christophe Girard Chargé de recherche

Identifiants chercheurs

IdHAL :

christophe-girard

ORCID :

0000-0002-4560-4479

ResearcherID :

http://www.researcherid.com/rid/O-8455-2016

Présentation

Situation et Adresse professionnelle actuelle

Chargé de Recherche 1ere classe CNRS

Centre Méditerranéen de Médecine Moléculaire (C3M)

Equipe 11 : 'Microenvironnement, signalisation et Cancer'

INSERM U1065, Bâtiment Archimed,

151 Route de Saint Antoine de Ginestière

BP2 3194

06204 Nice

email : christophe.girard@univ-cotedazur.fr

Tel : 33 4 89 15 38 52

Fax : 33 4 89 06 42 21

Internet : http://www.unice.fr/c3m/

Publications

Article dans une revue (26)

USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization Pierric Biber,Alexandrine Carminati,Walaa Mohager,Mickael Ohanna,Christophe Girardet al. Cell Reports, 2025, 44 (10), pp.116372. ⟨10.1016/j.celrep.2025.116372⟩ Article dans une revue hal-05347222v1
Secretion of IL1 by Dedifferentiated Melanoma Cells Inhibits JAK1-STAT3-Driven Actomyosin Contractility of Lymph Node Fibroblastic Reticular Cells Christopher Rovera,Ilona Berestjuk,Margaux Lecacheur,Cassandre Tavernier,Serena Diazziet al. Cancer Research, 2022, 82 (9), pp.1774-1788. ⟨10.1158/0008-5472.CAN-21-0501⟩ Article dans une revue inserm-03674501v1
Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma Serena Diazzi,Alberto Baeri,Julien Fassy,Margaux Lecacheur,Oskar Marin‐bejaret al. EMBO Molecular Medicine, 2022, 14 (3), ⟨10.15252/emmm.202115295⟩ Article dans une revue inserm-03574667v1
Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma Ilona Berestjuk,Margaux Lecacheur,Alexandrine Carminati,Serena Diazzi,Christopher Roveraet al. EMBO Molecular Medicine, 2021, ⟨10.15252/emmm.201911814⟩ Article dans une revue hal-03533365v1
Échappement thérapeutique du mélanome : la piste biomécanique Margaux Lecacheur,Christophe A. Girard,Marcel Deckert,Sophie Tartare-Deckert Médecine/Sciences, 2020, 36 (11), pp.961-965. ⟨10.1051/medsci/2020201⟩ Article dans une revue hal-02991398v1
A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Christophe Girard,Margaux Lecacheur,Rania Ben Jouira,Ilona Berestjuk,Serena Diazziet al. Cancer Research, 2020, 80 (10), pp.1927-1941. ⟨10.1158/0008-5472.CAN-19-2914⟩ Article dans une revue inserm-02889519v1
Inhibition of patched drug efflux increases vemurafenib effectiveness against resistant braf(V600E) melanoma Laurie Signetti,Nelli Elizarov,Méliné Simsir,Agnès Paquet,Dominique Douguetet al. Cancers, 2020, 12 (6), pp.1500. ⟨10.3390/cancers12061500⟩ Article dans une revue hal-02884136v1
Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-κB signaling pathway M. Rathore,Christophe Girard,M. Ohanna,M. Tichet,R. Ben Jouiraet al. Oncogene, 2019, 38 (30), pp.5873-5889. ⟨10.1038/s41388-019-0848-9⟩ Article dans une revue hal-02323965v1
Epitope Spreading of Autoantibody Response to PLA2R Associates with Poor Prognosis in Membranous Nephropathy Barbara Seitz-Polski,Guillaume Dolla,Christine Payré,Christophe Girard,Joel Polidoriet al. Journal of the American Society of Nephrology, 2016, 27, pp.1517-33 Article dans une revue hal-01455661v1
Nouveaux rôles physiopathologiques pour le récepteur PLA2R1 dans le cancer et la glomérulonéphrite extramembraneuse Christophe Girard,Barbara Seitz Seitz-Polski,Guillaume Dolla,Arnaud Augert,David Vindrieuxet al. Médecine/Sciences, 2014, 30 (5), pp.519-525. ⟨10.1051/medsci/20143005014⟩ Article dans une revue hal-03016069v1
PLA2R1 kills cancer cells by inducing mitochondrial stress Arnaud Augert,David Vindrieux,Christophe Girard,Benjamin Le Calvé,Baptiste Graset al. Free Radical Biology and Medicine, 2013, 65, pp.969-977. ⟨10.1016/j.freeradbiomed.2013.08.177⟩ Article dans une revue istex hal-02395811v1
PLA2R1 Mediates Tumor Suppression by Activating JAK2 David Vindrieux,Arnaud Augert,Christophe Girard,Delphine Gitenay,Helene Lallet-Daheret al. Cancer Research, 2013, 73 (20), pp.6334-6345. ⟨10.1158/0008-5472.CAN-13-0318⟩ Article dans une revue hal-02395807v1
Group X Secreted Phospholipase A2 Limits the Development of Atherosclerosis in LDL Receptor–Null Mice Hafid Ait Oufella,Alain Tedgui,Makoto Murakami,Olivier Herbin,Charlotte Lahouteet al. Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33 (3), pp.466-473. ⟨10.1161/ATVBAHA.112.300309⟩ Article dans une revue hal-03016106v1
Control of Pancreatic β Cell Regeneration by Glucose Metabolism Christophe Girard Cell Metabolism, 2011, 13 (4), pp.440-449. ⟨10.1016/j.cmet.2011.02.012⟩ Article dans une revue hal-03016133v1
Overexpression of Fto leads to increased food intake and results in obesity Chris Church,Christophe Girard,Lydia Teboul,Jens Brüning,P.M. Nolanet al. Nature Genetics, 2010, 42 (12), pp.1086-1092. ⟨10.1038/ng.713⟩ Article dans une revue hal-03016713v1
Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice. Makoto Murakami,Yoshitaka Taketomi,Christophe Girard,Kei Yamamoto,Gérard Lambeau Biochimie, 2010, 92 (6), pp.561-82. ⟨10.1016/j.biochi.2010.03.015⟩ Article dans une revue istex hal-00497527v1
Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic β cells recapitulates neonatal diabetes Christophe Girard Journal of Clinical Investigation, 2009, ⟨10.1172/JCI35772⟩ Article dans une revue hal-03016127v1
Adjacent mutations in the gating loop of Kir6.2 produce neonatal diabetes and hyperinsulinism Christophe Girard EMBO Molecular Medicine, 2009, 1 (3), pp.166-177. ⟨10.1002/emmm.200900018⟩ Article dans une revue hal-03016139v1
Permanent Neonatal Diabetes Caused by Dominant, Recessive, or Compound Heterozygous SUR1 Mutations with Opposite Functional Effects Christophe Girard American Journal of Human Genetics, 2007, 81 (2), pp.375-382. ⟨10.1086/519174⟩ Article dans une revue hal-03016441v1
The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase Thomas Gerken,Christophe Girard,Frances M. Ashcroft Science, 2007, 318 (5855), pp.1469-1472. ⟨10.1126/science.1151710⟩ Article dans une revue hal-03016428v1
Sulfonylurea improves CNS function in a case of intermediate DEND syndrome caused by a mutation in KCNJ11 Christophe Girard Nature Clinical Practice Neurology, 2007, 3 (11), pp.640-645. ⟨10.1038/ncpneuro0640⟩ Article dans une revue hal-03016431v1
Mechanism of action of a sulphonylurea receptor SUR1 mutation (F132L) that causes DEND syndrome Christophe Girard Human Molecular Genetics, 2007, 16 (16), pp.2011-2019. ⟨10.1093/hmg/ddm149⟩ Article dans une revue hal-03016446v1
Mutations at the Same Residue (R50) of Kir6.2 (KCNJ11) That Cause Neonatal Diabetes Produce Different Functional Effects Kenju Shimomura,Christophe Girard,Frances M. Ashcroft Diabetes, 2006, 55 (6), pp.1705-1712. ⟨10.2337/db05-1640⟩ Article dans une revue hal-03016473v1
Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes Christophe Girard,Frances M. Ashcroft Pflügers Archiv European Journal of Physiology, 2006, 453 (3), pp.323-332. ⟨10.1007/s00424-006-0112-3⟩ Article dans une revue hal-03016452v1
ATP Sensitivity of the ATP-Sensitive K + Channel in Intact and Permeabilized Pancreatic β-Cells Andrei I. Tarasov,Christophe Girard,Frances M. Ashcroft Diabetes, 2006, 55 (9), pp.2446-2454. ⟨10.2337/db06-0360⟩ Article dans une revue hal-03016460v1
Functional Effects of Mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), Causing Neonatal Diabetes, and Response to Sulfonylurea Therapy Peter Proks,Christophe Girard,Frances M. Ashcroft Diabetes, 2006, 55 (6), pp.1731-1737. ⟨10.2337/db05-1420⟩ Article dans une revue hal-03016732v1

Pré-publication, Document de travail (4)

USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization Pierric Biber,Alexandrine Carminati,Christophe Girard,Walaa Mohager,Mickael Ohannaet al. 2024 Pré-publication, Document de travail hal-04700967v1
Extracellular matrix stiffness determines the phenotypic behavior of dedifferentiated melanoma cells through a DDR1/2-dependent YAP mechanotransduction pathway Margaux Lecacheur,Ilona Berestjuk,Alexandrine Carminati,Océane Bouvet,Serena Diazziet al. 2024 Pré-publication, Document de travail hal-04700972v1
Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-induced phenotypic plasticity and resistance in melanoma S. Diazzi,A. Baeri,J. Fassy,M. Lecacheur,O. Marin-Bejaret al. 2021 Pré-publication, Document de travail hal-03417405v1
Targeting DDR1 and DDR2 overcomes matrix-mediated melanoma cell adaptation to BRAF-targeted therapy Ilona Berestjuk,Margaux Lecacheur,Serena Diazzi,Christopher Rovera,Virginie Prod'Hommeet al. 2020 Pré-publication, Document de travail hal-03016761v1

HDR (1)

Mécanobiologie du mélanome cutané : rôle de la mécanotransduction dans la plasticité, la progression et la résistance thérapeutique Christophe Girard Sciences du Vivant [q-bio]. Université Cote d'Azur, 2023 HDR tel-05149271v1