christine Bezombes

Publications

Article dans une revue (37)

Patient-Derived Lymphoma Spheroids Reveal Predictive Markers of Glofitamab Resistance in Relapsed/Refractory B-NHL Paul Marcoux,Fabien Gava,Marie Tosolini,Pauline Gravelle,Christina Schniederjohannet al. Blood, 2026, ⟨10.1182/blood.2025031309⟩ Article dans une revue hal-05549327v1
Goodbye flat lymphoma biology Carla Faria,Cèlia Dobaño‐lópez,Patricia Pérez‐galán,Christine Bezombes FEBS Letters, 2025, ⟨10.1002/1873-3468.70114⟩ Article dans une revue inserm-05247410v1
Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target Cèlia Dobaño-López,Juan García Valero,Ferran Araujo-Ayala,Ferran Nadeu,Fabien Gavaet al. Blood Cancer Journal, 2024, 14 (1), pp.75. ⟨10.1038/s41408-024-01041-7⟩ Article dans une revue inserm-04773418v1
Patient-derived lymphoma spheroids integrating immune tumor microenvironment as preclinical follicular lymphoma models for personalized medicine Carla Faria,Fabien Gava,Pauline Gravelle,Juan Garcia Valero,Celia Dobaño-Lópezet al. Journal for Immunotherapy of Cancer, 2023, 11 (10), pp.e007156. ⟨10.1136/jitc-2023-007156⟩ Article dans une revue inserm-04777458v1
3D Model Characterization by 2D and 3D Imaging in t(14;18)-Positive B-NHL: Perspectives for In Vitro Drug Screens in Follicular Lymphoma Fabien Gava,Carla Faria,Pauline Gravelle,Juan Valero,Cèlia Dobaño-Lópezet al. Cancers, 2021, 13 (7), pp.1490. ⟨10.3390/cancers13071490⟩ Article dans une revue hal-03365508v1
Immunotherapies in Non-Hodgkin’s Lymphoma Christine Bezombes,Patricia Pérez-Galán Cancers, 2021, 13 (14), pp.3625. ⟨10.3390/cancers13143625⟩ Article dans une revue inserm-04783622v1
Baseline SUVmax is related to tumor cell proliferation and patient outcome in follicular lymphoma Cédric Rossi,Marie Tosolini,Pauline Gravelle,Sarah Pericart,Salim Kanounet al. Haematologica, 2020, ⟨10.3324/haematol.2020.263194⟩ Article dans une revue hal-03365480v1
Monte Carlo dosimetry of a realistic multicellular model of follicular lymphoma in a context of radioimmunotherapy Julien Bordes,Sébastien Incerti,Erick Mora‐ramirez,Jonathan Tranel,Cédric Rossiet al. Medical Physics : The international journal of medical physics research and practice, 2020, 47 (10), mp.14370. ⟨10.1002/mp.14370⟩ Article dans une revue hal-02981284v1
Increasing Uptake of Silica Nanoparticles with Electroporation: From Cellular Characterization to Potential Applications Erick Phonesouk,Séverine Lechevallier,Audrey Ferrand,Marie-Pierre Rols,Christine Bezombeset al. Materials, 2019, Inorganic Nanoparticles for Targeted Therapy: Fabrication, Physical Properties, Biomedical Applications and Fate, 12 (1), pp.179. ⟨10.3390/ma12010179⟩ Article dans une revue hal-02061583v1
A Tridimensional Model for NK Cell-Mediated ADCC of Follicular Lymphoma Emilie Decaup,Cédric Rossi,Pauline Gravelle,Camille Laurent,Julie Bordenaveet al. Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.01943⟩ Article dans une revue hal-02347408v1
Profiling Immune Escape in Hodgkin’s and Diffuse large B-Cell Lymphomas Using the Transcriptome and Immunostaining Sarah Péricart,Marie Tosolini,Pauline Gravelle,Cédric Rossi,Alexandra Traverse-Glehenet al. Cancers, 2018, 10 (11), pp.415. ⟨10.3390/cancers10110415⟩ Article dans une revue hal-01927888v1
Boosting γδ T cell-mediated antibody-dependent cellular cytotoxicity by PD-1 blockade in follicular lymphoma Cédric Rossi,Pauline Gravelle,Emilie Decaup,Julie Bordenave,Mary Poupotet al. OncoImmunology, 2018, 8 (3), pp.1554175. ⟨10.1080/2162402x.2018.1554175⟩ Article dans une revue inserm-04820835v2
IL-33-expanded human Vγ9Vδ2 T cells have anti-lymphoma effect in a mouse tumor model Caroline Duault,Delphine Bétous,Christine Bezombes,Stéphane Roga,Corinne Cayrolet al. European Journal of Immunology, 2017, 47 (12), pp.2137-2141. ⟨10.1002/eji.201747093⟩ Article dans une revue inserm-02472191v1
Mechanisms of PD-1/PD-L1 expression and prognostic relevance in non-Hodgkin lymphoma: a summary of immunohistochemical studies Pauline Gravelle,Barbara Burroni,Sarah Péricart,Cédric Rossi,Christine Bezombeset al. Oncotarget, 2017, 8 (27), pp.44960-44975. ⟨10.18632/oncotarget.16680⟩ Article dans une revue inserm-04820866v1
Radiolabelling rituximab with 99m Tc in three steps procedure Charlotte Fontan,Christine Bezombes,Anne Sophie Salabert,Julien Costes,Raphael Lopezet al. Journal of Labelled Compounds and Radiopharmaceuticals, 2015, 58 (7), pp.274-280. ⟨10.1002/jlcr.3283⟩ Article dans une revue istex inserm-04820894v1
Cell growth in aggregates determines gene expression, proliferation, survival, chemoresistance, and sensitivity to immune effectors in follicular lymphoma. Pauline Gravelle,Christine Jean,Julien Familiades,Emilie Decaup,Amandine Blancet al. American Journal of Pathology, 2014, 184 (1), pp.282-95. ⟨10.1016/j.ajpath.2013.09.018⟩ Article dans une revue inserm-00905913v1
Phosphoantigens and butyrophilin 3A1 induce similar intracellular activation signaling in human TCRVγ9+ γδ T lymphocytes Emilie Decaup,Caroline Duault,Christine Bezombes,Mary Poupot,Ariel Savinaet al. Immunology Letters, 2014, 161 (1), pp.133-137. ⟨10.1016/j.imlet.2014.05.011⟩ Article dans une revue istex inserm-02472223v1
What lessons can be learned from γδ T cell-based cancer immunotherapy trials? Jean-Jacques Fournié,Helene Sicard,Mary Poupot,Christine Bezombes,Amandine Blancet al. Cellular and molecular immunology, 2013, 10 (1), pp.35-41. ⟨10.1038/cmi.2012.39⟩ Article dans une revue inserm-02472240v1
Anti-tumor activity of obinutuzumab and rituximab in a follicular lymphoma 3D model E Decaup,C Jean,C Laurent,P Gravelle,S Fruchonet al. Blood Cancer Journal, 2013, 3 (8), pp.e131. ⟨10.1038/bcj.2013.32⟩ Article dans une revue inserm-04820822v1
Direct Effect of Rituximab in B-Cell–Derived Lymphoid Neoplasias: Mechanism, Regulation, and Perspectives Christine Bezombes,Jean-Jacques Fournié,Guy Laurent Molecular Cancer Research, 2011, 9 (11), pp.1435 - 1442. ⟨10.1158/1541-7786.mcr-11-0154⟩ Article dans une revue inserm-04820849v1
Rituximab inhibits B-cell receptor signaling Samar Kheirallah,Pierre Caron,Emilie Gross,Anne Quillet-Mary,Justine Bertrand-Michelet al. Blood, 2010, 115 (5), pp.985-994. ⟨10.1182/blood-2009-08-237537⟩ Article dans une revue hal-02348969v1
Emerging Concepts for the Treatment of Hematological Malignancies with Therapeutic Monoclonal Antibodies Aude-Hélène Capietto,Samarh Keirallah,Emilie Gross,Nicolas Dauguet,Emilie Laprevotteet al. Current Drug Targets, 2010, 11 (7), pp.790-800. ⟨10.2174/138945010791320845⟩ Article dans une revue hal-02348959v1
Bromohydrin pyrophosphate enhances antibody-dependent cell-mediated cytotoxicity induced by therapeutic antibodies Julie Gertner,Cecile Bonnafous,Christine Bezombes,Aude-Hélène Capietto,Virginie Scaglioneet al. Blood, 2009, 113 (20), pp.4875-4884. ⟨10.1182/blood-2008-08-172296⟩ Article dans une revue hal-02348974v1
PKCzeta protects against UV-C-induced apoptosis by inhibiting acid sphingomyelinase-dependent ceramide production Alexandra Charruyer,Christine Jean,Audrey Colomba,Jean-Pierre Jaffrézou,Anne Quillet-Maryet al. Biochemical Journal, 2007, 405 (1), pp.77-83. ⟨10.1042/BJ20061528⟩ Article dans une revue hal-00478682v1
UV-C Light Induces Raft-associated Acid Sphingomyelinase and JNK Activation and Translocation Independently on a Nuclear Signal Alexandra Charruyer,Solène Grazide,Christine Bezombes,Sabina Müller,Guy Laurentet al. Journal of Biological Chemistry, 2005, 280 (19), pp.19196-19204. ⟨10.1074/jbc.M412867200⟩ Article dans une revue inserm-04820879v1
Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains C. Bezombes Blood, 2004, 104 (4), pp.1166-1173. ⟨10.1182/blood-2004-01-0277⟩ Article dans une revue hal-02349082v1
Implication of Raft Microdomains in Drug Induced Apoptosis Christine Bezombes,Guy Laurent,Jean-Pierre Jaffrezou Current Medicinal Chemistry Anticancer Agents, 2003, 3 (4), pp.263-270. ⟨10.2174/1568011033482413⟩ Article dans une revue istex inserm-04820881v1
Phosphatidylcholine‐derived phosphatidic acid and diacylglycerol are involved in the signaling pathways activated by docetaxel Nicolas Maestre,Christine Bezombes,Isabelle Plo,Thierry Levade,François Lavelleet al. Journal of Experimental Therapeutics and Oncology, 2003, 3 (1), pp.36-46. ⟨10.1046/j.1359-4117.2003.01065.x⟩ Article dans une revue istex inserm-04826850v1
Protein kinase Cζ mediated Raf-1/extracellular-regulated kinase activation by daunorubicin Véronique Mansat-De Mas,Hélène Hernandez,Isabelle Plo,Christine Bezombes,Nicolas Maestreet al. Blood, 2003, 101 (4), pp.1543-1550. ⟨10.1182/blood-2002-05-1585⟩ Article dans une revue hal-02349095v1
Overexpression of Protein Kinase Cζ Confers Protection Against Antileukemic Drugs by Inhibiting the Redox-Dependent Sphingomyelinase Activation Christine Bezombes,Aurélie de Thonel,Andriana Apostolou,Thierry Louat,Jean-Pierre Jaffrézouet al. Molecular Pharmacology, 2002, 62 (6), pp.1446-1455. ⟨10.1124/mol.62.6.1446⟩ Article dans une revue hal-03030310v1
Ara‐C‐ and daunorubicin‐induced recruitment of Lyn in sphingomyelinase‐enriched membrane rafts Solène Grazide,Nicolas Maestre,Robert Jan Veldman,Christine Bezombes,Stéphane Maddenset al. FASEB Journal, 2002, 16 (12), pp.1685-1687. ⟨10.1096/fj.01-0794fje⟩ Article dans une revue inserm-04820869v1
Overexpression of Protein Kinase Cζ Confers Protection Against Antileukemic Drugs by Inhibiting the Redox-Dependent Sphingomyelinase Activation Christine Bezombes,Aurélie de Thonel,Andriana Apostolou,Thierry Louat,Jean-Pierre Jaffrézouet al. Molecular Pharmacology, 2002, 62 (6), pp.1446-1455. ⟨10.1124/mol.62.6.1446⟩ Article dans une revue hal-02349104v1
Oxidative stress-induced activation of Lyn recruits sphingomyelinase and is requisite for its stimulation by Ara-C Christine Bezombes,Isabelle Plo,Véronique Mansat-de Mas,Anne Quillet-Mary,Anne Nègre-Salvayreet al. FASEB Journal, 2001, 15 (9), pp.1583-1585. ⟨10.1096/fj.00-0787fje⟩ Article dans une revue hal-02349143v1
Lysosomal sphingomyelinase is not solicited for apoptosis signaling Christine Bezombes,Bruno Ségui,Olivier Cuvillier,Alain Bruno,Emmanuelle Uro-Costeet al. FASEB Journal, 2000, 15 (2), pp.297-299. ⟨10.1096/fj.00-0466fje⟩ Article dans une revue inserm-04826847v1
Implication of Radical Oxygen Species in Ceramide Generation, c-Jun N-Terminal Kinase Activation and Apoptosis Induced by Daunorubicin Véronique Mansat-De Mas,Christine Bezombes,Anne Quillet-Mary,Ali Bettaieb,Aurélie de Thonel D’orgeixet al. Molecular Pharmacology, 1999, 56 (5), pp.867-874. ⟨10.1124/mol.56.5.867⟩ Article dans une revue hal-02349158v1
Implication of Radical Oxygen Species in Ceramide Generation, c-Jun N-Terminal Kinase Activation and Apoptosis Induced by Daunorubicin Véronique Mansat-De Mas,Christine Bezombes,Anne Quillet-Mary,Ali Bettaïeb,Aurélie de Thonel D’orgeixet al. Molecular Pharmacology, 1999, 56 (5), pp.867-874. ⟨10.1124/mol.56.5.867⟩ Article dans une revue hal-03028424v1
Restoration of TNF-α-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833 Christine Bezombes,Nicolas Maestre,Guy Laurent,Thierry Levade,Ali Bettaïebet al. FASEB Journal, 1998, 12 (1), pp.101-109. ⟨10.1096/fasebj.12.1.101⟩ Article dans une revue inserm-04826845v1

Poster de conférence (14)

Multicellular Aggregates of Lymphoma Cells (MALC) and Patient-Derived Lymphoma Spheroids (PDLS) as 3D preclinical B-cell non-Hodgkin lymphoma models for personalized medicine Carla Faria,Fabien Gava,C Dobano-Lopez,L Rimailho,S Quertinmontet al. 2nd Summer school: Micro-physiological models: From organoids to organ-on-chips., 2024, Cargese (Corse), France Poster de conférence inserm-04827746v1
Study of the efficacy of novel bispecific antibodies targeting immune checkpoints in a 3D model of B non-Hodgkin lymphoma. N. Gower,F. Gava,L. Rimailho,C. Faria,Pauline Gravelleet al. International Conference on Malignant Lymphoma, 2023, Lugano, Switzerland, Switzerland. 41 (S2), pp.287-288, 2023, ⟨10.1002/hon.3164_198⟩ Poster de conférence inserm-04830782v1
Identification of CD39 as a new therapeutic target in non-Hodgkin's lymphomas L Rimailho,C Faria,F Gava,P Gravelle,M Tosoliniet al. Journées de l'Ecole Doctorale BSB 2023, 2023, Toulouse, France Poster de conférence inserm-04827786v1
Role of CD39 on gamma delta T cells as a positive marker of anti-CD20-induced ADCC of non-Hodgkins lymphoma cells L Rimailho,N Gower,F Gava,C Faria,P Gravelleet al. Cancéropole Grand sud Ouest GSO, journée annuelle, 2023, Arcachon, France Poster de conférence inserm-04827759v1
TAyloring LYmphoma therapy with Immune Escape Signatures from 3D avatars of B‐cell NHL F. Gava,C. Faria,Pauline Gravelle,J. Garcia-Valero,C. Quelenet al. International Conference on Malignant Lymphoma, 2023, Lugano, Switzerland, Switzerland. 41 (S2), pp.286-287, 2023, ⟨10.1002/hon.3164_197⟩ Poster de conférence inserm-04830807v1
Multicellular Aggregates of Lymphoma Cells (MALC) and Patient-Derived Lymphoma Spheroids (PDLS) as 3D preclinical B-cell non-Hodgkin lymphoma models for personalized medicine F Gava,C Faria,P Gravelle,J García-Valero,C Dobaño-Lópezet al. GSO modèles alternatifs à l’expérimentation animale, May 2023, Toulouse, France Poster de conférence inserm-04827769v1
Study of γδ T cells from healthy donors usable for immunotherapy screening in non-Hodgkins Lymphomas L Rimailho,N Gower,F Gava,C Faria,P Gravelleet al. International gamma delta T cell conference, Jun 2023, Lisbonne, Portugal Poster de conférence inserm-04827776v1
TAyloring LYmphoma therapy with Immune Escape Signatures from 3D avatars of sMZL (TALYIES) F Gava,C Faria,Pauline Gravelle,Cathy Quelen,P Perez-Galanet al. Imcore summit 2022, Oct 2022, Amsterdam (NETHERLANDS), Netherlands Poster de conférence inserm-04830870v1
TAyloring LYmphoma therapy with Immune Escape Signatures from 3D avatars of B-cell NHL (TALYIES). Fabien Gava,Carla Faria,Pauline Gravelle,Juan Garcia-Valero,Cathy Quelenet al. Summit Imcore 2022, Oct 2022, Amsterdam (NETHERLANDS), Netherlands. 197, pp.286-287 Poster de conférence inserm-04830884v1
Immunocompetent 3D Follicular Lymphoma Model: A Preclinical Tool to Design Tailored Immunotherapies Cèlia Dobaño-López,Juan Valero,Ferran Araujo-Ayala,Ferran Nadeu,Fabien Gavaet al. 64th ASH Annual Meeting and Exposition, Nov 2022, New Orleans (LA), United States. 140 (Supplement 1), pp.9279-9280, 2022, ⟨10.1182/blood-2022-166131⟩ Poster de conférence inserm-04830843v1
3D Model Characterization by 2D and 3D Imaging in t(14;18)-Positive B-NHL: Perspectives for In Vitro Drug Screens in Follicular Lymphoma Carla Faria,Fabien Gava,Pauline Gravelle,Juan Garcia Valero,Celia Dobaño-Lópezet al. EACR Imaging cancer virtual conferences: Imaging Cancer: Gaining insights from cells to organisms, Jun 2021, Virtual, France Poster de conférence inserm-04831048v1
Patient derived lymphoma spheroids Carla Faria,Fabien Gava,Pauline Gravelle,Julie Bordenave,Chloé Laplagneet al. Retraite scientifique du Centre de Recherches en Cancérologie de Toulouse, Sep 2019, France (FR), France Poster de conférence inserm-04831113v1
Le SUVmax pré-thérapeutique est associé à la prolifération des cellules tumorales et non au micro-environnement immunitaire et prédit la survie sans progression des patients avec un lymphome folliculaire. Cédric Rossi,S Kanoun,Marie Tosolini,Sarah Pericart,Julia Gilhodeset al. Congrès de la Société Française d'Hématologie (SFH), 2019, Paris, France. Poster de conférence inserm-04831138v1
Le SUVmax pré-thérapeutique est associé à la prolifération des cellules tumorales et non au micro-environnement immunitaire et prédit la survie sans progression des patients avec un lymphome folliculaire C Rossi,S Kanoun,Marie Tosolini,S Pericart,J Gilhodeset al. SFH 2019 - 39e Société Française d'Hématologie, Mar 2019, Paris, France Poster de conférence inserm-04827449v1

Communication dans un congrès (5)

Organoids studies in Lymphoproliferative disorders. Christine Bezombes Roche webinar, Oct 2024, Webinar, France Communication dans un congrès inserm-04820548v1
Patient-Derived lymphoma spheroids integrating immune tumor micronevironment as preclinical follicular lymphoma models for personalized medicine. C Faria,F Gava,P Gravelle,J Garcia-Valero,C Dobaño-Lópezet al. 4 ème workshop « BioFabrication & Cancer » du Cancéropôle Grand Sud-Ouest., Cancéropôle Grand Sud-Ouest (GSO), Sep 2022, Bordeaux, France Communication dans un congrès inserm-04827365v1
New avatars for medical research. Christine Bezombes The 12th Summer School on Medicines, SSM12, Jul 2022, Toulouse, France Communication dans un congrès inserm-04827378v1
What lessons we learned on tumor microenvironment using non-Hodgkin's lymphoma 3D cultures? Christine Bezombes The tumor and its microenvironment symposium, Dec 2021, Toulouse, France Communication dans un congrès inserm-04827381v1
Patient Derived Lymphoma spheroids, a new pre-clinical model for Non-Hodgkin Lymphoma research Carla Faria,C Bezombes 3rd Workshop « BioFabrication & Cancer », GSO, Sep 2019, Montpellier, France Communication dans un congrès inserm-04827431v1