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Christophe Rochais

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Publications

Inducing neuronal regeneration and differentiation via the BDNF/TrkB signaling pathway: a key target against neurodegenerative diseases?

Mirjana Antonijevic , Patrick Dallemagne , Christophe Rochais
Neural Regeneration Research, 2024, 19 (3), pp.495-496. ⟨10.4103/1673-5374.380896⟩
Journal articles hal-04414820v1
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Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective Agents

Mirjana Antonijevic , Despoina Charou , Audrey Davis , Thomas Curel , Maria Valcarcel
Molecules, 2024, 29 (2), pp.515. ⟨10.3390/molecules29020515⟩
Journal articles hal-04414817v1

Conceptual Framework of the Design of Pleiotropic Drugs against Alzheimer’s Disease

Thomas Guiselin , Cédric Lecoutey , Christophe Rochais , Patrick Dallemagne
Pharmaceutics, 2023, 15 (10), pp.2382. ⟨10.3390/pharmaceutics15102382⟩
Journal articles hal-04414828v1
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C3-Symmetric Ligands in Drug Design: When the Target Controls the Aesthetics of the Drug

Mirjana Antonijevic , Christophe Rochais , Patrick Dallemagne
Molecules, 2023, 28 (2), pp.679. ⟨10.3390/molecules28020679⟩
Journal articles hal-03969919v1
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Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

Rim Malek , Alexey Simakov , Audrey Davis , Maciej Maj , Paul Bernard
Molecules, 2023, 28 (1), pp.71. ⟨10.3390/molecules28010071⟩
Journal articles hal-03969932v1

Advances in prodrug design for Alzheimer’s disease: the state of the art

Valentin Travers--Lesage , Serge Mignani , Patrick Dallemagne , Christophe Rochais
Expert Opinion on Drug Discovery, 2022, 17 (4), pp.325-341. ⟨10.1080/17460441.2022.2031972⟩
Journal articles hal-03969939v1
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Desirable drug–drug interactions or when a matter of concern becomes a renewed therapeutic strategy

Benjamin Guieu , Jean-Pierre Jourdan , Aurore Dreneau , Nicolas Willand , Christophe Rochais
Drug Discovery Today, 2021, 26 (2), pp.315-328. ⟨10.1016/j.drudis.2020.11.026⟩
Journal articles hal-03969988v1

Aminothiaindanone as an Accessible Scaffold for a Three-Point Chemical Diversity

Pauline Zipfel , Julien Lalut , Jana Sopková-de Oliveira Santos , Christophe Rochais , Patrick Dallemagne
Synthesis: Journal of Synthetic Organic Chemistry, 2021, 53 (20), pp.3799-3814. ⟨10.1055/a-1523-1409⟩
Journal articles hal-03969969v1
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Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer’s Disease Treatment through Rigidification Strategy

Cédric Lecoutey , Rémi Legay , Audrey Davis , Jana Sopková-de Oliveira Santos , Patrick Dallemagne
Molecules, 2021, 26 (9), pp.2536. ⟨10.3390/molecules26092536⟩
Journal articles hal-03969972v1
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First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer’s Disease

Benjamin Guieu , Cedric Lecoutey , Rémi Legay , Audrey Davis , Jana Sopkova de Oliveira Santos
Molecules, 2021, 26 (1), pp.80. ⟨10.3390/molecules26010080⟩
Journal articles hal-03969980v1

Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease

Basile Chrétien , Jean‐pierre Jourdan , Audrey Davis , Sophie Fedrizzi , Ronan Bureau
British Journal of Clinical Pharmacology, 2021, 87 (7), pp.2830-2837. ⟨10.1111/bcp.14690⟩
Journal articles hal-03969985v1

5-HT4R modulators: a patent landscape

Patrick Dallemagne , Christophe Rochais
Pharmaceutical Patent Analyst, 2021, 10 (4), pp.179-181. ⟨10.4155/ppa-2021-0017⟩
Journal articles hal-03969965v1
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Matrix metalloproteinases as new targets in Alzheimer's disease: Opportunities and Challenges

Pauline Zipfel , Christophe Rochais , Kévin Baranger , Santiago Rivera , Patrick Dallemagne
Journal of Medicinal Chemistry, 2020
Journal articles hal-03461436v1
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hERG toxicity assessment: Useful guidelines for drug design

Amanda Garrido , Alban Lepailleur , Serge M. Mignani , Patrick Dallemagne , Christophe Rochais
European Journal of Medicinal Chemistry, 2020, 195, pp.112290 -. ⟨10.1016/j.ejmech.2020.112290⟩
Journal articles hal-03490407v1
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Drug repositioning: a brief overview

Jean-Pierre Jourdan , Ronan Bureau , Christophe Rochais , Patrick Dallemagne
Journal of Pharmacy and Pharmacology, 2020, 72 (9), pp.1145-1151. ⟨10.1111/jphp.13273⟩
Journal articles hal-03961788v1

Impact of T161, Y318 and S363 alanine mutations on regulation of the human delta-opioid receptor (hDOPr) induced by peptidic and alkaloid agonists

Elise Camacho , Nicolas Marie , Quentin Dupas , Caroline Martel , Marie Nowoczyn
Neuropharmacology, 2020, 179, pp.108286. ⟨10.1016/j.neuropharm.2020.108286⟩
Journal articles hal-03969992v1

Facing the complexity of Alzheimer's disease

Patrick Dallemagne , Christophe Rochais
Future Medicinal Chemistry, 2020, 12 (3), pp.175-177. ⟨10.4155/fmc-2019-0310⟩
Journal articles hal-03970000v1
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Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer’s Disease Treatment

Thomas Adnet , Anne-Claire Groo , Céline Picard , Audrey Davis , Sophie Corvaisier
Pharmaceutics, 2020, 12 (3), pp.251. ⟨10.3390/pharmaceutics12030251⟩
Journal articles hal-03969997v1
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Donecopride, a Swiss army knife with potential interest against Alzheimer's disease

Christophe Rochais , Cédric Lecoutey , Katia Hamidouche , Patrizia Giannoni , Florence Gaven
British Journal of Pharmacology, inPress, 177 (9), pp.1988-2005. ⟨10.1111/bph.14964⟩
Journal articles hal-02428730v1
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Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease

Caroline Lanthier , Hugo Payan , Irene Liparulo , Bérénice Hatat , Cédric Lecoutey
European Journal of Medicinal Chemistry, 2019, 182, pp.111596. ⟨10.1016/j.ejmech.2019.111596⟩
Journal articles hal-02399942v1
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A chemical screen identifies two novel small compounds that alter Arabidopsis thaliana pollen tube growth

Ferdousse Laggoun , Flavien Dardelle , Jérémy Dehors , Denis Falconet , Azeddine Driouich
BMC Plant Biology, 2019, 19, pp.152. ⟨10.1186/s12870-019-1743-9⟩
Journal articles hal-02106475v1
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26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie

Patrick Dallemagne , Christophe Rochais , Pascal Marchand , Thierry Besson
Pharmaceuticals, 2019, 12 (2), pp.73. ⟨10.3390/ph12020073⟩
Journal articles hal-02330438v1
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Structure-activity relationships of serotonin 5-HT7 receptors ligands: A review

Sangeetha-Laura Thirumaran , Alban Lepailleur , Christophe Rochais
European Journal of Medicinal Chemistry, 2019, 183, pp.111705 -. ⟨10.1016/j.ejmech.2019.111705⟩
Journal articles hal-03488662v1

Modulating 5-HT 4 and 5-HT 6 receptors in Alzheimer’s disease treatment

Julien Lalut , Delphine Karila , Patrick Dallemagne , Christophe Rochais
Future Medicinal Chemistry, 2017, 9 (8), pp.781-795. ⟨10.4155/fmc-2017-0031⟩
Journal articles hal-02043735v1

Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment

Jean-Pierre Jourdan , Marc Since , Laïla El kihel , Cédric Lecoutey , Sophie Corvaisier
ChemMedChem, 2017, 12 (12), pp.913-916. ⟨10.1002/cmdc.201700102⟩
Journal articles hal-02043731v1

Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment

Jean-Pierre Jourdan , Marc Since , Laïla El Kihel , Cédric Lecoutey , Sophie Corvaisier
European Journal of Medicinal Chemistry, 2016, 114, pp.365-379. ⟨10.1016/j.ejmech.2016.03.023⟩
Journal articles hal-02043765v1

3-(Dipropylamino)-5-hydroxybenzofuro[2,3-f]quinazolin-1(2H)-one (DPA-HBFQ-1) plays an inhibitory role on breast cancer cell growth and progression

Pietro Rizza , Michele Pellegrino , Anna Caruso , Domenico Iacopetta , Maria Stefania Sinicropi
European Journal of Medicinal Chemistry, 2016, 107, pp.275-287. ⟨10.1016/j.ejmech.2015.11.004⟩
Journal articles hal-02043777v1

Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT 4 R) partial agonist and 5-HT 6 R antagonist activities, as potential treatment of Alzheimer’s disease

Samir Yahiaoui , Katia Hamidouche , Céline Ballandonne , Audrey Davis , Jana Sopkova-de Oliveira Santos
European Journal of Medicinal Chemistry, 2016, 121, pp.283-293. ⟨10.1016/j.ejmech.2016.05.048⟩
Journal articles hal-02043759v1

Therapeutic Potential of 5-HT 6 Receptor Agonists

Delphine Karila , Thomas Freret , Valentine Bouet , Michel Boulouard , Patrick Dallemagne
Journal of Medicinal Chemistry, 2015, 58 (20), pp.7901-7912. ⟨10.1021/acs.jmedchem.5b00179⟩
Journal articles hal-02043781v1

Recent Advances in Phenanthroindolizidine and Phenanthroquinolizidine Derivatives with Anticancer Activities

Maria Fatima Pereira , Christophe Rochais , Patrick Dallemagne
Anti-Cancer Agents in Medicinal Chemistry, 2015, 15 (9), pp.1080-1091. ⟨10.2174/1871520615666150520143600⟩
Journal articles hal-02043788v1

Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances

Anne Quiedeville , Michel Boulouard , Katia Hamidouche , Virginie da Silva Costa-Aze , Gerald Nee
Behavioural Brain Research, 2015, 293, pp.10-17. ⟨10.1016/j.bbr.2015.07.020⟩
Journal articles hal-02043824v1

Indenopyrazole oxime ethers: Synthesis and β1-adrenergic blocking activity

Tomaso Angelone , Anna Caruso , Christophe Rochais , Angela Caputa , Maria Cerra
European Journal of Medicinal Chemistry, 2015, 92, pp.672-681. ⟨10.1016/j.ejmech.2015.01.037⟩
Journal articles hal-01116512v1
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Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

Cédric Lecoutey , Damien Hedou , Thomas Freret , Patrizia Giannoni , Florence Gaven
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩
Journal articles hal-01800439v2

Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease.

David Genest , Christophe Rochais , Cédric Lecoutey , Jana Sopkova-de Oliveira Santos , Céline Ballandonne
MedChemComm, 2013, 4, pp.925-931
Journal articles hal-00840942v1

MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity.

Christophe Rochais , Thierry Cresteil , Vittoria Perri , Marie Jouanne , Aurélien Lesnard
Cancer Letters, 2013, 331 (1), pp.92-8. ⟨10.1016/j.canlet.2012.12.017⟩
Journal articles hal-00807871v1

Tripentones: A Promising Series of Potent Anti-Cancer Agents.

Christophe Rochais , Sylvain Rault , Patrick Dallemagne
Anti-Cancer Agents in Medicinal Chemistry, 2013, 2, pp.313-343
Journal articles hal-00840950v1

An unusual boron tribromide-mediated, one-pot bromination/cyclization reaction. Application to the synthesis of a highly strained cyclopenta[1,3]cyclopropa[1,2-b]pyrrolizin-8-one.

Jean-Pierre Jourdan , Christophe Rochais , Rémi Legay , Jana Sopkova-de Oliveira Santos , Patrick Dallemagne
Tetrahedron Letters, 2013, 54 (9), pp.1133-1136
Journal articles hal-00821455v1

2,5-Dimethoxytetrahydrofuran, first update.

Christophe Rochais , Patrick Dallemagne
Encyclopedia of Reagents for Organic Synthesis, 2012, pp.2012
Journal articles hal-00821463v1

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.

Thomas Freret , Valentine Bouet , Anne Quiedeville , Gérald Nee , Patrick Dallemagne
Behavioural Brain Research, 2012, 230 (1), pp.304-8. ⟨10.1016/j.bbr.2012.02.012⟩
Journal articles hal-00862757v1

Synthesis of dual AChE/5-HT4 receptor multi-target directed ligands.

Cédric Lecoutey , Christophe Rochais , David Genest , Sabrina Butt-Gueulle , Céline Ballandonne
MedChemComm, 2012, 3, pp.627-634
Journal articles hal-00764795v1

Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect

Elizabeth Chosson , Francesca Santoro , Christophe Rochais , Jana Sopkova-de Oliveira Santos , Rémi Legay
Bioorganic and Medicinal Chemistry Letters, 2012, 20 (8), pp.2614-2623. ⟨10.1016/j.bmc.2012.02.043⟩
Journal articles hal-02357753v1

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT4 receptor activation (RS67333) on object recognition in mice.

Thomas Freret , Valentine Bouet , Anne Quiedeville , Gerald Nee , Patrick Dallemagne
Behavioural Brain Research, 2012, 230, pp.304-308
Journal articles hal-00821461v1

First and mild synthesis of fluorene-9-malonic acid and some substituted derivatives via the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids

Elizabeth Chosson , Christophe Rochais , Rémi Legay , Jana Sopkova-de Oliveira Santos , Sylvain Rault
Tetrahedron, 2011, 67 (14), pp.2548-2554. ⟨10.1016/j.tet.2011.02.026⟩
Journal articles hal-01018072v1

One-pot synthesis of new aza- and diaza-aminopenanthrenes

Christophe Rochais , Rodrigue Yougnia , Thomas Cailly , Jana Sopkova-de Oliveira Santos , Sylvain Rault
Tetrahedron, 2011, 67 (32), pp.5806-5810. ⟨10.1016/j.tet.2011.05.116⟩
Journal articles hal-01061754v1

Intramolecular Cyclisation of β-Aryl-β-Amino Acids in the Design of Novel Heterocyclic Systems with Therapeutic Interest: An Unfailing Source of Diversity

Christophe Rochais , Sylvain Rault , Patrick Dallemagne
Current Medicinal Chemistry, 2010, 17 (35), pp.4342-4369
Journal articles hal-02045949v1

Hydrogenative desulphurization of thienopyrrolizinones: An easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity

Vittoria Perri , Christophe Rochais , Jana Sopkova-de Oliveira Santos , Rémi Legay , Thierry Cresteil
European Journal of Medicinal Chemistry, 2010, 45 (3), pp.1146-1150. ⟨10.1016/j.ejmech.2009.12.021⟩
Journal articles hal-02045946v1

One-pot synthesis of novel poly-substituted phenanthrenes

Rodrigue Yougnia , Christophe Rochais , Jana Sopkova-de Oliveira Santos , Patrick Dallemagne , Sylvain Rault
Tetrahedron, 2010, 66 (15), pp.2803-2808. ⟨10.1016/j.tet.2010.02.060⟩
Journal articles hal-02045958v1

Virtual Screening Discovery of New Acetylcholinesterase Inhibitors Issued from CERMN Chemical Library

Jana Sopkova-de Oliveira Santos , Aurélien Lesnard , Jean-Hugues Agondanou , Nathalie Dupont , Anne-Marie Godard
Journal of Chemical Information and Modeling, 2010, 50 (3), pp.422-428. ⟨10.1021/ci900491t⟩
Journal articles hal-00705935v1

Synthesis, reactivity and biological evaluation of novel halogenated tripentones.

Vittoria Perri , Christophe Rochais , Thierry Cresteil , Patrick Dallemagne , Sylvain Rault
Bioorganic and Medicinal Chemistry, 2009, 17 (22), pp.7783-8. ⟨10.1016/j.bmc.2009.09.027⟩
Journal articles hal-00433244v1

Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors.

Christophe Rochais , Nghia Vu Duc , Elodie Lescot , Jana Sopkova-de Oliveira Santos , Ronan Bureau
European Journal of Medicinal Chemistry, 2008, epub ahead of print. ⟨10.1016/j.ejmech.2008.05.011⟩
Journal articles hal-00319802v1