christophe sirac

Publications

Article dans une revue (42)

Untwisted amyloid fibrils from a transgenic mouse model of AL amyloidosis Luca Broggini,Diane Marie Valérie Bonnet,Karolina Swiderska,Sebastien Bender,Gilles Codoet al. Amyloid: The Journal of Protein Folding Disorders, 2025, pp.1-4. ⟨10.1080/13506129.2025.2605332⟩ Article dans une revue hal-05550137v1
Revisiting proliferative glomerulonephritis with monoclonal immunoglobulin deposits through immunoglobulin repertoire sequencing Vincent Javaugue,Virginie Pascal,Samih Nasr,Sébastien Bender,Paco Derouaultet al. Kidney International, 2025, 108 (6), pp.1146-1157. ⟨10.1016/j.kint.2025.07.039⟩ Article dans une revue hal-05550135v1
A mouse model of cardiac immunoglobulin light chain amyloidosis reveals insights into tissue accumulation and toxicity of amyloid fibrils Gemma Martinez-Rivas,Maria Victoria Ayala,Sebastien Bender,Gilles Roussine Codo,Weronika Karolina Swiderskaet al. Nature Communications, 2025, 16 (1), pp.2992. ⟨10.1038/s41467-025-58307-2⟩ Article dans une revue hal-05011638v1
In memoriam: Frank Bridoux (1963–2025) Christophe Sirac,Arnaud Jaccard,Nelson Leung,Jean-Paul Fermand Kidney International, 2025, 108 (6), pp.960-961. ⟨10.1016/j.kint.2025.09.017⟩ Article dans une revue hal-05550136v1
Single-hit genome editing optimized for maturation in B cells redirects their specificity toward tumor antigens Natsuko Ueda,Marine Cahen,Jenny Leonard,Laurent Deleurme,Stéphane Dreanoet al. Scientific Reports, 2024, 14 (1), pp.22432. ⟨10.1038/s41598-024-74005-3⟩ Article dans une revue hal-04723581v1
Monoclonal Immunoglobulin Crystalline Membranous Nephropathy Salvatore Mignano,Virginie Pascal,Nnaemezie Odioemene,William Forehand,Vincent Javaugueet al. American Journal of Kidney Diseases, 2024, ⟨10.1053/j.ajkd.2023.11.011⟩ Article dans une revue hal-04489789v1
RNA-based immunoglobulin repertoire sequencing is a new tool for the management of monoclonal gammopathy of renal (kidney) significance Vincent Javaugue,Virginie Pascal,Sébastien Bender,Sarah Nasraddine,Mathilde Dargeloset al. Kidney International, 2022, 101 (2), pp.331-337. ⟨10.1016/j.kint.2021.10.017⟩ Article dans une revue hal-03482172v1
Immunotherapy perspectives in the new era of B-cell editing Natsuko Ueda,Marine Cahen,Yannic Danger,Jérôme Moreaux,Christophe Siracet al. Blood Advances, 2021, 5 (6), pp.1770-1779. ⟨10.1182/bloodadvances.2020003792⟩ Article dans une revue hal-03202338v1
A rat model expressing a human amyloidogenic kappa light chain Maria Victoria Ayala,Sébastien Bender,Ignacio Anegon,Séverine Menoret,Frank Bridouxet al. Amyloid: The Journal of Protein Folding Disorders, 2021, 28 (3), pp.209-210. ⟨10.1080/13506129.2021.1877651⟩ Article dans une revue inserm-04574739v1
IgH 3’ regulatory region increases ectopic class switch recombination Sandrine Le Noir,Amélie Bonaud,Bastien Hervé,Audrey Baylet,François Boyeret al. PLoS Genetics, 2021, 17 (2), pp.e1009288. ⟨10.1371/journal.pgen.1009288⟩ Article dans une revue hal-03371044v1
Immunoglobulin light chain toxicity in a mouse model of monoclonal immunoglobulin light-chain deposition disease Sébastien Bender,Maria Victoria Ayala,Amélie Bonaud,Vincent Javaugue,Claire Carrionet al. Blood, 2020, ⟨10.1182/blood.2020005980⟩ Article dans une revue hal-03825748v1
Immunoglobulin variable domain high-throughput sequencing reveals specific novel mutational patterns in POEMS syndrome Sébastien Bender,Vincent Javaugue,Alexis Saintamand,Maria Victoria Ayala,Mehdi Alizadehet al. Blood, 2020, 135 (20), pp.1750-1758. ⟨10.1182/blood.2019004197⟩ Article dans une revue hal-03228600v1
Heavy Chain Fibrillary Glomerulonephritis: A Case Report Samih Nasr,Christophe Sirac,Frank Bridoux,Vincent Javaugue,Sebastien Benderet al. American Journal of Kidney Diseases, 2019, 74 (2), pp.276-280. ⟨10.1053/j.ajkd.2019.01.032⟩ Article dans une revue hal-02361885v1
Randall-type monoclonal immunoglobulin deposition disease: novel insights from a nationwide cohort study Florent Joly,Camille Cohen,Vincent Javaugue,Sébastien Bender,Mohamed Belmouazet al. Blood, 2019, 133 (6), pp.576-587. ⟨10.1182/blood-2018-09-872028⟩ Article dans une revue hal-02343953v1
Comprehensive molecular characterization of a heavy chain deposition disease case Sébastien Bender,Maria Victoria Ayala,Vincent Javaugue,Amélie Bonaud,Michel Cognéet al. Haematologica, 2018, 103 (11), pp.e557-e560. ⟨10.3324/haematol.2018.196113⟩ Article dans une revue hal-02343962v1
Animal models of monoclonal immunoglobulin-related renal diseases Christophe Sirac,Guillermo Herrera,Paul Sanders,Vecihi Batuman,Sébastien Benderet al. Nature Reviews Nephrology, 2018, 14 (4), pp.246-264. ⟨10.1038/nrneph.2018.8⟩ Article dans une revue hal-02344013v1
Physiological and druggable skipping of immunoglobulin variable exons in plasma cells Mohamad Omar Ashi,Nivine Srour,Jean-Marie Lambert,Anne Marchalot,Ophélie Martinet al. Cellular and molecular immunology, 2018, ⟨10.1038/s41423-018-0160-6⟩ Article dans une revue hal-02048156v1
Unravelling the immunopathological mechanisms of heavy chain deposition disease with implications for clinical management Frank Bridoux,Vincent Javaugue,Sébastien Bender,Fannie Leroy,Pierre Aucouturieret al. Kidney International, 2017, 91 (2), pp.423-434. ⟨10.1016/j.kint.2016.09.004⟩ Article dans une revue hal-02364147v1
A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig production Nivine Srour,Guillaume Chemin,Aurélien Tinguely,Mohamad Omar Ashi,Zéliha Orucet al. Journal of Experimental Medicine, 2016, 213 (1), pp.109-122. ⟨10.1084/jem.20131511⟩ Article dans une revue hal-01501807v1
Impaired Lysosomal Function Underlies Monoclonal Light Chain–Associated Renal Fanconi Syndrome Alessandro Luciani,Christophe Sirac,Sara Terryn,Vincent Javaugue,Jenny Ann Prangeet al. Journal of the American Society of Nephrology, 2016, 27 (7), pp.2049-2061. ⟨10.1681/ASN.2015050581⟩ Article dans une revue hal-02364437v1
Maladie de dépôts d’immunoglobulines monoclonales de type Randall : du diagnostic au traitement Camille Cohen,Vincent Javaugue,Florent Joly,Bertrand Arnulf,Jean-Paul Fermandet al. Néphrologie & Thérapeutique, 2016, 12 (3), pp.131-139. ⟨10.1016/j.nephro.2015.12.005⟩ Article dans une revue istex hal-02364443v1
A mouse model recapitulating human monoclonal heavy chain deposition disease evidences the relevance of proteasome inhibitor therapy. Amélie Bonaud,Sébastien Bender,G Touchard,C Lacombe,Nivine Srouret al. Blood, 2015 Article dans une revue hal-01212560v1
Kidney Diseases Associated With Monoclonal Immunoglobulin M-Secreting B-Cell Lymphoproliferative Disorders: A Case Series of 35 Patients. Sophie Chauvet,Franck Bridoux,L Ecotière,V Javaugue,Christophe Siracet al. American Journal of Kidney Diseases, 2015 Article dans une revue hal-01212509v1
Efficient AID targeting of switch regions is not sufficient for optimal class switch recombination. Amélie Bonaud,Fabien Lechouane,S Le Noir,O Monestier,Michel Cognéet al. Nature Communications, 2015 Article dans une revue hal-01212525v1
Production of human or humanized antibodies in mice. Brice Laffleur,Virginie Pascal,Christophe Sirac,Michel Cogné Methods in Molecular Biology, 2012, 901, pp.149-59. ⟨10.1007/978-1-61779-931-0_9⟩ Article dans une revue hal-00779395v1
Al amyloidosis. Estelle Desport,Franck Bridoux,Christophe Sirac,Sébastien Delbes,Sébastien Benderet al. Orphanet Journal of Rare Diseases, 2012, 7, pp.54. ⟨10.1186/1750-1172-7-54⟩ Article dans une revue hal-00903818v1
Cross talk between immunoglobulin heavy-chain transcription and RNA surveillance during B cell development. Aurélien Tinguely,Guillaume Chemin,Sophie Péron,Christophe Sirac,Stéphane Reynaudet al. Molecular and Cellular Biology, 2012, 32 (1), pp.107-17. ⟨10.1128/MCB.06138-11⟩ Article dans une revue hal-00696497v1
[Renal disorders associated with monoclonal gammopathies: diagnostic and therapeutic progress]. Franck Bridoux,Sébastien Delbes,Christophe Sirac,François Pourreau,Matthieu Puyadeet al. La Presse Médicale, 2012, 41 (3 Pt 1), pp.276-89. ⟨10.1016/j.lpm.2011.11.008⟩ Article dans une revue istex hal-00903817v1
The pathogenesis and diagnosis of acute kidney injury in multiple myeloma. Colin A Hutchison,Vecihi Batuman,Judith Behrens,Franck Bridoux,Christophe Siracet al. Nature Reviews Nephrology, 2012, 8 (1), pp.43-51. ⟨10.1038/nrneph.2011.168⟩ Article dans une revue hal-00696471v1
B-cell receptor signal strength influences terminal differentiation. Fabien Lechouane,Amélie Bonaud,Laurent Delpy,Stefano Casola,Zéliha Orucet al. European Journal of Immunology, 2012, epub ahead of print. ⟨10.1002/eji.201242912⟩ Article dans une revue hal-00779414v1
Toward understanding renal Fanconi syndrome: step by step advances through experimental models. Christophe Sirac,Franck Bridoux,Marie Essig,Olivier Devuyst,Guy Touchardet al. Contributions to Nephrology, 2011, 169, pp.247-61. ⟨10.1159/000313962⟩ Article dans une revue hal-00696465v1
Strategies to model AL amyloidosis in mice. Christophe Sirac,Sébastien Bender,Arnaud Jaccard,Franck Bridoux,C. Lacombeet al. Amyloid: The Journal of Protein Folding Disorders, 2011, 18 (Suppl 1), pp.45-47. ⟨10.3109/13506129.2011.574354016⟩ Article dans une revue hal-00617188v2
Premature replacement of {micro} with {alpha} immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation. Sophie Duchez,Rada Amin,Nadine Cogné,Laurent Delpy,Christophe Siracet al. Proceedings of the National Academy of Sciences of the United States of America, 2010, epub ahead of print. ⟨10.1073/pnas.0912393107⟩ Article dans une revue hal-00454129v1
Multiple RNA surveillance mechanisms cooperate to reduce the amount of nonfunctional Ig kappa transcripts. Guillaume Chemin,Aurélien Tinguely,Christophe Sirac,Fabien Lechouane,Sophie Duchezet al. Journal of Immunology, 2010, 184 (9), pp.5009-17. ⟨10.4049/jimmunol.0902949⟩ Article dans une revue hal-00511941v1
Light chain inclusion permits terminal B cell differentiation and does not necessarily result in autoreactivity. Christophe Sirac,Claire Carrion,Sophie Duchez,Isabelle Comte,Michel Cogné Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (20), pp.7747-52. ⟨10.1073/pnas.0509121103⟩ Article dans une revue hal-00073857v1
Role of the monoclonal kappa chain V domain and reversibility of renal damage in a transgenic model of acquired Fanconi syndrome. Christophe Sirac,Franck Bridoux,Claire Carrion,Olivier Devuyst,Béatrice Fernandezet al. Blood, 2006, 108 (2), pp.536-543. ⟨10.1182/blood-2005-11-4419⟩ Article dans une revue hal-00085051v1
Interallelic Class Switch Recombination Contributes Significantly to Class Switching in Mouse B Cells Stéphane Reynaud,Laurent Delpy,Laurence Fleury,Hei-Lanne Dougier,Christophe Siracet al. Journal of Immunology, 2005, 174, pp.5905-5906 Article dans une revue hal-00022865v1
Interallelic class switch recombination contributes significantly to class switching in mouse B cells. Stéphane Reynaud,Laurent Delpy,Laurence Fleury,Hei-Lanne Dougier,Christophe Siracet al. Journal of Immunology, 2005, 174 (10), pp.6176-83 Article dans une revue hal-00458866v1
Fanconi's syndrome induced by a monoclonal Vkappa3 light chain in Waldenstrom's macroglobulinemia. Franck Bridoux,Christophe Sirac,V. Hugue,Catherine Decourt,A. Thierryet al. American Journal of Kidney Diseases, 2005, 45 (4), pp.749-57. ⟨10.1053/j.ajkd.2004.12.020⟩ Article dans une revue hal-00022808v1
Transcription-dependent somatic hypermutation occurs at similar levels on functional and nonfunctional rearranged IgH alleles. Laurent Delpy,Christophe Sirac,Caroline Le Morvan,Michel Cogné Journal of Immunology, 2004, 173 (3), pp.1842-8 Article dans une revue hal-00023372v1
RNA surveillance down-regulates expression of nonfunctional kappa alleles and detects premature termination within the last kappa exon. Laurent Delpy,Christophe Sirac,Emmanuelle Magnoux,Sophie Duchez,Michel Cogné Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (19), pp.7375-80. ⟨10.1073/pnas.0305586101⟩ Article dans une revue hal-00023270v1
Immunologic basis for the rare occurrence of true nonsecretory plasma cell dyscrasias. Catherine Decourt,Horia Radu Galea,Christophe Sirac,Michel Cogné Journal of Leukocyte Biology, 2004, 76 (3), pp.528-36. ⟨10.1189/jlb.0803382⟩ Article dans une revue hal-00023271v1

Communication dans un congrès (2)

Bilan des modèles murins de maladies de dépôts d'Immunoglobulines monoclonales Christophe Sirac Réunion annuelle du centre de référence des amyloses et maladies de dépôts d'immunoglobulines monoclonales, Jan 2014, PARIS, France Communication dans un congrès hal-00947189v1
Déterminants de la toxicité rénale des immunoglobulines monoclonales Christophe Sirac Réunion annuelle du Club des Jeunes Néphrologues, Mar 2012, Montpellier, France Communication dans un congrès hal-00947188v1

Ouvrages (1)

Disruption of immunoglobulin heavy and light chain assembly by antisense oligonucleotides impairs protein homeostasis and myeloma cell survival Catherine Horiot,Murielle Roussel,Antoine Praité,Justine Pollet,Sébastien Benderet al. 2023, ⟨10.1101/2023.08.29.555385⟩ Ouvrages hal-04306136v1

Chapitre d'ouvrage (2)

Atteintes uro-néphrologiques au cours des amyloses Franck Bridoux,Arnaud Jaccard,Christophe Sirac,J. Gillmore,Michel Cognéet al. Atteintes uro-néphrologiques au cours des maladies systémiques, Flammarion Médecine Sciences, pp.1-22, 2009 Chapitre d'ouvrage hal-00453323v1
Renal disease in cryoglobulinemic vasculitis Franck Bridoux,Christophe Sirac,Arnaud Jaccard,R. Abou Ayache,Jm Goujonet al. The kidney in systemic autoimmune diseases, Elsevier, pp.215-240, 2008 Chapitre d'ouvrage hal-00453329v1

Brevet (1)

Mammifère non-humain transgénique pour la région constante de la chaîne lourde des IgA humaines et ses applications (monoclonaux humanisés à destinée muqueuse) Michel Cogné,Caroline Le Morvan,Christophe Sirac N° de brevet: WO2005047333. 2005 Brevet hal-00514480v1

Pré-publication, Document de travail (4)

A mouse model of cardiac AL amyloidosis unveils mechanisms of tissue accumulation and toxicity of amyloid fibrils G Martinez-Rivas,M V Ayala,S Bender,G R Codo,K Swiderskaet al. 2024 Pré-publication, Document de travail hal-04797319v1
Selective killing of plasma cell clones using splice-switching oligonucleotides targeting immunoglobulin variable exons Jean-Marie Lambert,Antoine Praité,Marion Contini,Mohamad Omar Ashi,Anne Marchalotet al. 2024 Pré-publication, Document de travail hal-04797326v1
Disruption of immunoglobulin heavy and light chain assembly by antisense oligonucleotides impairs protein homeostasis and myeloma cell survival Catherine Horiot,Murielle Roussel,Antoine Praité,Justine Pollet,Sébastien Benderet al. 2024 Pré-publication, Document de travail hal-04797311v1
Glomerulosclerosis and kidney failure in a mouse model of monoclonal immunoglobulin light-chain deposition disease Sébastien Bender,Maria Victoria Ayala,Amélie Bonaud,Vincent Javaugue,Claire Carrionet al. 2019 Pré-publication, Document de travail (preprint/prepublication) hal-03967308v1