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Christophe Hirtz




Mass Spectrometry-Based Pipeline for Identifying RNA Modifications Involved in a Functional Process: Application to Cancer Cell Adaptation

Amandine Amalric , Aurore Attina , Amandine Bastide , Marion Buffard , Stéphanie Mateus
Analytical Chemistry, 2024, 96 (5), pp.1825-1833. ⟨10.1021/acs.analchem.3c02635⟩
Journal articles hal-04430022v1
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Multiplexed LC‐MS / MS quantification of salivary RNA modifications in periodontitis

Margaux Vignon , Amandine Bastide , Aurore Attina , Alexandre David , Philippe Bousquet
Journal of Periodontal Research, 2023, 58 (5), pp.959-967. ⟨10.1111/jre.13155⟩
Journal articles inserm-04244619v1
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New Perspectives of Multiplex Mass Spectrometry Blood Protein Quantification on Microsamples in Biological Monitoring of Elderly Patients

Jérôme Vialaret , Margaux Vignon , Stéphanie Badiou , Gregory Baptista , Laura Fichter
International Journal of Molecular Sciences, 2023, 24 (8), pp.6989. ⟨10.3390/ijms24086989⟩
Journal articles hal-04092116v2
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Neurofilament-Light, a Promising Biomarker: Analytical, Metrological and Clinical Challenges

Salomé Coppens , Sylvain Lehmann , Christopher Hopley , Christophe Hirtz
International Journal of Molecular Sciences, 2023, 24 (14), pp.11624. ⟨10.3390/ijms241411624⟩
Journal articles hal-04595869v1
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Nicotianamine synthase activity affects nucleolar iron accumulation and impacts rDNA silencing and RNA methylation in Arabidopsis

Charlotte Montacié , Christophe Riondet , Lili Wei , Tommy Darrière , Alizée Weiss
Journal of Experimental Botany, 2023, 74 (15), pp.4384-4400. ⟨10.1093/jxb/erad180⟩
Journal articles hal-04097969v1
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Development of a candidate reference measurement procedure by ID-LC-MS/MS for total tau protein measurement in cerebrospinal fluid (CSF)

Chiara Giangrande , Hélène Vaneeckhoutte , Amandine Boeuf , Béatrice Lalere , Christophe Hirtz
Clinical Chemistry and Laboratory Medicine, 2023, 61 (7), pp.1235-1244. ⟨10.1515/cclm-2022-1250⟩
Journal articles hal-04598085v1

Use of dried blood spots for monitoring inflammatory and nutritional biomarkers in the elderly

Jérôme Vialaret , Margaux Vignon , Christophe Hirtz , Stéphanie Badiou , Gregory Baptista
Clinical Chemistry and Laboratory Medicine, 2023, 62 (5), pp.881-890. ⟨10.1515/cclm-2023-0312⟩
Journal articles inserm-04435829v1

Lifelong exposure to high‐altitude hypoxia in humans is associated with improved redox homeostasis and structural‐functional adaptations of the neurovascular unit

Benjamin Stacey , Ryan Hoiland , Hannah Caldwell , Connor Howe , Tyler Vermeulen
The Journal of Physiology, 2023, 601 (6), pp.1095-1120. ⟨10.1113/JP283362⟩
Journal articles hal-03946525v1

Multiplexed LC-MS/MS quantification of salivary RNA modifications in periodontitis

Margaux Vignon , Amandine Bastide , Alexandre David , Philippe Bousquet , Valérie Orti
Journal of Periodontal Research, inPress, ⟨10.1111/jre.13155⟩
Journal articles hal-04138466v1
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Comparison of ultrasensitive and mass spectrometry quantification of blood-based amyloid biomarkers for Alzheimer’s disease diagnosis in a memory clinic cohort

Christophe Hirtz , Germain Busto , Karim Bennys , Jana Kindermans , Sophie Navucet
Alzheimer's Research and Therapy, 2023, 15 (1), pp.34. ⟨10.1186/s13195-023-01188-8⟩
Journal articles hal-04598384v1

Quantifying RNA modifications by mass spectrometry: a novel source of biomarkers in oncology

Amandine Amalric , Amandine Bastide , Aurore Attina , Armelle Choquet , Jerome Vialaret
Critical Reviews in Clinical Laboratory Sciences, inPress, 59 (1), pp.1-18. ⟨10.1080/10408363.2021.1958743⟩
Journal articles hal-03340697v1
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Intra-articular delivery of full-length antibodies through the use of an in situ forming depot

Alexis Fayd'Herbe de Maudave , Wilhem Leconet , Karine Toupet , Michael Constantinides , Guillaume Bossis
Journal of Controlled Release, 2022, 341, pp.578-590. ⟨10.1016/j.jconrel.2021.12.010⟩
Journal articles hal-03563900v1
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Repeated neurofilament light chain measurements did not capture Riluzole therapeutic effect in amyotrophic lateral sclerosis patients

Florence Esselin , Elisa de la Cruz , Christophe Hirtz , Laurent Tiers , Sébastien Alphandery
CNS Neuroscience & Therapeutics, 2022, 28 (10), pp.1532-1538. ⟨10.1111/cns.13894⟩
Journal articles hal-04471223v1
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Rheology predicts sputum eosinophilia in patients with muco-obstructive lung diseases

Mathilde Volpato , Jérôme Vialaret , Christophe Hirtz , Aurélie Petit , Carey Suehs
Biochemical and Biophysical Research Communications, 2022, 622, pp.64-71. ⟨10.1016/j.bbrc.2022.07.025⟩
Journal articles hal-03725444v1
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Deciphering Black Extrinsic Tooth Stain Composition in Children Using Metaproteomics

Christophe Hirtz , Atef Mahmoud Mannaa , Estelle Moulis , Olivier Pible , Robin O’flynn
ACS Omega, 2022, 7 (10), pp.8258-8267. ⟨10.1021/acsomega.1c04770⟩
Journal articles hal-04080011v1
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β-Synuclein as a candidate blood biomarker for synaptic degeneration in Alzheimer’s disease

Pablo Mohaupt , Marie-Laure Pons , Jérôme Vialaret , Constance Delaby , Christophe Hirtz
Alzheimer's Research and Therapy, 2022, 14 (1), pp.179. ⟨10.1186/s13195-022-01125-1⟩
Journal articles hal-04258435v1
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The alternative proteome in neurobiology

Pablo Mohaupt , Xavier Roucou , Constance Delaby , Jérôme Vialaret , Sylvain Lehmann
Frontiers in Cellular Neuroscience, 2022, 16, ⟨10.3389/fncel.2022.1019680⟩
Journal articles hal-04256275v1
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Multivariate Analysis of RNA Chemistry Marks Uncovers Epitranscriptomics-Based Biomarker Signature for Adult Diffuse Glioma Diagnostics

Sébastien Relier , Amandine Amalric , Aurore Attina , Izoudine Blaise Koumare , Valérie Rigau
Analytical Chemistry, 2022, 94 (35), pp.11967-11972. ⟨10.1021/acs.analchem.2c01526⟩
Journal articles lirmm-03761119v1
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Use of plasma biomarkers for AT(N) classification of neurodegenerative dementias

Daniel Alcolea , Constance Delaby , Laia Muñoz , Soraya Torres , Teresa Estellés
Journal of Neurology, Neurosurgery and Psychiatry, 2021, 92 (11), pp.1206-1214. ⟨10.1136/jnnp-2021-326603⟩
Journal articles hal-03653194v1
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FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell

Sébastien Relier , Julie Ripoll , Hélène Guillorit , Amandine Amalric , Cyrinne Achour
Nature Communications, 2021, 12 (1), pp.1716. ⟨10.1038/s41467-021-21758-4⟩
Journal articles hal-03178788v2

Analytical comparison of ELISA and mass spectrometry for quantification of serum hepcidin in critically ill patients

Constance Delaby , Jérôme Vialaret , Christophe Hirtz , Thibaud Lefebvre , Matthias Herkert
Bioanalysis, inPress, ⟨10.4155/bio-2021-0069⟩
Journal articles hal-03258593v1
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Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection

Christian Selinger , Massilva Rahmoun , Carmen Lia Murall , Claire Bernat , Vanina Boué
Immunologic Research, 2021, 69 (3), pp.255-263. ⟨10.1007/s12026-021-09196-2⟩
Journal articles hal-03354891v1

Cytokines as new biomarkers of skin wound vitality

Pierre-Antoine Peyron , Sophie Colomb , Dorian Becas , Aurélie Adriansen , Guillaume Gauchotte
International Journal of Legal Medicine, 2021, 135 (6), pp.2537-2545. ⟨10.1007/s00414-021-02659-z⟩
Journal articles hal-03651889v1

The potential impact of salivary peptides in periodontitis

Christophe Hirtz , Robin O'Flynn , Pierre Marie Voisin , Dominique Deville de Périère , Sylvain Lehmann
Critical Reviews in Clinical Laboratory Sciences, 2021, 58 (7), pp.479-492. ⟨10.1080/10408363.2021.1907298⟩
Journal articles hal-03659724v1
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Peripheral Blood and Salivary Biomarkers of Blood–Brain Barrier Permeability and Neuronal Damage: Clinical and Applied Concepts

Damir Janigro , Damian Bailey , Sylvain Lehmann , Jerome Badaut , Robin O'Flynn
Frontiers in Neurology, 2021, 11, ⟨10.3389/fneur.2020.577312⟩
Journal articles hal-03151054v1

Tau protein in cerebrospinal fluid: a novel biomarker of the time of death?

Pierre-Antoine Peyron , Christophe Hirtz , Eric Baccino , Nelly Ginestet , Laurent Tiers
International Journal of Legal Medicine, 2021, 135 (5), pp.2081-2089. ⟨10.1007/s00414-021-02558-3⟩
Journal articles hal-03669478v1
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Editorial: Proteomics as a Tool for Biomarker and Drug Target Discovery: Improving the Diagnosis and Treatment of Neurodegenerative Diseases

Olivia Belbin , Sylvain Lehmann , Eduard Sabidó , Christophe Hirtz
Frontiers in Aging Neuroscience, 2020, 12, pp.232. ⟨10.3389/fnagi.2020.00232⟩
Journal articles hal-03177444v1
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Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity

Xavier Ayrignac , Emmanuelle Le Bars , Claire Duflos , Christophe Hirtz , Aleksandra Maleska Maceski
Scientific Reports, 2020, 10 (1), pp.10923. ⟨10.1038/s41598-020-67934-2⟩
Journal articles inserm-02904593v1

Detection of amyloid beta peptides in body fluids for the diagnosis of alzheimer’s disease: Where do we stand?

Bhavana Veerabhadrappa , Constance Delaby , Christophe Hirtz , Jérôme Vialaret , Daniel Alcolea
Critical Reviews in Clinical Laboratory Sciences, 2020, 57 (2), pp.99-113. ⟨10.1080/10408363.2019.1678011⟩
Journal articles hal-03374586v1
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Laccases 2 & 3 as biomarkers of Botrytis cinerea infection in sweet white wines

S. Ployon , A. Attina , J. Vialaret , Anne Sophie Walker , Christophe Hirtz
Food Chemistry, 2020, 315, pp.126233. ⟨10.1016/j.foodchem.2020.126233⟩
Journal articles hal-02505356v1
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Hepcidin and ferritin levels in restless legs syndrome: a case–control study

Sofiene Chenini , Constance Delaby , Anna-Laura Rassu , Lucie Barateau , Jérôme Vialaret
Scientific Reports, 2020, 10 (1), pp.11914. ⟨10.1038/s41598-020-68851-0⟩
Journal articles inserm-02938904v1

Gravitational Transitions Increase Posterior Cerebral Perfusion and Systemic Oxidative-nitrosative Stress: Implications for Neurovascular Unit Integrity

Damian Bailey , Damien Lanéelle , Jean-Eudes Trihan , Nicola Marchi , Benjamin Stacey
Neuroscience, 2020, 441, pp.142-160. ⟨10.1016/j.neuroscience.2020.05.048⟩
Journal articles hal-02863966v1

Variation of human salivary alpha-amylase proteoforms in three stimulation models

María D Contreras-Aguilar , Jérôme Vialaret , Dominique Deville de Périère , Damian Escribano , Sylvain Lehmann
Clinical Oral Investigations, 2020, 24 (1), pp.475-486. ⟨10.1007/s00784-019-03021-9⟩
Journal articles hal-02505323v1
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Cellules souches dentaires : mythe ou espoir en médecine neurorégénératrice ?

Syrine Dimassi , Aroa Relaño-Ginés , Christophe Hirtz , Sylvain Lehmann , Dominique Deville de Périère
Annales de Biologie Clinique, 2020, 78 (6), pp.593-603. ⟨10.1684/abc.2020.1611⟩
Journal articles hal-03174618v1
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Cerebrospinal Fluid and Plasma Biomarkers do not Differ in the Presenile and Late-Onset Behavioral Variants of Frontotemporal Dementia

Nicolas Menjot de Champfleur , Aleksandra Maleska , Cecilia Marelli , Claire Hourregue , Laure-Anne Gutierrez
Journal of Alzheimer's Disease, 2020, pp.1-9. ⟨10.3233/JAD-190378⟩
Journal articles hal-02505372v1
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Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer’s disease and PET amyloid-positive patient identification

Nicolas Barthelemy , Randall Bateman , Christophe Hirtz , Philippe Marin , François Becher
Alzheimer's Research and Therapy, 2020, 12 (1), ⟨10.1186/s13195-020-00596-4⟩
Journal articles hal-03017889v1
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SILK studies — capturing the turnover of proteins linked to neurodegenerative diseases

Ross Paterson , Audrey Gabelle , Brendan Lucey , Nicolas Barthelemy , Claire Leckey
Nature Reviews Neurology, 2019, 15 (7), pp.419-427. ⟨10.1038/s41582-019-0222-0⟩
Journal articles hal-02505307v1
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The prognostic value of the Tau protein serum level in metastatic breast cancer patients and its correlation with brain metastases

Amélie Darlix , Christophe Hirtz , Simon Thèzenas , Aleksandra Maceski , Audrey Gabelle
BMC Cancer, 2019, 19 (1), pp.110. ⟨10.1186/s12885-019-5287-z⟩
Journal articles inserm-02050007v1
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The m 6 A pathway protects the transcriptome integrity by restricting RNA chimera formation in plants

Dominique Pontier , Claire Picart , Moaine El Baidouri , François Roudier , Tao Xu
Life Science Alliance, 2019, 2 (3), pp.e201900393. ⟨10.26508/lsa.201900393⟩
Journal articles hal-02505328v1
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Biochemical markers of time since death in cerebrospinal fluid: A first step towards “Forensomics”

Pierre-Antoine Peyron , Sylvain Lehmann , Constance Delaby , Eric Baccino , Christophe Hirtz
Critical Reviews in Clinical Laboratory Sciences, 2019, 56 (4), pp.274-286. ⟨10.1080/10408363.2019.1619158⟩
Journal articles hal-02505396v1
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Bystander effectors of chondrosarcoma cells irradiated at different LET impair proliferation of chondrocytes

Charlotte Lepleux , Aurélie Marie-Brasset , Mihaela Temelie , Marion Boulanger , Émilie Brotin
Journal of Cell Communication and Signaling, 2019, 13 (3), pp.343-356. ⟨10.1007/s12079-019-00515-9⟩
Journal articles inserm-02125509v1
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Sylvain Lehmann , Christophe Hirtz , Jérôme Vialaret , Maxence Ory , Guillaume Gras Combes
Analytical Chemistry, 2019, 91 (24), pp.15500-15508. ⟨10.1021/acs.analchem.9b03328⟩
Journal articles hal-02368099v1
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Natural history, dynamics, and ecology of human papillomaviruses in genital infections of young women: protocol of the PAPCLEAR cohort study

Carmen Murall , Massilva Rahmoun , Christian Selinger , Monique Baldellou , Claire Bernat
BMJ Open, 2019, 9 (6), pp.e025129. ⟨10.1136/bmjopen-2018-025129⟩
Journal articles hal-02157154v1

Dental stem cells as a promising source for cell therapies in neurological diseases

Aroa Relaño-Ginès , Sylvain Lehmann , Dominique Deville de Périère , Christophe Hirtz
Critical Reviews in Clinical Laboratory Sciences, 2019, 56 (3), pp.170-181. ⟨10.1080/10408363.2019.1571478⟩
Journal articles hal-02505362v1

Association between serum hepcidin level and restless legs syndrome

Yves Dauvilliers , Sofiene Chenini , Jérôme Vialaret , Constance Delaby , Lily Guiraud
Movement Disorders, 2018, 33 (4), pp.618 - 627. ⟨10.1002/mds.27287⟩
Journal articles hal-01842236v1

Albumin depletion of human serum to improve quantitative clinical proteomics

Jerome Vialaret , Sarah Kadiri , Laurent Tiers , Robin O’flynn , Dominique Deville de Périère
Current Topics in Peptide and Protein Research, 2018, 19, pp.53-62
Journal articles hal-03123191v1

Nano-flow vs standard-flow: Which is the more suitable LC/MS method for quantifying hepcidin-25 in human serum in routine clinical settings?

Jérôme Vialaret , Alexia Picas , Constance Delaby , Pauline Bros , Sylvain Lehmann
Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2018, 1086, pp.110 - 117. ⟨10.1016/j.jchromb.2018.04.003⟩
Journal articles hal-01842184v1

What sample preparation should be chosen for targeted MS monoclonal antibody quantification in human serum?

Jérôme Vialaret , Sophie Broutin , Célia Pugnier , Sophie Santelé , Aurore Jaffuel
Bioanalysis, 2018, 10 (10), pp.723 - 735. ⟨10.4155/bio-2018-0027⟩
Journal articles hal-01842189v1

Plasma and CSF biomarkers for the diagnosis of Alzheimer's disease in adults with Down syndrome: a cross-sectional study

Juan Fortea , María Carmona-Iragui , Bessy Benejam , Susana Fernandez , Laura Videla
The Lancet Neurology, 2018, 17 (10), pp.860-869. ⟨10.1016/S1474-4422(18)30285-0⟩
Journal articles hal-02315310v1

Towards a routine application of Top-Down approaches for label-free discovery workflows

Pierre-Olivier Schmit , Jérôme Vialaret , Hans J.C.T. Wessels , Alain van Gool , Sylvain Lehmann
Journal of Proteomics, 2018, 175, pp.12 - 26. ⟨10.1016/j.jprot.2017.08.003⟩
Journal articles hal-01757595v1

Regulatory context and validation of assays for clinical mass spectrometry proteomics (cMSP) methods

Christophe Hirtz , Pauline Bros , Cato Brede , Pierre Lescuyer , Aleksandra Maceski
Critical Reviews in Clinical Laboratory Sciences, 2018, 55 (5), pp.346 - 358. ⟨10.1080/10408363.2018.1470159⟩
Journal articles hal-01842214v1
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Sample Pooling and Inflammation Linked to the False Selection of Biomarkers for Neurodegenerative Diseases in Top–Down Proteomics: A Pilot Study

Nicolas Molinari , Stéphane Roche , Katell Peoc’h , Laurent Tiers , Martial Séveno
Frontiers in Molecular Neuroscience, 2018, 11, pp.477. ⟨10.3389/fnmol.2018.00477⟩
Journal articles hal-02061536v1

Strain effect on extracellular laccase activities from Botrytis cinerea

Natalia Quijada Morin , François Garcia , Karen Lambert , Anne-Sophie Walker , Laurent Tiers
Australian Journal of Grape and Wine Research, 2018, 24 (2), pp.241-251. ⟨10.1111/ajgw.12322⟩
Journal articles hal-01837855v1

Impact of biological matrix on inflammatory protein biomarker quantification based on targeted mass spectrometry

Anne Incamps , Celia Saez-Boiteau , Svenja Lena Tiede , Pauline Rebillard , Janin Schulte
Bioanalysis, 2018, 10 (17), pp.1383--1399. ⟨10.4155/bio-2018-0149⟩
Journal articles hal-02316826v1

Alzheimer’s Disease: Advances in Drug Development

Morgane Piton , Christophe Hirtz , Caroline Desmetz , Jacqueline Milhau , Anne Dominique Lajoix
Journal of Alzheimer's Disease, 2018, 65 (1), pp.3 - 13. ⟨10.3233/JAD-180145⟩
Journal articles hal-01876065v1
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Data from a targeted proteomics approach to discover biomarkers in saliva for the clinical diagnosis of periodontitis

Brenda Mertens , Valérie Orti , J. Vialaret , Philippe Gibert , A. Relaño-Ginés
Data in Brief, 2018, 18, pp.294-299. ⟨10.1016/j.dib.2018.03.036⟩
Journal articles hal-02498960v2

Assessing a multiplex-targeted proteomics approach for the clinical diagnosis of periodontitis using saliva samples

Brenda Mertens , Valérie Orti , Jérôme Vialaret , Philippe Gibert , Aroa Relaño-Ginès
Bioanalysis, 2018, 10 (1), pp.35 - 45. ⟨10.4155/bio-2017-0218⟩
Journal articles hal-01842210v1

La salive un avenir prometteur dans le monde du diagnostic médical et parodontal

Brenda Mertens , Mendy Labau , Margaux Vignon , Christophe Hirtz
Information Dentaire, 2018
Journal articles hal-03984163v1
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Identification of multiple proteoforms biomarkers on clinical samples by routine Top-Down approaches

Jérôme Vialaret , Pierre-Olivier Schmit , Sylvain Lehmann , Audrey Gabelle , Jason Wood
Data in Brief, 2018, 18, pp.1013 - 1021. ⟨10.1016/j.dib.2018.03.114⟩
Journal articles hal-01842181v1

Quantification of hepcidin-25 in human cerebrospinal fluid using LC–MS/MS

Constance Delaby , Pauline Bros , Jérôme Vialaret , Amandine Moulinier , Vincent Delatour
Bioanalysis, 2017, 9 (4), pp.337 - 347. ⟨10.4155/bio-2016-0240⟩
Journal articles hal-01792350v1

Clinical perspectives of dried blood spot protein quantification using mass spectrometry methods

Sylvain Lehmann , Alexia Picas , Laurent Tiers , Jérôme Vialaret , Christophe Hirtz
Critical Reviews in Clinical Laboratory Sciences, 2017, 54 (3), pp.173 - 184. ⟨10.1080/10408363.2017.1297358⟩
Journal articles hal-01763080v1

Clinical mass spectrometry proteomics (cMSP) for medical laboratory: What does the future hold?

Sylvain Lehmann , Cato Brede , Pierre Lescuyer , José Cocho , Jérôme Vialaret
Clinica Chimica Acta, 2017, 467, pp.51 - 58. ⟨10.1016/j.cca.2016.06.001⟩
Journal articles hal-01842326v1

Cerebrospinal fluid levels of orexin-A and histamine, and sleep profile within the Alzheimer process

Audrey Gabelle , Isabelle Jaussent , Christophe Hirtz , Jérôme Vialaret , Sophie Navucet
Neurobiology of Aging, 2017, 53, pp.59 - 66. ⟨10.1016/j.neurobiolaging.2017.01.011⟩
Journal articles hal-01781465v1

Impurity determination for hepcidin by liquid chromatography-high resolution and ion mobility mass spectrometry for the value assignment of candidate primary calibrators

Pauline Bros , Ralf Josephs , Norbert Stoppacher , Guillaume Cazals , Sylvain Lehmann
Analytical and Bioanalytical Chemistry, 2017, 409 (10), pp.2559 - 2567. ⟨10.1007/s00216-017-0202-4⟩
Journal articles hal-01785651v1
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RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma

E Viziteu , B Klein , J. Basbous , Yea-Lih Lin , Christophe Hirtz
Leukemia, 2017, 31 (10), pp.2104 - 2113. ⟨10.1038/leu.2017.54⟩
Journal articles hal-01630891v1
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Comparison of HbA1c detection in whole blood and dried blood spots using an automated ion-exchange HPLC system

Aleksandra Maleska , Christophe Hirtz , Elise Casteleyn , Orianne Villard , Jacques Ducos
Bioanalysis, 2017, 9 (5), pp.427-434. ⟨10.4155/bio-2016-0278⟩
Journal articles hal-01781609v1

Characterizing Deep White Matter Hyperintensities in Patients with Symptomatic Isolated Cortical Superficial Siderosis

Dimitri Renard , Lavinia Tatu , Christophe Demattei , Christophe Hirtz , Sylvain Lehmann
Journal of Stroke and Cerebrovascular Diseases, 2017, 26 (3), pp.465 - 469. ⟨10.1016/j.jstrokecerebrovasdis.2016.12.022⟩
Journal articles hal-01792463v1

Proteomic profile of cerebrospinal fluid in patients with multiple sclerosis using two dimensional gel electrophoresis

Dina Hassan , Monique Provansal , Sylvain Lehmann , Moustafa Rizk , Pacint Moez
British Journal of Biomedical Science, 2016, 73 (3), pp.143 - 146. ⟨10.1080/09674845.2016.1186310⟩
Journal articles hal-01842395v1

Cerebrospinal Fluid Alzheimer’s Disease Biomarkers in Isolated Supratentorial Cortical Superficial Siderosis

Dimitri Renard , Audrey Gabelle , Christophe Hirtz , Christophe Demattei , Eric Thouvenot
Journal of Alzheimer's Disease, 2016, 54 (4), pp.1291 - 1295. ⟨10.3233/JAD-160400⟩
Journal articles hal-01825499v1
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From radioimmunoassay to mass spectrometry: a new method to quantify orexin-A (hypocretin-1) in cerebrospinal fluid

Christophe Hirtz , Jérôme Vialaret , Audrey Gabelle , Nora Nowak , Yves Dauvilliers
Scientific Reports, 2016, 6, pp.25162. ⟨10.1038/srep25162⟩
Journal articles hal-01842392v1

Tau Protein Quantification in Human Cerebrospinal Fluid by Targeted Mass Spectrometry at High Sequence Coverage Provides Insights into Its Primary Structure Heterogeneity

Nicolas Barthélemy , François Fenaille , Christophe Hirtz , Nicolas Sergeant , Susanna Schraen-Maschke
Journal of Proteome Research, 2016, 15 (2), pp.667 - 676. ⟨10.1021/acs.jproteome.5b01001⟩
Journal articles hal-01842426v1

Development of new quantitative mass spectrometry and semi-automatic isofocusing methods for the determination of Apolipoprotein E typing

Christophe Hirtz , Jérôme Vialaret , Georges Nouadje , Susanna Schraen , Pascal Benlian
Clinica Chimica Acta, 2016, 454, pp.33 - 38. ⟨10.1016/j.cca.2015.12.020⟩
Journal articles hal-01842388v1

Cerebrospinal Fluid Alzheimer’s Disease Biomarkers in Cerebral Amyloid Angiopathy-Related Inflammation

Dimitri Renard , Anne Wacongne , Xavier Ayrignac , Mahmoud Charif , Genevieve Fourcade
Journal of Alzheimer's Disease, 2016, 50 (3), pp.759 - 764. ⟨10.3233/JAD-150621⟩
Journal articles hal-01842362v1

Differential Mass Spectrometry Profiles of Tau Protein in the Cerebrospinal Fluid of Patients with Alzheimer’s Disease, Progressive Supranuclear Palsy, and Dementia with Lewy Bodies

Nicolas Barthélemy , Audrey Gabelle , Christophe Hirtz , François Fenaille , Nicolas Sergeant
Journal of Alzheimer's Disease, 2016, 51 (4), pp.1033 - 1043. ⟨10.3233/JAD-150962⟩
Journal articles hal-01842422v1

Absolute quantification of 35 plasma biomarkers in human saliva using targeted MS

Christophe Hirtz , Jérôme Vialaret , Nora Nowak , Audrey Gabelle , Dominique Deville de Périère
Bioanalysis, 2016, 8 (1), pp.43 - 53. ⟨10.4155/bio.15.228⟩
Journal articles hal-01842381v1
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Multi-omics profiling reveals that eating difficulties developed consecutively to artificial nutrition in the neonatal period are associated to specific saliva composition

Martine Morzel , Eric Neyraud , Hélène Brignot , Patrick Ducoroy , Aline Jeannin
Journal of Proteomics, 2015, 128, pp.105-112. ⟨10.1016/j.jprot.2015.07.028⟩
Journal articles hal-01216253v2

What is the potential of dried matrix spot sampling for cerebrospinal fluid analysis?

Christophe Hirtz , Sylvain Lehmann
Bioanalysis, 2015, 7 (22), pp.2849 - 2851. ⟨10.4155/bio.15.201⟩
Journal articles hal-01842456v1

Stable Isotope Labeling by Amino acid in Vivo (SILAV): a new method to explore protein metabolism

Sylvain Lehmann , Jérôme Vialaret , Guillaume Gras Combe , Luc Bauchet , Olivier Hanon
Rapid Communications in Mass Spectrometry, 2015, 29 (20), pp.1917 - 1925. ⟨10.1002/rcm.7289⟩
Journal articles hal-01842452v1

[Blood sampling using "dried blood spot": a clinical biology revolution underway?].

Christophe Hirtz , Sylvain Lehmann
Annales de Biologie Clinique, 2015, pp.25-37. ⟨10.1684/abc.2014.1007⟩
Journal articles hal-01842461v1

Préparation injectable de leucine marquée au carbone 13 pour un programme de recherche clinique sur la maladie d’Alzheimer : contrôle pharmaceutique des matières premières et du produit fini et étude de stabilité

L. Tall , Sylvain Lehmann , E. Diouf , C. Gérard , S. Filali
Annales Pharmaceutiques Françaises, 2015, 73 (1), pp.43 - 59. ⟨10.1016/j.pharma.2014.06.002⟩
Journal articles hal-01842440v1
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Comparison of Hydrophobic, Lipophilic and Immunodepletion Pre- Fractionation Methods for Label-Free LC-MS/MS Identification of Biomarkers in Human Cerebrospinal Fluid

Sylvain Lehmann , Jérôme Vialaret , Martial Séveno , Laurent Tiers , Audrey Gabelle
Journal of Proteomics and Bioinformatics, 2015, s5, ⟨10.4172/JPB.S5-003⟩
Journal articles hal-03108550v1
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Antibody-free quantification of seven tau peptides in human CSF using targeted mass spectrometry

Pauline Bros , Jérôme Vialaret , Nicolas Barthelemy , Vincent Delatour , Audrey Gabelle
Frontiers in Neuroscience, 2015, 9, ⟨10.3389/fnins.2015.00302⟩
Journal articles hal-01842470v1

Human S100A10 plays a crucial role in the acquisition of the endometrial receptivity phenotype

Laurence Bissonnette , Loubna Drissennek , Yannick Antoine , Laurent Tiers , Christophe Hirtz
Cell Adhesion and Migration, 2015, 10 (3), pp.282 - 298. ⟨10.1080/19336918.2015.1128623⟩
Journal articles hal-01842413v1

Quantitative detection of amyloid-β peptides by mass spectrometry: state of the art and clinical applications

Pauline Bros , Vincent Delatour , Jérôme Vialaret , Béatrice Lalere , Nicolas Barthelemy
Clinical Chemistry and Laboratory Medicine, 2015, 53 (10), pp.1483-93. ⟨10.1515/cclm-2014-1048⟩
Journal articles hal-02077074v1
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Clinical measurement of Hepcidin-25 in human serum: Is quantitative mass spectrometry up to the job?

Constance Delaby , Jérôme Vialaret , Pauline Bros , Audrey Gabelle , Thibaud Lefebvre
EuPA Open Proteomics, 2014, 3, pp.60-67. ⟨10.1016/j.euprot.2014.02.004⟩
Journal articles hal-03096687v1
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Excreted/secreted proteins from Trypanosome procyclic strains

C.M.A. Nten , Nicolas Sommerer , Valerie Rofidal , Christophe Hirtz , Michel Rossignol
Journal of Biomedicine and Biotechnology, 2010, 2010, pp.212817. ⟨10.1155/2010/212817⟩
Journal articles hal-02668579v1
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Exocytosis and protein secretion in Trypanosoma

Anne Geiger , Christophe Hirtz , Thierry Becue , Eric Bellard , Delphine D. Centeno
BMC Microbiology, 2010, 10, pp.20. ⟨10.1186/1471-2180-10-20⟩
Journal articles hal-02502942v1

Proteins and proteolysis in pre-term and term human milk and possible implications for infant formulae

Emanuele Armaforte , Erika Curran , Thom Huppertz , C. Anthony Ryan , Maria Caboni
International Dairy Journal, 2010, 20 (10), pp.715-723. ⟨10.1016/j.idairyj.2010.03.008⟩
Journal articles hal-02502695v1
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Matrix-assisted laser desorption/ionization imaging mass spectrometry of oxaliplatin derivatives in heated intraoperative chemotherapy (HIPEC)-like treated rat kidney.

Amina Bouslimani , Nicole Bec , Matthias Glueckmann , Christophe Hirtz , Christian Larroque
Rapid Communications in Mass Spectrometry, 2010, 24 (4), pp.415-21. ⟨10.1002/rcm.4408⟩
Journal articles inserm-00452373v1

Use of Reducing/Nonreducing Two-Dimensional Electrophoresis for the Study of Disulfide-Mediated Interactions between Proteins in Raw and Heated Bovine Milk

François Chevalier , Christophe Hirtz , Nicolas Sommerer , Alan Kelly
Journal of Agricultural and Food Chemistry, 2009, 57 (13), pp.5948-5955. ⟨10.1021/jf900518n⟩
Journal articles hal-02502915v1

Use of Reducing/Nonreducing Two-Dimensional Electrophoresis for the Study of Disulfide-Mediated Interactions between Proteins in Raw and Heated Bovine Milk

François Chevalier , Christophe Hirtz , Nicolas Sommerer , Alan Kelly
Journal of Agricultural and Food Chemistry, 2009, 57 (13), pp.5948-5955. ⟨10.1021/jf900518n⟩
Journal articles hal-02502451v1
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The effect of environmental salinity on the proteome of the sea bass (Dicentrarchus labrax L.)

Chin-Long Ky , Julien de Lorgeril , Christophe Hirtz , Nicolas Sommerer , Michel Rossignol
Animal Genetics, 2007, 38 (6), pp.601-608. ⟨10.1111/j.1365-2052.2007.01647.x⟩
Journal articles hal-02663397v1
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Proteomic Studies of Saliva: A Proposal for a Standardized Handling of Clinical Samples

François Chevalier , Christophe Hirtz , Sandrine Chay , Frédéric Cuisinier , Nicolas Sommerer
Clinical Proteomics, 2007, 3 (1-4), pp.13 - 21. ⟨10.1007/s12014-007-9000-x⟩
Journal articles hal-01743573v1

Salivary protein profiling in type I diabetes using two-dimensional electrophoresis and mass spectrometry

Christophe Hirtz , François Chevalier , Nicolas Sommerer , Isabelle Raingeard , Jacques Bringer
Clinical Proteomics, 2006, 2 (1-2), pp.117-127. ⟨10.1385/CP:2:1:117⟩
Journal articles hal-02502403v1

MS characterization of multiple forms of alpha-amylase in human saliva

Christophe Hirtz , François Chevalier , Delphine D. Centeno , Valerie Rofidal , Jean-Christophe Egea
Proteomics, 2005, 5 (17), pp.4597-4607. ⟨10.1002/pmic.200401316⟩
Journal articles hal-02501106v1

Preproinsulin I and II mRNA expression in adult rat submandibular glands

Jean-Christophe Egea , Christophe Hirtz , René Gross , Anne-Dominique Lajoix , Estelle Traskawka
European Journal of Oral Sciences, 2000, 108 (4), pp.292-296. ⟨10.1034/j.1600-0722.2000.108004292.x⟩
Journal articles hal-02502634v1
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B2 kinin receptor upregulation by cAMP is associated with BK-induced PGE2 production in rat mesangial cells

Maria E. Marin Castaño , Joost P Schanstra , Christophe Hirtz , Christiane Pecher , Jean-Pierre Girolami
AJP Renal Physiology, 1998, 274 (3), pp.532-540. ⟨10.1152/ajprenal.1998.274.3.F532⟩
Journal articles hal-02502598v1
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The B1-agonist [des-Arg10 ]-kallidin Activates Transcription Factor NF-B and Induces Homologous Upregulation of the Bradykinin B1-receptor in Cultured Human Lung Fibroblasts

Joost Schanstra , E Bataillé , Maria E. Marin Castaño , Yannick Barascud , Christophe Hirtz
Journal of Clinical Investigation, 1998, 101 (10), pp.2080-2091. ⟨10.1172/JCI1359⟩
Journal articles hal-02502902v1

Children with eating disorders secondarily to artificial nutrition in the neonatal period have specific food preferences and saliva composition

Martine Morzel , Eric Neyraud , Géraldine Lucchi , Hélène Brignot , Patrick Ducoroy
49. annual meeting of the European society for paediatric gastroenterology, hepatology and nutrition, European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). USA., May 2016, Athènes, Greece
Conference papers hal-01512124v1

Multi-omics profiling reveals that eating difficulties developed consecutively to artificial nutrition in the neonatal period are associated to specific saliva composition

Géraldine Lucchi , Martine Morzel , Eric Neyraud , Hélène Brignot , Patrick Ducoroy
Congrès français de Spectrométrie de Masse et d'Analyse Protéomique (SMAP 2015), 2015, Ajaccio, Corse, France
Conference papers hal-01595504v1

Intact Protein Analysis by LC-MS for Characterizing Biomarkers in Cerebrospinal Fluid

Jérôme Vialaret , Sylvain Lehmann , Christophe Hirtz
Virginie Brun; Yohann Couté. Proteomics for Biomarker Discovery. Methods and Protocols, 1959, Springer, pp.163-172, 2019, Methods in Molecular Biology, 978-1-4939-9163-1. ⟨10.1007/978-1-4939-9164-8_11⟩
Book sections hal-02505319v1