Charly Helaine

Publications

Article dans une revue (11)

Proton radiotherapy offers immune-sparing benefits in glioblastoma treatment Proton therapy reduced radiation-induced lymphopenia Julie Coupey,Thao-Nguyen Pham,Jérôme Toutain,Viktoriia Ivanova,Erika Hueet al. International Journal of Radiation Oncology, Biology, Physics, In press, ⟨10.1016/j.ijrobp.2025.12.051⟩ Article dans une revue hal-05478222v1
Injectable Biocompatible Zeolite Nanocrystals for Enhanced Tumor Oxygenation and MRI Imaging Abdallah Amedlous,C Hélaine,Francesco Dalena,Clément Anfray,Thomas Ménardet al. ACS Applied Materials & Interfaces, 2025, 17 (5), pp.8003-8016. ⟨10.1021/acsami.4c20383⟩ Article dans une revue hal-04920878v1
In vivo biodistribution and tumor uptake of [64Cu]-FAU nanozeolite via positron emission tomography Imaging Charly Hélaine,Abdallah Amedlous,Jérôme Toutain,Carole Brunaud,Oleg Lebedevet al. Nanoscale, 2024, 16, pp.11959-11968. ⟨10.1039/d3nr05947b⟩ Article dans une revue hal-04614420v1
Assessment of hypoxia and oxidative-related changes in a lung-derived brain metastasis model by [64Cu][Cu(ATSM)] PET and proteomic studies Jade Fantin,Jérôme Toutain,Elodie A. Pérès,Benoit Bernay,Sarina Maya Mehaniet al. EJNMMI Research, 2023, 13 (102), ⟨10.1186/s13550-023-01052-8⟩ Article dans une revue hal-04308804v1
Functional impact of oxygen-saturated zeolite nanoparticles on macrophages in the context of glioblastoma: an in vitro and in vivo study Aurélie E Ferre,Sarah Komaty,C Hélaine,Clément Anfray,Sajjad Ghojavandet al. Colloids and Surfaces B: Biointerfaces, 2023, 230, pp.113524. ⟨10.1016/j.colsurfb.2023.113524⟩ Article dans une revue hal-04190367v1
Gadolinium-loaded LTL nanosized zeolite for efficient oxygen delivery and magnetic resonance imaging Abdallah Amedlous,C Hélaine,Rémy Guillet-Nicolas,Oleg Lebedev,Valable Samuelet al. Inorganic Chemistry Frontiers, 2023, 10 (9), pp.2665-2676. ⟨10.1039/D3QI00169E⟩ Article dans une revue hal-04250335v1
Internalization study of nanosized zeolite crystals in human glioblastoma cells C Hélaine,Hayriye Özçelik,Sarah Komaty,Abdallah Amedlous,Sajjad Ghojavandet al. Colloids and Surfaces B: Biointerfaces, 2022, 218, pp.112732. ⟨10.1016/j.colsurfb.2022.112732⟩ Article dans une revue hal-03752239v1
Nanosized zeolites as a gas delivery platform in a glioblastoma model Clement Anfray,Sarah Komaty,Aurélien Corroyer-Dulmont,Moussa Zaarour,Charly Hélaineet al. Biomaterials, 2020, 257, pp.120249. ⟨10.1016/j.biomaterials.2020.120249⟩ Article dans une revue hal-02912573v1
Angiopoietin-2 Combined with Radiochemotherapy Impedes Glioblastoma Recurrence by Acting in an Autocrine and Paracrine Manner: A Preclinical Study Charly Hélaine,Aurélie Ferré,Marine Leblond,Elodie Pérès,Myriam Bernaudinet al. Cancers, 2020, 12 (12), pp.3585. ⟨10.3390/cancers12123585⟩ Article dans une revue hal-03082539v1
Copper exchanged FAU nanozeolite as non-toxic nitric oxide and carbon dioxide gas carrier Kamila Goldyn,Clément Anfray,Sarah Komaty,Valerie Ruaux,Charly Hélaineet al. Microporous and Mesoporous Materials, 2019, Special Issue dedicated to the 65 birthday of Prof. Wieslaw J. Roth, 280, pp.271-276. ⟨10.1016/j.micromeso.2019.02.022⟩ Article dans une revue hal-02086878v1
M2 macrophages are more resistant than M1 macrophages following radiation therapy in the context of glioblastoma Marine Leblond,Elodie A. Pérès,Charly Hélaine,Aurélie Gérault,Damien Moulinet al. Oncotarget, 2017, 8 (42), pp.72597-72612. ⟨10.18632/oncotarget.19994⟩ Article dans une revue hal-02100869v1

Communication dans un congrès (14)

Nanoémulsions combinant fénofibrate et oxydes de fer pour le traitement du glioblastome Yasmine Chokry,Anne-Claire Groo,Sophie Corvaisier,C Hélaine,Aurélie Malzert-Fréonet al. 17ème Journée Scientifique du Cancéropôle Nord-Ouest, May 2025, Deauville, France Communication dans un congrès hal-05387187v1
Overcoming chemoresistance in glioblastoma with fenofibrate-loaded nanoemulsions combined with iron oxide nanoparticles (SPIONs) Yasmine Chokry,Anne-Claire Groo,Ons Ben Hadj Hassen,C Hélaine,Katel Hervé-Aubertet al. 16èmes Journées Scientifiques du Cancéropôle Nord-Ouest, May 2024, Deauville, France Communication dans un congrès hal-04683731v1
Nanoemulsions combining fenofibrate and SPIONs for the treatment of glioblastoma Yasmine Chokry,Anne-Claire Groo,Ons Ben Hadj Hassen,C Hélaine,Katel Hervé-Aubertet al. International Workshop on NanoImmunoOncology, Nov 2024, Caen, France Communication dans un congrès hal-04835352v1
Development and validation of a new theranostic textile material by MRI for the treatment of chemoresistant cancers Géraldine Gouhier,Bernard Martel,Laura Gouriou,François Estour,Ramakrishna Gandikotaet al. 21st International Cyclodextrin Symposium, Jun 2024, Dunkerque, France Communication dans un congrès hal-04683679v1
Magnetic supramolecular assemblies based on amphiphilic cyclodextrins with intratumoral theranostic features Antonino Mazzaglia,Roberto Zagami,Angela Scala,Anna Piperno,C Hélaineet al. 21st International Cyclodextrin Symposium, Jun 2024, Dunkerque, France Communication dans un congrès hal-04683664v1
Preclinical study of the comparative effects of protons vs conventional x-rays radiotherapy on radiation-induced lymphopenia in the context of brain irradiation Julie Coupey,Thao-Nguyen Pham,Jérôme Toutain,Viktoriia Ivanova,Erika Hueet al. Journées de l'EDnBISE 2023, Jun 2023, Rouen, France Communication dans un congrès hal-04685305v1
Hadrontherapy to target glioblastoma stem cells to overcome radioresistance Juliette Aury-Landas,E.A. Pérès,Nolwenn Pasquet,C Hélaine,D Lebhertzet al. Assemblée générale du GDR Mi2B (Outils et méthodes nucléaires pour la lutte contre le cancer), Oct 2023, Bordeaux, France Communication dans un congrès hal-04262139v1
Investigating the effects of protons vs conventional x-rays on radiation-induced lymphopenia in a context of brain irradiation Julie Coupey,Thao-Nguyen Pham,Jérôme Toutain,Viktoriia Ivanova,Erika Hueet al. Journées Resplandir, Mar 2023, Strasbourg, France Communication dans un congrès hal-04685282v1
Comparative preclinical study of the effect of proton therapy versus conventional radiotherapy on circulating leukocytes in a context of brain tumour irradiation Julie Coupey,Thao Nguyen Pham,Jérôme Toutain,Erika Hue,C Hélaineet al. 5th Conference on Small Animal Precision Image-Guided Radiotherapy, Mar 2022, Munich, Germany Communication dans un congrès hal-03618448v1
Preclinical study of the interest of proton therapy vs conventional x-ray to limit radiation-induced lymphopenia in a context of brain irradiation Julie Coupey,Thao-Nguyen Pham,Jérôme Toutain,Viktoriia Ivanova,Erika Hueet al. RadioTransNet, Nov 2022, Caen, France Communication dans un congrès hal-04685066v1
Comparative study of proton versus X-rays on circulating leukocytes in a context of brain irradiation: a preclinical study Samuel Valable,Julie Coupey,Thao Nguyen Pham,Jérôme Toutain,V. Ivanovaet al. Premier congrès de radiobiologie de la SFBR, SFBR, Nov 2022, Agay-Saint Raphaël, France Communication dans un congrès hal-03845697v1
Investigating the interest of proton therapy to obtund radiation-induced lymphopenia in a context of brain tumour irradiation: a preclinical study Julie Coupey,Jérôme Toutain,Erika Hue,C Hélaine,Jade Richardet al. Adaptation of the tumour and its ecosystem to radiotherapies workshop (14th CGO), Sep 2021, Le Bono, France Communication dans un congrès hal-03444560v1
Impact of tumor reoxygenation by nanoparticles on tumors associated macrophages. A Ferré,H Ozcelik,M.M. Leblond,C Anfray,C Hélaineet al. 24ème édition des journées de l'école doctorale EdNBISE, Mar 2019, Caen, France Communication dans un congrès hal-02266827v1
Interventions en écoles A Corroyer-Dulmont,G Ropars,L Chazalviel,O Touzani,Y Khelifet al. Semaine du Cerveau, Mar 2017, Villy Bocage, France Communication dans un congrès hal-02331958v1

Poster de conférence (31)

Overcoming chemoresistance in glioblastoma with fenofibrate-loaded nanoemulsions Yasmine Chokry,Anne-Claire Groo,Sophie Corvaisier,C Hélaine,Aurélie Malzert-Fréonet al. 17èmes Journées Scientifiques du CNO, May 2025, DEAUVILLE, France Poster de conférence hal-05080050v1
Overcoming chemoresistance in glioblastoma with fenofibrate-loaded nanoemulsions Yasmine Chokry,Anne-Claire Groo,Sophie Corvaisier,C Hélaine,Aurélie Malzert-Fréonet al. Journée Normande de Recherche Biomédicale, Jun 2025, Caen, France Poster de conférence hal-05229753v1
Nanoemulsions combining fenofibrate and SPIONs for the treatment of glioblastoma Yasmine Chokry,Anne-Claire Groo,Ons Ben Hadj Hassen,C Hélaine,Katel Hervé-Aubertet al. 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Mar 2024, Vienne, Austria Poster de conférence hal-04683954v1
Overcoming chemoresistance in glioblastoma with fenofibrate-loaded nanoemulsions combined with iron oxide nanoparticles (SPIONs) Yasmine Chokry,Anne-Claire Groo,Ons Ben Hadj Hassen,C Hélaine,Katel Hervé-Aubertet al. 16èmes Journées Scientifiques du Cancéropôle Nord-Ouest, May 2024, Deauville, France Poster de conférence hal-04683996v1
Understanding the effects of protons versus x-rays on radiation-induced lymphopenia after brain irradiation: a preclinical study Julie Coupey,Thao-Nguyen Pham,Jérôme Toutain,Viktoriia Ivanova,Erika Hueet al. FENS 2024, Jun 2024, Vienne, Austria Poster de conférence hal-04685339v1
Nanoemulsions combining fenofibrate and SPIONs for the treatment of glioblastoma Yasmine Chokry,Anne-Claire Groo,Ons Ben Hadj Hassen,C Hélaine,Hervé-Aubert Katelet al. 50ième anniversaire du Centre d’Etudes et de Recherche sur le Médicament de Normandie, Nov 2024, Caen, France Poster de conférence hal-04835492v1
Overcoming chemoresistance in glioblastoma with fenofibrate-loaded nanoemulsions combined with iron oxide nanoparticles (SPIONs) Yasmine Chokry,Anne-Claire Groo,Ons Ben Hadj Hassen,C Hélaine,Katel Hervé-Aubertet al. Journées de l'Ecole Doctorale nBISE, May 2024, Deauville, France Poster de conférence hal-04683975v1
Overcoming hypoxia induced chemoresistance with fenofibrate-loaded nanoemulsions in glioblastoma Yasmine Chokry,Anne-Claire Groo,C Hélaine,Aurélie Malzert-Fréon,Valable Samuel Journée Normande de Recherche Biomédicale (JNRB), Jun 2023, Caen, France Poster de conférence hal-04192455v1
Protons or X-rays-based radiotherapy: a preclinical study of the comparative effects on radiation-induced lymphopenia in the context of brain irradiation Julie Coupey,Pham Thao-Nguyen,Jérôme Toutain,Ivanova Viktoriia,Hue Erikaet al. 15èmes journées scientifiques du Cancéropôle Nord-Ouest, May 2023, Deauville, France Poster de conférence hal-04685329v1
Kinetics and oxygen dependence of uptake of nanozeolites by human glioblastoma cells C Hélaine,Hayriye Özçelik,S. Komaty,A. Amedlous,Sajjad Ghojavandet al. Groupe Français des Zéolithes, Mar 2022, Voguë, France Poster de conférence hal-03643253v1
Preclinical study of the effects of proton therapy vs conventional X-rays on circulating leukocytes to obtund radiation-induced lymphopenia in a context of brain tumor irradiation Julie Coupey,Thao Nguyen Pham,Jérôme Toutain,Erika Hue,C Hélaineet al. 14ème journées scientifiques du Cancéropôle Nord-Ouest, May 2022, Deauville, France Poster de conférence hal-03699322v1
Investigating the interest of proton therapy to obtund radiation-induced lymphopenia in a context of brain tumour irradiation: a preclinical study Julie Coupey,Jérôme Toutain,Erika Hue,C Hélaine,Jade Richardet al. 46th Annual Meeting of the European Radiation Research Society (ERRS 2021), Nov 2021, Caen, France. Poster de conférence hal-03444552v1
Ang2 overexpression optimizes the efficacy of radiochemotherapy in glioblastoma by acting in an autocrine and paracrine manner C Hélaine,Aurélie Ferré,M.M. Leblond,Elodie A. Pérès,Myriam Bernaudinet al. SF Angiogenèse, Nov 2021, e-congrès, France Poster de conférence hal-03557900v1
Preclinical study of the effects of proton therapy vs conventional X-rays on circulating leukocytes to obtund radiation-induced lymphopenia in a context of brain tumor irradiation Julie Coupey,Jérôme Toutain,Erika Hue,C Hélaine,Jade Richardet al. 46th Annual Meeting for the European Radiation Research Society, Nov 2021, Caen, France Poster de conférence hal-03699307v1
Effets de la surexpression de Ang2 dans la récidive du glioblastome après chimio-radiothérapie Charly Hélaine,Aurélie Ferré,M.M. Leblond,Aurélien Corroyer-Dulmont,E.A. Pérèset al. Journée Normande de Recherche Biomédicale, JNRb, Nov 2019, Caen, France Poster de conférence hal-02318474v1
Effets de la surexpression de Ang2 dans la récidive du glioblastome après chimio-radiothérapie. Charly Hélaine,Aurélie Ferré,M.M. Leblond,Corroyer-Dulmont Aurélien,E.A. Pérèset al. 12èmes journées scientifiques du Cancéropôle Nord-Ouest, May 2019, Deauville, France Poster de conférence hal-02266383v1
Ang2 overexpression optimizes the efficacy of chemo-radiotherapy in glioblastoma Charly Hélaine,Aurélie Ferré,M.M. Leblond,E.A. Pérès,Bernaudin Myriamet al. LARC Neurosciences, Oct 2019, Nantes, France Poster de conférence hal-02318483v1
Interest of various radiotherapies to modulate glioblastoma inflammation A.E. Ferré,M.M. Leblond,Charly Hélaine,E.A. Pérès,Petit Edwigeet al. Journée Normande de Recherche Biomédicale, JNRb, Nov 2019, Caen, France Poster de conférence hal-02328559v1
Influence of Ang2 overexpression in the recurrence of glioblastoma after chemo-radiotherapy. Charly Hélaine,Aurélie Ferré,M.M. Leblond,Corroyer-Dulmont Aurélien,E.A. Pérèset al. Journées de l’Ecole Doctorale EdNBise, Mar 2019, Caen, France Poster de conférence hal-02266381v1
Impact of Angiopoietin-2 on glioblastoma response to combined chemo-radiotherapy Charly Hélaine,Aurélie Ferré,M.M. Leblond,E.A. Pérès,Bernaudin Myriamet al. European society for medical oncology, ESMO, Sep 2019, Barcelone, Spain. Annals of oncology, 30, pp.1997P Poster de conférence hal-02266445v1
Impact of tumor reoxygenation by nanoparticles on Tumor Associated Macrophages (TAMs) A.E. Ferré,Clément Anfray,M.M. Leblond,H. Ozcelik,Charly Hélaineet al. European Society of Medical Oncology, Sep 2019, Barcelone, Spain. Annals of oncology, 30, pp.1999P, ⟨10.1093/annonc/mdz269.017⟩ Poster de conférence hal-02328503v1
Interest of various radiothérapies to modulate glioblastoma inflammation A.E. Ferré,M.M. Leblond,Charly Hélaine,E.A. Pérès,Petit Edwigeet al. ENLIGHT meeting 2019, Jul 2019, Caen, France Poster de conférence hal-02328451v1
Impact de stratégies nanoparticulaires de réoxygénation sur les macrophages associés aux glioblastomes. Aurélie Ferré,Clement Anfray,M.M. Leblond,H. Ozcelik,Charly Hélaineet al. 12èmes journées scientifiques du Cancéropôle Nord-Ouest, May 2019, Deauville, France Poster de conférence hal-02266389v1
HAF inhibition in glioma cells reduces tumor growth without modifying the efficacy of chemo- and adiotherapy. Lambert G,E.A. Pérès,Charly Hélaine,Didier Divoux,Jérôme Toutainet al. 25th Biennial Congress of the European Association for Cancer Research, Jun 2018, Amsterdam, Netherlands Poster de conférence hal-02266195v1
Involvement of tumor microenvironment on the sensitivity of glioblastoma vascularization to irradiation. Charly Hélaine,Aurélie Ferré,M.M. Leblond,Gaelle Lambert,Divoux Didieret al. SF Angiogenèse, Oct 2018, Reims, France. 2018 Poster de conférence hal-02266227v1
A dialogue between endothelial cells and macrophages might contribute to vasculopathy in response to brain radiotherapy. Charly Hélaine,An Gérault,M.M. Leblond,Corroyer-Dulmont Aurélien,Lambert Get al. 21e Journée de l'Ecole Doctorale NBISE, Mar 2018, Rouen, France Poster de conférence hal-02266455v1
Macrophages contribute to vascular damage after irradiation in glioblastoma: in vitro and in vivo studies Charly Hélaine,Aurélie Ferré,M.M. Leblond,Gaelle Lambert,Divoux Didieret al. International Marie Sklodowska-Curie Meeting: From Radiation to Innovation in Medicine, Oct 2018, Paris, France Poster de conférence hal-02266224v1
Effect of radio-induced products from glioblastoma cells on macrophages Aurélie Ferré,M.M. Leblond,Charly Hélaine,E.A. Pérès,Petit Edwigeet al. International Marie Sklodowska-Curie Meeting: From Radiation to Innovation in Medicine, Oct 2018, Paris, France Poster de conférence hal-02266228v1
Influence du microenvironnement tumoral sur la radiosensibilité de la composante vasculaire des glioblastomes : études in vivo et in vitro Charly Hélaine,An Gérault,M.M. Leblond,Aurélie Ferré,Corroyer-Dulmont Aurélienet al. Journée Normande de Recherche biomédicale, JNRb 2017, Nov 2017, Caen, France Poster de conférence hal-02268986v1
Etude de la radiosensibilité du compartiment vasculaire dans un contexte de glioblastome Charly Hélaine,An Gérault,M.M. Leblond,Corroyer-Dulmont Aurélien,Gaelle Lambertet al. 10èmes journées scientifiques du Cancéropôle Nord-Ouest, May 2017, Deauville, France Poster de conférence hal-02269210v1
L’irradiation par rayons X favorise le phénotype M2 des macrophages dans les glioblastomes M.M. Leblond,E.A. Pérès,An Gérault,Charly Hélaine,Clement Anfrayet al. 10èmes journées scientifiques du Cancéropôle Nord-Ouest, May 2017, Deauville, France Poster de conférence hal-02269183v1