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Shaping Future Medicinal Chemists: Perspectives from European Schools of Pharmacy within the GP 2 A Network
Gülşah Bayraktar
,
Laura Carro
,
Michael Decker
,
Francesca Giuntini
,
Jean-Jacques Helesbeux
et al.
Article dans une revue
hal-04950824
v1
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Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer’s disease by administration through an intranasal route
Anne-Claire Groo
,
Thomas Curel
,
Aurélie Malzert-Fréon
,
Line Séguy
,
Ophélie Bento
et al.
Article dans une revue
hal-04927352
v1
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Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders
Mirjana Antonijevic
,
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-04893240
v1
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Implication of Central β 2 Adrenergic Receptor for the Development of Novel Drugs Against Alzheimer's Disease
Alice Wang
,
Marc Since
,
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-05020271
v1
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Anti-Breast Cancer Properties and In Vivo Safety Profile of a Bis-Carbazole Derivative
Jessica Ceramella
,
Camillo Rosano
,
Domenico Iacopetta
,
Iméne Ben Toumia
,
Leila Chekir-Ghedira
et al.
Article dans une revue
hal-05014835
v1
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Analysis of skeletal diversity of multi-target directed ligands (MTDLs) targeting Alzheimer's disease
Uzma Azam
,
Muhammad Moazzam Naseer
,
Christophe Rochais
Article dans une revue
hal-04912969
v1
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Inducing neuronal regeneration and differentiation via the BDNF/TrkB signaling pathway: a key target against neurodegenerative diseases?
Mirjana Antonijevic
,
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-04414820
v1
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Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective Agents
Mirjana Antonijevic
,
Despoina Charou
,
Audrey Davis
,
Thomas Curel
,
Maria Valcarcel
et al.
Article dans une revue
hal-04414817
v1
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Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT4 receptors with potential interest in the treatment of Alzheimer's disease
Christophe Rochais
,
Cédric Lecoutey
,
Julien Lalut
,
Audrey Davis
,
Emilie Duval
et al.
Article dans une revue
hal-04768607
v1
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Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT4 receptors with potential interest in the treatment of Alzheimer's disease
Christophe Rochais
,
Cédric Lecoutey
,
Julien Lalut
,
Audrey Davis
,
Emilie Duval
et al.
Article dans une revue
hal-04760765
v1
|
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Studies on the mechanisms of action of MR33317
Joachim Neumann
,
C. Hesse
,
S. Yahiaoui
,
P. Dallemagne
,
Christophe Rochais
et al.
Article dans une revue
hal-04768605
v1
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Synthesis and interest in medicinal chemistry of β-phenylalanine derivatives (β-PAD): an update (2010–2022)
Chloé Rémondin
,
Serge Mignani
,
Christophe Rochais
,
Patrick Dallemagne
Article dans une revue
hal-04627791
v1
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Discovery of a pocket network on the domain 5 of the TrkB receptor – A potential new target in the quest for the new ligands
Mirjana Antonijevic
,
Jana Sopkova-de Oliveira Santos
,
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-04672962
v1
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Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy
Maxime Mistretta
,
Mena Cimino
,
Pascal Campagne
,
Stevenn Volant
,
Etienne Kornobis
et al.
Article dans une revue
hal-04578611
v1
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C3-Symmetric Ligands in Drug Design: When the Target Controls the Aesthetics of the Drug
Mirjana Antonijevic
,
Christophe Rochais
,
Patrick Dallemagne
Article dans une revue
hal-03969919
v1
|
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Conceptual Framework of the Design of Pleiotropic Drugs against Alzheimer’s Disease
Thomas Guiselin
,
Cédric Lecoutey
,
Christophe Rochais
,
Patrick Dallemagne
Article dans une revue
hal-04414828
v1
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Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation
Rim Malek
,
Alexey Simakov
,
Audrey Davis
,
Maciej Maj
,
Paul Bernard
et al.
Article dans une revue
hal-03969932
v1
|
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Advances in prodrug design for Alzheimer’s disease: the state of the art
Valentin Travers--Lesage
,
Serge Mignani
,
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-03969939
v1
|
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Aminothiaindanone as an Accessible Scaffold for a Three-Point Chemical Diversity
Pauline Zipfel
,
Julien Lalut
,
Jana Sopková-de Oliveira Santos
,
Christophe Rochais
,
Patrick Dallemagne
Article dans une revue
hal-03969969
v1
|
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Desirable drug–drug interactions or when a matter of concern becomes a renewed therapeutic strategy
Benjamin Guieu
,
Jean-Pierre Jourdan
,
Aurore Dreneau
,
Nicolas Willand
,
Christophe Rochais
et al.
Article dans une revue
hal-03969988
v1
|
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First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer’s Disease
Benjamin Guieu
,
Cedric Lecoutey
,
Rémi Legay
,
Audrey Davis
,
Jana Sopkova de Oliveira Santos
et al.
Article dans une revue
hal-03969980
v1
|
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Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease
Basile Chrétien
,
Jean‐pierre Jourdan
,
Audrey Davis
,
Sophie Fedrizzi
,
Ronan Bureau
et al.
Article dans une revue
hal-03969985
v1
|
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5-HT4R modulators: a patent landscape
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-03969965
v1
|
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Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer’s Disease Treatment through Rigidification Strategy
Cédric Lecoutey
,
Rémi Legay
,
Audrey Davis
,
Jana Sopková-de Oliveira Santos
,
Patrick Dallemagne
et al.
Article dans une revue
hal-03969972
v1
|
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Donecopride, a Swiss army knife with potential interest against Alzheimer's disease
Christophe Rochais
,
Cédric Lecoutey
,
Katia Hamidouche
,
Patrizia Giannoni
,
Florence Gaven
et al.
Article dans une revue
hal-02428730
v1
|
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hERG toxicity assessment: Useful guidelines for drug design
Amanda Garrido
,
Alban Lepailleur
,
Serge M Mignani
,
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-04951714
v1
|
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Matrix metalloproteinases as new targets in Alzheimer's disease: Opportunities and Challenges
Pauline Zipfel
,
Christophe Rochais
,
Kévin Baranger
,
Santiago Rivera
,
Patrick Dallemagne
Article dans une revue
hal-03461436
v1
|
|
Drug repositioning: a brief overview
Jean-Pierre Jourdan
,
Ronan Bureau
,
Christophe Rochais
,
Patrick Dallemagne
Article dans une revue
hal-03961788
v1
|
|
hERG toxicity assessment: Useful guidelines for drug design
Amanda Garrido
,
Alban Lepailleur
,
Serge M. Mignani
,
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-03490407
v1
|
|
Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer’s Disease Treatment
Thomas Adnet
,
Anne-Claire Groo
,
Céline Picard
,
Audrey Davis
,
Sophie Corvaisier
et al.
Article dans une revue
hal-03969997
v1
|
|
Facing the complexity of Alzheimer's disease
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-03970000
v1
|
|
Structure-activity relationships of serotonin 5-HT7 receptors ligands: A review
Sangeetha-Laura Thirumaran
,
Alban Lepailleur
,
Christophe Rochais
Article dans une revue
hal-03488662
v1
|
|
26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie
Patrick Dallemagne
,
Christophe Rochais
,
Pascal Marchand
,
Thierry Besson
Article dans une revue
hal-02330438
v1
|
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A chemical screen identifies two novel small compounds that alter Arabidopsis thaliana pollen tube growth
Ferdousse Laggoun
,
Flavien Dardelle
,
Jérémy Dehors
,
Denis Falconet
,
Azeddine Driouich
et al.
Article dans une revue
hal-02106475
v1
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Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease
Caroline Lanthier
,
Hugo Payan
,
Irene Liparulo
,
Bérénice Hatat
,
Cédric Lecoutey
et al.
Article dans une revue
hal-02399942
v1
|
|
Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment
Jean-Pierre Jourdan
,
Marc Since
,
Laïla El kihel
,
Cédric Lecoutey
,
Sophie Corvaisier
et al.
Article dans une revue
hal-02043731
v1
|
|
Modulating 5-HT 4 and 5-HT 6 receptors in Alzheimer’s disease treatment
Julien Lalut
,
Delphine Karila
,
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-02043735
v1
|
|
3-(Dipropylamino)-5-hydroxybenzofuro[2,3-f]quinazolin-1(2H)-one (DPA-HBFQ-1) plays an inhibitory role on breast cancer cell growth and progression
Pietro Rizza
,
Michele Pellegrino
,
Anna Caruso
,
Domenico Iacopetta
,
Maria Stefania Sinicropi
et al.
Article dans une revue
hal-02043777
v1
|
|
Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT 4 R) partial agonist and 5-HT 6 R antagonist activities, as potential treatment of Alzheimer’s disease
Samir Yahiaoui
,
Katia Hamidouche
,
Céline Ballandonne
,
Audrey Davis
,
Jana Sopkova-de Oliveira Santos
et al.
Article dans une revue
hal-02043759
v1
|
|
Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment
Jean-Pierre Jourdan
,
Marc Since
,
Laïla El Kihel
,
Cédric Lecoutey
,
Sophie Corvaisier
et al.
Article dans une revue
hal-02043765
v1
|
|
Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances
Anne Quiedeville
,
Michel Boulouard
,
Katia Hamidouche
,
Virginie da Silva Costa-Aze
,
Gerald Nee
et al.
Article dans une revue
hal-02043824
v1
|
|
Therapeutic Potential of 5-HT 6 Receptor Agonists
Delphine Karila
,
Thomas Freret
,
Valentine Bouet
,
Michel Boulouard
,
Patrick Dallemagne
et al.
Article dans une revue
hal-02043781
v1
|
|
Indenopyrazole oxime ethers: Synthesis and β1-adrenergic blocking activity
Tomaso Angelone
,
Anna Caruso
,
Christophe Rochais
,
Angela Caputa
,
Maria Cerra
et al.
Article dans une revue
hal-01116512
v1
|
|
Recent Advances in Phenanthroindolizidine and Phenanthroquinolizidine Derivatives with Anticancer Activities
Maria Fatima Pereira
,
Christophe Rochais
,
Patrick Dallemagne
Article dans une revue
hal-02043788
v1
|
|
Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment
Cédric Lecoutey
,
Damien Hedou
,
Thomas Freret
,
Patrizia Giannoni
,
Florence Gaven
et al.
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩
Article dans une revue
hal-01800439
v2
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MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity.
Christophe Rochais
,
Thierry Cresteil
,
Vittoria Perri
,
Marie Jouanne
,
Aurélien Lesnard
et al.
Article dans une revue
istex
hal-00807871
v1
|
|
Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease.
David Genest
,
Christophe Rochais
,
Cédric Lecoutey
,
Jana Sopkova-de Oliveira Santos
,
Céline Ballandonne
et al.
MedChemComm, 2013, 4, pp.925-931
Article dans une revue
hal-00840942
v1
|
|
An unusual boron tribromide-mediated, one-pot bromination/cyclization reaction. Application to the synthesis of a highly strained cyclopenta[1,3]cyclopropa[1,2-b]pyrrolizin-8-one.
Jean-Pierre Jourdan
,
Christophe Rochais
,
Rémi Legay
,
Jana Sopkova-de Oliveira Santos
,
Patrick Dallemagne
Tetrahedron Letters, 2013, 54 (9), pp.1133-1136
Article dans une revue
hal-00821455
v1
|
|
Tripentones: A Promising Series of Potent Anti-Cancer Agents.
Christophe Rochais
,
Sylvain Rault
,
Patrick Dallemagne
Anti-Cancer Agents in Medicinal Chemistry, 2013, 2, pp.313-343
Article dans une revue
hal-00840950
v1
|
|
Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.
Thomas Freret
,
Valentine Bouet
,
Anne Quiedeville
,
Gérald Nee
,
Patrick Dallemagne
et al.
Article dans une revue
istex
hal-00862757
v1
|
|
Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT4 receptor activation (RS67333) on object recognition in mice.
Thomas Freret
,
Valentine Bouet
,
Anne Quiedeville
,
Gérald Nee
,
Patrick Dallemagne
et al.
Article dans une revue
istex
hal-00821461
v1
|
|
Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect
Elizabeth Chosson
,
Francesca Santoro
,
Christophe Rochais
,
Jana Sopkova-de Oliveira Santos
,
Rémi Legay
et al.
Article dans une revue
istex
hal-02357753
v1
|
|
Synthesis of dual AChE/5-HT4 receptor multi-target directed ligands.
Cédric Lecoutey
,
Christophe Rochais
,
David Genest
,
Sabrina Butt-Gueulle
,
Céline Ballandonne
et al.
MedChemComm, 2012, 3, pp.627-634
Article dans une revue
hal-00764795
v1
|
|
One-pot synthesis of new aza- and diaza-aminopenanthrenes
Christophe Rochais
,
Rodrigue Yougnia
,
Thomas Cailly
,
Jana Sopkova-de Oliveira Santos
,
Sylvain Rault
et al.
Article dans une revue
istex
hal-01061754
v1
|
|
First and mild synthesis of fluorene-9-malonic acid and some substituted derivatives via the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids
Elizabeth Chosson
,
Christophe Rochais
,
Rémi Legay
,
Jana Sopkova-de Oliveira Santos
,
Sylvain Rault
et al.
Article dans une revue
istex
hal-01018072
v1
|
|
One-pot synthesis of novel poly-substituted phenanthrenes
Rodrigue Yougnia
,
Christophe Rochais
,
Jana Sopkova-de Oliveira Santos
,
Patrick Dallemagne
,
Sylvain Rault
Article dans une revue
hal-02045958
v1
|
|
Intramolecular Cyclisation of β-Aryl-β-Amino Acids in the Design of Novel Heterocyclic Systems with Therapeutic Interest: An Unfailing Source of Diversity
Christophe Rochais
,
Sylvain Rault
,
Patrick Dallemagne
Article dans une revue
hal-02045949
v1
|
|
Virtual Screening Discovery of New Acetylcholinesterase Inhibitors Issued from CERMN Chemical Library
Jana Sopkova-de Oliveira Santos
,
Aurélien Lesnard
,
Jean-Hugues Agondanou
,
Nathalie Dupont
,
Anne-Marie Godard
et al.
Article dans une revue
hal-00705935
v1
|
|
Hydrogenative desulphurization of thienopyrrolizinones: An easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity
Vittoria Perri
,
Christophe Rochais
,
Jana Sopkova-de Oliveira Santos
,
Rémi Legay
,
Thierry Cresteil
et al.
Article dans une revue
istex
hal-02045946
v1
|
|
Synthesis, reactivity and biological evaluation of novel halogenated tripentones.
Vittoria Perri
,
Christophe Rochais
,
Thierry Cresteil
,
Patrick Dallemagne
,
Sylvain Rault
Article dans une revue
istex
hal-00433244
v1
|
|
Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors.
Christophe Rochais
,
Nghia Vu Duc
,
Elodie Lescot
,
Jana Sopkova-de Oliveira Santos
,
Ronan Bureau
et al.
Article dans une revue
istex
hal-00319802
v1
|