Christophe Klein

Identifiants chercheurs

IdHAL :

christophe-klein

ORCID :

0000-0001-8015-287X

Présentation

Publications

Article dans une revue (38)

Neutralization of acyl coenzyme A binding protein for the experimental prevention and treatment of hepatocellular carcinoma Sijing Li,Omar Motiño,Flavia Lambertucci,Jonathan Pol,Hui Chenet al. Cell Reports Medicine, 2025, 6, ⟨10.1016/j.xcrm.2025.102232⟩ Article dans une revue hal-05210901v1
Laser-activated nanoparticles rewire tumor microenvironment enhancing PD-1 blockade and T cell response in cholangiocarcinoma Mirko Minini,Giulio Avveduto,Sonia Becharef,Marie Meunier-Thaens,Bouchra Lekbabyet al. Hepatology, 2025, ⟨10.1097/HEP.0000000000001545⟩ Article dans une revue hal-05411190v1
Spatial Profiling of Ovarian Carcinoma and Tumor Microenvironment Evolution under Neoadjuvant Chemotherapy Elisa Yaniz-Galende,Qinghe Zeng,Juan Bejar-Grau,Christophe Klein,Felix Blanc-Durandet al. Clinical Cancer Research, 2024, 30 (13), pp.2790-2800. ⟨10.1158/1078-0432.CCR-23-3836⟩ Article dans une revue hal-05029732v1
Artificial intelligence-based pathology as a biomarker of sensitivity to atezolizumab–bevacizumab in patients with hepatocellular carcinoma: a multicentre retrospective study Qinghe Zeng,Christophe Klein,Stefano Caruso,Pascale Maille,Daniela Allendeet al. Lancet Oncology, 2023, 24 (12), pp.1411-1422. ⟨10.1016/S1470-2045(23)00468-0⟩ Article dans une revue hal-05391478v1
Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma Julien Calderaro,Narmin Ghaffari Laleh,Qinghe Zeng,Pascale Maille,Loetitia Favreet al. Nature Communications, 2023, 14 (1), pp.8290. ⟨10.1038/s41467-023-43749-3⟩ Article dans une revue hal-04439486v1
A RAD51 functional assay as a candidate test for homologous recombination deficiency in ovarian cancer Félix Blanc-Durand,Elisa Yaniz-Galende,Alba Llop-Guevara,Catherine Genestie,Violeta Serraet al. Gynecologic Oncology, 2023, 171, pp.106-113. ⟨10.1016/j.ygyno.2023.01.026⟩ Article dans une revue hal-04210315v1
Artificial intelligence predicts immune and inflammatory gene signatures directly from hepatocellular carcinoma histology Qinghe Zeng,Christophe Klein,Stefano Caruso,Pascale Maille,Narmin Ghaffari Lalehet al. Journal of Hepatology, 2022, 77 (1), pp.116-127. ⟨10.1016/j.jhep.2022.01.018⟩ Article dans une revue hal-04210277v1
Artificial intelligence for solid tumour diagnosis in digital pathology Christophe Klein,Qinghe Zeng,Floriane Arbaretaz,Estelle Devêvre,Julien Calderaroet al. British Journal of Pharmacology, 2021, 178 (21), pp.4291-4315. ⟨10.1111/bph.15633⟩ Article dans une revue hal-04210289v1
Metabolic features of cancer cells impact immunosurveillance Adrien Joseph,Pan Juncheng,Michele Mondini,Nizar Labaied,Mauro Loiet al. Journal for Immunotherapy of Cancer, 2021, 9 (6), pp.e002362. ⟨10.1136/jitc-2021-002362⟩ Article dans une revue hal-03272265v1
Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients Marion Picard,Satoru Yonekura,Karolina Slowicka,Ioanna Petta,Conrad Rauberet al. Cell Death and Differentiation, 2021, 28 (5), pp.1532-1547. ⟨10.1038/s41418-020-00684-w⟩ Article dans une revue hal-03682003v1
Acidosis‐induced activation of distal nephron principal cells triggers Gdf15 secretion and adaptive proliferation of intercalated cells Lydie Cheval,Benoit Viollet,Christophe Klein,Chloé Rafael,Lucile Figuereset al. Acta Physiologica, 2021, pp.e13661. ⟨10.1111/apha.13661⟩ Article dans une revue hal-03208550v1
Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer Maria Paula Roberti,Satoru Yonekura,Connie P. M. Duong,Marion Picard,Gladys Ferrereet al. Nature Medicine, 2020, 26 (6), p. 919-931. ⟨10.1038/s41591-020-0882-8⟩ Article dans une revue hal-03313676v1
Sostdc1 is expressed in all major compartments of developing and adult mammalian eyes Maud Valensi,Gabrielle Goldman,Dominique Marchant,Loïc van den Berghe,Laurent Jonetet al. Graefe's Archive for Clinical and Experimental Ophthalmology, 2019, 257 (11), pp.2401-2427. ⟨10.1007/s00417-019-04462-4⟩ Article dans une revue hal-02461550v1
Polyploidy spectrum: a new marker in HCC classification Myriam Bou-Nader,Stefano Caruso,Romain Donne,Séverine Celton-Morizur,Julien Calderaroet al. Gut, In press, pp.gutjnl-2018-318021. ⟨10.1136/gutjnl-2018-318021⟩ Article dans une revue hal-02102441v1
CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complex Céline Borras,Jérémie Canonica,Sylvie Jorieux,Toufik Abache,Mohamed El Sanharawiet al. Scientific Reports, 2019, 9 (1), pp.13873. ⟨10.1038/s41598-019-50420-9⟩ Article dans une revue hal-02345038v1
Metabolic enzymes expressed by cancer cells impact the immune infiltrate Gautier Stoll,Margerie Kremer,Normal Bloy,Adrien Joseph,Maria Castedoet al. OncoImmunology, 2019, 8 (6), pp.e1571389. ⟨10.1080/2162402X.2019.1571389⟩ Article dans une revue hal-02461563v1
Active Fluctuations of the Nuclear Envelope Shape the Transcriptional Dynamics in Oocytes Maria Almonacid,Adel Al Jord,Stephany El-Hayek,Alice Othmani,Fanny Coulpieret al. Developmental Cell, 2019, 51 (2), pp.145-157.e10. ⟨10.1016/j.devcel.2019.09.010⟩ Article dans une revue hal-03003444v1
Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade Nicolas Jacquelot,Takahiro Yamazaki,Maria Roberti,Connie Duong,Miles Andrewset al. Cell Research, 2019, 29 (10), pp.846-861. ⟨10.1038/s41422-019-0224-x⟩ Article dans une revue hal-02461559v1
Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors Bertrand Routy,Emmanuelle Le Chatelier,Lisa Derosa,Connie Duong,Maryam Tidjani Alouet al. Science, 2018, 359 (6371), pp.91-97. ⟨10.1126/science.aan3706⟩ Article dans une revue hal-02126484v1
Involvement of neural crest and paraxial mesoderm in oral mucosal development and healing Juliane Isaac,Ali Nassif,Audrey Asselin,Ihsène Taïhi,Hélène Fohrer-Tinget al. Biomaterials, 2018, 172, pp.41-53. ⟨10.1016/j.biomaterials.2018.04.036⟩ Article dans une revue istex hal-02461579v1
ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy Pierre-Raphaël Rothschild,Sawsen Salah,Marianne Berdugo,Emmanuelle Gelize,Kimberley Delaunayet al. Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-07329-y⟩ Article dans une revue hal-02461587v1
Three-dimensional Organization of pKi-67: A Comparative Fluorescence and Electron Tomography Study Using Fluoronanogold Thierry Cheutin,Marie-Françoise O'Donohue,Adrien Beorchia,Christophe Klein,Hervé H. Kaplanet al. Journal of Histochemistry and Cytochemistry, 2016, 51 (11), pp.1411-1423. ⟨10.1177/002215540305101102⟩ Article dans une revue hal-02328305v1
Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy Heng Yang,Yuting Ma,Guo Chen,Heng Zhou,Takahiro Yamazakiet al. OncoImmunology, 2016, 5 (6), pp.e1149673. ⟨10.1080/2162402X.2016.1149673⟩ Article dans une revue hal-02461588v1
Targeting iron-mediated retinal degeneration by local delivery of transferrin Émilie Picard,Quentin Le Rouzic,Antonin Oudar,Marianne Berdugo,Mohamed El Sanharawiet al. Free Radical Biology and Medicine, 2015, 89, pp.1105-1121. ⟨10.1016/j.freeradbiomed.2015.08.018⟩ Article dans une revue inserm-02980617v1
Anti-vascular endothelial growth factor acts on retinal microglia/macrophage activation in a rat model of ocular inflammation Aude Couturier,Elodie Bousquet,Min Zhao,Marie-Christine Naud,Christophe Kleinet al. Molecular Vision, 2014, 20, pp.908-920 Article dans une revue hal-01332123v1
Protective effect of intravitreal injection of vasoactive intestinal peptide-loaded liposomes on experimental autoimmune uveoretinitis. Emmanuelle Duron,Jean-Sébastien Vidal,Benoît Funalot,Cécile Viollet,Marie-Laure Seuxet al. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2014, 69 (8), pp.1025-1032. ⟨10.1093/gerona/glt206⟩ Article dans une revue hal-02446108v1
DsRed-mediated oligomerization stabilizes HMGB1 on chromatin in vivo and on DNA in vitro Melanie Messmer,Christophe Klein,Rachel Boniface,Nina F. Gnaedig,Maxime Lecerfet al. Biochimie, 2013, 95 (4), pp.962-966. ⟨10.1016/j.biochi.2012.11.001⟩ Article dans une revue istex hal-01546170v1
Live-cell imaging reveals multiple interactions between Epstein-Barr virus nuclear antigen 1 and cellular chromatin during interphase and mitosis. Nathalie Jourdan,Aude Jobart-Malfait,Gabriel dos Reis,Frédérique Quignon,Tristan Piolotet al. Journal of Virology, 2012, 86 (9), pp.5314-29. ⟨10.1128/JVI.06303-11⟩ Article dans une revue inserm-00679274v1
Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages. Serge Camelo,William Raoul,Sophie Lavalette,Bertrand Calippe,Brunella Cristofaroet al. Angiogenesis, 2012, 15 (4), pp.609-22. ⟨10.1007/s10456-012-9290-0⟩ Article dans une revue inserm-00853034v1
Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects Cedric M Blouin,Soazig Le Lay,Anita Eberl,Harald Köfeler,Ida Chiara Guerreraet al. Journal of Lipid Research, 2010, 51 (5), pp.945-956. ⟨10.1194/jlr.M001016⟩ Article dans une revue hal-02450951v1
Protective Effect of Intravitreal Injection of Vasoactive Intestinal Peptide–Loaded Liposomes on Experimental Autoimmune Uveoretinitis Serge Camelo,Laure Lajavardi,Amélie Bochot,Brigitte Goldenberg,Marie-Christine Naudet al. Journal of Ocular Pharmacology and Therapeutics, 2009, 25 (1), pp.9-22. ⟨10.1089/jop.2008.0074⟩ Article dans une revue hal-02507538v1
Insulin internalizes GLUT2 in the enterocytes of healthy but not insulin-resistant mice. Vanessa Tobin,Maude Le Gall,Xavier Fioramonti,Emilie Stolarzcyk,Alba G Blazquezet al. Diabetes, 2008, 57 (3), pp.555-62. ⟨10.2337/db07-0928⟩ Article dans une revue hal-00195152v1
NKCC2 Surface Expression in Mammalian Cells Boubacar Benziane,Sylvie Demaretz,Nadia Defontaine,Nancy Zaarour,Lydie L Chevalet al. Journal of Biological Chemistry, 2007, 282 (46), pp.33817-33830. ⟨10.1074/jbc.M700195200⟩ Article dans une revue hal-03160997v1
QN1/KIAA1009: a new essential protein for chromosome segregation and mitotic spindle assembly. A. Leon,Boubaker Omri,A. Gely,Christophe Klein,Patricia Crisanti Oncogene, 2006, 25 (13), pp.1887-95. ⟨10.1038/sj.onc.1209215⟩ Article dans une revue inserm-00146728v1
Nonrandom distribution of metaphase AgNOR staining patterns on human acrocentric chromosomes. Laurent Héliot,Fabien Mongelard,Christophe Klein,Marie-Françoise O'Donohue,Jean-Marc Chasseryet al. Journal of Histochemistry and Cytochemistry, 2000, 48 (1), pp.13-20. ⟨10.1177/002215540004800102⟩ Article dans une revue hal-00192550v1
Mounting Technique Allows Observation of Immuno-Labeled Cells on Plastic Coverslips M.F. O'Donohue,T. Cheutin,C. Klein,H. Kaplan,D. Ploton Biotechniques, 1998, 24 (6), pp.910-914. ⟨10.2144/98246bm01⟩ Article dans une revue hal-02328366v1
The Three-dimensional Study of Chromosomes and Upstream Binding Factor-immunolabeled Nucleolar Organizer Regions Demonstrates Their Nonrandom Spatial Arrangement during Mitosis Christophe Klein,Thierry Cheutin,Lawrence Rothblum,Hervé H. Kaplan,Adrien Beorchiaet al. Molecular Biology of the Cell, 1998, 9 (11), pp.3147-3159. ⟨10.1091/mbc.9.11.3147⟩ Article dans une revue hal-02328359v1
Electron Tomography of Metaphase Nucleolar Organizer Regions: Evidence for a Twisted-Loop Organization Laurent Héliot,Hervé H. Kaplan,Laurent Lucas,Christophe Klein,Adrien Beorchiaet al. Molecular Biology of the Cell, 1997, 8 (11), pp.2199-2216. ⟨10.1091/mbc.8.11.2199⟩ Article dans une revue hal-02328373v1

Communication dans un congrès (1)

Évaluation et adaptation de réseaux VGG16 pour la détection de carcinome sur des lames d'histologie: de la résection à la biopsie Qinghe Zeng,Nicolas Loménie,Christophe Klein,Julien Calderaro ORASIS 2021, Centre National de la Recherche Scientifique [CNRS], Sep 2021, Saint Ferréol, France Communication dans un congrès hal-03339691v1

Chapitre d'ouvrage (1)

A novel tool for detecting lysosomal membrane permeabilization by high-throughput fluorescence microscopy Karla Alvarez-Valadez,Allan Sauvat,Hélène Fohrer-Ting,Christophe Klein,Oliver Keppet al. Monitoring Vesicular Trafficking in Cellular Responses to Stress - Part B, 165, Elsevier, pp.1-12, 2021, Methods in Cell Biology, ⟨10.1016/bs.mcb.2020.10.004⟩ Chapitre d'ouvrage inserm-03653036v1

Pré-publication, Document de travail (1)

Transcriptional regulation of jaw osteoblasts: development to pathology Ali Nassif,Guilhem Lignon,Audrey Asselin,Charles Zadikian,Stephane Petitet al. 2022 Pré-publication, Document de travail hal-03557330v1