizec Journal of Chromatography A, 2008, 1201 (1), pp.91-99. ⟨10.1016/j.chroma.2008.06.024⟩ Article dans une revue istex hal-02663818v1

Communication dans un congrès (6)

FINE-TUNED REGULATION OF THE RESPIRATORY SYNCYTIAL VIRUS NUCLEOPROTEIN BY POSTTRANSLATIONAL MODIFICATIONS Vincent Basse,Julien Sourimant,Carine Machado Rodrigues,Céline Henry,Charles-Adrien Richardet al. negative sense virus meeting 2025, Jun 2025, Montpellier, France Communication dans un congrès hal-05156402v1
Disordered, fuzzy and sticky: NMR insights into respiratory syncytial virus phosphoprotein, an adaptor-like protein. Christophe Cardone,Silva Khodjoyan,Stéphanie Deville-Foillard,Philippe Durand,Charles-Adrien Richardet al. Symposium ICSN60(2+), Jun 2022, Gif-sur-Yvette, France Communication dans un congrès hal-04397333v1
NMR insight into transient structures and interactions within the RNA polymerase of the bronchiolitis virus. Christophe Cardone,Nelson Pereira,Safa Lassoued,Déborha Morissette,Charles-Adrien Richardet al. EUROISMAR 2019, Aug 2019, Berlin, Germany Communication dans un congrès hal-04397556v1
Cartographie et caractérisation de la région d'interaction de la phosphoprotéine P avec la protéine M2-1 du Virus Respiratoire Syncytial Charles-Adrien Richard,Safa Lassoued,Christina Sizun,Jean Francois Eleouet 13. Journées d'Animation Scientifique du Département de Santé Animale (JAS), May 2016, Futuroscope - Poitiers, France Communication dans un congrès hal-01604086v1
Highly infectious prions generated by a single round of microplate-based protein misfolding cyclic amplification Mohammed M. Moudjou,Pierre Sibille,Guillaume Fichet,Fabienne Reine,Jerome Chapuiset al. International Prion Congress 2014, May 2014, Trieste, Italy. ⟨10.4161/pri.29370⟩ Communication dans un congrès hal-02739413v1
Prion-like Shadoo protein and its interactions with lipid membranes. Qiaojing Li,Danica Ciric,Charles-Adrien Richard,Stephane Biacchesi,Christophe Chevalieret al. SFBBM-SFB congrès 2012, 2012, Grenoble, France Communication dans un congrès hal-01191378v1

Poster de conférence (13)

Structural and dynamic insights into RSV phosphoprotein, a viral platform protein. Christophe Cardone,Charles-Adrien Richard,Monika Bajorek,Jean-François Eleouet,Marie Gallouxet al. 66th Biophysical Society Annual Meeting, Feb 2022, San Francisco (CA), United States Poster de conférence hal-04397351v1
Structural and dynamic insights by NMR into RSV phosphoprotein, a viral platform protein. Christophe Cardone,Charles-Adrien Richard,Monika Bajorek,Jean-François Eleouet,Marie Gallouxet al. XXIVemes Journées Francophones de Virologie, Apr 2022, Strasbourg, France Poster de conférence hal-04397347v1
The identification of a porcine pneumovirus from an immunological perspective Caroline Hervet,Charles-Adrien Richard,Irina Gutsche,Valérie Normand,Mily Leblanc-Maridoret al. International Veterinary Immunology Symposium (IVIS), Aug 2019, Seattle, United States. , 176 p., 2019, International Veterinary Immunology Symposium (IVIS) Poster de conférence hal-02737240v1
Quand un virus pathogène détourne la machinerie cellulaire à son avantage Charles-Adrien Richard,Vincent Rincheval,Christophe Cardone,Camille Esneau,Marie Gallouxet al. Journées d'Animation Scientifique du Département Santé Animale, Oct 2018, Nantes, France. 2018 Poster de conférence hal-01901481v1
Effect of mutations in the gene-end sequence on RSV transcription Jean-François Eleouet,Charles-Adrien Richard 17. International Conference on Negative Strand Viruses (NSV 2018), Jun 2018, Vérone, Italy. , 354 p., 2018, 17th NSV 2018 - Abstract Book Poster de conférence hal-01833633v1
Dephosphorylation of respiratory syncytial M2-1 protein by the cellular phosphatase PP1 is required for its mRNA binding ability Jean-François Eleouet,Charles-Adrien Richard,Vincent Rincheval,Christophe Cardone,Camille Esneauet al. 17. International Conference on Negative Strand Viruses (NSV 2018), Jun 2018, Vérone, Italy. , 354 p., 2018, 17th NSV 2018 - Abstract Book Poster de conférence hal-01833641v1
How structural order/disorder transitions modulate interactions in RSV phosphoprotein Christophe Cardone,Nelson Pereira,Safa Lassoued,Charles-Adrien Richard,Jenna Fixet al. 19. IUPAB Congress / 11. EBSA Congress, Jul 2017, Édimbourg, United Kingdom. Editions Springer, European Biophysics Journal, 46 (Supplement 1), 449 p., 2017, 19th IUPAB and 11th EBSA Congress, Edinburgh, Scotland, 16–20 July, 2017 – Abstracts. ⟨10.1007/s00249-017-1222-x⟩ Poster de conférence hal-02738385v1
La phosphoprotéine P du Virus Respiratoire Syncytial recrute la protéine phosphatase-1 cellulaire afin de réguler la phosphorylation de M2-1, facteur viral de transcription, ainsi que son activité Charles-Adrien Richard,Safa Lassoued,Jenna Fix,Camille Esneau,Sergeï Nekhaiet al. 19. Journées Francophones de Virologie, Mar 2017, Paris, France. John Libbey Eurotex, Virologie, 21 (2), pp.112, 2017, Virologie Poster de conférence hal-01545647v1
Cartographie et caractérisation du domaine d'interaction de la Phosphoprotéine P avec le protéine M2-1 du Virus Respiratoire Syncytial Humain Charles-Adrien Richard,Safa Lassoued,Christina Sizun,Jean Francois Eleouet XVIIIièmes Journées Francophones de Virologie, Mar 2016, Paris, France. Virologie, 20 (2), 136 p., 2016, Virologie. ⟨10.1684/vir.2016.0641⟩ Poster de conférence hal-01491465v1
Fine mapping and characterization of the binding domain of the HRSV Phosphoprotein with the M2-1 protein Charles-Adrien Richard,Anne-Laure Gaillard,Camille Esneau,Christina Sizun,Jean Francois Eleouet 16. International Conference on Negative Strand Viruses, Jun 2015, Siena, Italy. , 2015 Poster de conférence hal-01408013v1
La protéine M2-1 du Virus Respiratoire Syncytial, une nouvelle cible potentiel pour des antiviraux Charles-Adrien Richard,Benjamin Bailly,Ralf Altmeyer,John N. Barr,Jean Francois Eleouet XVIIièmes Journées Francophones de Virologie, Apr 2015, Paris, France. Virologie, 19 (2), pp.108, 2015, Virologie. ⟨10.1684/vir.2015.0596⟩ Poster de conférence hal-01354216v1
Etude fonctionnelle de la protéine M2-1 du virus respiratoire syncytial à l'aide d'un miniréplicon en cellules eucaryotes Charles-Adrien Richard,Marie-Lise Blondot,Jean Francois Eleouet 16. Journées Francophones de Virologie, 2014, Paris, France. Virologie, 18 (suppl.), pp.72, 2014, Virologie Poster de conférence hal-01309646v1
Etude fonctionnelle de la protéine M2-1 du virus respiratoire syncytial à l'aide d'un minigénome en cellules eucaryotes Charles-Adrien Richard,Marie-Lise Blondot,Jean-François Eléouët Journées d'Animation Scientifique du Département Santé Animale, Oct 2013, Cap d'Agde, France. 2013 Poster de conférence hal-02750318v1

Thèse (1)

La protéine M2-1 du Virus Respiratoire Syncytial : structure et interactions avec des partenaires viraux et cellulaires Charles-Adrien Richard Virologie. Université Paris Saclay (COMUE), 2017. Français. ⟨NNT : ⟩ Thèse tel-02789859v1