Christophe Rochais

Documents

Publications

Combining β 2 -AR agonism with butyrylcholinesterase inhibition, a synergistic neuroprotective action against Alzheimer's disease

Alice Wang , Thomas Curel , Sylvie Claeysen , Valentin Travers-Lesage , Marie Cadot et al.

RSC Medicinal Chemistry, 2026, Online ahead of print. ⟨10.1039/d6md00250a⟩

Article dans une revue hal-05686489v1

Polyfunctionalized N-Arylsulfonyl Indoles: Identification of (E)-N-Hydroxy-3-{3-[(5-(3-(piperidin-1-yl)propoxy]-1H-indol-1-yl)sulfonyl]phenyl}acrylamide (MTP150) for the Epigenetic-based Therapy of Parkinson’s Disease

Mireia Toledano-Pinedo , Alicia Porro-Pérez , Linda Schäker-Hübner , Daniel Diez-Iriepa , Isabel Iriepa et al.

International Journal of Molecular Sciences, 2026, 27 (7), pp.3135. ⟨10.3390/ijms27073135⟩

Article dans une revue hal-05577025v1

Radiobiology Contributions and Perspectives in Hadron Therapy, with a focus on carbon ions: Report from the workshop Hadron therapy for life, Caen, March 2025

Siamak Haghdoost , Juliette Thariat , Iluliana Toma-Dasu , Benjamin Frey , Claire Rodriguez-Lafrasse et al.

International Journal of Particle Therapy, 2026, 19, pp.101289. ⟨10.1016/j.ijpt.2025.101289⟩

Article dans une revue hal-05386921v2

An efficient step-by-step approach to select pleiotropic drug candidates against Alzheimer's disease: The discovery of neocopride

Christophe Rochais , Cédric Lecoutey , Georgia Culley , Thomas Curel , Audrey Davis et al.

Journal of Alzheimer's Disease, In press, 110 (4), pp.1654-1666. ⟨10.1177/13872877261424925⟩

Article dans une revue hal-05559851v1

A combined experimental and computational insights into novel sulfa drug derivatives: Synthesis, DNA binding, molecular docking and DFT studies

Uzma Azam , Christophe Rochais , Muhammad Moazzam Naseer

Journal of Molecular Structure, 2025, 1348, pp.143351. ⟨10.1016/j.molstruc.2025.143351⟩

Article dans une revue hal-05334308v1

Targeting together cholinesterases and serotonin reuptake against Alzheimer’s disease

Thomas Guiselin , Cédric Lecoutey , Christophe Rochais , Patrick Dallemagne

Journal of Pharmacy and Pharmacology, 2025, 77 (10), pp.1303-1318. ⟨10.1093/jpp/rgaf041⟩

Article dans une revue hal-05297207v1

Implication of Central β 2 Adrenergic Receptor for the Development of Novel Drugs Against Alzheimer's Disease

Alice Wang , Marc Since , Patrick Dallemagne , Christophe Rochais

Archiv der Pharmazie / Chemistry in Life Sciences, 2025, 358 (4), ⟨10.1002/ardp.202400750⟩

Article dans une revue hal-05020271v1

Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer’s disease by administration through an intranasal route

Anne-Claire Groo , Thomas Curel , Aurélie Malzert-Fréon , Line Séguy , Ophélie Bento et al.

Communications Biology, 2025, 8 (1), pp.155. ⟨10.1038/s42003-025-07599-7⟩

Article dans une revue hal-04927352v1

Analysis of skeletal diversity of multi-target directed ligands (MTDLs) targeting Alzheimer's disease

Uzma Azam , Muhammad Moazzam Naseer , Christophe Rochais

European Journal of Medicinal Chemistry, 2025, 286, pp.117277. ⟨10.1016/j.ejmech.2025.117277⟩

Article dans une revue hal-04912969v1

Shaping Future Medicinal Chemists: Perspectives from European Schools of Pharmacy within the GP 2 A Network

Gülşah Bayraktar , Laura Carro , Michael Decker , Francesca Giuntini , Jean-Jacques Helesbeux et al.

Journal of Medicinal Chemistry, 2025, 68 (3), pp.2045-2047. ⟨10.1021/acs.jmedchem.4c03103⟩

Article dans une revue hal-04950824v1

Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders

Mirjana Antonijevic , Patrick Dallemagne , Christophe Rochais

Medicinal Research Reviews, 2025, 45 (1), pp.274-310. ⟨10.1002/med.22075⟩

Article dans une revue hal-04893240v1

Anti-Breast Cancer Properties and In Vivo Safety Profile of a Bis-Carbazole Derivative

Jessica Ceramella , Camillo Rosano , Domenico Iacopetta , Iméne Ben Toumia , Leila Chekir-Ghedira et al.

Pharmaceutics, 2025, 17 (4), pp.415. ⟨10.3390/pharmaceutics17040415⟩

Article dans une revue hal-05014835v1

Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy

Maxime Mistretta , Mena Cimino , Pascal Campagne , Stevenn Volant , Etienne Kornobis et al.

Nature Communications, 2024, 15 (1), pp.4175. ⟨10.1038/s41467-024-48269-2⟩

Article dans une revue hal-04578611v1

Studies on the mechanisms of action of MR33317

Joachim Neumann , C. Hesse , S. Yahiaoui , P. Dallemagne , Christophe Rochais et al.

Naunyn-Schmiedeberg's Archives of Pharmacology, 2024, 397 (11), pp.8893-8902. ⟨10.1007/s00210-024-03226-0⟩

Article dans une revue hal-04768605v1

Synthesis and interest in medicinal chemistry of β-phenylalanine derivatives (β-PAD): an update (2010–2022)

Chloé Rémondin , Serge Mignani , Christophe Rochais , Patrick Dallemagne

Future Medicinal Chemistry, 2024, 16 (11), pp.1147-1162. ⟨10.1080/17568919.2024.2347063⟩

Article dans une revue hal-04627791v1

Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT4 receptors with potential interest in the treatment of Alzheimer's disease

Christophe Rochais , Cédric Lecoutey , Julien Lalut , Audrey Davis , Emilie Duval et al.

European Journal of Medicinal Chemistry, 2024, 280, pp.116975. ⟨10.1016/j.ejmech.2024.116975⟩

Article dans une revue hal-04760765v1

Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective Agents

Mirjana Antonijevic , Despoina Charou , Audrey Davis , Thomas Curel , Maria Valcarcel et al.

Molecules, 2024, 29 (2), pp.515. ⟨10.3390/molecules29020515⟩

Article dans une revue hal-04414817v1

Inducing neuronal regeneration and differentiation via the BDNF/TrkB signaling pathway: a key target against neurodegenerative diseases?

Mirjana Antonijevic , Patrick Dallemagne , Christophe Rochais

Neural Regeneration Research, 2024, 19 (3), pp.495-496. ⟨10.4103/1673-5374.380896⟩

Article dans une revue hal-04414820v1

Discovery of a pocket network on the domain 5 of the TrkB receptor – A potential new target in the quest for the new ligands

Mirjana Antonijevic , Jana Sopkova-de Oliveira Santos , Patrick Dallemagne , Christophe Rochais

Molecular Informatics, 2024, 43 (8), pp.e202400043. ⟨10.1002/minf.202400043⟩

Article dans une revue hal-04672962v1

Conceptual Framework of the Design of Pleiotropic Drugs against Alzheimer’s Disease

Thomas Guiselin , Cédric Lecoutey , Christophe Rochais , Patrick Dallemagne

Pharmaceutics, 2023, 15 (10), pp.2382. ⟨10.3390/pharmaceutics15102382⟩

Article dans une revue hal-04414828v1

Design, synthesis and biological characterization of novel activators of the TrkB neurotrophin receptor

Mirjana Antonijevic , Despoina Charou , Isbaal Ramos , Maria Valcarcel , Achille Gravanis et al.

European Journal of Medicinal Chemistry, 2023, 248, pp.115111. ⟨10.1016/j.ejmech.2023.115111⟩

Article dans une revue hal-03969185v1

C3-Symmetric Ligands in Drug Design: When the Target Controls the Aesthetics of the Drug

Mirjana Antonijevic , Christophe Rochais , Patrick Dallemagne

Molecules, 2023, 28 (2), pp.679. ⟨10.3390/molecules28020679⟩

Article dans une revue hal-03969919v1

Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

Rim Malek , Alexey Simakov , Audrey Davis , Maciej Maj , Paul Bernard et al.

Molecules, 2023, 28 (1), pp.71. ⟨10.3390/molecules28010071⟩

Article dans une revue hal-03969932v1

Advances in prodrug design for Alzheimer’s disease: the state of the art

Valentin Travers--Lesage , Serge Mignani , Patrick Dallemagne , Christophe Rochais

Expert Opinion on Drug Discovery, 2022, 17 (4), pp.325-341. ⟨10.1080/17460441.2022.2031972⟩

Article dans une revue hal-03969939v1

Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer’s Disease Treatment through Rigidification Strategy

Cédric Lecoutey , Rémi Legay , Audrey Davis , Jana Sopková-de Oliveira Santos , Patrick Dallemagne et al.

Molecules, 2021, 26 (9), pp.2536. ⟨10.3390/molecules26092536⟩

Article dans une revue hal-03969972v1

Desirable drug–drug interactions or when a matter of concern becomes a renewed therapeutic strategy

Benjamin Guieu , Jean-Pierre Jourdan , Aurore Dreneau , Nicolas Willand , Christophe Rochais et al.

Drug Discovery Today, 2021, 26 (2), pp.315-328. ⟨10.1016/j.drudis.2020.11.026⟩

Article dans une revue hal-03969988v1

Aminothiaindanone as an Accessible Scaffold for a Three-Point Chemical Diversity

Pauline Zipfel , Julien Lalut , Jana Sopková-de Oliveira Santos , Christophe Rochais , Patrick Dallemagne

Synthesis: Journal of Synthetic Organic Chemistry, 2021, 53 (20), pp.3799-3814. ⟨10.1055/a-1523-1409⟩

Article dans une revue hal-03969969v1

Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease

Basile Chrétien , Jean‐pierre Jourdan , Audrey Davis , Sophie Fedrizzi , Ronan Bureau et al.

British Journal of Clinical Pharmacology, 2021, 87 (7), pp.2830-2837. ⟨10.1111/bcp.14690⟩

Article dans une revue hal-03969985v1

First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer’s Disease

Benjamin Guieu , Cedric Lecoutey , Rémi Legay , Audrey Davis , Jana Sopkova de Oliveira Santos et al.

Molecules, 2021, 26 (1), pp.80. ⟨10.3390/molecules26010080⟩

Article dans une revue hal-03969980v1

5-HT4R modulators: a patent landscape

Patrick Dallemagne , Christophe Rochais

Pharmaceutical Patent Analyst, 2021, 10 (4), pp.179-181. ⟨10.4155/ppa-2021-0017⟩

Article dans une revue hal-03969965v1

Facing the complexity of Alzheimer's disease

Patrick Dallemagne , Christophe Rochais

Future Medicinal Chemistry, 2020, 12 (3), pp.175-177. ⟨10.4155/fmc-2019-0310⟩

Article dans une revue hal-03970000v1

Matrix metalloproteinases as new targets in Alzheimer's disease: Opportunities and Challenges

Pauline Zipfel , Christophe Rochais , Kévin Baranger , Santiago Rivera , Patrick Dallemagne

Journal of Medicinal Chemistry, 2020, ⟨10.1021/acs.jmedchem.0c00352⟩

Article dans une revue hal-03461436v1

Drug repositioning: a brief overview

Jean-Pierre Jourdan , Ronan Bureau , Christophe Rochais , Patrick Dallemagne

Journal of Pharmacy and Pharmacology, 2020, 72 (9), pp.1145-1151. ⟨10.1111/jphp.13273⟩

Article dans une revue hal-03961788v1

hERG toxicity assessment: Useful guidelines for drug design

Amanda Garrido , Alban Lepailleur , Serge M Mignani , Patrick Dallemagne , Christophe Rochais

European Journal of Medicinal Chemistry, 2020, 195, pp.112290 -. ⟨10.1016/j.ejmech.2020.112290⟩

Article dans une revue hal-04951714v1

Donecopride, a Swiss army knife with potential interest against Alzheimer's disease

Christophe Rochais , Cédric Lecoutey , Katia Hamidouche , Patrizia Giannoni , Florence Gaven et al.

British Journal of Pharmacology, In press, 177 (9), pp.1988-2005. ⟨10.1111/bph.14964⟩

Article dans une revue hal-02428730v1

Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer’s Disease Treatment

Thomas Adnet , Anne-Claire Groo , Céline Picard , Audrey Davis , Sophie Corvaisier et al.

Pharmaceutics, 2020, 12 (3), pp.251. ⟨10.3390/pharmaceutics12030251⟩

Article dans une revue hal-03969997v1

Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease

Caroline Lanthier , Hugo Payan , Irene Liparulo , Bérénice Hatat , Cédric Lecoutey et al.

European Journal of Medicinal Chemistry, 2019, 182, pp.111596. ⟨10.1016/j.ejmech.2019.111596⟩

Article dans une revue hal-02399942v1

Structure-activity relationships of serotonin 5-HT7 receptors ligands: A review

Sangeetha-Laura Thirumaran , Alban Lepailleur , Christophe Rochais

European Journal of Medicinal Chemistry, 2019, 183, pp.111705 -. ⟨10.1016/j.ejmech.2019.111705⟩

Article dans une revue hal-03488662v1

26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie

Patrick Dallemagne , Christophe Rochais , Pascal Marchand , Thierry Besson

Pharmaceuticals, 2019, 12 (2), pp.73. ⟨10.3390/ph12020073⟩

Article dans une revue hal-02330438v1

A chemical screen identifies two novel small compounds that alter Arabidopsis thaliana pollen tube growth

Ferdousse Laggoun , Flavien Dardelle , Jérémy Dehors , Denis Falconet , Azeddine Driouich et al.

BMC Plant Biology, 2019, 19, pp.152. ⟨10.1186/s12870-019-1743-9⟩

Article dans une revue hal-02106475v1

Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment

Jean-Pierre Jourdan , Marc Since , Laïla El kihel , Cédric Lecoutey , Sophie Corvaisier et al.

ChemMedChem, 2017, 12 (12), pp.913-916. ⟨10.1002/cmdc.201700102⟩

Article dans une revue hal-02043731v1

Modulating 5-HT 4 and 5-HT 6 receptors in Alzheimer’s disease treatment

Julien Lalut , Delphine Karila , Patrick Dallemagne , Christophe Rochais

Future Medicinal Chemistry, 2017, 9 (8), pp.781-795. ⟨10.4155/fmc-2017-0031⟩

Article dans une revue hal-02043735v1

3-(Dipropylamino)-5-hydroxybenzofuro[2,3-f]quinazolin-1(2H)-one (DPA-HBFQ-1) plays an inhibitory role on breast cancer cell growth and progression

Pietro Rizza , Michele Pellegrino , Anna Caruso , Domenico Iacopetta , Maria Stefania Sinicropi et al.

European Journal of Medicinal Chemistry, 2016, 107, pp.275-287. ⟨10.1016/j.ejmech.2015.11.004⟩

Article dans une revue hal-02043777v1

Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT 4 R) partial agonist and 5-HT 6 R antagonist activities, as potential treatment of Alzheimer’s disease

Samir Yahiaoui , Katia Hamidouche , Céline Ballandonne , Audrey Davis , Jana Sopkova-de Oliveira Santos et al.

European Journal of Medicinal Chemistry, 2016, 121, pp.283-293. ⟨10.1016/j.ejmech.2016.05.048⟩

Article dans une revue hal-02043759v1

Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment

Jean-Pierre Jourdan , Marc Since , Laïla El Kihel , Cédric Lecoutey , Sophie Corvaisier et al.

European Journal of Medicinal Chemistry, 2016, 114, pp.365-379. ⟨10.1016/j.ejmech.2016.03.023⟩

Article dans une revue istex hal-02043765v1

Therapeutic Potential of 5-HT 6 Receptor Agonists

Delphine Karila , Thomas Freret , Valentine Bouet , Michel Boulouard , Patrick Dallemagne et al.

Journal of Medicinal Chemistry, 2015, 58 (20), pp.7901-7912. ⟨10.1021/acs.jmedchem.5b00179⟩

Article dans une revue hal-02043781v1

Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances

Anne Quiedeville , Michel Boulouard , Katia Hamidouche , Virginie da Silva Costa-Aze , Gerald Nee et al.

Behavioural Brain Research, 2015, 293, pp.10-17. ⟨10.1016/j.bbr.2015.07.020⟩

Article dans une revue hal-02043824v1

Indenopyrazole oxime ethers: Synthesis and β1-adrenergic blocking activity

Tomaso Angelone , Anna Caruso , Christophe Rochais , Angela Caputa , Maria Cerra et al.

European Journal of Medicinal Chemistry, 2015, 92, pp.672-681. ⟨10.1016/j.ejmech.2015.01.037⟩

Article dans une revue hal-01116512v1

Recent Advances in Phenanthroindolizidine and Phenanthroquinolizidine Derivatives with Anticancer Activities

Maria Fatima Pereira , Christophe Rochais , Patrick Dallemagne

Anti-Cancer Agents in Medicinal Chemistry, 2015, 15 (9), pp.1080-1091. ⟨10.2174/1871520615666150520143600⟩

Article dans une revue hal-02043788v1

Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

Cédric Lecoutey , Damien Hedou , Thomas Freret , Patrizia Giannoni , Florence Gaven et al.

Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩

Article dans une revue hal-01800439v2

Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease.

David Genest , Christophe Rochais , Cédric Lecoutey , Jana Sopkova-de Oliveira Santos , Céline Ballandonne et al.

MedChemComm, 2013, 4, pp.925-931

Article dans une revue hal-00840942v1

MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity.

Christophe Rochais , Thierry Cresteil , Vittoria Perri , Marie Jouanne , Aurélien Lesnard et al.

Cancer Letters, 2013, 331 (1), pp.92-8. ⟨10.1016/j.canlet.2012.12.017⟩

Article dans une revue istex hal-00807871v1

Tripentones: A Promising Series of Potent Anti-Cancer Agents.

Christophe Rochais , Sylvain Rault , Patrick Dallemagne

Anti-Cancer Agents in Medicinal Chemistry, 2013, 2, pp.313-343

Article dans une revue hal-00840950v1

An unusual boron tribromide-mediated, one-pot bromination/cyclization reaction. Application to the synthesis of a highly strained cyclopenta[1,3]cyclopropa[1,2-b]pyrrolizin-8-one.

Jean-Pierre Jourdan , Christophe Rochais , Rémi Legay , Jana Sopkova-de Oliveira Santos , Patrick Dallemagne

Tetrahedron Letters, 2013, 54 (9), pp.1133-1136

Article dans une revue hal-00821455v1

Synthesis of dual AChE/5-HT4 receptor multi-target directed ligands.

Cédric Lecoutey , Christophe Rochais , David Genest , Sabrina Butt-Gueulle , Céline Ballandonne et al.

MedChemComm, 2012, 3, pp.627-634

Article dans une revue hal-00764795v1

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.

Thomas Freret , Valentine Bouet , Anne Quiedeville , Gérald Nee , Patrick Dallemagne et al.

Behavioural Brain Research, 2012, 230 (1), pp.304-8. ⟨10.1016/j.bbr.2012.02.012⟩

Article dans une revue istex hal-00862757v1

Synthesis of dual AChE/5-HT4 receptor multi-target directed ligands

Cédric Lecoutey , Christophe Rochais , David Genest , Sabrina Butt-Gueulle , Céline Ballandonne et al.

MedChemComm, 2012, 3 (5), pp.627. ⟨10.1039/c2md20063e⟩

Article dans une revue hal-05481533v1

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT4 receptor activation (RS67333) on object recognition in mice.

Thomas Freret , Valentine Bouet , Anne Quiedeville , Gérald Nee , Patrick Dallemagne et al.

Behavioural Brain Research, 2012, 230 (1), pp.304-308. ⟨10.1016/j.bbr.2012.02.012⟩

Article dans une revue istex hal-00821461v1

Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect

Elizabeth Chosson , Francesca Santoro , Christophe Rochais , Jana Sopkova-de Oliveira Santos , Rémi Legay et al.

Bioorganic and Medicinal Chemistry Letters, 2012, 20 (8), pp.2614-2623. ⟨10.1016/j.bmc.2012.02.043⟩

Article dans une revue istex hal-02357753v1

First and mild synthesis of fluorene-9-malonic acid and some substituted derivatives via the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids

Elizabeth Chosson , Christophe Rochais , Rémi Legay , Jana Sopkova-de Oliveira Santos , Sylvain Rault et al.

Tetrahedron, 2011, 67 (14), pp.2548-2554. ⟨10.1016/j.tet.2011.02.026⟩

Article dans une revue istex hal-01018072v1

One-pot synthesis of new aza- and diaza-aminopenanthrenes

Christophe Rochais , Rodrigue Yougnia , Thomas Cailly , Jana Sopkova-de Oliveira Santos , Sylvain Rault et al.

Tetrahedron, 2011, 67 (32), pp.5806-5810. ⟨10.1016/j.tet.2011.05.116⟩

Article dans une revue istex hal-01061754v1

Hydrogenative desulphurization of thienopyrrolizinones: An easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity

Vittoria Perri , Christophe Rochais , Jana Sopkova-de Oliveira Santos , Rémi Legay , Thierry Cresteil et al.

European Journal of Medicinal Chemistry, 2010, 45 (3), pp.1146-1150. ⟨10.1016/j.ejmech.2009.12.021⟩

Article dans une revue istex hal-02045946v1

Intramolecular Cyclisation of β-Aryl-β-Amino Acids in the Design of Novel Heterocyclic Systems with Therapeutic Interest: An Unfailing Source of Diversity

Christophe Rochais , Sylvain Rault , Patrick Dallemagne

Current Medicinal Chemistry, 2010, 17 (35), pp.4342-4369. ⟨10.2174/092986710793361261⟩

Article dans une revue hal-02045949v1

One-pot synthesis of novel poly-substituted phenanthrenes

Rodrigue Yougnia , Christophe Rochais , Jana Sopkova-de Oliveira Santos , Patrick Dallemagne , Sylvain Rault

Tetrahedron, 2010, 66 (15), pp.2803-2808. ⟨10.1016/j.tet.2010.02.060⟩

Article dans une revue hal-02045958v1

Virtual Screening Discovery of New Acetylcholinesterase Inhibitors Issued from CERMN Chemical Library

Jana Sopkova-de Oliveira Santos , Aurélien Lesnard , Jean-Hugues Agondanou , Nathalie Dupont , Anne-Marie Godard et al.

Journal of Chemical Information and Modeling, 2010, 50 (3), pp.422-428. ⟨10.1021/ci900491t⟩

Article dans une revue hal-00705935v1

Synthesis, reactivity and biological evaluation of novel halogenated tripentones.

Vittoria Perri , Christophe Rochais , Thierry Cresteil , Patrick Dallemagne , Sylvain Rault

Bioorganic and Medicinal Chemistry, 2009, 17 (22), pp.7783-8. ⟨10.1016/j.bmc.2009.09.027⟩

Article dans une revue istex hal-00433244v1

Synthesis and Biological Evaluation of Thienopyrrolizines, a New Family of CDK/GSK-3 Inhibitors

Christophe Rochais , Elodie Lescot , Vincent Lisowski , Alban Lepailleur , Jana Sopkova-de Oliveira Santos et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, 2008, 19 (6), pp.585-593. ⟨10.1080/14756360400004565⟩

Article dans une revue hal-05481708v1

Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors.

Christophe Rochais , Nghia Vu Duc , Elodie Lescot , Jana Sopkova-de Oliveira Santos , Ronan Bureau et al.

European Journal of Medicinal Chemistry, 2008, epub ahead of print. ⟨10.1016/j.ejmech.2008.05.011⟩

Article dans une revue hal-00319802v1

Stress-responsive Mycobacterium tuberculosis subpopulations manipulate macrophage polarization and can be targeted to limit inflammation

Laura Pokorny , Lalit Kumar Singh , Nicolas Gangneux , Margaux Pillon , Claudia Chica et al.

2026

Pré-publication, Document de travail pasteur-05573086v1

Pharmacokinetic and safety of a novel pleiotropic compound in C57BL/6J mice with potential therapeutic interest in Alzheimer’s disease

Lahogue Caroline , Largilliere Stacy , Nee Gérald , Wang Alice , Lagadu Stéphanie et al.

FENS 2024, Jun 2024, Vienna, Austria

Poster de conférence hal-05334712v1

Pharmacokinetic and safety of a novel pleiotropic compound in C57BL/6J mice with potential therapeutic interest in Alzheimer’s disease

Caroline Lahogue , Stacy Largilliere , Gérald Nee , Alice Wang , Stéphanie Lagadu et al.

FENS 2024, Jun 2024, Vienne, Austria

Poster de conférence hal-04632974v1

29th Annual GP2A Medicinal Chemistry Conference

Jean-Jacques Helesbeux , Laura Carro , Florence Mccarthy , Vânia Moreira , Francesca Giuntini et al.

29th Annual GP2A Medicinal Chemistry Conference, Aug 2021, On line, France. Pharmaceuticals, 14 (12), MDPI, pp.1278, 2021, ⟨10.3390/ph14121278⟩

Proceedings/Recueil des communications hal-03969961v1

Dérivés du m-Gaïacol, leur préparation et leurs utilisations en tant que biocides, notamment en tant qu’antibactériens ou désinfectants. Brevet Français LABÉO-CERMN (Université de Caen)

Christophe Rochais , Stéphane Lemaitre , Feng Xiao , Sylvain Rault , Patrick Dallemagne et al.

France, N° de brevet: F073100004/FR/BN, INPI N°1856125. 2018

Brevet hal-03095627v1

Acetylcholinesterase Inhibitor Compounds and 5ht4 Serotonergic Receptor Agonists, with Promnesia Effect, Methods for the Preparation Thereof and Pharmaceutical Compositions Containing Same

Patrick Dallemagne , Christophe Rochais , Cédric Lecoutey , Michel Boulouard , Thomas Freret

France, Patent n° : WO2014195593 (A2). 2014

Brevet hal-02042939v1

2,5-Dimethoxytetrahydrofuran, first update

Christophe Rochais , Patrick Dallemagne

John Wiley & Sons, pp.2012, 2012, 9780471936237. ⟨10.1002/047084289X.rd289.pub2⟩

Ouvrages (dictionnaire, encyclopédie) hal-00821463v1

Chargement...

Christophe Rochais

Publications

Publications

Combining β 2 -AR agonism with butyrylcholinesterase inhibition, a synergistic neuroprotective action against Alzheimer's disease

Polyfunctionalized N-Arylsulfonyl Indoles: Identification of (E)-N-Hydroxy-3-{3-[(5-(3-(piperidin-1-yl)propoxy]-1H-indol-1-yl)sulfonyl]phenyl}acrylamide (MTP150) for the Epigenetic-based Therapy of Parkinson’s Disease

Radiobiology Contributions and Perspectives in Hadron Therapy, with a focus on carbon ions: Report from the workshop Hadron therapy for life, Caen, March 2025

An efficient step-by-step approach to select pleiotropic drug candidates against Alzheimer's disease: The discovery of neocopride

A combined experimental and computational insights into novel sulfa drug derivatives: Synthesis, DNA binding, molecular docking and DFT studies

Targeting together cholinesterases and serotonin reuptake against Alzheimer’s disease

Implication of Central β 2 Adrenergic Receptor for the Development of Novel Drugs Against Alzheimer's Disease

Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer’s disease by administration through an intranasal route

Analysis of skeletal diversity of multi-target directed ligands (MTDLs) targeting Alzheimer's disease

Shaping Future Medicinal Chemists: Perspectives from European Schools of Pharmacy within the GP 2 A Network

Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders

Anti-Breast Cancer Properties and In Vivo Safety Profile of a Bis-Carbazole Derivative

Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy

Studies on the mechanisms of action of MR33317

Synthesis and interest in medicinal chemistry of β-phenylalanine derivatives (β-PAD): an update (2010–2022)

Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT4 receptors with potential interest in the treatment of Alzheimer's disease

Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective Agents

Inducing neuronal regeneration and differentiation via the BDNF/TrkB signaling pathway: a key target against neurodegenerative diseases?

Discovery of a pocket network on the domain 5 of the TrkB receptor – A potential new target in the quest for the new ligands

Conceptual Framework of the Design of Pleiotropic Drugs against Alzheimer’s Disease

Design, synthesis and biological characterization of novel activators of the TrkB neurotrophin receptor

C3-Symmetric Ligands in Drug Design: When the Target Controls the Aesthetics of the Drug

Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

Advances in prodrug design for Alzheimer’s disease: the state of the art

Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer’s Disease Treatment through Rigidification Strategy

Desirable drug–drug interactions or when a matter of concern becomes a renewed therapeutic strategy

Aminothiaindanone as an Accessible Scaffold for a Three-Point Chemical Diversity

Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease

First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer’s Disease

5-HT4R modulators: a patent landscape

Facing the complexity of Alzheimer's disease

Matrix metalloproteinases as new targets in Alzheimer's disease: Opportunities and Challenges

Drug repositioning: a brief overview

hERG toxicity assessment: Useful guidelines for drug design

Donecopride, a Swiss army knife with potential interest against Alzheimer's disease

Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer’s Disease Treatment

Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease

Structure-activity relationships of serotonin 5-HT7 receptors ligands: A review

26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie

A chemical screen identifies two novel small compounds that alter Arabidopsis thaliana pollen tube growth

Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment

Modulating 5-HT 4 and 5-HT 6 receptors in Alzheimer’s disease treatment

3-(Dipropylamino)-5-hydroxybenzofuro[2,3-f]quinazolin-1(2H)-one (DPA-HBFQ-1) plays an inhibitory role on breast cancer cell growth and progression

Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT 4 R) partial agonist and 5-HT 6 R antagonist activities, as potential treatment of Alzheimer’s disease

Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment

Therapeutic Potential of 5-HT 6 Receptor Agonists

Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances

Indenopyrazole oxime ethers: Synthesis and β1-adrenergic blocking activity

Recent Advances in Phenanthroindolizidine and Phenanthroquinolizidine Derivatives with Anticancer Activities

Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease.

MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity.

Tripentones: A Promising Series of Potent Anti-Cancer Agents.

An unusual boron tribromide-mediated, one-pot bromination/cyclization reaction. Application to the synthesis of a highly strained cyclopenta[1,3]cyclopropa[1,2-b]pyrrolizin-8-one.

Synthesis of dual AChE/5-HT4 receptor multi-target directed ligands.

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.

Synthesis of dual AChE/5-HT4 receptor multi-target directed ligands

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT4 receptor activation (RS67333) on object recognition in mice.

Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect

First and mild synthesis of fluorene-9-malonic acid and some substituted derivatives via the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids

One-pot synthesis of new aza- and diaza-aminopenanthrenes

Hydrogenative desulphurization of thienopyrrolizinones: An easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity

Intramolecular Cyclisation of &#946;-Aryl-&#946;-Amino Acids in the Design of Novel Heterocyclic Systems with Therapeutic Interest: An Unfailing Source of Diversity

One-pot synthesis of novel poly-substituted phenanthrenes

Virtual Screening Discovery of New Acetylcholinesterase Inhibitors Issued from CERMN Chemical Library

Synthesis, reactivity and biological evaluation of novel halogenated tripentones.

Synthesis and Biological Evaluation of Thienopyrrolizines, a New Family of CDK/GSK-3 Inhibitors

Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors.

Stress-responsive Mycobacterium tuberculosis subpopulations manipulate macrophage polarization and can be targeted to limit inflammation

Pharmacokinetic and safety of a novel pleiotropic compound in C57BL/6J mice with potential therapeutic interest in Alzheimer’s disease

Pharmacokinetic and safety of a novel pleiotropic compound in C57BL/6J mice with potential therapeutic interest in Alzheimer’s disease

29th Annual GP2A Medicinal Chemistry Conference

Dérivés du m-Gaïacol, leur préparation et leurs utilisations en tant que biocides, notamment en tant qu’antibactériens ou désinfectants. Brevet Français LABÉO-CERMN (Université de Caen)

Acetylcholinesterase Inhibitor Compounds and 5ht4 Serotonergic Receptor Agonists, with Promnesia Effect, Methods for the Preparation Thereof and Pharmaceutical Compositions Containing Same

2,5-Dimethoxytetrahydrofuran, first update

Intramolecular Cyclisation of β-Aryl-β-Amino Acids in the Design of Novel Heterocyclic Systems with Therapeutic Interest: An Unfailing Source of Diversity