Christophe Guignabert

Identifiants chercheurs

IdHAL :

christophe-guignabert

ORCID :

0000-0002-8545-4452

IdRef :

095316213

ResearcherID :

G-3873-2013

Présentation

Publications

Article dans une revue (89)

Evolving paradigms in pulmonary hypertension: Highlights of the 6th French Pulmonary Hypertension Network Meeting Athénaïs Boucly,Antoine Beauvais,Thomas Lacoste-Palasset,Mitja Jevnikar,Marianne Riouet al. Respiratory Medicine and Research, 2025, 88, pp.101215. ⟨10.1016/j.resmer.2025.101215⟩ Article dans une revue hal-05468026v1
Bone Morphogenetic Protein-9 Controls Pulmonary Vascular Growth and Remodeling Nihel Berrebeh,Yvon Mbouamboua,Raphaël Thuillet,Mina Ottaviani,Fabien Robertet al. Proceedings of the National Academy of Sciences of the United States of America, 2025, 122 (26), ⟨10.1073/pnas.2410229122⟩ Article dans une revue hal-05190343v1
Exploring the Endothelin-1 pathway in chronic thromboembolic pulmonary hypertension microvasculopathy Benchenouf Feriel,Cuomo Alessandra,Gorth Deborah,Normand Corinne,Thuillet Raphaëlet al. Scientific Reports, 2024, 14 (1), pp.28308. ⟨10.1038/s41598-024-79623-5⟩ Article dans une revue hal-04877626v1
Evidence and unresolved questions in pulmonary hypertension: Insights from the 5th French Pulmonary Hypertension Network Meeting Athénaïs Boucly,Laurent Bertoletti,Charles Fauvel,Mélanie Gallant Dewavrin,Christian Gergeset al. Respiratory Medicine and Research, 2024, 86, pp.101123. ⟨10.1016/j.resmer.2024.101123⟩ Article dans une revue hal-04953892v1
Placental growth factor modulates endothelial NO production and exacerbates experimental hepatopulmonary syndrome Fabien Robert,Feriel Benchenouf,My Ngoc Ha,Alessandra Cuomo,Mina Ottavianiet al. JHEP Reports Innovation in Hepatology, 2024, 7 (3), pp.101297. ⟨10.1016/j.jhepr.2024.101297⟩ Article dans une revue hal-05190311v1
Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome Fabien Robert,Marie-Caroline Certain,Audrey Baron,Raphaël Thuillet,Léa Duhautet al. American Journal of Respiratory and Critical Care Medicine, 2024, 210 (5), pp.648 - 661. ⟨10.1164/rccm.202307-1289oc⟩ Article dans une revue hal-05202933v1
Pulmonary vascular phenotype identified in patients with GDF2 ( BMP9 ) or BMP10 variants: an international multicentre study Julien Grynblat,Harm Jan Bogaard,Mélanie Eyries,Olivier Meyrignac,Laurent Savaleet al. European Respiratory Journal, 2024, 63 (4), pp.2301634. ⟨10.1183/13993003.01634-2023⟩ Article dans une revue hal-04651213v1
Retour triomphant des J2R 2023 à Tours : un tourbillon d’échanges scientifiques et d’émotion I. Annesi-Maesano,Philippe Bonniaud,G. Bouchaud,L. Boyer,Sylvie Gazzeriet al. Revue des Maladies Respiratoires, 2024, 41 (3), pp.180-182. ⟨10.1016/j.rmr.2024.03.002⟩ Article dans une revue hal-04550861v1
Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors T. Al Tabosh,H. Liu,D. Koça,M. Al Tarrass,L. Tuet al. Angiogenesis, 2024, ⟨10.1007/s10456-023-09902-8⟩ Article dans une revue hal-04478405v1
Role of KCNK3 Dysfunction in Dasatinib-associated Pulmonary Arterial Hypertension and Endothelial Cell Dysfunction Hélène Le Ribeuz,Anaïs Saint-Martin Willer,Benoit Chevalier,Maria Sancho,Bastien Massonet al. American Journal of Respiratory Cell and Molecular Biology, 2024, 71 (1), pp.95-109. ⟨10.1165/rcmb.2023-0185OC⟩ Article dans une revue hal-04754075v1
Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome Fabien Robert,Marie-Caroline Certain,Audrey Baron,Raphaël Thuillet,Léa Duhautet al. American Journal of Respiratory and Critical Care Medicine, 2024, 210 (5), pp.648-661. ⟨10.1164/rccm.202307-1289OC⟩ Article dans une revue hal-04989021v1
Inhibition of Soluble Epoxide Hydrolase Does Not Promote or Aggravate Pulmonary Hypertension in Rats Matthieu Leuillier,Valentin Platel,Ly Tu,Guillaume Feugray,Raphaël Thuilletet al. Cells, 2023, 12 (4), pp.665. ⟨10.3390/cells12040665⟩ Article dans une revue hal-04532894v1
Endothelial cells in pulmonary fibrosis: more than a bystander Toyoshi Yanagihara,Christophe Guignabert,Martin R.J. Kolb European Respiratory Journal, 2023, 61 (6), pp.2300407. ⟨10.1183/13993003.00407-2023⟩ Article dans une revue hal-04532858v1
Serum and Pulmonary Expression Profiles of the Activin Signaling System in Pulmonary Arterial Hypertension Christophe Guignabert,Laurent Savale,Athénaïs Boucly,Raphaël Thuillet,Ly Tuet al. Circulation, 2023, 147 (24), pp.1809-1822. ⟨10.1161/CIRCULATIONAHA.122.061501⟩ Article dans une revue hal-04092113v1
IL ‐2‐related regulatory CD4 T‐cell deficiency leads to the development of lung fibrosis and vascular remodeling Camelia Frantz,Anne Cauvet,Aurélie Durand,Virginie Gonzalez,Rémi Pierreet al. Arthritis & rheumatology, 2022, Online ahead of print. ⟨10.1002/art.42111⟩ Article dans une revue inserm-03652770v1
Smooth muscle Rac1 contributes to pulmonary hypertension Short running title: Role of Rac1 in pulmonary hypertension Florian Dilasser,Marc Rio,Lindsay Rose,Angela Tesse,Christophe Guignabertet al. British Journal of Pharmacology, In press Article dans une revue hal-03582408v1
Loss of cAbl Tyrosine Kinase in Pulmonary Arterial Hypertension Causes Dysfunction of Vascular Endothelial Cells Benjamin Le Vely,Carole Phan,Nihel Berrebeh,Raphaël Thuillet,Mina Ottavianiet al. American Journal of Respiratory Cell and Molecular Biology, 2022, 67 (2), pp.215-226. ⟨10.1165/rcmb.2021-0332OC⟩ Article dans une revue hal-04608774v1
Loss of cAbl Tyrosine Kinase in Pulmonary Arterial Hypertension Causes Dysfunction of Vascular Endothelial Cells Benjamin Le Vely,Carole Phan,Nihel Berrebeh,Raphaël Thuillet,Mina Ottavianiet al. American Journal of Respiratory Cell and Molecular Biology, 2022, Online ahead of print. ⟨10.1165/rcmb.2021-0332oc⟩ Article dans une revue inserm-03678207v1
New Mutations and Pathogenesis of Pulmonary Hypertension: Progress and Puzzles in Disease Pathogenesis Micheala Aldred,Nicholas Morrell,Christophe Guignabert Circulation Research, 2022, 130 (9), pp.1365-1381. ⟨10.1161/CIRCRESAHA.122.320084⟩ Article dans une revue inserm-03654919v1
Erythrocytes are altered in pulmonary arterial hypertension Etienne-Marie Jutant,Ly Tu,Raphaël Thuillet,Véronique Picard,Christophe Guignabertet al. European Respiratory Journal, 2022, 59 (6), pp.2200506. ⟨10.1183/13993003.00506-2022⟩ Article dans une revue hal-04532754v1
Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT, and is associated with pulmonary hypertension Siyu Tian,Zongye Cai,Payel Sen,Denise van Uden,Esther van de Kampet al. AJP - Heart and Circulatory Physiology, 2022, 323 (5), pp.H958 - H974. ⟨10.1152/ajpheart.00220.2022⟩ Article dans une revue inserm-04270340v1
Platelet‐Derived Growth Factor Receptor Type α Activation Drives Pulmonary Vascular Remodeling Via Progenitor Cell Proliferation and Induces Pulmonary Hypertension Julien Solinc,Jessica Raimbault‐machado,France Dierick,Lamiaa El Bernoussi,Ly Tuet al. Journal of the American Heart Association, 2022, ⟨10.1161/JAHA.121.023021⟩ Article dans une revue hal-03629264v1
Cytokines as Prognostic Biomarkers in Pulmonary Arterial Hypertension Athénaïs Boucly,Ly Tu,Christophe Guignabert,Christopher Rhodes,Pascal de Grooteet al. European Respiratory Journal, 2022, 61 (3), pp.2201232. ⟨10.1183/13993003.01232-2022⟩ Article dans une revue hal-03911708v1
Smooth muscle Rac1 contributes to pulmonary hypertension Florian Dilasser,Marc Rio,Lindsay Rose,Angela Tesse,Christophe Guignabertet al. British Journal of Pharmacology, 2022, Online ahead of print. ⟨10.1111/bph.15805⟩ Article dans une revue inserm-03558860v1
Identifying new drugs associated with pulmonary arterial hypertension: A WHO pharmacovigilance database disproportionality analysis Alex Hlavaty,Matthieu Roustit,David Montani,Marie‐camille Chaumais,Christophe Guignabertet al. British Journal of Clinical Pharmacology, 2022, 88 (12), pp.5227-5237. ⟨10.1111/bcp.15436⟩ Article dans une revue hal-04520451v1
Preventing the Increase in Lysophosphatidic Acids: A New Therapeutic Target in Pulmonary Hypertension? Thomas Duflot,Ly Tu,Matthieu Leuillier,Hind Messaoudi,Déborah Groussardet al. Metabolites, 2021, 11 (11), pp.784. ⟨10.3390/metabo11110784⟩ Article dans une revue hal-04532610v1
Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10 Claire Bouvard,Ly Tu,Martina Rossi,Agnès Desroches-Castan,Nihel Berrebehet al. Cardiovascular Research, 2021, 118 (7), pp.1805-1820. ⟨10.1093/cvr/cvab187⟩ Article dans une revue hal-03264032v1
An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension Gusty Ryanto,Koji Ikeda,Kazuya Miyagawa,Ly Tu,Christophe Guignabertet al. Nature Communications, 2021, 12 (1), pp.1720. ⟨10.1038/s41467-021-21961-3⟩ Article dans une revue hal-04532633v1
Cibler les ligands du récepteur de l’activine de type IIA pour traiter l’hypertension artérielle pulmonaire Marc Humbert,David Montani,Laurent Savale,Ly Tu,Christophe Guignabert Médecine/Sciences, 2021, 37 (10), pp.839-843. ⟨10.1051/medsci/2021131⟩ Article dans une revue hal-03379128v1
Serum and Pulmonary Uric Acid in Pulmonary Arterial Hypertension Laurent Savale,Satoshi Akagi,Ly Tu,Amélie Cumont,Raphaël Thuilletet al. European Respiratory Journal, 2021, 58 (2), pp.2000332. ⟨10.1183/13993003.00332-2020⟩ Article dans une revue inserm-03118201v1
Altered TGFβ/SMAD Signaling in Human and Rat Models of Pulmonary Hypertension: An Old Target Needs Attention Takayuki Jujo Sanada,Xiao-Qing Sun,Chris Happé,Christophe Guignabert,Ly Tuet al. Cells, 2021, 10 (1), pp.84. ⟨10.3390/cells10010084⟩ Article dans une revue hal-04526974v1
The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy Nicolas Ricard,Sabine Bailly,Christophe Guignabert,Michael Simons Nature Reviews Cardiology, 2021, 18, pp.565-580. ⟨10.1038/s41569-021-00517-4⟩ Article dans une revue inserm-03153011v1
Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling Florian Dilasser,Lindsay Rose,Dorian Hassoun,Martin Klein,Morgane Rousselleet al. Thorax, In press, ⟨10.1136/thoraxjnl-2020-216271⟩ Article dans une revue hal-03142499v2
Screening for pulmonary arterial hypertension in adults carrying a BMPR2 mutation David Montani,Barbara Girerd,Xavier Jaïs,Pierantonio Laveneziana,Edmund M.T. Lauet al. European Respiratory Journal, 2021, 58 (1), pp.2004229. ⟨10.1183/13993003.04229-2020⟩ Article dans une revue hal-04007994v1
Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort Jessie van Wezenbeek,Joanne A Groeneveldt,Aida Llucià-Valldeperas,Cathelijne E van Der Bruggen,Samara M A Jansenet al. The Journal of Heart and Lung Transplantation, 2021, 41 (4), Online ahead of print. ⟨10.1016/j.healun.2021.11.004⟩ Article dans une revue inserm-03558871v1
The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient Chris Happé,Kondababu Kurakula,Xiao-Qing Sun,Denielli da Silva Goncalves Bos,Nina Rolet al. Cells, 2020, 9 (6), pp.1422. ⟨10.3390/cells9061422⟩ Article dans une revue hal-04526850v1
Pulmonary complications of Bcr-Abl tyrosine kinase inhibitors Jason Weatherald,Louise Bondeelle,Marie-Camille Chaumais,Christophe Guignabert,Laurent Savaleet al. European Respiratory Journal, 2020, 56 (4), pp.2000279. ⟨10.1183/13993003.00279-2020⟩ Article dans une revue hal-04526808v1
Multiple roles of macrophage migration inhibitory factor in pulmonary hypertension Gael Jalce,Christophe Guignabert American Journal of Physiology - Lung Cellular and Molecular Physiology, 2020, 318 (1), pp.L1-L9. ⟨10.1152/ajplung.00234.2019⟩ Article dans une revue inserm-02454988v1
Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension Zongye Cai,Theo Klein,Laurie Geenen,Ly Tu,Siyu Tianet al. Journal of Clinical Medicine, 2020, 9 (5), pp.1248. ⟨10.3390/jcm9051248⟩ Article dans une revue inserm-02581568v1
Additive Protective Effects of Sacubitril/Valsartan and Bosentan on Vascular Remodeling in Experimental Pulmonary Hypertension Marie-Camille Chaumais,Mohamed Reda Amar Djessas,Raphaël Thuillet,Amélie Cumont,Ly Tuet al. Cardiovascular Research, 2020, pp.cvaa200. ⟨10.1093/cvr/cvaa200⟩ Article dans une revue inserm-02907132v1
Targeting Transforming Growth Factor Beta Receptors in Pulmonary Hypertension Christophe Guignabert,Marc Humbert European Respiratory Journal, 2020, pp.2002341. ⟨10.1183/13993003.02341-2020⟩ Article dans une revue inserm-02918857v1
Connexin-43 is a promising target for pulmonary hypertension due to hypoxaemic lung disease Claire Bouvard,Nafiisha Genet,Carole Phan,Baptiste Rode,Raphaël Thuilletet al. European Respiratory Journal, 2020, 55 (3), pp.1900169. ⟨10.1183/13993003.00169-2019⟩ Article dans une revue hal-04608766v1
Endothelial cell dysfunction: a major player in SARS-CoV-2 infection (COVID-19)? Alice Huertas,David Montani,Laurent Savale,Jérémie Pichon,Ly Tuet al. European Respiratory Journal, 2020, 56 (1), pp.2001634. ⟨10.1183/13993003.01634-2020⟩ Article dans une revue hal-04526866v1
Dendritic Cells in Pulmonary Hypertension: Foot Soldiers or Hidden Enemies? Christophe Guignabert American Journal of Respiratory Cell and Molecular Biology, 2020, ⟨10.1165/rcmb.2020-0330ED⟩ Article dans une revue inserm-02918859v1
Lineage Tracing Reveals the Dynamic Contribution of Pericytes to the Blood Vessel Remodeling in Pulmonary Hypertension Jennifer Bordenave,Ly Tu,Nihel Berrebeh,Raphaël Thuillet,Amélie Cumontet al. Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, 40 (3), pp.766-782. ⟨10.1161/ATVBAHA.119.313715⟩ Article dans une revue inserm-02454982v2
Neutralization of CXCL12 attenuates established pulmonary hypertension in rats Short Title: CXCL12 neutraligands in severe PH in the rat Jennifer Bordenave,Raphaël Thuillet,Ly Tu,Carole Phan,Amélie Cumontet al. Cardiovascular Research, inPress, pp.cvz153. ⟨10.1093/cvr/cvz153⟩ Article dans une revue hal-02195697v1
Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure Edda Spiekerkoetter,Elena Goncharova,Christophe Guignabert,Kurt Stenmark,Grazyna Kwapiszewskaet al. Pulmonary Circulation, 2019, 9 (4), pp.204589401988977. ⟨10.1177/2045894019889775⟩ Article dans une revue inserm-02612634v1
Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension Ly Tu,Agnes Desroches-Castan,Christine Mallet,Laurent Guyon,Amélie Cumontet al. Circulation Research, 2019, 124 (6), pp.846-855. ⟨10.1161/CIRCRESAHA.118.313356⟩ Article dans une revue inserm-02581297v1
Role of MIF and D-DT in immune-inflammatory, autoimmune, and chronic respiratory diseases: from pathogenic factors to therapeutic targets Sven Günther,Paolo Fagone,Gaël Jalce,Atanas Atanasov,Christophe Guignabertet al. Drug Discovery Today, 2019, 24 (2), pp.428-439. ⟨10.1016/j.drudis.2018.11.003⟩ Article dans une revue istex hal-04526640v1
Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives Marc Humbert,Christophe Guignabert,Sébastien Bonnet,Peter Dorfmüller,James Klingeret al. European Respiratory Journal, 2019, 53 (1), pp.1801887. ⟨10.1183/13993003.01887-2018⟩ Article dans une revue inserm-02612658v1
Prevention of progression of pulmonary hypertension by the Nur77 agonist 6-mercaptopurine: role of BMP signalling Kondababu Kurakula,Xiao-Qing Sun,Chris Happé,Denielli da Silva Goncalves Bos,Robert Szulceket al. European Respiratory Journal, 2019, 54 (3), pp.1802400. ⟨10.1183/13993003.02400-2018⟩ Article dans une revue inserm-02612640v1
Nouveau regard sur la physiopathologie de l’hypertension artérielle pulmonaire Jennifer Bordenave,Ly Tu,Laurent Savale,Alice Huertas,Marc Humbertet al. Revue des Maladies Respiratoires, 2019, 36 (4), pp.433-437. ⟨10.1016/j.rmr.2019.03.003⟩ Article dans une revue inserm-02454990v1
Functional interaction between PDGFβ and GluN2B-containing NMDA receptors in smooth muscle cell proliferation and migration in pulmonary arterial hypertension Marceau Quatredeniers,K Nakhleh Morad,J Dumas Sebastien,Audrey Courboulin,C Vinhas Mariaet al. American Journal of Physiology - Lung Cellular and Molecular Physiology, 2019, 316 (3), pp.L445-L455. ⟨10.1152/ajplung.00537.2017⟩ Article dans une revue hal-02411597v1
Chronic Inflammation Within the Vascular Wall in Pulmonary Arterial Hypertension: More than a Spectator Alice Huertas,Ly Tu,Marc Humbert,Christophe Guignabert Cardiovascular Research, 2019, pp.cvz308. ⟨10.1093/cvr/cvz308⟩ Article dans une revue inserm-02454983v1
Optimising experimental research in respiratory diseases: an ERS statement Philippe Bonniaud,Aurélie Fabre,Nelly Frossard,Christophe Guignabert,Mark Inmanet al. European Respiratory Journal, 2018, 51 (5), pp.1702133. ⟨10.1183/13993003.02133-2017⟩ Article dans une revue hal-01996906v1
Macrophage Migration Inhibitory Factor (MIF) Inhibition in a Murine Model of Bleomycin-Induced Pulmonary Fibrosis Sven Günther,Jennifer Bordenave,Thông Hua-Huy,Carole Nicco,Amélie Cumontet al. International Journal of Molecular Sciences, 2018, 19 (12), pp.4105. ⟨10.3390/ijms19124105⟩ Article dans une revue inserm-02612651v1
Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases Alice Huertas,Christophe Guignabert,Joan Barberà,Peter Bärtsch,Jahar Bhattacharyaet al. European Respiratory Journal, 2018, 51 (4), pp.1700745. ⟨10.1183/13993003.00745-2017⟩ Article dans une revue hal-04526502v1
Therapeutic effect of pirfenidone in the sugen/hypoxia rat model of severe pulmonary hypertension Paul-Benoit Poble,Carole Phan,Timothée Quatremare,Jennifer Bordenave,Raphaël Thuilletet al. FASEB Journal, 2018, 33 (3), pp.3670-3679. ⟨10.1096/fj.201801659R⟩ Article dans une revue inserm-02581079v1
ACE2 as therapy for pulmonary arterial hypertension: the good outweighs the bad Christophe Guignabert,Frances S de Man,Marc M. Lombès European Respiratory Journal, 2018, 51 (6), pp.1800848. ⟨10.1183/13993003.00848-2018⟩ Article dans une revue inserm-02582393v1
Design, Synthesis, and Biological Activity of New N -(Phenylmethyl)-benzoxazol-2-thiones as Macrophage Migration Inhibitory Factor (MIF) Antagonists: Efficacies in Experimental Pulmonary Hypertension Morane Le Hiress,Bernardin Akagah,Guillaume Bernadat,Ly Tu,Raphaël Thuilletet al. Journal of Medicinal Chemistry, 2018, 61 (7), pp.2725-2736. ⟨10.1021/acs.jmedchem.7b01312⟩ Article dans une revue inserm-02580381v1
Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension Tinne Mertens,Ankit Hanmandlu,Ly Tu,Carole Phan,Scott Collumet al. Frontiers in Physiology, 2018, 9, pp.555. ⟨10.3389/fphys.2018.00555⟩ Article dans une revue inserm-02580921v1
Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension Yuichi Tamura,Carole Phan,Ly Tu,Morane Le Hiress,Raphaël Thuilletet al. Journal of Clinical Investigation, 2018, 128 (5), pp.1956-1970. ⟨10.1172/JCI96462⟩ Article dans une revue inserm-02580448v1
Pharmacovigilance in a rare disease: example of the VIGIAPATH program in pulmonary arterial hypertension Marie-Camille Chaumais,Caroline O’connell,Laurent Savale,Christophe Guignabert,Frédéric Perroset al. International Journal of Clinical Pharmacy, 2018, 40 (4), pp.790-794. ⟨10.1007/s11096-018-0712-y⟩ Article dans une revue hal-04526544v1
[IL6R is the key therapeutical target in pulmonary arterial hypertension] Ly Tu,Carole Phan,Marc Humbert,Christophe Guignabert Médecine/Sciences, 2018, 34 (10), pp.765-768. ⟨10.1051/medsci/2018201⟩ Article dans une revue inserm-02580983v1
Dasatinib increases endothelial permeability leading to pleural effusion Carole Phan,Etienne-Marie Jutant,Ly Tu,Raphaël Thuillet,Andrei Seferianet al. European Respiratory Journal, 2018, 51 (1), pp.1701096. ⟨10.1183/13993003.01096-2017⟩ Article dans une revue inserm-02580192v1
Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension Christophe Guignabert,Carole Phan,Andrei Seferian,Alice Huertas,Ly Tuet al. Journal of Clinical Investigation, 2016, 126 (9), pp.3207-3218. ⟨10.1172/JCI86249⟩ Article dans une revue inserm-02579754v1
Vers de nouvelles cibles pour le traitement de l’hypertension artérielle pulmonaire : Importance des communications cellulaires Ly Tu,Maria-Rosa Ghigna,Carole Phan,Jennifer Bordenave,Morane Le Hiresset al. Biologie Aujourd'hui, 2016, 210 (2), pp.65-78. ⟨10.1051/jbio/2016010⟩ Article dans une revue inserm-02579962v1
Regulatory T Cell Dysfunction in Idiopathic, Heritable and Connective Tissue-Associated Pulmonary Arterial Hypertension Alice Huertas,Carole Phan,Jennifer Bordenave,Ly Tu,Raphaël Thuilletet al. Chest, 2016, 149 (6), pp.1482-1493. ⟨10.1016/j.chest.2016.01.004⟩ Article dans une revue inserm-02593143v1
Telomere Maintenance Is a Critical Determinant in the Physiopathology of Pulmonary Hypertension Mohamed Izikki,Eric Hoang,Irena Draskovic,Olaf Mercier,Florence Lecerfet al. Journal of the American College of Cardiology, 2015, 66 (17), pp.1942 - 1943. ⟨10.1016/j.jacc.2015.08.869⟩ Article dans une revue hal-01764142v1
Leptin signalling system as a target for pulmonary arterial hypertension therapy Alice Huertas,Ly Tu,Raphaël Thuillet,Morane Le Hiress,Carole Phanet al. European Respiratory Journal, 2015, 45 (4), pp.1066-1080. ⟨10.1183/09031936.00193014⟩ Article dans une revue inserm-02579431v1
Proinflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension. Role of the Macrophage Migration Inhibitory Factor/CD74 Complex Morane Le Hiress,Ly Tu,Nicolas Ricard,Carole Phan,Raphaël Thuilletet al. American Journal of Respiratory and Critical Care Medicine, 2015, 192 (8), pp.983-997. ⟨10.1164/rccm.201402-0322OC⟩ Article dans une revue inserm-02579320v1
Role of Nerve Growth Factor in Development and Persistence of Experimental Pulmonary Hypertension Véronique Freund-Michel,Marcelina Cardoso dos Santos,Christophe Guignabert,David Montani,Carole Phanet al. American Journal of Respiratory and Critical Care Medicine, 2015, 192 (3), pp.342-355. ⟨10.1164/rccm.201410-1851OC⟩ Article dans une revue inserm-02578672v1
Role of Nerve Growth Factor in Development and Persistence of Experimental Pulmonary Hypertension Véronique Freund-Michel,Marcelina Cardoso dos Santos,Christophe Guignabert,David Montani,Carole Phanet al. American Journal of Respiratory and Critical Care Medicine, 2015, 192, pp.342 - 355. ⟨10.1164/rccm.201410-1851oc⟩ Article dans une revue hal-03329041v1
Clinical Pharmacology of Endothelin Receptor Antagonists Used in the Treatment of Pulmonary Arterial Hypertension Marie-Camille Chaumais,Christophe Guignabert,Laurent Savale,Xavier Jaïs,Athénaïs Bouclyet al. American Journal of Cardiovascular Drugs, 2015, 15 (1), pp.13-26. ⟨10.1007/s40256-014-0095-y⟩ Article dans une revue inserm-03224640v1
Increased Pericyte Coverage Mediated by Endothelial-Derived Fibroblast Growth Factor-2 and Interleukin-6 Is a Source of Smooth Muscle–Like Cells in Pulmonary Hypertension Nicolas Ricard,Ly Tu,Morane Le Hiress,Alice Huertas,Carole Phanet al. Circulation, 2014, 129 (15), pp.1586-1597. ⟨10.1161/CIRCULATIONAHA.113.007469⟩ Article dans une revue inserm-02578269v1
Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension Marine Germain,Mélanie Eyries,David Montani,Odette Poirier,Barbara Girerdet al. Nature Genetics, 2013, 45 (5), pp.518-521. ⟨10.1038/ng.2581⟩ Article dans une revue hal-02565627v1
Leptin and regulatory T-lymphocytes in idiopathic pulmonary arterial hypertension. Alice Huertas,Ly Tu,Natalia Gambaryan,Barbara Girerd,Frédéric Perroset al. European Respiratory Journal, 2012, 40 (4), pp.895-904. ⟨10.1183/09031936.00159911⟩ Article dans une revue inserm-00913076v1
Pulmonary arterial hypertension in patients treated by dasatinib. David Montani,Emmanuel Bergot,Sven Günther,Laurent Savale,Anne Bergeronet al. Circulation, 2012, 125 (17), pp.2128-37. ⟨10.1161/CIRCULATIONAHA.111.079921⟩ Article dans une revue inserm-00697146v1
A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents. Ly Tu,Frances S. de Man,Barbara Girerd,Alice Huertas,Marie-Camille Chaumaiset al. American Journal of Respiratory and Critical Care Medicine, 2012, 186 (7), pp.666-76. ⟨10.1164/rccm.201202-0309OC⟩ Article dans une revue inserm-00905191v1
Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension. Frances S. de Man,Ly Tu,Louis Handoko,Silvia Rain,Gerrina Ruiteret al. American Journal of Respiratory and Critical Care Medicine, 2012, 186 (8), pp.780-9. ⟨10.1164/rccm.201203-0411OC⟩ Article dans une revue inserm-00905193v1
Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension. Ly Tu,Laurence Dewachter,Benoit Gore,Elie Fadel,Philippe Dartevelleet al. American Journal of Respiratory Cell and Molecular Biology, 2011, 45 (2), pp.311-22. ⟨10.1165/rcmb.2010-0317OC⟩ Article dans une revue inserm-00579959v1
Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents. Mohamed Izikki,Christophe Guignabert,Elie Fadel,Marc Humbert,Ly Tuet al. Journal of Clinical Investigation, 2009, 119 (3), pp.512-23. ⟨10.1172/JCI35070⟩ Article dans une revue inserm-00499635v1
Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization. Christophe Guignabert,Cristina Alvira,Tero-Pekka Alastalo,Hirofumi Sawada,Georg Hansmannet al. American Journal of Physiology - Lung Cellular and Molecular Physiology, 2009, 297 (6), pp.L1082-90. ⟨10.1152/ajplung.00199.2009⟩ Article dans une revue inserm-00499633v1
Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension. Laurence Dewachter,Serge Adnot,Christophe Guignabert,Ly Tu,Elisabeth Marcoset al. European Respiratory Journal, 2009, 34 (5), pp.1100-10. ⟨10.1183/09031936.00183008⟩ Article dans une revue inserm-00433927v1
Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter. Christophe Guignabert,Ly Tu,Mohamed Izikki,Laurence Dewachter,Patricia Zadigueet al. FASEB Journal, 2009, 23 (12), pp.4135-47. ⟨10.1096/fj.09-131664⟩ Article dans une revue inserm-00499630v1
Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing. François Maquerlot,Stéphane D. Galiacy,Michel Malo,Christophe Guignabert,Daniel A. Lawrenceet al. American Journal of Pathology, 2006, 169 (5), pp.1624-32 Article dans une revue inserm-00186832v1
Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension. Christophe Guignabert,Mohamed Izikki,Ly Ieng Tu,Zhenlin Li,Patricia Zadigueet al. Circulation Research, 2006, 98 (10), pp.1323-30. ⟨10.1161/01.RES.0000222546.45372.a0⟩ Article dans une revue inserm-00499636v1
Effect of doxycycline on sulfur mustard-induced respiratory lesions in guinea pigs. Christophe Guignabert,Laurent Taysse,Jean-Henri Calvet,Emmanuelle Planus,Séraphin Delamancheet al. American Journal of Physiology - Lung Cellular and Molecular Physiology, 2005, 289 (1), pp.L67-74. ⟨10.1152/ajplung.00475.2004⟩ Article dans une revue inserm-00499644v1
Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats. Christophe Guignabert,Bernadette Raffestin,Rima Benferhat,William Raoul,Patricia Zadigueet al. Circulation, 2005, 111 (21), pp.2812-9. ⟨10.1161/CIRCULATIONAHA.104.524926⟩ Article dans une revue inserm-00499643v1

Communication dans un congrès (1)

Pulmonary Arterial Hypertension associated with Protein Kinase Inhibitors: A pharmacovigilance-pharmacodynamic study Lucie Cornet,Charles Khouri,Mathieu Roustit,Christophe Guignabert,Marie-Camille Chaumaiset al. European Congres of Clinical Pharmacology and Therapeutics, Jun 2019, Stockholm, Sweden Communication dans un congrès hal-04892354v1