Charlie Wilson

Identifiants chercheurs

IdHAL :

charlie-wilson

ORCID :

0000-0001-9497-919X

ResearcherID :

http://www.researcherid.com/rid/H-3059-2014

Présentation

I study the neural dynamics of frontal cortical networks during adaptive behaviour and learning to learn in humans and macaques. I want to understand how the brain dynamics linked to cognition emerge during long term learning, and how those dynamics contribute to a cognitive system that is flexible and efficient. To do this we make recordings of neural activity whilst human and monkey subjects perform cognitive tasks, and in particular learn to perform those tasks more efficiently. The aim is to track the emergence of so-called executive processes, and in particular to track the neural dynamics that are necessary to put in place such processes. My recent and future work in this field has focused on cortical oscillations. Cortical oscillations subserve interaction between assemblies in the brain, and we wish to reveal how cortical oscillations build up the dynamical networks necessary to acquire and perform complex cognitive tasks.

Current projects

We are studying the way in which cortical assemblies interact in order to subserve 'learning to learn', the principle of improving one's learning, becoming flexible in one's learning, and applying task sets appropriate to a given situation. We will study the very specific interactions of the midcingulate cortex and posterior parietal cortex with prefrontal cortex. This project also involves the development of pathway specific DREADD interventions, to reveal the causal influence of the interaction mechanisms revealed by the neurophysiological recordings. Finally the project will also see the development of free-access testing and recording in macaques, a significant refinement in this work. The project is funded by the French ANR.

In collaboration with Véronique Sgambato of the Institut des Sciences Cognitives Marc Jeannerod also in Lyon, we are further developing the pathway specific DREADD interventions to target striato-cortical pathways implicated in impulsivity. As part of this project we will use PET scanning to provide detailed pharmacological analysis of novel and prospective DREADD actuators, specifically within the dopaminergic and serotoninergic systems. This project is funded by Fondation Neurodis.

We are studying the bursting properties of frontal and parietal cortical oscillations, in the context of tasks requiring animals to explore and exploit their environment, and to decide when to switch between the two behaviours.

We seek to understand how oscillations and other neurophysiological markers change during the early stages of Parkinson's disease prior to the development of the classical symptoms of the disease. This project has clear clinical benefits in terms of understanding early neuro-degeneration, but also brings fundamental knowledge about the assemblies of the frontal cortex and their relation to dopamine.

Publications

Article dans une revue (36)

Motivational control is implemented by a cingulo-prefrontal network Clémence Gandaux,Jérôme Sallet,Céline Amiez,Delphine Autran-Clavagnier,Valentine Morel-Latouret al. Current Biology, 2025, ⟨10.1016/j.cub.2025.10.003⟩ Article dans une revue hal-05360035v1
The prefrontal operculum, a human-specific hub for the cognitive control of speech Charles Verstraete,Elsa Lazzaro,Delphine Autran-Clavagnier,Manon Dirheimer,Fadila Hadj-Bouzianeet al. Communications Biology, 2025, 8, pp.1731. ⟨10.1038/s42003-025-09110-8⟩ Article dans une revue hal-05393101v1
Simulations reveal that beta burst detection may inappropriately characterize the beta band Zachary Langford,Charles Wilson Journal of Neurophysiology, 2025, ⟨10.1152/jn.00125.2024⟩ Article dans une revue hal-05125810v1
Differential functional organization of amygdala-medial prefrontal cortex networks in macaque and human Camille Giacometti,Delphine Autran-Clavagnier,Audrey Dureux,Laura Viñales,Franck Lambertonet al. Communications Biology, 2024, 7 (1), pp.269. ⟨10.1038/s42003-024-05918-y⟩ Article dans une revue hal-04749607v1
Medial to lateral frontal functional connectivity mapping reveals the organization of cingulate cortex Marion Ducret,Camille Giacometti,Manon Dirheimer,Audrey Dureux,Delphine Autran-Clavagnieret al. Cerebral Cortex, 2024, 34 (8), pp.bhae322. ⟨10.1093/cercor/bhae322⟩ Article dans une revue hal-04671739v1
A revised perspective on the evolution of the lateral frontal cortex in primates Céline Amiez,Jérôme Sallet,Camille Giacometti,Charles Verstraete,Clémence Gandauxet al. Science Advances , 2023, 9 (20), pp.eadf9445. ⟨10.1126/sciadv.adf9445⟩ Article dans une revue hal-04237941v1
The relevance of the unique anatomy of the human prefrontal operculum to the emergence of speech Céline Amiez,Charles Verstraete,Jérôme Sallet,Fadila Hadj-Bouziane,Suliann Ben Hamedet al. Communications Biology, 2023, 6 (1), pp.693. ⟨10.1038/s42003-023-05066-9⟩ Article dans une revue hal-04237943v1
Frontal effective connectivity increases with task demands and time on task: a Dynamic Causal Model of electrocorticogram in macaque monkeys Katharina Wegner,Charles Wilson,Emmanuel Procyk,Karl Friston,Frederik van de Steenet al. Neurons, Behavior, Data analysis, and Theory, 2023, 6 (1), ⟨10.51628/001c.68433⟩ Article dans une revue hal-04749640v1
A response to claims of emergent intelligence and sentience in a dish Fuat Balci,Suliann Ben Hamed,Thomas Boraud,Sébastien Bouret,Thomas Brochieret al. Neuron, 2023, 111 (5), pp.604-605. ⟨10.1016/j.neuron.2023.02.009⟩ Article dans une revue (compte-rendu de lecture) hal-04012408v1
Toward next-generation primate neuroscience: A collaboration-based strategic plan for integrative neuroimaging Michael Milham,Chris Petkov,Pascal Belin,Suliann Ben Hamed,Henry Evrardet al. Neuron, 2022, 110 (1), pp.16-20. ⟨10.1016/j.neuron.2021.10.015⟩ Article dans une revue hal-03800370v1
Induced Cognitive Impairments Reversed by Grafts of Neural Precursors: a Longitudinal Study in a Macaque Model of Parkinson’s Disease Florence Wianny,Kwamivi Dzahini,Karim Fifel,Charles R.E. Wilson,Agnieszka Bernatet al. Advanced Science, 2022, 9 (10), pp.2103827. ⟨10.1002/advs.202103827⟩ Article dans une revue hal-03436232v2
Frontal cortical functional connectivity is impacted by anaesthesia in macaques Camille Giacometti,Audrey Dureux,Delphine Autran-Clavagnier,Charles Wilson,Jérôme Salletet al. Cerebral Cortex, 2022, 32 (18), pp.4050-4067. ⟨10.1093/cercor/bhab465⟩ Article dans une revue hal-03811064v1
The midcingulate cortex and temporal integration Emmanuel Procyk,Vincent Fontanier,Matthieu Sarazin,Bruno Delord,Clément Goussiet al. International Review of Neurobiology, 2021, What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology, 158, pp.395 - 419. ⟨10.1016/bs.irn.2020.12.004⟩ Article dans une revue hal-03755027v1
Formalising planning and information search in naturalistic decision-making Hunt Lt,N. Daw,P. Kaanders,M A Maclaver,U. Muganet al. Nature Neuroscience, 2021, 24 (8), pp.1051-1064. ⟨10.1038/s41593-021-00866-w⟩ Article dans une revue inserm-03354461v1
Imaging evolution of the primate brain: the next frontier? Patrick Friedrich,Stephanie Forkel,Céline Amiez,Joshua H Balsters,Olivier A Coulonet al. NeuroImage, 2021, 228, pp.117685. ⟨10.1016/j.neuroimage.2020.117685⟩ Article dans une revue hal-03167237v1
Accelerating the Evolution of Nonhuman Primate Neuroimaging Michael Milham,Christopher I Petkov,Daniel Margulies,Charles E Schroeder,Michele A Bassoet al. Neuron, 2020, 105 (4), pp.600 - 603. ⟨10.1016/j.neuron.2019.12.023⟩ Article dans une revue hal-02993101v1
Sulcal organization in the medial frontal cortex provides insights into primate brain evolution Céline Amiez,Jerome Sallet,William D. Hopkins,Adrien Meguerditchian,Fadila Hadj-Bouzianeet al. Nature Communications, 2019, 10 (1), pp.3437. ⟨10.1038/s41467-019-11347-x⟩ Article dans une revue hal-02326265v1
An Open Resource for Non-human Primate Imaging Michael Milham,Lei Ai,Bonhwang Koo,Ting Xu,Céline Amiezet al. Neuron, 2018, 100 (1), pp.61-74.e2. ⟨10.1016/j.neuron.2018.08.039⟩ Article dans une revue hal-02326351v1
Variations of cingulate sulcal organization and link with cognitive performance Céline Amiez,Charles R E Wilson,Emmanuel Procyk Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-32088-9⟩ Article dans une revue hal-02324077v1
The Rhesus Monkey Hippocampus Critically Contributes to Scene Memory Retrieval, But Not New Learning Sean Froudist-Walsh,Philip G.F. Browning,Paula L Croxson,Kathy L Murphy,Jul Lea Shamyet al. Journal of Neuroscience, 2018, 38 (36), pp.7800-7808. ⟨10.1523/JNEUROSCI.0832-18.2018⟩ Article dans une revue hal-04802044v1
Midcingulate Motor Map and Feedback Detection: Converging Data from Humans and Monkeys Emmanuel Procyk,Charles R E Wilson,Frederic M Stoll,Maïlys C M Faraut,Michael Petrideset al. Cerebral Cortex, 2016, 26 (2), pp.467-76. ⟨10.1093/cercor/bhu213⟩ Article dans une revue hal-02358077v1
Prefrontal Markers and Cognitive Performance Are Dissociated during Progressive Dopamine Lesion Charles R E Wilson,Julien Vezoli,Frederic M Stoll,Maïlys C M Faraut,Vincent Levielet al. PLoS Biology, 2016, 14 (11), pp.e1002576. ⟨10.1371/journal.pbio.1002576⟩ Article dans une revue inserm-02136898v1
Learning to learn about uncertain feedback Maïlys C.M. Faraut,Emmanuel Procyk,Charles R.E. Wilson Perceptual and Motor Skills, 2016, 23 (2), pp.90-98. ⟨10.1101/lm.039768.115⟩ Article dans une revue hal-04802053v1
The Effects of Cognitive Control and Time on Frontal Beta Oscillations Frederic M Stoll,Charles R.E. Wilson,Maïlys C.M. Faraut,Julien Vezoli,Kenneth Knoblauchet al. Cerebral Cortex, 2016, 26 (4), pp.1715-1732. ⟨10.1093/cercor/bhv006⟩ Article dans une revue hal-02358071v1
A unilateral medial frontal cortical lesion impairs trial and error learning without visual control Céline Amiez,Anne Sophie Champod,Charles R.E. Wilson,Emmanuel Procyk,Michael Petrides Neuropsychologia, 2015, 75, pp.314-321. ⟨10.1016/j.neuropsychologia.2015.06.022⟩ Article dans une revue hal-04819104v1
Increased DAT binding in the early stage of the dopaminergic lesion: A longitudinal [11C]PE2I binding study in the MPTP-monkey Julien Vezoli,Kwamivi Dzahini,Nicolas Costes,Charles R.E. Wilson,Karim Fifelet al. NeuroImage, 2014, 102, pp.249-261. ⟨10.1016/j.neuroimage.2014.07.059⟩ Article dans une revue hal-04804860v1
Causal effect of disconnection lesions on interhemispheric functional connectivity in rhesus monkeys Jill X O’reilly,Paula L Croxson,Saad Jbabdi,Jerome Sallet,Maryann P Noonanet al. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (34), pp.13982-13987. ⟨10.1073/pnas.1305062110⟩ Article dans une revue hal-04804850v1
Degraded transfer of memories between the visual hemifields in normal macaques revealed by a novel infrared eyetracking method without head fixation Charles R.E. Wilson,Mark J Buckley,David Gaffan Neuropsychologia, 2010, 48 (5), pp.1376-1384. ⟨10.1016/j.neuropsychologia.2010.01.003⟩ Article dans une revue hal-04819067v1
Functional localization within the prefrontal cortex: missing the forest for the trees? Charles R.E. Wilson,David Gaffan,Philip G.F. Browning,Mark G Baxter Trends in Neurosciences, 2010, 33 (12), pp.533-540. ⟨10.1016/j.tins.2010.08.001⟩ Article dans une revue hal-04804828v1
Dissociable Roles for Cortical and Subcortical Structures in Memory Retrieval and Acquisition Anna S Mitchell,Philip G F Browning,Charles R E Wilson,Mark G Baxter,David Gaffan Journal of Neuroscience, 2008, 28 (34), pp.8387-8396. ⟨10.1523/JNEUROSCI.1924-08.2008⟩ Article dans une revue hal-04804994v1
Prefrontal–Inferotemporal Interaction Is Not Always Necessary for Reversal Learning Charles R E Wilson,David Gaffan Journal of Neuroscience, 2008, 28 (21), pp.5529-5538. ⟨10.1523/JNEUROSCI.0952-08.2008⟩ Article dans une revue hal-04805000v1
Fornix transection impairs visuospatial memory acquisition more than retrieval. Mark J Buckley,Charles R E Wilson,David Gaffan Behavioral Neuroscience, 2008, 122 (1), pp.44-53. ⟨10.1037/0735-7044.122.1.44⟩ Article dans une revue hal-04818966v1
Addition of fornix transection to frontal‐temporal disconnection increases the impairment in object‐in‐place memory in macaque monkeys C R E Wilson,M G Baxter,A. Easton,D. Gaffan European Journal of Neuroscience, 2008, 27 (7), pp.1814-1822. ⟨10.1111/j.1460-9568.2008.06140.x⟩ Article dans une revue hal-04805013v1
Medial temporal and prefrontal function: Recent behavioural disconnection studies in the macaque monkey David Gaffan,Charles R E Wilson Cortex, 2008, 44 (8), pp.928-935. ⟨10.1016/j.cortex.2008.03.005⟩ Article dans une revue hal-04818436v1
Neurotoxic lesions of ventrolateral prefrontal cortex impair object‐in‐place scene memory Charles R E Wilson,David Gaffan,Anna S Mitchell,Mark G Baxter European Journal of Neuroscience, 2007, 25 (8), pp.2514-2522. ⟨10.1111/j.1460-9568.2007.05468.x⟩ Article dans une revue hal-04805033v1
Fornix Transection Impairs Learning of Randomly Changing Object Discriminations Charles R E Wilson,David P Charles,Mark J Buckley,David Gaffan Journal of Neuroscience, 2007, 27 (47), pp.12868-12873. ⟨10.1523/JNEUROSCI.3536-07.2007⟩ Article dans une revue hal-04805044v1

Communication dans un congrès (2)

COGNITIVE EFFORT MODULATES FRONTAL EFFECTIVE CONNECTIONS: A DYNAMIC CAUSAL MODELING STUDY ON MACAQUE MONKEYS Katharina Wegner,Charles R E Wilson,Emmanuel Procyk,Karl J Friston,Daniele Marinazzo 13th National Congress of the Belgian Society for Neuroscience, 2019, Brussels, Belgium. ⟨10.3389/conf.fnins.2019.96.00059⟩ Communication dans un congrès hal-04969361v1
Cognitive Effort Modulates Frontal Effective Connections Katharina Wegner,Charlie Wilson,Emmanuel Procyk,Karl Friston,Daniele Marinazzo Cognitive Computational Neuroscience Meeting, Sep 2019, Berlin, France Communication dans un congrès hal-04805081v1

Poster de conférence (19)

Network-specific chemogenetic modulation of noradrenergic input to cingulate cortex in macaque C Gandaux,J Sallet,M Ducret,C Goussi-Denjean,P Miseryet al. Symposium on the Biology of Decision Making SBDM 2025, Jun 2025, Lyon, France Poster de conférence hal-05136191v1
Frontal network modulations by pathway-selective chemogenetics modify behaviour of monkeys in a spatial foraging task Clémence Gandaux,Charles R E Wilson,Jérôme Sallet,Marion Ducret,Valentine Morel-Latouret al. Foraging Meeting 2024, Dec 2024, Lyon, France Poster de conférence hal-04971315v1
The neurophysiological basis of learning to learn in macaque monkeys Marion Ducret,Emmanuel Procyk,Charles R E Wilson FENS 2024, Jun 2024, Vienna, Austria Poster de conférence hal-04969210v1
Transcranial ultrasound neuromodulation induces metabolic and resting-state changes in amygdala J Claron,C Giacometti,S Manickam,V Morel-Latour,C R E Wilsonet al. FENS 2024, Jul 2024, Vienna, Austria Poster de conférence hal-05136208v1
MCC-DLPFC network modulation by pathway-specific DREADDs in macaque monkeys: behavioral, resting-state fMRI and histological validation Clémence Gandaux,Charles R E Wilson,Jérôme Sallet,Céline Amiez,Delphine Autran-Clavagnieret al. FENS 2024, Jul 2024, Vienna, Austria Poster de conférence hal-04971286v1
Environment reward structure shapes exploration and strategy in humans and non-human primates Mojtaba Alavi,Charles R E Wilson,Emmanuel Procyk,S. Ben Hamed NeuroFrance 2023, May 2023, Lyon, France Poster de conférence hal-04969348v1
The neurophysiological basis of learning in naive macaque monkeys Marion Ducret,Emmanuel Procyk,Charles R E Wilson NeuroFrance 2023, May 2023, Lyon, France Poster de conférence hal-04969300v1
Frontal beta burst properties are an index of motivation and apathy in a macaque model; of Parkinson’s disease Charles R E Wilson,Agathe Godet,Zachary D Langford,Emmanuel Procyk Motivation and Cognitive Control, Oct 2023, Lyon, France Poster de conférence hal-04969229v1
The neurophysiological basis of learning to learn in macaque monkeys Marion Ducret,Emmanuel Procyk,Charles R E Wilson Motivation and Cognitive Control, Oct 2023, Lyon, France Poster de conférence hal-04969235v1
Learning to learn about feedback, and about uncertain feedback Charles R E Wilson,Marion Ducret,Maïlys C.M. Faraut,Emmanuel Procyk FENS Brain Conference: Structuring Knowledge for Flexible Behaviour, Oct 2023, Rungstedgaard, Denmark Poster de conférence hal-04969220v1
Network modulation by pathway specific chemogenetics in frontal cortex of macaque monkey Clémence Gandaux,Charles R E Wilson,Jérôme Sallet,Céline Amiez,Delphine Autran-Clavagnieret al. NeuroFrance 2023, Jun 2023, Lyon, France Poster de conférence hal-04971306v1
Description of foraging behavior in a naturalistic search task in macaque monkey: Behavioural description and LC/NA-MCC network modulation with pathway-specific chemogenetic Clémence Gandaux,Charles R E Wilson,Marion Ducret,Valentine Morel-Latour,Pierre Miseryet al. Motivation and Cognitive Control, Oct 2023, Lyon, France Poster de conférence hal-04969286v1
What is a burst? Transient beta band phenomena in single-trial frontal oscillatory dynamics have different properties depending on the burst detection method used Zachary D Langford,Emmanuel Procyk,Charles R E Wilson NeuroFrance 2023, May 2023, Lyon, France Poster de conférence hal-04969297v1
Beta oscillations and its role in cognitive control Marion Ducret,Charles R E Wilson GDR NeuralNet 2022, Sep 2022, Lyon, France Poster de conférence hal-04969394v1
What is a burst? Transient beta band phenomena in single-trial frontal oscillatory dynamics have different properties depending on the burst detection method used Zachary D Langford,Emmanuel Procyk,Charles R E Wilson GDR Neural Net 2022, Sep 2022, Lyon, France Poster de conférence hal-04969389v1
MCC-DLPFC network modulation by pathway-specific DREADDs in macaque monkeys: behavioral, restingstate fMRI and histological validation Clémence Gandaux,Charles R E Wilson,Jérôme Sallet,Céline Amiez,Delphine Autran-Clavagnieret al. ViMaMo 2022, Oct 2022, Paris, France Poster de conférence hal-04969408v1
What is a burst? Transient beta band phenomena in single-trial frontal oscillatory dynamics have different properties depending on the burst detection method used Zachary D Langford,Emmanuel Procyk,Charles R E Wilson FENS 2022, Jul 2022, Paris, France Poster de conférence hal-04969398v1
What is a burst? How to systematically detect single trial oscillatory dynamics. Zachary D Langford,Emmanuel Procyk,Charles R E Wilson Symposium on Biology of Decision Making, May 2021, Paris, France Poster de conférence hal-04970802v1
Development of pathway specific DREADDs in macaque monkeys: behavioral and histological studies Clémence Gandaux,Delphine Autran-Clavagnier,Clément Goussi,Marina Lavigne,Eric Kremeret al. NeuroFrance 2021, May 2021, Paris, France Poster de conférence hal-04970773v1

Chapitre d'ouvrage (1)

Meta-learning, cognitive control, and physiological interactions between medial and lateral prefrontal cortex Mehdi Khamassi,Charles R E Wilson,Marie Rothé,René Quilodran,Peter F Domineyet al. Mars, R., Sallet, J., Rushworth, M. and Yeung, N. (Eds.), Neural Bases of Motivational and Cognitive Control, MIT Press, 2011 Chapitre d'ouvrage hal-03415847v1

Pré-publication, Document de travail (6)

Motivational control is implemented by a cingulo-prefrontal pathway Clémence Gandaux,Jérôme Sallet,Céline Amiez,Delphine Autran-Clavagnier,Valentine Morel-Latouret al. 2025 Pré-publication, Document de travail hal-04960709v1
Recherches biomédicales, innovations thérapeutiques et nouvelles technologies médicales en neurosciences -Apports majeurs des modèles primates non-humains R Aron-Badin,T Brochier,F Chavane,J Cléry,E Comoyet al. 2025 Pré-publication, Document de travail hal-05352659v1
Brain Charts for the Rhesus Macaque Lifespan S. Alldritt,J.S.B. Ramirez,R. Vos de Wael,R. Bethlehem,J. Seidlitzet al. 2024 Pré-publication, Document de travail hal-04799859v1
Frontal oscillatory beta bursts have rhythmically distinct regimes with differing functional relevance Zachary D Langford,Emmanuel Procyk,Charles R E Wilson 2024 Pré-publication, Document de travail hal-04801747v1
Simulations reveal that beta burst detection may inappropriately characterize the beta band Zachary D Langford,Charles R E Wilson 2024 Pré-publication, Document de travail hal-04801753v1
Induced Cognitive Impairments Reversed by Grafts of Neural Precursors: a Longitudinal Study in a Macaque Model of Parkinson’s Disease Florence Wianny,Kwamivi Dzahini,Karim Fifel,Charles R.E. Wilson,Agnieszka Bernatet al. 2021 Pré-publication, Document de travail hal-05029500v1

Vidéo (1)

Stem Cell & Brain Research Institute: The NeuroTour of France Charles R E Wilson 2022 Vidéo hal-04970728v1