Charline Kieffer

Publications

Article dans une revue (24)

ID Card of Mcl-1 PROTAC degrader: From in silico design to biological validation in chemoresistant ovarian cancer Marie Cornu,Jocelyn Pezeril,Nicolas Guedeney,Hippolyte Paysant,Thomas Lemaitreet al. European Journal of Medicinal Chemistry Reports, 2026, 17, pp.100336. ⟨10.1016/j.ejmcr.2026.100336⟩ Article dans une revue hal-05583537v1
PROTAC : Nouvelles stratégies thérapeutiques basées sur l’exploitation des voies de dégradation des protéines Marie Cornu,Thomas Lemaitre,Florian Schwalen,Charline Kieffer,Anne Sophie Voisin-Chiret Biologie Aujourd'hui, 2025, 218 (3-4), pp.105-113. ⟨10.1051/jbio/2024010⟩ Article dans une revue istex hal-05583533v1
UBE2N: Hope on the Cancer Front, How to Inhibit This Promising Target Prospect? Florian Schwalen,Côme Ghadi,Léonie Ibazizene,Shafi Ullah Khan,Jana Sopkova-de Oliveira Santoset al. Journal of Medicinal Chemistry, 2025, ⟨10.1021/acs.jmedchem.4c01517⟩ Article dans une revue hal-04885402v1
PROTAC 2.0: Expanding the frontiers of targeted protein degradation Marie Cornu,Thomas Lemaitre,Charline Kieffer,Anne Sophie Voisin-Chiret Drug Discovery Today, 2025, 30 (6), pp.104376. ⟨10.1016/j.drudis.2025.104376⟩ Article dans une revue hal-05583536v1
PROTAC 2.0: Expanding the frontiers of targeted protein degradation Marie Cornu,Thomas Lemaitre,Charline Kieffer,Anne Sophie Voisin-Chiret Drug Discovery Today, 2025, 30 (6), pp.104376. ⟨10.1016/j.drudis.2025.104376⟩ Article dans une revue hal-05472074v1
Towards New Anti‐Inflammatory Agents: Design, Synthesis and Evaluation of Molecules Targeting XIAP‐BIR2 Marc Farag,Nicolas Guedeney,Florian Schwalen,Aymeric Zadoroznyj,Amélie Barczyket al. ChemMedChem, 2024, 20 (2), ⟨10.1002/cmdc.202400567⟩ Article dans une revue hal-05583526v1
Towards New Anti‐inflammatory Agents: Design, Synthesis and Evaluation of Molecules Targeting XIAP‐BIR2 Marc Ragui Farag,Nicolas Guedeney,Florian Schwalen,Aymeric Zadorovnyj,Amelie Barczyket al. ChemMedChem, 2024, pp.e202400567. ⟨10.1002/cmdc.202400567⟩ Article dans une revue hal-04772005v1
Target fishing reveals PfPYK-1 and PfRab6 as potential targets of an antiplasmodial 4-anilino-2-trichloromethylquinazoline hit compound C. Kieffer,N. Primas,S. Hutter,A. Merckx,L. Reiningeret al. Bioorganic and Medicinal Chemistry, 2024, 102, pp.117654. ⟨10.1016/j.bmc.2024.117654⟩ Article dans une revue hal-04503278v1
Molecular glue degraders: exciting opportunities for novel drug discovery Thomas Lemaitre,Marie Cornu,Florian Schwalen,Marc Since,Charline Kiefferet al. Expert Opinion on Drug Discovery, 2024, 19 (4), pp.433-449. ⟨10.1080/17460441.2024.2306845⟩ Article dans une revue hal-04711906v1
Molecular glue degraders: exciting opportunities for novel drug discovery Thomas Lemaitre,Marie Cornu,Florian Schwalen,Marc Since,Charline Kiefferet al. Expert Opinion on Drug Discovery, 2024, 19 (4), pp.433-449. ⟨10.1080/17460441.2024.2306845⟩ Article dans une revue hal-05583519v1
PROTAC technology: A new drug design for chemical biology with many challenges in drug discovery Nicolas Guedeney,Marie Cornu,Florian Schwalen,Charline Kieffer,Anne Sophie Voisin-Chiret Drug Discovery Today, 2023, 28 (1), pp.103395. ⟨10.1016/j.drudis.2022.103395⟩ Article dans une revue hal-03936766v1
Computational Tool to Design Small Synthetic Inhibitors Selective for XIAP-BIR3 Domain Marc Farag,Charline Kieffer,Nicolas Guedeney,Anne Sophie Voisin-Chiret,Jana Sopkova-de Oliveira Santos Molecules, 2023, 28 (13), pp.5155. ⟨10.3390/molecules28135155⟩ Article dans une revue hal-04222485v1
Computational Tool to Design Small Synthetic Inhibitors Selective for XIAP-BIR3 Domain Marc Farag,Charline Kieffer,Nicolas Guedeney,Anne Sophie,Jana Sopkova-de Oliveira Santos Molecules, 2023, ⟨10.3390/molecules28135155⟩ Article dans une revue hal-04148037v1
PROTAC technology: A new drug design for chemical biology with many challenges in drug discovery Nicolas Guedeney,Marie Cornu,Florian Schwalen,Charline Kieffer,Anne Sophie Voisin-Chiret Drug Discovery Today, 2023, 28 (1), pp.103395. ⟨10.1016/j.drudis.2022.103395⟩ Article dans une revue hal-05583541v1
Noncellular screening for the discovery of protein–protein interaction modulators Charline Kieffer,Jean Pierre Jourdan,Marie Jouanne,Anne Sophie Voisin-Chiret Drug Discovery Today, 2020, 25, pp.1592 - 1603. ⟨10.1016/j.drudis.2020.07.012⟩ Article dans une revue hal-03493870v1
Discovery of new hit-molecules targeting Plasmodium falciparum through a global SAR study of the 4-substituted-2-trichloromethylquinazoline antiplasmodial scaffold Justine Desroches,Charline Kieffer,Nicolas Primas,Sébastien Hutter,Armand Gelliset al. European Journal of Medicinal Chemistry, 2017, 125 (128), pp.68-86. ⟨10.1016/j.ejmech.2016.09.029⟩ Article dans une revue hal-01416990v1
Sequential one pot double C H heteroarylation of thiophene using bromopyridines to synthesize unsymmetrical 2,5-bipyridylthiophenes Charline Kieffer,Victor Babin,Marie Jouanne,Ikram Slimani,Yohann Berhaultet al. Tetrahedron, 2017, 73 (37), pp.5509-5516. ⟨10.1016/j.tet.2017.07.049⟩ Article dans une revue istex hal-02043719v1
Preventing the contamination of hospital personnel by cytotoxic agents: evaluation and training of the para-professional healthcare workers in oncology units C. Kieffer,Pierre Verhaeghe,S. Lagrassa,R. Gregoire,Z. Moussaouiet al. European Journal of Cancer Care, 2015, 24 (3), pp.404-410. ⟨10.1111/ecc.12249⟩ Article dans une revue istex hal-01460563v1
Antileishmanial pharmacomodulation in 8-nitroquinolin-2(1H)-one series Charline Kieffer,Anita Cohen,Pierre Verhaeghe,Lucie Paloque,Sébastien Hutteret al. Bioorganic and Medicinal Chemistry, 2015, 23 (10), pp.2377-2386. ⟨10.1016/j.bmc.2015.03.064⟩ Article dans une revue istex hal-01460646v1
Looking for new antileishmanial derivatives in 8-nitroquinolin-2(1H)-one series Charline Kieffer,Anita Cohen,Pierre Verhaeghe,Sébastien Hutter,Caroline Castera-Ducroset al. European Journal of Medicinal Chemistry, 2015, 92, pp.282-294. ⟨10.1016/j.ejmech.2014.12.056⟩ Article dans une revue istex hal-01460569v1
Synthesis and in vitro evaluation of 4-trichloromethylpyrrolo[1,2-a]quinoxalines as new antiplasmodial agents Nicolas Primas,Peggy Suzanne,Pierre Verhaeghe,Sébastien Hutter,Charline Kiefferet al. European Journal of Medicinal Chemistry, 2014, 83, pp.26-35. ⟨10.1016/j.ejmech.2014.06.014⟩ Article dans une revue hal-01417058v1
A new DMAP-catalyzed and microwave-assisted approach for introducing heteroarylamino substituents at position 4 of the quinazoline ring. Armand Gellis,Charline Kieffer,Nicolas Primas,Gilles Lanzada,Michel Giorgiet al. Tetrahedron, 2014, 78 (44), pp.8257-8266. ⟨10.1016/j.tet.2014.09.024⟩ Article dans une revue hal-01417081v1
Sonogashira cross-coupling reaction in 4-chloro-2-trichloromethylquinazoline series is possible despite a side dimerization reaction Charline Kieffer,Pierre Verhaeghe,Nicolas Primas,C. Castera-Ducros,A. Gelliset al. Tetrahedron, 2013, 69 (14), pp.2987-2995. ⟨10.1016/j.tet.2013.01.094⟩ Article dans une revue istex hal-00821454v1
A New Synthetic Route to Original Sulfonamide Derivatives in 2-Trichloromethylquinazoline Series: A Structure-Activity Relationship Study of Antiplasmodial Activity Nicolas Primas,Pierre Verhaeghe,Anita Cohen,Charline Kieffer,Aurélien Dumètreet al. Molecules, 2012, 17 (7), pp.8105-8117. ⟨10.3390/molecules17078105⟩ Article dans une revue hal-01772858v1